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Development of donor specific antibodies after SARS-CoV-2 vaccination:What do we know so far?

World journal of Meta-Analysis 2024年第2期12卷 1-4页

作者： Ahmed Daoud Karim Soliman maria Aurora Posadas Salas Sakshi Vaishnav Genta Uehara AhmedAbdelkader Tibor Fulop Michael j Casey Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States Department of Medicine Cairo University Medical SchoolCairo 11211Egypt Department of Medicine Medical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States Department of Medicine Division of NephrologyMedical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States

Vaccination against Coronavirus disease-19(COVID-19)was pivotal to limit spread,morbidity and *** aim is to find out whether vaccines against COVID-19 lead to an immunological response stimulating the production of de novo donor specific antibodies(DSAs)or increase in mean fluorescence intensity(MFI)of pre-existing DSAs in kidney transplant recipients(KTRs).This study involved a detailed literature search through December 2nd,2023 using PubMed as the primary *** search strategy incorporated a combination of relevant Medical Subject Headings terms and keywords:"COVID-19","SARS-CoV-2 Vaccination","Kidney,Renal Transplant",and"Donor specific antibodies".The results from related studies were collated and analyzed.A total of 6 studies were identified,encompassing 460 KTRs vaccinated against *** responses were detected in 8 KTRs of which 5 had increased MFIs,1 had de novo DSA,and 2 were categorized as either having de novo DSA or increased *** were 48 KTRs with pre-existing DSAs prior to vaccination,but one study(Massa et al)did not report whether pre-existing DSAs were associated with post vaccination *** the remaining 5 studies,35 KTRs with pre-existing DSAs were identified of which 7 KTRs(20%)developed de novo DSAs or increased ***,no immunological response was detected in 452(98.3%)*** study affirms prior reports that COVID-19 vaccination is safe for KTRs,especially if there are no pre-existing ***,if KTRs have pre-existing DSAs,then an increased immunological risk may be *** findings need to be taken cautiously as they are based on a limited number of patients so further studies are still needed for confirmation.

关键词： COVID-19 SARS-CoV-2 vaccination Kidney Renal transplant Donor specific antibodies

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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da Silva Abreu Taysse Holanda joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio Silva dos Santos Thais Benincá Patrícia da Silva Malheiros júlio César Sousa Prado Raquel de Oliveira Fontenelle maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Compressive property and energy absorption characteristic of interconnected porous Mg-Zn-Y alloys with adjusting Y addition

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journal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： j.A.Liu S.j.Liu B.Wang W.B.Sun X.j.Liu Z.W.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weihai Institute for Bionics-jilin University Weihai 264205PR China

In this study,interconnected porous Mg-2Zn-xY alloys with different phase compositions were prepared by various Y additions(x=0.4,3,and 6 wt.%)to adjust the compressive properties and energy absorption *** characterization methods were then applied to identify the microstructure of the porous Mg-Zn-Y and describe the details of the second *** tests were performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-Zn-Y ternary phases appear:I-phase(Mg_(3)Zn_(6)Y),W-phase(Mg_(3)Zn_(3)Y_(2)),and LPSO phase(Mg_(12)ZnY).When the Y content ranges between 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy absorption capacity increases from 7.33 Mj/m^(3)to 10.97 Mj/m^(3)at RT,which is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous Mg-Zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous Mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive behavior Energy absorption characteristic

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The quasi-Gramian solution of a non-commutative extension of the higher-order nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 51-61页

作者： H W A Riaz j Lin Department of Physics Zhejiang Normal UniversityJinhua 321004China

The nonlinear Schr?dinger(NLS)equation,which incorporates higher-order dispersive terms,is widely employed in the theoretical analysis of various physical *** this study,we explore the non-commutative extension of the higher-order NLS *** treat real or complex-valued functions,such as g_(1)=g_(1)(x,t)and g_(2)=g_(2)(x,t)as non-commutative,and employ the Lax pair associated with the evolution equation,as in the commutation *** derive the quasi-Gramian solution of the system by employing a binary Darboux *** soliton solutions are presented explicitly within the framework of *** visually understand the dynamics and solutions in the given example,we also provide simulations illustrating the associated ***,the solution can be used to study the stability of plane waves and to understand the generation of periodic patterns within the context of modulational instability.

