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National Science Review 2022年第9期9卷 10-18页

作者： J.Miguel Carceller Karen S.arias maria J.Climent Sara Iborra Avelino Corma Instituto de Tecnologia Química (UPV-CSIC) Universitat Politècnica de València

Amino transaminases(ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived from biomass. We have extended the biocatalyst applications by designing a chemo-enzymatic process that allows, as the first step, prochiral ketones to be obtained from biomass-derived compounds through an aldol condensation–reduction step using a bifunctional metal/base catalyst. The prochiral ketone is subsequently converted into the chiral amine using the immobilized ATA. We show that it is feasible to couple both steps in a semi-continuous process to produce industrially relevant chiral amines with yields of >95% and ～100% enantiomer excess.

关键词： amino transaminase ITQ-2 zeolite chemo-enzymatic process biomass semi-continuous process Pd/MgO

Splanchnic-aortic inflammatory axis in experimental portal hypertension

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World Journal of Gastroenterology 2013年第44期19卷 7992-7999页

作者： maria-Angeles Aller Natalia de las Heras maria-Paz Nava Javier Regadera Jaime arias Vicente Lahera Surgery Department School of Medicine Complutense University of Madrid 28040 MadridSpain Department of Physiology School of Medicine Complutense University of Madrid28040 Madrid Spain Animal Physiology II School of BiologyComplutense University of Madrid 28040 Madrid Spain Department of Histology and Neuroscience School of Medicine Universidad Autonoma Madrid 28046Spain

Splanchnic and systemic low-grade inflammation has been proposed to be a consequence of long-term prehepatic portal *** experimental model causes minimal alternations in the liver,thus making a more selective study possible for the pathological changes characteristic of prehepatic portal ***-grade splanchnic inflammation after longterm triple partial portal vein ligation could be associated with liver steatosis and portal hypertensive intestinal *** fact,we have previously shown that prehepatic portal hypertension in the rat induces liver steatosis and changes in lipid and carbohydrate metabolism similar to those produced in chronic inflammatory conditions described in metabolic syndrome in *** and bacterial translocation in this experimental model suggest the existence of a portal hypertensive intestinal microbiome implicated in both the splanchnic and systemic alterations related to prehepatic portal *** the systemic impairments,aortopathy characterized by oxidative stress,increased levels of proinflammatory cytokines and profibrogenic mediators stand *** this experimental model of long-term triple portal vein ligated-rats,the abdominal aortic proinflammatory response could be attributed to oxidative ***,the increased aortic reduced-nicotinamide-adenine dinucleotide phosphate[NAD(P)H]oxidase activity could be associated with reactive oxygen species production and promote aortic ***,oxidative stress mediated by NAD(P)H oxidase has been associated with risk factors for inflammation and *** splanchnic and systemic pathology that is produced in the long term after triple partial portal vein ligation in the rat reinforces the validity of this experimental model to study the chronic low-grade inflammatory response induced by prehepatic portal hypertension.

关键词： Portal hypertension Inflammation Aortopathy Hepatic steatosis

A half century (1961-2011) of applying microsurgery to experimental liver research

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World Journal of Hepatology 2012年第7期4卷 199-208页

作者： maria-Angeles Aller Natalia arias Isabel Prieto Salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis arias Jaime arias Surgery I Department School of Medicine Complutense University of Madrid 28040 Madrid Spain Neurosciences Lab Psychobiology Department School of Psychology University of Oviedo 33003 Oviedo Spain Surgery Department La Paz Hospital School of Medicine Autonomous University of Madrid 28049 Madrid Spain General Surgery Unit Sudeste Hospital Arganda del Rey 28500 Madrid Spain

The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies.

关键词： Microsurgery Portacaval shunts Cholestasis Hepatectomies Liver transplantation Portal hypertension

Bean yellow disorder virus： Parameters of transmission by Bemisia tabaci and host plant range

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Insect Science 2011年第1期18卷 50-56页

作者： German martin Isabel maria Cuadrado Dirk Janssen Instituto Andaluz de Investigacion y Formacion Agraria y Pesquera Centro La Mojonera Almeria Spain

