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Advances in teleophthalmology and artificial intelligence for diabetic retinopathy screening:a narrative review

Annals of Eye Science 2024年第2期9卷 24-37页

作者： Tanvi Chokshi maria jessica cruz Jonathon Ross Glenn Yiu Tschannen Eye Institute Department of OphthalmologyUniversity of CaliforniaDavis HealthSacramentoCAUSA Department of Research College of MedicineCalifornia Northstate UniversityElk GroveCAUSA

Background and Objective:Advances in teleophthalmology and artificial intelligence(AI)for diabetic retinal screening is of growing public health ***,only 30–40%of patients with diabetes adhere to recommended diabetes screening *** enhance early detection and reduce vision threatening complications,there has been a growing number of teleophthalmology programs and novel AI algorithms with the aim to improve eye care *** purpose of this review is to assess current literature on teleophthalmology and AI for use in diabetic retinopathy(DR)screening,and to discuss advances and barriers to these innovative ***:Literature review involving teleophthalmology and AI for DR screening,with focus on the past *** Content and Findings:Teleophthalmology has demonstrated the ability to increase DR screening rates,enable earlier eye care access,and reduce healthcare *** AI-based DR screening programs appear accurate and effective,but detection of other ocular pathologies is still under development and not yet approved in the United ***,technological,financial,and legal barriers limit widespread adoption and long-term sustainability of teleophthalmology ***:The use of teleophthalmology and AI algorithms expands eye care access and helps prevent vision loss from DR and potentially other sight threatening *** in the process utilized for arriving at a particular diagnosis or decision to refer,often referred to as the“black box”,remains a multifaceted issue within the field of telemedicine for developing trust and improving patient-centered outcomes.

关键词： Teleophthalmology artificial intelligence(AI) diabetic retinopathy(DR) screening public health

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Unraveling the routes to distant metastases in colorectal cancer:Tumor deposits and lymph node metastases as the gateway

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Cancer Communications 2024年第10期44卷 1209-1213页

作者： Nelleke Pietronella maria Brouwer Ayse Selcen Oguz Erdogan Shannon van Vliet Natasja Rutgers Nikki Knijn Gesina van Lijnschoten jessica Juliana Tan Johannes Hendrik Willem de Wilt Niek Hugen Gina Brown Femke Simmer Iris Dionne Nagtegaal Department of Pathology Radboud University Medical CenterNijmegenGelderlandThe Netherlands Department of Pathology PathologyDNAArnhemGelderlandThe Netherlands Department of Pathology Eurofins/Laboratoria voor Pathologie en Medische Microbiologie NederlandEindhovenNoord-BrabantThe Netherlands GI Cancer Imaging Research Unit The Royal Marsden HospitalSuttonLondonUnited Kingdom Department of Surgery Radboud University Medical CenterNijmegenGelderlandThe Netherlands Department of Surgery Netherlands Cancer InstituteAmsterdamNoord-HollandThe Netherlands Department of Surgery Rijnstate HospitalArnhemGelderlandThe Netherlands Imperial College London Hammersmith Campus LondonLondonUnited Kingdom

Currently,lymph node metastases(LNM)are seen as the gateway to distant metastases in CRC and play a crucial role in the Tumor Node Metastasis(TNM)staging system[1,2].Tumor deposits(TD)have been identified as another histological feature with a strong prognostic impact but are currently only deemed clinically relevant in the absence of LNM[2,3].TD are clusters of tumor cells in the fat surrounding the bowel and are often associated with nerves,vessels and lymphatic tissue,giving the cancer cells access to multiple routes of spread[4].

关键词： metastases cancer gateway

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The Heme-Binding Protein SOUL3 of Chlamydomonas reinhardtii Influences Size and Position of the Eyespot

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Molecular Plant 2013年第3期6卷 931-944页

作者： Thomas Schulze Sandra Schreiber Dobromir Iliev Jens Boesger jessica Trippens Georg Kreimer maria Mittag Institute of General Botany and Plant Physiology Friedrich Schiller University Jena 07743 Jena Germany Department of Biology Cell Biology Friedrich Alexander University Erlangen 91058 Erlangen Germany

