Race modifies default mode connectivity in Alzheimer’s disease

作     者：Maria B.Misiura J.Christina Howell Junjie Wu Deqiang Qiu Monica W.Parker Jessica A.Turner William T.Hu 

作者机构：Department of PsychologyGeorgia State UniversityAtlantaGAUSA Departments of NeurologyEmory University615 Michael StreetSuite 505AtlantaGA 30322USA Departments of RadiologyEmory UniversityAtlantaGAUSA 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2020年第9卷第1期

页      面：81-95页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：This work was supported by National Institutes of Health grants AG43885 AG42856 AG25688 and AG61660 

主　　题：Alzheimer’s disease Cognitive impairment Functional connectivity Default mode network Disparities 

摘      要：Background:Older African Americans are more likely to develop Alzheimer’s disease(AD)than older Caucasians,and this difference cannot be readily explained by cerebrovascular and socioeconomic factors *** previously showed that mild cognitive impairment and AD dementia were associated with attenuated increases in the cerebrospinal fluid(CSF)levels of total and phosphorylated tau in African Americans compared to Caucasians,even though there was no difference in beta-amyloid 1–42 level between the two ***:We extended our work by analyzing early functional magnetic resonance imaging(fMRI)biomarkers of the default mode network in older African Americans and *** calculated connectivity between nodes of the regions belonging to the various default mode network subsystems and correlated these imaging biomarkers with non-imaging biomarkers implicated in AD(CSF amyloid,total tau,and cognitive performance).Results:We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance,tau,and amyloid ***:These findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition,and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization.