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Effects of Unsaturated Fatty Acid Esters of Testosterone on Neuronal, Behavioral and Hormonal Parameters in Male Rats Subjected to the Formalin Test

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Open Journal of Endocrine and Metabolic Diseases 2014年第6期4卷 167-179页

作者： Anna Petroni Paolo Fiorenzani Valentina Tomei Antonio Garofalo Francesca Aiello Daniele Della Seta Antonio giordano Stella Vodo Ilaria Ceccarelli Anna maria Aloisi Department of Medicine Surgery and Neuroscience University of Siena Siena Italy Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy Department of Pharmacy and Health Nutrition Sciences University of Calabria Rende Italy

Chronic diseases are often accompanied by inflammatory and degenerative processes. Estrogens have repeatedly been found to be involved in these processes. Testosterone (T) is the main precursor of estrogen in the brain and T replacement in chronic diseases has become important in recent years, prompting research on new T-conjugated molecules. We recently synthesized three new molecules including unsaturated fatty acid esters: T-linoleate (TL), T-oleate (TO) and T-eicosapentanoate (TEPA). These substances were s.c. administered for 7 days to intact male rats subjected to the formalin test (FT). Three other groups were included as comparisons: NAIVE, receiving no substance, OIL, treated with almond oil (vehicle), and TN, treated with T-undecanoate, a?saturated?fatty acid. Spontaneous behaviors and pain-induced responses were determined during the FT, hormones (T and dihydrotestosterone, DHT) were determined in blood, while estrogen receptors (ERα?and?β) were detected at the genomic and proteomic levels in the hippocampus, hypothalamus and spinal cord. In the hippocampus, ERα?and ERβ?mRNA levels were increased respectively by TN and TL treatments with respect to OIL, whereas the hypothalamus TO and TL caused a decrease of ERα?mRNA levels. At the proteomic level, TO, TL and TEPA decreased the levels of ERα?in the hypothalamus, whereas TEPA decreased ERβ?in the spinal cord, hippocampus and hypothalamus. There was no effect of treatment on the spontaneous behaviors, while the TO and TL groups showed lower pain-induced behaviors (paw jerk frequency and licking duration) than the OIL group. TN increased paw jerk frequency and decreased licking duration with respect to OIL. The treatments had no effect on T and DHT plasma levels. These results clearly indicate the possibility of pain and ER modulation by T-esters.

关键词： Testosterone CNS Fatty Acids Pain Estrogen Receptors

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Hepatitis C virus infection and thyroid autoimmunedisorders:A model of interactions between the host and theenvironment

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World Journal of Hepatology 2016年第2期8卷 83-91页

作者： francesca pastore antonio martocchia manuela stefanelli pietro prunas stefania giordano lavinia toussan antonio devito paolo falaschi “Sapienza”University of Rome Faculty of Medicine and PsychologyS.Andrea Hospital00189 RomeItaly

The hepatitis C virus(HCV) infection is an important public health problem and it is associated with hepatic and extrahepatic manifestations. Autoimmune thyroid diseases are common in HCV infected patients and the standard interferon-based treatment is associated with an increase of the immune-mediated thyroid damage. Recent evidence in the literature analyzed critical points of the mechanisms of thyroid damage, focusing on the balance between the two sides of the interaction: The environment(virus infection with potential crossreaction) and the host(susceptibility genes with consistent immune response). The spectrum of antiviral treatment for chronic HCV infection is rapidly expanding for the development of dual o triple therapy. The availability of interferon-free combined treatment with direct antiviral agents for HCV is very promising, in order to ameliorate the patient compliance and to reduce the development of thyroid autoimmunity.

关键词： Hepatitis C virus Thyroid autoimmunity Interferon Antiviral agents Self-tolerance

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猪精子细胞中胰岛素诱导产生的一氧化氮自由基促进精子获能

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Asian Journal of Andrology 2013年第6期15卷 835-837,I0011页

作者： Saveria Aquila Francesca giordano Carmela Guido Vittoria Rago Amalia Carpino Department of Pharmacy Health Science and Nutrition University of Calabria Arcavacata di Rende Cosenza 87036 Italy Health Centre University of Calabria Arcavacata di Rende Cosenza 87036 Italy

Insulin （Ins） has recently been demonstrated to have the ability to induce the capacitation process in pig spermatozoa. In various mammalian species, capacitation has been linked to the nitric oxide （NO） signalling; therefore, this study investigated NO production in Ins-treated pig spermatozoa by fluorescence-activated cell sorting. For the same samples, sperm capacitation was evaluated chlortetracycline staining, protein tyrosine phosphorylation pattern and acrosomal status. A significant increase of the intrasperm NO level and the activation of three capacitation indices were detected in response to Ins treatment. Conversely, sperm preincubation with an NO synthase inhibitor （N-nitro-L-arginine methyl ester） or with the anti-Ins receptor β （IRβ） antibody reversed all of the Ins-related effects. These results suggest that Ins has the capacity to enhance intracellular NO concentrations in pig spermatozoa and indicate a oossible NO implication upon Ins oromotion of caoacitation.