关键词： integrable systems Darboux transformation solitons

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Complement factor H in molecular regulation of angiogenesis

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Medical Review 2024年第5期4卷 452-466页

作者： jiang Li Kaili Wang maria N.Starodubtseva Eldar Nadyrov Carolyn M.Kapron josephine Hoh ju Liu Laboratory of Translational Medicine in Microvascular Regulation Institute of Microvascular MedicineMedical Research CenterThe First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanShandong Province250014China Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging JinanShandong ProvinceChina Medical Research Center Shandong Provincial Qianfoshan HospitalShandong UniversityJinanShandong Province 250014China Gomel State Medical University GomelBelarus Institute of Radiobiology of NAS of Belarus GomelBelarus Department of Biology Trent UniversityPeterboroughONCanada Department of Ophthalmology Yale School of MedicineNew HavenCTUSA

Angiogenesis,the process of formation of new capillaries from existing blood vessels,is required for multiple physiological and pathological *** factorH(CFH)is a plasma protein that inhibits the alternative pathway of the complement *** of CFH enhances the alternative pathway and increases complement activation fragments with pro-angiogenic capacity,including complement 3a,complement 5a,and membrane attack *** protein contains binding sites for C-reactive protein,malondialdehyde,and endothelial heparan *** of CFH prevents its interaction with these molecules and initiates pro-angiogenic *** in the CFH gene have been found in patients with age-related macular degeneration characterized by choroidal *** Cfh-deficient mice show an increase in angiogenesis,which is decreased by administration of recombinant CFH pro*** this review,we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH *** therapeutic potential of recombinant CFH protein in angiogenesisrelated diseases has also been discussed.

关键词： complement factor H angiogenesis mechanical properties therapeutic target

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Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： M.P.SALAIMANIMAGUDAM j.jAYAPRAKASH Department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,injection concrete 3D printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subjective and objective weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3D printing

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Reply to the note by Li Piani et al.

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Defence Technology（防务技术） 2024年第1期31卷 603-606页

作者： T.Li Piani j.Weerheijm L.j.Sluys TU Delft Stevinweg 12628 CNDelftthe Netherlands TNO PO Box 452280 AARijswijkthe Netherlands NLDA Faculty of Military Sciences1781 CADen Helderthe Netherlands

In 2017,a ballistic phenomenological model was proposed by the authors of Ref.[1] to numerically simulate the experimental depths of small caliber projectiles impacting walls made of *** opportunity for a new model in the field revealed from the observation that two older models recently used by the authors of Ref.[2] shared a linear relationship between the penetration depth P and the impacting velocity v_(O).

关键词： Penetration Adobe Modeling

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Wettability,reactivity,and interface structure in Mg/Ni system

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journal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka N.Sobczak Ł.Maj P.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop method was applied to the experimental investigation of the wetting and spreading behaviors of liquid Mg drops on pure Ni *** comparison,the experiments were performed in two variants:(1)using the Capillary Purification(CP)procedure,which allows the non-contact heating and squeezing of a pure oxide-free Mg drop;(2)by classical Contact Heating(CH)*** high-temperature tests were performed under isothermal conditions(CP:760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop tests,images of the Mg/Ni couples were recorded by CCD cameras(57 fps),which were then applied to calculate the contact angles of metal/substrate *** and transmission electron microscopy analyses,both coupled with energy-dispersive X-ray spectroscopy,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop obtained by the CP procedure showed a wetting phenomenon on the Ni substrate(an average contact angleθ<90°in<1 s),followed by fast spreading and good wetting over the Ni substrate(θ_((CP))~20°in 5 s)to form a final contact angle ofθ_(f(CP))~18°.In contrast,a different wetting behavior was observed for the CH procedure,where the unavoidable primary oxide film on the Mg surface blocked the spreading of liquid Mg showing apparently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep craters formed in the Ni substrates under the Mg drops and significant change in the structure of initially pure Mg drops to Mg-Ni alloys suggest a strong dissolution of Ni in liquid Mg and apparent values of the final contact angles measured for the Mg/Ni system.