Bean yellow disorder virus （BnYDV） was recently identified as the first crinivirus （family Closteroviridae） that infects members of the family Leguminosae. It was first observed during the autumn of 2003, causing heavy losses in French bean （Phaseolus vulgaris L.） grown commercially in Spain. The virus is transmitted by the sweetpotato whitefly, Bemisia tabaci （Hemiptera： Aleyrodidae） Q-biotype, and disease symptoms resemble nutritional disorders consisting of interveinal mottling and yellowing in leaves, combined with stiffness or brittleness, and are typically produced on the middle to lower parts of the plant. Transmission experiments showed that 50% and 100% of B. tabaci adults acquired the virus after a feeding period of 3 and 7 h, respectively. Viruliferous whiteflies infected 66% and 100% ofP. vulgaris plants after a feeding period of 12 and 24 h, respectively. The transmission efficiency of single whiteflies was 37% and persistence of BnYDV in the vector lasted up to 2 weeks with a half-life of 9 days. BnYDV was transmitted to P. vulgaris, Pisum sativum L., Lens culinaris Medik., and Vicia faba L., but not to Vigna unguiculata L., Glycine max （L.） Merr., Cicer arietum L., and to crop species belonging to families of the Solanaceae and Cucurbitaceae. No virus was detected in field samples collected from 30 different species from Boraginaceae, Asteraceae, Geraniaceae, Lamiaceae, Leguminosae, Malvaceae, Scrophulariaceae, Thymelaeaceae and Verbenaceae. The restricted host range and efficient management of crops regarding whitefly infestation may be key elements in the control of BnYDV.

关键词： bean Closteroviridae Crinivirus disease vector whiteflies

The many faces of cGAS:how cGAS activation is controlled in the cytosol,the nucleus,and during mitosis

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2261-2263页

作者： Anna-maria Herzner martin Schlee Eva Bartok Department of Cancer Immunology and Immune Modulation Boehringer Ingelheim Pharma GmbH&Co.KGBiberach an der RiBGermany lnstitute of Clinical Chemistry and Clinical Pharmacology University HospitalUniversity of BonnBonnGermany Unit of Experimental Immunology Department of Biomedical SciencesInstitute of Tropical MedicineAntwerpBelgium

In their recently published study in Science,Li et al.1 unravel how hyperphosphorylation and chromatin-tethering of the double-stranded(dsDNA)sensor cGAMP synthase(cGAS)prevent self DNA recognition during mitosis(Fig.1);providing important insight into how this innate immune sensor balances its essential function for pathogen defense against potential autoinflammation.

关键词： activation sensor insight

Estimating Risk-aware Flexibility Areas for Electric Vehicle Charging Pools via AC Stochastic Optimal Power Flow

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1247-1256页

作者： Juan S.Giraldo Nataly Bañol arias Pedro P.Vergara maria Vlasiou Gerwin Hoogsteen Johann L.Hurink Energy Transition Studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Department of Electrical Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Electrical Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduces an AC stochastic optimal power flow(SOPF)for the flexibility management of electric vehicle(EV)charging pools in distribution networks under *** AC SOPF considers discrete utility functions from charging pools as a compensation mechanism for eventual energy not served to their charging *** application of the AC SOPF is described where a distribution system operator(DSO)requires flexibility to each charging pool in a day-ahead time frame,minimizing the cost for flexibility while guaranteeing technical *** areas are defined for each charging pool and calculated as a function of a risk parameter involving the uncertainty of the *** show that all players can benefit from this approach,i.e.,the DSO obtains a riskaware solution,while charging pools/tasks perceive a reduction in the total energy payment due to flexibility services.

关键词： Electric vehicle flexibility management stochastic optimal power flow(SOPF) risk awareness compensation mechanism

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Sex dimorphism and metabolic profiles in management of metabolic-associated fatty liver disease

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World Journal of Clinical Cases 2023年第6期11卷 1236-1244页

作者： maria martin-Grau Daniel Monleon Department of Pathology University of ValenciaValencia 46010Spain

Metabolic-associated fatty liver disease(MAFLD)refers to the build-up of fat in the liver associated with metabolic dysfunction and has been estimated to affect a quarter of the population *** metabolism is highly influenced by the effects of sex hormones,studies of sex differences in the incidence and progression of MAFLD are *** represents a powerful approach to studying these differences and identifying potential biomarkers and putative ***,metabolomics makes it possible to obtain the molecular phenotype of the individual at a given ***,metabolomics may be a helpful tool for classifying patients according to the severity of the disease and obtaining diagnostic *** studies demonstrate associations between circulating metabolites and early and established MAFLD,but little is known about how metabolites relate to and encompass sex differences in disease progression and risk *** this review,we will discuss the epidemiological metabolomic studies for sex differences in the development and progression of MAFLD,the role of metabolic profiles in understanding mechanisms and identifying sex-dependent biomarkers,and how this evidence may help in the future management of the disease.

