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Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing

Regenerative Biomaterials 2021年第5期8卷 75-86页

作者： Alessia Ajovalasit Carlos Redondo-Go´mez maria antonietta sabatino Babatunde OOkesola Kristin Braun Alvaro Mata Clelia Dispenza Dipartimento di Ingegneria(DI) Universitadegli Studi di PalermoViale delle ScienzeEdificio 6Palermo 90128Italy School of Engineering&Materials Science Queen Mary University of LondonLondon E14NSUK Institute of Bioengineering Queen Mary University of LondonLondon E14NSUK Blizard Institute Barts and The London School of Medicine and DentistryThe Blizard Building4 Newark StreetLondon E12ATUK School of Pharmacy University of NottinghamNottingham NG72RDUK Department of Chemical and Environmental Engineering University of NottinghamNottingham NG72RDUK Biodiscovery Institute University of NottinghamNottinghamNG72RDUK Istituto di Biofisica(IBF) Consiglio Nazionale Delle Ricerche(CNR)Via U.La Malfa 153Palermo 90146Italy

Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound *** work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular *** this aim,the co-assembly behaviour of a carboxylated variant of xyloglucan(CXG)with a peptide amphiphile(PA-H3)has been investigated to generate hierarchical constructs with tuneable molecular composition,structure,and *** electron microscopy and circular dichroism at a low concentration shows that CXG and PA-H3 co-assemble into nanofibres by hydrophobic and electrostatic interactions and further aggregate into nanofibre bundles and *** a higher concentration,CXG and PA-H3 yield hydrogels that have been characterized for their morphology by scanning electron microscopy and for the mechanical properties by smallamplitude oscillatory shear rheological measurements and compression tests at different CXG/PAH3 ratios.A preliminary biological evaluation has been carried out both in vitro with HaCat cells and in vivo in a mouse model.

关键词： self-assembly peptide nanofiber hydrogel wound healing skin tissue engineering

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Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo Andrea maria Morace Francesca Guida sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

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Large-area Analysis of Soil Erosion and Landslides Induced by Rainfall: A Case of Unsaturated Shallow Deposits

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Journal of Mountain Science 2015年第4期12卷 783-796页

作者： CUOMO sabatino DELLA SALA maria Department of Civil Engineering University of Salerno

Unsaturated shallow soil deposits may be affected by either superficial soil erosion or shallow landslides in adjacent or overlapping source areas and in different seasons when a different soil suction *** triggering analysis of both these processes is a relevant issue for the hazard analysis while the literature mostly provides specific approaches for erosion or for *** paper proposes a largearea analysis for a case study of Southern Italy,consisting of unsaturated shallow deposits of loose pyroclastic(air-fall) volcanic soils that have been repeatedly affected by erosion and landslides in special *** a past catastrophic event, the simulated source areas of shallow landslides are smaller than those observed in the field while the simulated eroded areas with thickness greater than 5cm are comparable with the in-situ evidences, if the analysis takes into account high rainfall intensity and a spatially variable soil cover *** in general, the results of the paper are consistent with the previous literature and also provide a methodological contribution about the application of distinct tools over large *** added value is that the paper shows how the combination of distinct large-area analyses may help with understanding the dominant slope instability *** once this goal is fully achieved, can specific physically-based analyses be confidently performed at detailed scales and for smaller specific areas.

关键词： Soil Erosion Landslide Soil Suction Slope instability mechanism Modelling

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Hydrogeological hazards and weather events:Triggering and evolution of shallow landslides

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International Soil and Water Conservation Research 2014年第2期2卷 23-29页

作者： Salvatore Monteleone maria sabatino Dipartimento di Scienze della Terra e del Mare University of PalermoItaly