The flagellated green alga Chlamydomonas reinhardtii has a primitive visual system, the eyespot. It is situated at the cells equator and allows the cell to phototax. In a previous proteomic analysis of the eyespot, the SOUL3 protein was identified among 202 proteins. Here, we investigate the properties and functions of SOUL3. Heterologously expressed SOUL3 is able to bind specifically to hemin. In C. reinhardtii, SOUL3 is expressed at a constant level over the diurnal cycle, but forms protein complexes that differ in size during day and night phases. SOUL3 is primarily localized in the eyespot and it is situated in the pigment globule layer thereof. This is in contrast to the channelrhodopsin photoreceptors, which are localized in the plasma membrane region of the eyespot. Knockdown lines with a significantly reduced SOUL3 level are characterized by mislocalized eyespots, a decreased eyespot size, and alterations in phototactic behavior. Mislocalizations were either anterior or posterior and did not affect association with acetylated microtubules of the daughter four-membered rootlet. Our data suggest that SOUL3 is involved in the organization and placement of the eyespot within the cell.

关键词： Chlamydomonas reinhardtii eyespot heme-binding protein SOUL3.

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Overview of HIV drug resistance and its implications for China

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Chinese Medical Journal 2006年第23期119卷 1999-2004页

作者： maria Au jessica Haberer Division of Treatment and Care National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

Since the initiation of China＇s nationwide free antiretroviral therapy （ART） in 2002, the availability of highly active antiretroviral therapy （HAART） in China has increased dramatically. HAART has been proven to prolong survival and control HIV disease progression. At the same time, experience in developed countries indicates that the high mutation rate of the virus in the presence of HAART is associated with drug resistance and diminished efficacy. The increase in HAART availability and use in China therefore also comes with the potential for increased resistance. Transmission of drug-resistant strains to individuals who have never been exposed to ART is on the rise. Moreover, studies have shown that new infections by drug-resistant virus result in suboptimal response to ART. With the rapid scale up of ART in China in recent years, the prevalence of HIV drug resistance will likely increase, posing a major public health concern in China. This review article provides an overview of ART resistance, the current worldwide trends in HIV drug resistance, the effect of HIV drug resistance in clinical management, and the implications for China＇s HIV treatment and care.

关键词： human immunodeficiency virus drug resistance antiretroviral therapy mutation

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A Comparative Study of the Effect of Gold Seed Particle Preparation Method on Nanowire Growth

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Nano Research 2010年第7期3卷 506-519页

作者： maria E.Messing Karla Hillerich jessica Bolinsson Kristian Storm Jonas Johansson Kimberly A.Dick Knut Deppert Solid State Physics Lund UniversityBox 118S-22100 LundSweden Polymer&Materials Chemistry Lund UniversityBox 124S-22100 LundSweden

Highly controlled particle-assisted growth of semiconductor nanowires has been performed for many years,and a number of novel nanowire-based devices have been *** control of the epitaxial growth is required to optimize the performance of devices,and gold seed particles are known to provide the most controlled *** nanowire growth from gold particles generated and deposited by various different methods has been reported,but no investigation has yet been performed to compare the effects of gold particle generation and deposition methods on nanowire *** this article we present a direct comparative study of the effect of the gold particle creation and deposition methods on nanowire growth characteristics and nanowire crystal structure,and investigate the limitations of the different generation and deposition methods used.

关键词： Nanowire growth nanoparticles gold epitaxy electron microscopy

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Raman spectra and vibrational analysis of CsPbI3:A fast and reliable technique to identify lead halide perovskite polymorphs

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Journal of Materiomics 2021年第1期7卷 127-135页

作者： jessica Satta Claudio Melis Carlo maria Carbonaro Andrea Pinna Manuel Salado Daniel Salazar Pier Carlo Ricci Department of Physics University of CagliariS.p.No.8 Km 0.70009042MonserratoCAItaly Department of Mechanical Chemical and Materials EngineeringCINSAINSTMUniversity of CagliariVia Marengo 2CagliariI-09123Italy BCMaterials Basque Center for MaterialsApplications and NanostructuresUPV/EHU Science Park48940LeioaSpain

A major issue in the development of Lead halide perovskites is the assessment of the crystal structure of the samples,due to their typically limited time-stability,and the understanding of the role of external factors that can induce a crystal phase transformation(such as humidity,intense light flux,temperature,etc.).In this perspective,it is of utmost importance to have at disposal a fast and reliable experimental tool able to give an immediate indication of the polymorph of the sample with the possibility to integrate in-situ measurements for constant *** this paper we propose Raman spectroscopy as the ideal technique to solve this *** vibrational analysis of CsPbI3 in the a-phase and 5-phase and of the Cs4PbI6 secondary phase is reported and all the vibrational modes are assigned by comparing experimental spectra of the phases to Raman modes calculated within the DFT ***,the mechanism of laser induced phase degradation was studied using in-situ Raman measurements providing new insights on the secondary phase generated during the process.