关键词： acrosome reaction insulin nitric oxide pig sperm capacitation

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Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 376-380页

作者： Eleonora Cella Ivan Gabrielli Gianguglielmo Zehender Marta Giovanetti Alessandra Lo Presti Alessia Lai giordano Dicuonzo Silvia Angeletti Marco Salemi Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health Department of Public Health and Infectious Diseases.Sapienza University of Rome University of Rome 'La Sapienza' L.Sacco Department of Biomedical and Clinical Sciences University of Milan University of Rome 'Tor Vergata' Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome Department of Pathology and Laboratory Medicine.University of Florida University Hospital Campus Bio-Medico

Objective:To study the genetic diversity of Murray Valley encephalitis virus(MVEV) in Australia and Papua New ***:MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with *** v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset wa.s investigated by the likelihood mapping *** Bayesian phylogenetic tree was built using ***:The phylogenetic trees showed two main *** clade Ⅰincluding eight strains isolated from West *** clade Ⅱ was characterized by at least four epidemic entries,three of which localized in Northern West Australia and one in Papua New *** estimated mean evolutionary rate value of the MVEV envelope gene wa.s0.407 × 10^(-3) substitution/site/year(95%HPD:0.623 × 10~4-0.780× 10^(-3)).Population dynamics defines a relative constant population until the year *** a reduction occurred,probably due to a ***:This study has been useful in supporting the probable connection between climate changes and viral evolution also by the vector point of view:multidisciplinary monitoring studies are important to prevent new viral epidemics inside and outside new endemic areas.

关键词： Murray Valley encephalitis virus Phylogeny Evolution

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The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents

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World Journal of Stem Cells 2010年第1期2卷 5-12页

作者： Umberto Galderisi Antonio giordano Marco G Paggi Sbarro Institute for Cancer Research and Molecular Medicine Center for BiotechnologyTemple UniversityPhiladelphiaPA 19122United States Department of Experimental Medicine Biotechnology and Molecular Biology SectionSecond University of NaplesNaples 80138Italy Human Health Foundation Terni 05100Italy National Cancer Institute"Regina Elena" Rome 00144Italy

In cancer biology,mesenchymal stem cells(MSCs)display aspects that can appear *** one hand,these cells possess several features which give them the ability to specifically target and then sustain cancer cells in their ability to survive the multifaceted host response against *** the other hand,due to this excellent aptitude to home-in on tumor tissues,regardless their location in the host’s body,MSCs are considered to be extremely selective vehicles to reach cancer cells ***,MSC sustainment of cancer cell growth is a hot research ***,these cells are known to sustain tumor angiogenesis and metastasis formation,to create a microenvironment favorable for cancer cell growth and to down-modulate the immune system capabilities in the host *** the other hand,since scientists became able to take advantage of their extremely selective capability to target cancer cells,MSCs are now also thought of in a different ***,MSCs are now considered a promising vehicle for local expression or delivery of even particularly toxic anticancer agents,ranging from Herpes Simplex Virus to locally-acting antineoplastic *** this basis,investigation is now focused on how to impair the pro-neoplastic features of MSCs on one hand whilst taking advantage of their specific tropism toward cancer cells,on the *** with the two faces of Janus,this review will concisely explore the research activity in these two apparently conflicting fields.

关键词： Mesenchymal stem cells Cancer Cell therapy Angiogenesis Niche Immunomodulation

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Novel findings about management of gastric cancer: A summary from 10^(th) IGCC

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World Journal of Gastroenterology 2014年第27期20卷 8986-8992页

作者： Danila Penon Letizia Cito Antonio giordano Department of Biochemistry and Medical Biotechnology University of Naples Federico Ⅱ 80131 Naples Italy Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" IRCCS 80131 Naples Italy Sbarro Institute for Cancer Research and Molecular Medicine Philadelphia PA 19122 United States Center of Biotechnology College of Science and Technology Temple University Philadelphia PA 19122 United States Department of Medicine Surgery and Neuroscience University of Siena 53100 Siena Italy

The Tenth International Gastric Cancer Congress(IGCC) was held in Verona, Italy, from June 19 to 22, 2013. The meeting enclosed various aspects of stomach tumor management, including both tightly clinical approaches, and topics more related to basic research. Moreover, an overview on gastrointestinal stromal tumors was provided too, although here not discussed. Here we will discuss some topics related to molecular biology of gastric cancer(GC), inherent to prognostic, diagnostic and therapeutic tools shown at the conference. Results about well known subjects, such as E-cadherin loss of expression/function, were presented. They revealed that other mutations of the gene were identified, showing a continuous research to improve diagnosis and prognosis of stomach tumor. Simultaneously, new possible molecular markers with an established role for other neoplasms, were discussed, such as mesothelin, stomatin-like protein 2 and Notch-1. Hence, a wide overview including both old and new diagnostic/prognostic tools was offered. Great attention was also dedicated to possible drugs to be used against GC. They included monoclonal antibodies, such as MS57-2.1, drugs used in other pathologies, such as maraviroc, and natural extracts from plants such as biflorin. We would like to contribute to summarize the most impressive studies presented at the IGCC, concerning novel findings about molecular biology of gastric cancer. Although further investigations will be necessary, it can be inferred that more and more tools were developed, so as to better face stomach neoplasms.