关键词： MAFLD Sex differences Metabolic profiles Metabolism

A tale of two tails:asymmetry in Great Grey Shrike(Lanius excubitor)

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Avian Research 2018年第1期9卷 19-26页

作者： Reuven Yosef Anna maria Kubicka martin Brandsma Piotr Tryjanowski Ben-Gurion University of the Negev-Eilat Campus RO.Box 27288106 EilatIsrael. Institute of Zoology Poznan University of Life SciencesWojska Polskiego 71 C60-625 Poznari Poland. Noordwolde The Netherlands

Background: Asymmetry in the wild is a controversial, and to date, unresolved *** asymmetry(FA) is the developmental instability(intra-individual variation) while, directional asymmetry(DA) expresses the asymmetry of the population ***: We analysed 63 Great Grey Shrike(Lanius excubitor) skins at the Naturalis Biodiversity Center, Leiden, the *** black markings on the tails were digitized in order to evaluate the symmetry of the two sides of each *** helped understand if nutritional condition affected ***: ANOVA revealed no significant differences in size of the tail between sexes(F = 1.67, p > 0.05).However, there was significant difference in the shape of the black area in feathers between the sexes(F = 2.14, p < 0.05), and males had more elongated and slender black ***, DA was observed only in males, but FA was noted in both *** correlation showed no significant association between FA score and tail features in both the ***, in females, we observed a negative significant correlation between the number of fault and growth *** shape of the black area in the tail displayed no statistically significant association with the tail features in both sexes although growth bars influenced tail shape more than the number of fault ***: We concluded that the characteristics discovered by us need to also be checked in the field and if they can be used to sex ***, chromatic manipulative studies are require to verify if DA influences sexual selection in the Great Grey Shrike.

关键词： Lanius excubitor Ptilochronology Geometric morphometrics Fluctuating Directional asymmetry

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Effect of asphalt thin beams mixed with three nominal maximum aggregate sizes in the bending beam rheometer on the prediction of thermal properties of bituminous material

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 1-7页

作者： Chun-Hsing HO maria Francisca martinez GONZALEZ Cristina Pilar martin LINARES Department of Civil Engineering Construction Management and Environmental Engineering Northern Arizona UniversityFlagstaff Arizona 86001 USA

The objective of this research is to evaluate an impact of asphalt mixture beams with varying sizes of aggregate in the Bending Beam Rheometer （BBR） for testing/predicting thermal cracking properties of asphalt pavements. The BBR test has following benefits： the equipment is cheaper, it uses smaller specimens, faster conditioning, easier availability for quality control, easier to manage, etc. However some concerns have been raised： some consider that the size of the aggregate may affect the test＇s results; the other concern is that such small beams cannot represent the whole properties of the asphalt pavement. To address these criticisms, imaging techniques, statistical analysis, and viscoelastic modeling are used. Asphalt thin beams prepared with three different nominal maximum aggregate size （NMAS）（12.5mm, 9.5 mm, and 4.75 mm） were tested at three different temperatures （-18℃, -24℃, and -30℃）. Based on results from statistical analyses and viscoelasticity, the ratio of asphalt binders and voids and stiffness differences among the three NMAS specimens are not significant, meaning that the impact of asphalt thin beams prepared with the three NMAS on the prediction of thermal cracking is minimal and can be neglected.

关键词： bending beam rheometer thin beams thermal cracking

Structural and mechanical properties of La_(1/3)NbO_3 and La_(1/3)TaO_3 thin films prepared by chemical solution deposition

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Journal of Rare Earths 2017年第11期35卷 1115-1125页

作者： Helena Brunckova Lubomir Medvecky Alexandra Kovalcikova martin Fides Erika Mudra Juraj Durisin martin Sebek maria Kanuchova Jiri Skvarla Institute of Materials Research Slovak Academy of Sciences Watsonova 47040O1 Kosice Slovakia Technical "University of Kosice BERG Faculty Letna 9 04200 Kosice SIovakia

In this work, properties of perovskite lanthanum niobate La1/3NbO3(LN) and tantalate La1/3TaO3(LT)transparent thin films(200 nm thickness) prepared by chemical solution deposition on Pt/SiO2/Si substrates were described. The precursors and films were analyzed using FTIR and XPS spectra, XRD and SEM imaging. The both films after annealing at 1100 ℃ contained perovskite phase with a small fraction of pyrochlore LaNb5O14(in LN). The heterogeneous micro structure of LN film was composed from spherical or needle-like particles and homogeneous LT film that resulted in significant changes of their mechanical properties. The elastic modulus and hardness of these films were characterized for the first time by conventional and continuous stiffness(CSM) nanoindentation. The LT film modulus(E) and hardness(H) were higher(105.7 and 5.3 GPa) than LN(91.5 and 3.8 GPa). The effect of microstructure on mechanical properties is significant. In addition, the average Derjaguin-Muller-Toporov(DMT)-based elastic modulus of LN film surface were estimated50 GPa using AFM PeakForce QNM elastic mapping. The findings presented here can contribute to the fabrication of LN and LT films for the application to electrolytic thin film devices.

关键词： Thin films Sol-gel Perovskites Microstructures Mechanical properties

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