Landslides are the most intense and serious manifestations of the degradation of slopes and they are the main causes of geological hazard when they,directly or indirectly,involving towns and *** are a global environment problem;there are several examples that have produced untold damages and loss of human lives in many parts of the *** 1920 the landslides mobilization,as a result of a strong earthquake in China,in the province of Kansu,killed 200,000 people;in 1938 fast debris flow,triggered by heavy rainfalls in Japan,caused the death of 600 people;in 1963 in Italy the Vajont disaster caused the death of 1,899 people,as a result of a landslide localized in the underlying artificial *** the last years there have been many tragedies linked to intense rainfall events which have sparked many shallow landslides:1996 in Garfagnana,1998 in Sarno,2009 in the Ionic side of Messina,2011 in *** throw light on this problem,over the past decades,the assessment and mitigation of landslides hazard and the danger related to it,have become goals of paramount importance in territorial planning and,more generally,in its management and with it the safeguard of the historical and cultural heritage within *** occurrence of events which are considered exceptional thus implies a re-reading in terms of spatial planning to renovate the slopes and river-beds,as well as urban planning,infrastructural and socio-economic *** complex nature of these instability events that affect anthropized areas does not allow specific approaches for the defence of single good,but it finds a more effective solution based on the extensive knowledge of territory,perhaps at the scale of individual or several watersheds.

关键词： Geo-environmental hazard Hydrogeological instability Urban planning

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Investigating the role of stratigraphy in large-area physically-based analysis of December 1999 Cervinara shallow landslides

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Journal of Mountain Science 2016年第1期13卷 104-115页

作者： sabatino CUOMO Aniello IERVOLINO Department of Civil Engineering University of SalernoFisciano(sA)84084Italy

The paper describes a large-area analysis of the triggering zones of shallow landslides on a case of unsaturated layered volcanic air-fall(pyroclastic) soil deposits in Cervinara site(18 km^2),Southern *** physically-based model TRIGRS(Transient Rainfall Infiltration-Based Grid Regional Slope-Stability) is used,which is used with either saturated or unsaturated conditions and implemented in a GIS *** addition to using the TRIGRS model to simulate some recent landslides,a new simplified approach is also tested to take into account the actual layered soil *** consistency check of the model and of the input data is performed with reference to slope stable conditions before *** performances of the models are evaluated through the ROC curves and two other quantitative indexes taken from the literature referring to the slope failures caused by December 1999 *** the simplifications and limitations of the present work,both unsaturated conditions and layered stratigraphy are outlined as key factors for the slope stability of shallow deposits of unsaturated coarse-grained soils subjected to short heavy rainfall.

关键词： Shallow landslide Pore pressure Rainfall Modelling Stratigraphy Stability

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Does the autonomic nervous system contribute to the initiation and progression of prostate cancer？

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Asian Journal of Andrology 2013年第6期15卷 715-716页

作者： sabatino Ventura Bronwyn A Evans Drug Discovery Biology Monash Institute of PharmaceuticalSciences Monash University Parkville Vic. 3052 Australia

In the July 12 issue of Science maga-zine, researchers from the AlbertEinstein College of Medicine, the Mount Sinai School of Medicine, the Durham VA Medical Centre and Duke University published an elegant study demonstrating that the sym-pathetic nervous system, acting through β2 and β3-adrenoceptors in the prostate, plays an important role in the initiation of prostate can-cer, while the parasympathetic nervous system plays a role in the dissemination of tumour metastases via M1 muscarirdc receptors. These findings are significant because they indicate that receptors associated with the autonomic nervous system may be viable tar-gets for prostate cancer therapy.

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Scimitar Syndrome:Role of Right Atrial Longitudinal Strain.A Case Report

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Congenital Heart Disease 2021年第4期16卷 411-416页

作者： Isabella Leo Jolanda sabatino Sabrina La Bella Antonio Strangio Iolanda Aquila Concetta Procopio Carmen Anna maria Spaccarotella maria Petullà Salvatore De Rosa Ciro Indolfi Division of Cardiology Department of Medical and Surgical SciencesMagna Graecia UniversityCatanzaroItaly Cardiovascular Research Center Magna Graecia UniversityCatanzaroItaly Department of Paediatric Cardiology Royal Brompton HospitalLondonUK Department of Radiology Magna Graecia UniversityCatanzaroItaly Mediterranea Cardiocentro NapoliItaly

We describe a case of a rare congenital heart disorder,scimitar syndrome,diagnosed in an adult woman presenting with dyspnea on exertion,chest pain and recurrent episodes of pulmonary *** hallmark of the syndrome is the presence of an enlarged anomalous pulmonary vein draining into the inferior vena *** tracking echocardiography,including the often-forgotten atrial strain evaluation,is a sensitive parameter that should be routinely used for a better clinical and prognostic evaluation of patients with congenital heart disease(CHD).

