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Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

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Frontiers of Chemical science and Engineering 2019年第2期13卷 330-339页

作者： Ana Mora-Boza Francisco J.Aparicio maria Alcaire Carmen López-santos Juan P.Espinós Daniel Torres-Lagares Ana Borrás Angel Barranco Consejo superior de Investigaciones Cientificas. Instituto de Ciencia de Materiales de sevilla (CsIC-Universidad de sevilla) c/Americo Vespucio 49 41092 SevillaSpain Facultad de Odontologia Universidad de Sevilla (USE) c/Avicena41009 SevillaSpain

Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMs) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against Escherichia coli K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMs surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.

关键词： plasma polymers conformal plasma deposition chlorhexidine bactericide PDMs biocompatibility

synthesis, Characterization and Thermophysical Properties of Three Neoteric solvents-Ionic Liquids Based on Choline Chloride

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Chemical Research in Chinese Universities 2014年第1期30卷 119-124页

作者： POPEsCU Ana-maria CONsTANTIN Virgil Laboratory of Molten salts llie Murgulescu Institute of Physical Chemistry of the Romanian Academy Bucharest 006021 Romania

The authors prepared,characterized and preliminary studied the properties of some neoteric solvents-ionic liquids based on choline chloride,i.e.,three ionic liquids based on the eutectics of choline chloride（2-hydroxyN,N,N-trimethylethanaminium chloride） with,respectively,urea,malonic acid and citric *** obtained mixtures were clear and colorless ionic liquids at room *** thermophysical properties,namely,density,viscosity,and electrical conductivity of these mixtures were investigated as a function of temperature within a range of 298-353 *** for the temperature dependence of the measured properties were generated and discussed in terms of Arrhenius *** the electrochemical windows of the eutectic liquids were determined.

关键词： Neoteric solvent Ionic liquid Choline chloride Malonic acid Citric acid Density Viscosity Conductivity

Large-area Analysis of soil Erosion and Landslides Induced by Rainfall: A Case of Unsaturated shallow Deposits

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Journal of Mountain science 2015年第4期12卷 783-796页

作者： CUOMO sabatino DELLA sALA maria Department of Civil Engineering University of Salerno

Unsaturated shallow soil deposits may be affected by either superficial soil erosion or shallow landslides in adjacent or overlapping source areas and in different seasons when a different soil suction *** triggering analysis of both these processes is a relevant issue for the hazard analysis while the literature mostly provides specific approaches for erosion or for *** paper proposes a largearea analysis for a case study of southern Italy,consisting of unsaturated shallow deposits of loose pyroclastic(air-fall) volcanic soils that have been repeatedly affected by erosion and landslides in special *** a past catastrophic event, the simulated source areas of shallow landslides are smaller than those observed in the field while the simulated eroded areas with thickness greater than 5cm are comparable with the in-situ evidences, if the analysis takes into account high rainfall intensity and a spatially variable soil cover *** in general, the results of the paper are consistent with the previous literature and also provide a methodological contribution about the application of distinct tools over large *** added value is that the paper shows how the combination of distinct large-area analyses may help with understanding the dominant slope instability *** once this goal is fully achieved, can specific physically-based analyses be confidently performed at detailed scales and for smaller specific areas.

关键词： soil Erosion Landslide soil suction slope instability mechanism Modelling

FRACTIONAL 2D-sTOCHAsTIC CURRENTs

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Acta Mathematica scientia 2013年第6期33卷 1507-1521页

作者： Ciprian A.TUDOR maria TUDOR Laboratoire Paul Painlev Universit de Lille 1 F-59655 Villeneuve d’AscqFrance Department of Mathematics Academy of Economical StudiesBucharestRomania

Using multiple stochastic integrals and the stochastic calculus for the frac-tional Brownian sheet, we define and we analyze the 2D-fractional stochastic currents.

关键词： currents multiple stochastic integrals fractional Brownian sheet two-parameter processes Hurst parameter

Physical aspects of f(R,G_(μν)T^(μν))modified gravity theories

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Chinese Physics C 2023年第10期47卷 237-248页

作者： Mihai Marciu Dana maria Ioan Faculty of Physics University of Bucharest405 AtomistilorPOB MG-11RO-077125Bucharest-MagureleRomania

The paper extends basic Einstein–Hilbert action by incorporating an invariant derived from a specific contraction between the Einstein tensor and energy momentum *** represents a non–minimal coupling between the space–time geometry and matter *** fundamental Einstein–Hilbert action is extended by considering a generic function f(R,GμνTμν).This function is subsequently dissected into its primary components:a geometric part reliant on the scalar curvature,and another segment encapsulating the interaction between geometry and matter *** cosmological models are formulated at the backdrop of these dynamics,rooted in specific associations between the matter energy-momentum tensor and Einstein *** deriving the consequent field equations,the cosmological model's physical implications are explored through a dynamical system analysis applied to diverse coupling *** exploration reveals that the current model aligns with various phases in the Universe's evolution,potentially elucidating several late-time historical epochs.

