A half century (1961-2011) of applying microsurgery to experimental liver research
A half century (1961-2011) of applying microsurgery to experimental liver research作者机构：Surgery I Department School of Medicine Complutense University of Madrid 28040 Madrid Spain Neurosciences Lab Psychobiology Department School of Psychology University of Oviedo 33003 Oviedo Spain Surgery Department La Paz Hospital School of Medicine Autonomous University of Madrid 28049 Madrid Spain General Surgery Unit Sudeste Hospital Arganda del Rey 28500 Madrid Spain
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2012年第4卷第7期
页 面：199-208页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Supported by grants from the Mutua Madrile a Foundation, No. FMM Ref.no AP 69772009 the National Department of Science and Innovation, No. MICINN, Ref. no PSIC2010-19348, in part
主 题：Microsurgery Portacaval shunts Cholestasis Hepatectomies Liver transplantation Portal hypertension
摘 要：The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies.
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