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Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers

Acta Pharmacologica Sinica 2005年第4期26卷 447-452页

作者： Márcio Goncalves de SOUSA Juan Carlos YUGAR-TOLEDO Marcelo RUBIRA Sílvia Elaine FERREIRA-MELO Rodrigo PLENTZ Deise BARBIERI Fernanda CONSOLIM-COLOMBO maria cláudia irigoyen Heitor MORENO Jr Cardiovascular Pharmacology and Cardiology clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Cardiovascular Pharmacology and Cardiology clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Hypertension Unit InCor clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil

Aim:To compare the acute effects of ascorbic acid on vasodilation of veins andarteries in ***:Twenty-six healthy non-smokers and 23 healthy moder-ate smokers were recruited in this *** dorsal hand vein compliance tech-nique and flow-mediated dilation were ***-response curves to bradykininand sodium nitroprusside were constructed to test the endothelium-dependentand-independent relaxation before and after acute infusion of ascorbic ***:Smokers had an impaired venodilation with bradykinin compared withnon-smokers(68.3%±13.2% vs 93.7%±20.1%,respectively;P<0.05).Ascorbic acidadministration in the dorsal hand vein significantly increased the venodilationwith bradykinin in smokers(68.3%±13.2% vs 89.5%±6.3% before and after infusion,respectively;P<0.05)but not in non-smokers(93.7%±20.1% vs 86.4%±12.4% be-fore and after infusion,respectively).Similarly,the arterial response in smokershad an impaired endothelium-dependent dilation compared with that in non-smok-ers(8.8%±2.7% vs 15.2%±2.3%,respectively;P<0.05)and ascorbic acid restoredthis response in smokers(8.8%±2.7% vs 18.7%±6.5% before and after infusion,respectively;P<0.05),but no difference was seen in non-smokers(15.2%±2.3% vs14.0%±4.4% before and after infusion,respectively).The endothelium-indepen-dent dilation did not differ in both the groups *** important hemody-namic change was detected using the Portapress ***:Smokershad impaired endothelium-dependent vasodilation responsiveness in both arte-rial and venous *** acid restores this responsiveness in smokers.

关键词： ascorbic acid vasodilation vascular endothelium arterioles venules dorsal hand vein flow-mediated dilation

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Impact of conditioning hyperglycemic on myocardial infarction rats:Cardiac cell survival factors

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World Journal of Cardiology 2014年第6期6卷 449-454页

作者： Christiane Malfitano Alcione Lescano de Souza Junior maria cláudia irigoyen Laboratório de Fisiologia Translacional UNINOVE01504001 S?o PauloBrazil Universidade Nove de Julho-Medicine Program 01504001 S?o PauloBrazil Instituto do Cora??o Universidade de S?o PauloFaculdade de Medicina05403900 S?o PauloBrazil Nursing Department University of Mato-Grosso78200000 Mato GrossoBrazil

While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease(IHD),animal data have so far pointed to a lower probability of IHD. Thus,the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned hyperglycemia may confer to the heart against ischemic injury. Several mechanisms have been proposed to explain the cardioprotective action of high glucose exposure,namely,upregulation of anti-apoptotic factor Bcl-2,inactivation of pro-apoptotic factor bad,and activation of pro-survival factors such as protein kinase B(Akt),vascular endothelial growth factor(VEGF),hypoxia inducible factor-1α and protein kinase C-ε. Indeed,cytosolic increase in Ca2+ concentration,the mitochondrial permeability transition pore,plays a key role in the genesis of ischemic injury. Previous studies have shown that the diabetic heart decreased Na+/Ca2+ and Na+/H+ exchanger activity and as such it accumulates less Ca2+ in cardiomyocyte,thus preventing cardiac injury and the associated heart dysfunctions. In addition,the expression of VEGFin diabetic animals leads to increased capillary density before myocardial infarction. Despite poor prognostic in the long-term,all these results suggest that diabetes mellitus and consequently hyperglycemia may indeed play a cardioprotective role against myocardial infarction in the short term.