关键词： Magnesium-based alloys Sessile drop tests Capillary purification procedure Wettability Reactivity Contact angle

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Theory and classification of mass extinction causation

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National Science Review 2024年第1期11卷 16-36页

作者： Thomas j.Algeo jun Shen State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences—Wuhan State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences—Wuhan Department of Geosciences University of Cincinnati

Theory regarding the causation of mass extinctions is in need of systematization, which is the focus of this contribution. Every mass extinction has both an ultimate cause, i.e. the trigger that leads to various climato-environmental changes, and one or more proximate cause(s), i.e. the specific climato-environmental changes that result in elevated biotic mortality. With regard to ultimate causes, strong cases can be made that bolide(i.e. meteor) impacts, large igneous province(LIP) eruptions and bioevolutionary events have each triggered one or more of the Phanerozoic Big Five mass extinctions, and that tectono-oceanic changes have triggered some second-order extinction events. Apart from bolide impacts, other astronomical triggers(*** flares, gamma bursts and supernova explosions) remain entirely in the realm of speculation. With regard to proximate mechanisms, most extinctions are related to either carbon-release or carbon-burial processes, the former being associated with climatic warming, ocean acidification, reduced marine productivity and lower carbonate δ13C values, and the latter with climatic cooling, increased marine productivity and higher carbonate δ13C values. Environmental parameters such as marine redox conditions and terrestrial weathering intensity do not show consistent relationships with carbon-cycle *** this context, mass extinction causation can be usefully classified using a matrix of ultimate and proximate factors. Among the Big Five mass extinctions, the end-Cretaceous biocrisis is an example of a bolide-triggered carbon-release event, the end-Permian and end-Triassic biocrises are examples of LIP-triggered carbon-release events, and the Late Ordovician and Late Devonian biocrises are examples of bioevolution-triggered carbon-burial events. Whereas the bolide-impact and LIP-eruption mechanisms appear to invariably cause carbon release, bioevolutionary triggers can result in variable carbon-cycle changes, e.g. carbon burial durin

关键词： biocrisis ultimate cause proximate cause bolide large igneous province bioevolutionary event

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An analytical model to estimate the time delay to reach spontaneous ignition considering heat loss in oil reservoirs

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Petroleum Science 2024年第4期21卷 2469-2474页

作者： james j.Sheng Er-Long Yang College of Petroleum Engineering Northeast Petroleum University

During air injection into an oil reservoir, an oxidation reaction generates some heat to raise the reservoir temperature. When the reservoir temperature reaches an ignition temperature, spontaneous ignition occurs. There is a time delay from the injection to ignition. There are mixed results regarding the feasibility of spontaneous ignition in real-field projects and in laboratory experiments. No analytical model is available in the literature to estimate the oxidation time required to reach spontaneous ignition with heat *** paper discusses the feasibility of spontaneous ignition from theoretical points and experimental and field project observations. An analytical model considering heat loss is proposed. Analytical models with and without heat loss investigate the factors that affect spontaneous ignition. Based on the discussion and investigations, we find that it is more difficult for spontaneous ignition to occur in laboratory experiments than in oil reservoirs; spontaneous ignition is strongly affected by the initial reservoir temperature, oil activity, and heat loss; spontaneous ignition is only possible when the initial reservoir temperature is high, the oil oxidation rate is high, and the heat loss is low.

关键词： Spontaneous ignition Time delay Air injection Heat loss Low temperature oxidation Combustion

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