关键词： Gastric cancer Prognostic tools Markers Therapy

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H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease

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World Journal of Gastroenterology 2006年第48期12卷 7815-7820页

作者： Cristina Lenzi Alberto Palazzuoli Nicola giordano Giuliano Alegente Catia Gonnelli maria Stella Campagna Annalisa Santucci Michele Sozzi Panagiotis Papakostas Fabio Rollo Ranuccio Nuti Natale Figura Department of In-ternal Medicine Endocrine-Metabolic Sciences and Biochemistry University of Siena Siena Italy Unit of Microbiology General Hospital Siena Italy Department of Molecular Biology University of Siena Siena Italy Unit of Gastroenterology and Digestive Endos-copy General Hospital Trieste Italy

AIM: To determine the overall prevalence of H pylori and CagA positive H pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (CHD), and the potential role of anti-heat-shock protein 60 (Hsp60) anti- body response to these proteins in increasing the risk of CHD development. METHODS: Eighty patients with CHD and 160 controls were employed. We also compared the levels of anti- heat-shock protein 60 (Hsp60) antibodies in the two groups. The H pylori infection and the CagA status were determined serologically, using commercially available enzyme-linked immunosorbent assays (ELISA), and a Western blotting method developed in our laboratory. Systemic antibodies to Hsp60 were determined by a sandwich ELISA, using a polyclonal antibody to Hsp60 to sensitise polystyrene plates and a commercially available human Hsp60 as an antigen. RESULTS: The overall prevalence of H pylori infec- tion was 78.7% (n = 63) in patients and 76.2% (n = 122) in controls (P = 0.07). Patients infected by CagA- positive (CagA+) H pylori strains were 71.4% (n = 45) vs 52.4% of infected controls (P = 0.030, OR = 2.27). Sys-temic levels of IgG to Hsp60 were increased in H pylori- negative patients compared with uninfected controls (P < 0.001) and CagA-positive infected patients compared with CagA-positive infected controls (P = 0.007). CONCLUSION: CagA positive H pylori infection may concur to the development of CHD; high levels of anti- Hsp60 antibodies may constitute a marker and/or a con- comitant pathogenic factor of the disease.

关键词：幽门螺杆菌热休克蛋白冠心病治疗

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面向快速变化中的世界人口、粮食、环境的水管理(英文)

面向快速变化中的世界人口、粮食、环境的水管理(英文)

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2009水资源与可持续发展高层论坛

作者： David Molden Mark giordano Director General for Research at the International Water Management Institute and coordinated the assessment program

＜正＞*** Trends indicate that we are not doing the right things with our water *** pollution and depletion of rivers and groundwater will *** in the benefits of water use will grow between haves and *** food grown at...

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Expanding the horizons of clinical applications of proximal humerus locking plates in the lower extremities:A technical note

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Chinese Journal of Traumatology 2020年第6期23卷 331-335页

作者： Robinson E.Pires Richard S.Yoon Frank A.Liporace Daniel Balbachevsky Rogerio CBitar Vincenzo giordano Andre Wajnsztejn Mauricio Kfuri Departamento do Aparelho Locomotor-Universidade Federal de Minas Gerais Belo HorizonteMGBrazil Division of Orthopedic Trauma&Adult Reconstruction Department of Orthopedic SurgeryJersey City Medical Center-RWJ Barnabas Health Jersey CityNJUnited States Departamento de Ortopedia e Traumatologia Universidade Federal de São PauloSão PauloSPBrazil Departamento de Ortopedia e Anestesiologia Universidade de São PauloRibeirão PretoSPBrazil Serviço de Ortopedia e Traumatologia Prof.Nova Monteiro Hospital Municipal Miguel CoutoRio de JaneiroRJBrazil Serviço de Ortopedia e Traumatologia Hospital Israelita Albert Einstein HospitalSão PauloSPBrazil Missouri Orthopaedic Institute University of MissouriColumbiaUnited States

Pre-contoured anatomical locking plates were designed to address the clinical need of fixing small epiphyseal segments with a larger number of *** plates match the contour and shape of a variety of bones allowing for optimal buttress *** aim of this manuscript is to highlight the benefits of applying proximal humerus locking plates in the fixation of lower extremity *** designed for the proximal humerus,the low-profile plate shape and anatomic contour also provides versatile use in certain areas of the lower *** technical narrative highlights the versatile and reliable use of this plate for other anatomical areas than the one to which it has been originally conceived.

关键词： Proximal humerus Locking plate Distal femur Proximal tibia Distal tibia

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A first course in mathematical modeling = 3rd ed.

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2005年

作者： giordano Frank R.

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