关键词： Conditioned hyperglycemia Diabetes mellitus Myocardial infarction Cardioprotection Survival factors

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Isolated Soy Protein-Based Diet Ameliorates Glycemia and Antioxidants Enzyme Activities in Streptozotocin-Induced Diabetes

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Food and Nutrition Sciences 2014年第21期5卷 2089-2096页

作者： Roberta Hack Mendes Martine Kienzle Hagen Jaqueline Barp Erna Vogt de Jong Jú lia Dubois Moreira lvaro Reischak-Oliveira maria clá udia irigoyen Adriane Belló -Klein Physiology Departament Federal University of Rio Grande do Sul Porto Alegre Brazil Institute of Nutrition Josué de Castro Rio de Janeiro Federal University Rio de Janeiro Brazil Department of Internal Medicine Federal University of Rio Grande do Sul Porto Alegre Brazil Institute of Food Science and Technology Federal University of Rio Grande do Sul Porto Alegre Brazil Department of Nutrition Health Sciences Centre Federal University of Santa Catarina Florian&#243 polis Brazil School of Physical Education Federal University of Rio Grande do Sul Porto Alegre Brazil Hypertension Unit Heart Institute Federal University of S&#227 o Paulo S&#227 o Paulo Brazil

The objective of this study was to evaluate the changes induced by isolated soy protein (ISP)-based diet on glycemia and oxidative stress biomarkers in diabetic rats. Fifteen male Wistar rats (35 ± 4 g, aged 21 days) were assigned to three groups: Casein (C group), which received casein-based diet during experimental protocol;Diabetic treated with Casein (D + C group) that received casein-based diet before and after diabetes induction;Diabetic treated with ISP (D + S group) that received casein-based diet before diabetes induction and after received ISP-based diet for the experimental protocol. Diabetes was induced by a single dose of streptozotocin (50 mg/kg body weight i.v.). After three weeks of dietary treatment, total nitrates, lipid peroxidation, antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) were measured in heart homogenates. ISP-based diet promoted an improvement in the glycemic levels of diabetic rats compared with casein-based diet (362 ± 25 vs 461 ± 30 mg/dL). CAT activity demonstrated a significant decrease in D + C and D + S groups. D + S group presented a significant increase in SOD and GST activities. Lipid peroxidation was not different among experimental groups. The overall results suggested the potential benefits of ISP-based diet consumption to improve the life quality of diabetic patients.

关键词： Isolated Soy Protein Diabetes Oxidative Stress

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Fluorosis and Dental Caries in the Hydrogeological Environments of Southeastern Communities in the State of Morelos, Mexico

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Journal of Environmental Protection 2013年第9期4卷 994-1001页

作者： Gricelda G. Varela-González Alvaro García-Pérez Rafael Huizar-Alvarez maria Esther irigoyen-Camacho maria M. Espinoza-Jaramillo Departamento de Atención a la Salud Universidad Autónoma Metropolitana Xochimilco Mexico City Mexico Departamento de Geología Regional Instituto de Geología Universidad Nacional Autónoma de México Mexico City Mexico División de Estudios de Posgrado e Investigación Facultad de Odontología Universidad Nacional Autónoma de México Mexico City Mexico

Objectives: 1) To identify the hydrogeological characteristics and fluoride (F-) concentration in drinking water in the southeast of the state of Morelos, Mexico, and 2) to estimate the association between the prevalence and severity of fluorosis, dental caries, and water F-?concentration. Methods: A hydrogeological model was developed to determine the vertical distribution of lithostratigraphic units, rocks’ hydraulic conductivities, and groundwater flow characteristics. A total of 649 schoolchildren from two communities received oral examinations. One community was located in an area with 0.75 mg F-/L in the water supply and the other in an area with 1.6 mg F-/L. Fluorosis was assessed using the Thylstrup & Fejerskov Index (TFI) and the dental caries were assessed with the decayed, missing, and filled teeth (DMFT) index. The region groundwater was extracted from an inter-granular aquifer consisting of volcano clasts of intermediate volcanic chemical composition. Results: Oral examinations showed that 32.35% of the children had severe forms of fluorosis (TFI ≥ 4) in the community with 1.60 mg F-/L and 7.8% in the 0.75 mg F-/L community (p clusions: The increasing extraction of underground water was associated with deeper water flows and higher F-?concentration. In the community with high F-concentration, a third of the children showed objectionable levels of fluorosis. Adequate groundwater management actions are required to reduce fluorosis risk.

关键词： Fluoride Drinking Water Fluorosis Dental Caries México

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