关键词： dark energy cosmology modified gravity theories

Hepatitis B and inflammatory bowel disease: Role of antiviral prophylaxis

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World Journal of Gastroenterology 2013年第9期19卷 1342-1348页

作者： Pilar López-serrano Jose Lázaro Pérez-Calle maria Dolores sánchez-Tembleque Department of Gastroenterology University Hospital Fundación Alcorcón 28922 Madrid Spain Department of Gastroenterology University Hospital of Guadalajara 19002 Guadalajara Spain

Hepatitis B virus (HBV) is a very common infection worldwide. Its reactivation in patients receiving immunosuppression has been widely described as being associated with significant morbidity and mortality unless anti-viral prophylaxis is administered. Treatment in inflammatory bowel disease (IBD) patients has changed in recent years and immunosuppression and biological therapies are now used more frequently than before. Although current studies have reported an incidence of hepatitis B in inflammatory bowel disease patients similar to that in the general population, associated liver damage remains an important concern in this setting. Liver dysfunction may manifest in several ways, from a subtle change in serum aminotransferase levels to fulminant liver failure and death. Patients undergoing double immunosuppression are at a higher risk, and reactivation usually occurs after more than one year of treatment. As preventive measures, all IBD patients should be screened for HBV markers at diagnosis and those who are positive for the hepatitis B surface antigen should receive antiviral prophylaxis before undergoing immunosuppression in order to avoid HBV reactivation. Tenofovir/entecavir are preferred to lamivudine as nucleos(t)ide analogues due to their better resistance profile. In patients with occult or resolved HBV, viral reactivation does not appear to be a relevant issue and regular DNA determination is recommended during immunosuppression therapy. Consensus guidelines on this topic have been published in recent years. The prevention and management of HBV infection in IBD patients is addressed in this review in order to address practical

关键词： Hepatitis B virus Inflammatory bowel disease Anti-tumor necrosis factor Prophylaxis Immunosuppressants

Current stage in inflammatory bowel disease: What is next?

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World Journal of Gastroenterology 2015年第40期21卷 11282-11303页

作者： Gonzalo Jesús Gómez-Gómez ángeles Masedo Carmen Yela maria del Pilar Martínez-Montiel Begona Casís Unidad de Enfermedad Inflamatoria Intestinal Hospital 12 de Octubre

In recent years,the incidence of inflammatory bowel disease(IBD) has been on the rise,extending to countries where it was infrequent in the past. As a result,the gap between high and low incidence countries is decreasing. The disease,therefore,has an important economic impact on the healthcare system. Advances in recent years in pharmacogenetics and clinical pharmacology have allowed for the development of treatment strategies adjusted to the patient profile. Concurrently,new drugs aimed at inflammatory targets have been developed that may expand future treatment options. This review examines advances in the optimization of existing drug treatments and the development of novel treatment options for IBD.

关键词： Inflammatory bowel disease Future directions Pharmacogenetic Pharmacokinetics New drugs

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten s.Hansen Kaja Madsen maria Price Kent søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and systems Research(IMsR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density sNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(ssTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating ssTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Larch growth across thermal and moisture gradients in the siberian Mountains

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Journal of Mountain science 2023年第1期20卷 101-114页

作者： KHARUK Viacheslav I. PETROV Il'ya A. GOLYUKOV Alexey s. DVINsKAYA maria L. IM sergei T. sHUsHPANOV Alexander s. sukachev Institute of Forest Federal Scientific CenterRussian Academy of ScienceSiberian BranchAcademgorodok 50/28Krasnoyarsk660036Russia siberian Federal University Svobodny str.79Krasnoyarsk660041Russia Reshetnev siberian state University of science and Technology Krasnoyarsky rabochy str.31Krasnoyarsk660014Russia Tomsk state University Lenina str.36Tomsk634050Russia

Climate-driven changes in the thermal and moisture regimes may variously influence different tree species growth and *** hypothesize that drought resistant siberian larch(Larix sibirica Ledeb.)and precipitation-sensitive siberian pine(Pinus sibirica Du Tour)responded differently to climate change along the elevational thermal and precipitation *** studied the influence of air temperature,precipitation,soil moisture,and atmospheric drought(indicated by the drought index sPEI)on larch and pine growth along the southward megaslope of the West sayan *** found that since 2000 climate change resulted in increasing larch and pine radial growth index(GI)(c.1.5–3times)within treeline(2000–2300 m)and timberline(1900–2000 m)ecotones,*** high precipitation *** the forest-steppe ecotone(1100–1200 m)in which *** is the only species,larch GI stagnated or even *** total forested area increased since 2000 up to+50%in the high elevations,whereas in the low elevations(s were *** treeline and timberline,trees’GI was stimulated by summer ***,temperature increase in early spring reduces GI due to living tissue activation followed by tissue damage by *** forest-steppe,larch radial growth was mostly dependent on soil *** shifted dependence on moisture to the early dates of the growing *** droughts decreased GI within forest-steppe as well as within treeline,whereas the drought influence on both species within highlands was *** forest-steppe seedlings establishment was poor,whereas it was successful within treeline and *** climate change leads to stagnation or even decrease in Larix sibirica growth in the southern lowland *** combination with poor seedlings establishment,reduced growth threatens the transformation of open lowland forests into forest-steppe and steppe ***,in the highlands warming

关键词： Larch siberian pine Climate influence on tree radial growth Mountain forests Treeline Timberline Foreststeppe Drought stress Moisture stress