关键词： Raman spectroscopy CsPb13 Inorganic lead halide perovskites Phase transformation

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Management of single pulmonary metastases from colorectal cancer:State of the art

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 820-832页

作者： Marco Chiappetta Lisa Salvatore maria Teresa Congedo maria Bensi Viola De Luca Leonardo PetraccaCiavarella Floriana Camarda jessica Evangelista Vincenzo Valentini Giampaolo Tortora StefanoMargaritora Filippo Lococo Department of Thoracic Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Oncologia Medica Comprehensive Cancer Center Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Radiation Therapy Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy

Colorectal cancer(CRC)is one of the most common causes of death from *** seeding occurs in approximately 10%of patients surgically treated for primary CRC with radical intent:the lung is the most common site of metastases after the *** surgical treatment of liver metastases is widely accepted to affect long-term outcomes,more controversial and not standardized is the therapy for CRC patients developing lung *** suggests the potential curative role of pulmonary metastasectomy,especially in oligometastatic ***,the optimal strategy of care and the definition of prognostic factors after treatment still need to be *** review focused on the uncommon scenario of single pulmonary metastases from *** explored pertinent literature and provide an overview of the epidemiology,clinical characteristics and imaging of single pulmonary metastases from ***,we identified the best available evidence for overall *** particular,we analyzed the role and results of locoregional approaches(surgery,radiotherapy or ablative procedures)and their integration with systemic therapy.

关键词： Colorectal cancer Pulmonary metastases Oligometastases Chemotherapy Surgery Radiotherapy

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The influence of electrochemical treatment on electrode reactions for vanadium redox-flow batteries

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Journal of Energy Chemistry 2018年第5期27卷 1341-1352页

作者： Jens Noack Nataliya RoznYatovskaya jessica Kunzendorf maria Skyllas-Kazacos Chris Menictas Jens Tubke German-Australian Alliance for Electrochemical Technologies for Storage of Renewable Energy (CENELEST) Mechanical and Manufacturing Engineering University of New South Wales (UNSW) UNSW Sydney NSW 2052 Australia Fraunhofer-Institute for Chemical Technology Applied Electrochemistry Joseph-von-Fraunhofer-Str. 7 76327 Pfinztal Germany Chemical Engineering University of New South Wales (UNSW) UNSW Sydney NSW 2052 Australia Mechanical and Manufacturing Engineering University of New South Wales (UNSW) UNSW Sydney NSW 2052 Australia

Through targeted and reproducible electrochemical treatment of glassy carbon electrodes, investigations have been carried out on the electrochemical behaviour of the oxidation of V2＋, VO2＋ and the reductions of VO2＋, VO2＋ and V3＋ in order to pretreat electrodes specifically for use in vanadium redox flow batter- ies and, if possible, to treat them in situ. For this purpose, a glassy carbon electrode was treated poten- tiostatically for a period of 30 s at different potentials in the range of 500 mV-2000 mV vs. Hg/Hg_2SO_4 in 2 M H_2SO_4 and then linear sweep voltammograms were performed in the different vanadium-containing solutions. With this method, it could be shown that all reactions are extremely surface sensitive and the reaction speeds changed by several decades. The reaction rates increased significantly in all reac- tions compared to polished electrodes and had an optimum treatment potential of approx. 1600 mV vs. Hg/Hg_2SO_4, although the oxidation reaction of V2＋ and the reduction reactions of V3＋ and VO2＋ had opposite tendencies to oxidation of VO2＋ and the reduction of VO2＋ in the area of low treatment po- tentials. In the former, the kinetics increased and in the latter, they decreased. In addition, causes were investigated using confocal microscopy and XPS. No correlation was found to the roughness or size of the stretched surfaces, although these changed significantly as a result of the treatment. XPS measure- ments gave indications of a dependence on hydroxyl groups for the oxidation of VO2＋ and the reduction of VO2＋, while for the reactions of oxygen-free cations and the reduction of VO2＋ weak indications of a dependence on carboxyl groups were obtained.

