Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers

作     者：Márcio Goncalves de SOUSA Juan Carlos YUGAR-TOLEDO Marcelo RUBIRA Sílvia Elaine FERREIRA-MELO Rodrigo PLENTZ Deise BARBIERI Fernanda CONSOLIM-COLOMBO Maria Cláudia IRIGOYEN Heitor MORENO Jr 

作者机构：Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2005年第26卷第4期

页      面：447-452页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Project supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo(FAPESP) Sao Paulo  Brazil 

主　　题：ascorbic acid vasodilation vascular endothelium arterioles venules dorsal hand vein flow-mediated dilation 

摘      要：Aim:To compare the acute effects of ascorbic acid on vasodilation of veins andarteries in ***:Twenty-six healthy non-smokers and 23 healthy moder-ate smokers were recruited in this *** dorsal hand vein compliance tech-nique and flow-mediated dilation were ***-response curves to bradykininand sodium nitroprusside were constructed to test the endothelium-dependentand-independent relaxation before and after acute infusion of ascorbic ***:Smokers had an impaired venodilation with bradykinin compared withnon-smokers(68.3%±13.2% vs 93.7%±20.1%,respectively;P0.05).Ascorbic acidadministration in the dorsal hand vein significantly increased the venodilationwith bradykinin in smokers(68.3%±13.2% vs 89.5%±6.3% before and after infusion,respectively;P0.05)but not in non-smokers(93.7%±20.1% vs 86.4%±12.4% be-fore and after infusion,respectively).Similarly,the arterial response in smokershad an impaired endothelium-dependent dilation compared with that in non-smok-ers(8.8%±2.7% vs 15.2%±2.3%,respectively;P0.05)and ascorbic acid restoredthis response in smokers(8.8%±2.7% vs 18.7%±6.5% before and after infusion,respectively;P0.05),but no difference was seen in non-smokers(15.2%±2.3% vs14.0%±4.4% before and after infusion,respectively).The endothelium-indepen-dent dilation did not differ in both the groups *** important hemody-namic change was detected using the Portapress ***:Smokershad impaired endothelium-dependent vasodilation responsiveness in both arte-rial and venous *** acid restores this responsiveness in smokers.