关键词： Vanadium Battery Voltammetry Treatment Electrodes Surface Groups Kinetics

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Race modifies default mode connectivity in Alzheimer’s disease

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Translational Neurodegeneration 2020年第1期9卷 81-95页

作者： maria B.Misiura J.Christina Howell Junjie Wu Deqiang Qiu Monica W.Parker jessica A.Turner William T.Hu Department of Psychology Georgia State UniversityAtlantaGAUSA Departments of Neurology Emory University615 Michael StreetSuite 505AtlantaGA 30322USA Departments of Radiology Emory UniversityAtlantaGAUSA

Background:Older African Americans are more likely to develop Alzheimer’s disease(AD)than older Caucasians,and this difference cannot be readily explained by cerebrovascular and socioeconomic factors *** previously showed that mild cognitive impairment and AD dementia were associated with attenuated increases in the cerebrospinal fluid(CSF)levels of total and phosphorylated tau in African Americans compared to Caucasians,even though there was no difference in beta-amyloid 1–42 level between the two ***:We extended our work by analyzing early functional magnetic resonance imaging(fMRI)biomarkers of the default mode network in older African Americans and *** calculated connectivity between nodes of the regions belonging to the various default mode network subsystems and correlated these imaging biomarkers with non-imaging biomarkers implicated in AD(CSF amyloid,total tau,and cognitive performance).Results:We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance,tau,and amyloid ***:These findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition,and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization.

关键词： Alzheimer’s disease Cognitive impairment Functional connectivity Default mode network Disparities

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Nutritional,rheological and sensory properties of butter processed with different mixtures of cow and sheep milk cream

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Food Bioscience 2022年第2期46卷 487-497页

作者： Renata S Dias Celso F.Balthazar Rodrigo N.Cavalcanti Louise A.Sobral jessica F.Rodrigues Roberto P.CNeto maria Inˆes B.Tavares Ana Paula B.Ribeiro Renato Grimaldi Celso Sant’Anna Erick A.Esmerino Tatiana C.Pimentel Marcia Cristina Silva Adriano G.cruz Instituto Federal de Educaç˜ao Ciˆencia e Tecnologia do Rio de Janeiro(IFRJ)Departamento de AlimentosRJBrazil Universidade Estadual de Campinas(UNICAMP) Faculdade de Engenharia de AlimentosCampinasSPBrazil Universidade Federal do Rio de Janeiro(UFRJ) Escola de QuimicaRJBrazil Instituto Federal of Minas Gerais(IFMG) Departamento de Ciˆencias Agr´ariasBambuíMGBrazil Universidade Federal do Rio de Janeiro(UFRJ) Instituto de Macromol´eculas Professora Eloisa Mano(IMA)Rio de JaneiroBrazil Instituto Federal do Paran´a(IFPR) ParanavaíPRBrazil g Instituto Nacional de MetrologiaNormalizaç˜ao Qualidade Industrial(affnInmetro) Duque de Caxias25250-020Rio de JaneiroBrazil Universidade Federal Fluminense(UFF) Faculdade de Medicina VeterinariaNiter´oiRJBrazil

This study assessed the quality parameters and consumer perception and behavior of butter processed with different ratios of cow and sheep milk *** milk cream butter(CMCB)showed lower moisture content and higher fat content,smaller fat globules,and higher concentrations of long-chain saturated fatty acids and monounsaturated fatty acids,resulting in improved potential health *** addition,CMCB showed yellow color,little salt,and butter taste as the main sensory characteristics,resulting in grateful and good digestibility *** milk cream addition improved the rheological properties of the products(lower viscosity,consistency index,and rigidity(J0),and higher fluidity and viscoelastic behavior(J1)),mainly due to the increased concentrations of short-chain and medium-chain saturated fatty acids and polyunsaturated fatty ***,sheep milk cream butter(SMCB)was characterized by a greasy and striking aroma,with a lower perception of good digestibility and good appearance,and a higher bitter *** association of cow and sheep milk cream could be an exciting option to obtain products with improved fatty acid profiles,health indices,and yet maintain desired rheological and sensory *** formulation with 60%sheep milk cream and 40%cow milk cream would be the suggested combination.

关键词： Sheep milk Bovine milk Quality parameters Butter

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