关键词： Scimitar syndrome RV overload congenital heart disease myocardial strain

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Grafting affects yield and phenolic prof ile of Solanum melongena L. landraces

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Journal of Integrative Agriculture 2016年第5期15卷 1017-1024页

作者： L sabatino G Iapichino A Maggio E D’ Anna M Bruno F D’ Anna Department of Agricultural and Forest Sciences University of Palermo Department of Biological Chemical and Pharmaceutical Sciences and Technologies University of Palermo Regional Centres for Agricultural Technologies (Ce.R.T.A.) University of Foggia

The influence of grafting on agronomical and qualitative characteristics of four Sicilian eggplant landraces was investigated. Grafted and ungrafted plants were compared in the open field in the northern coast of Sicily. Solanum torvum seedlings were used as rootstock. Regardless of genotypes tested, grafting significantly increased total fruit production, marketable production, and number of marketable fruits, but did not affect weight of marketable fruits and waste production. Landrace 2（Sciacca）, with black epidermal tissue and pyriform fruit shape, when grafted onto S. torvum not only gave a higher yield performance than ungrafted plants, but also showed a higher phenolic antioxidant content. Landrace 4（Sicilia）, with black epidermal tissue and small cylindrical fruits also benefited, when grafted onto S. torvum, from a substantial increase in antioxidant fruit content. As consumers＇ demand for fruits and vegetables rich in compounds important for human health is steadily increasing, these landrace/rootstock combinations should deserve more attention by plant nurseries involved in grafted seedling production and interested in the valorization and conservation of eggplant biodiversity.

关键词： eggplant propagation technique yield polyphenols HPLC analysis

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Vacuum Assisted Closure (VAC) and Platelet-Rich Plasma (PRP): A Successful Combination in a Challenging Case of Gastroschisis

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Open Journal of Pediatrics 2015年第3期5卷 274-278页

作者： Vincenzo Domenichelli Simona Straziuso maria Domenica sabatino Silvana Federici Pediatric Surgical Unit “Infermi” Hospital AUSL Romagna Rimini Italy

Giant gastroschisis could be a surgical challenge concerning the abdominal wall reconstruction. Many techniques have been described for both primary or staged closure but sometimes neither of them is succesful in all patients. We are presenting the combined use of Vacuum Assisted Closure (VAC) and Platelet-Rich Plasma (PRP) to improve the result in this difficult case. The use of VAC device is a well known procedure in the treatment of adult difficult wounds closure. It consists of a sponge applied directly on the abdominal wall defect, covered with a transparent dressing and connected to a controlled continuous negative pressure system [1]. Platelet-rich plasma (PRP) is an autologous concentration of human platelets in a small volume of plasma. Due to this combination it provides multiple growth and healing factors actively secreted by platelets which have been shown to begin and accelerate wound healing [2] [3]. The association between VAC and PRP was effective in the shrinkage and reduction of the abdominal defect. Fifteen months after the removal of the VAC device the fascia appears competent with a cutaneus scar that will need a plastic correction in the future. The VAC should be considered as a helpful and effective device in case of complicated giant gastroschisis or omphalocele when traditional treatment is not sufficient.

关键词： Vacuum Assisted Closure Gastroschisis Platelet-Rich Plasma Abdominal Wall Defect

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Is it worth investigating splenic function in patients with celiac disease?

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World Journal of Gastroenterology 2013年第15期19卷 2313-2318页

作者： Antonio Di sabatino Laura Brunetti Gabriella Carnevale Maffè Paolo Giuffrida Gino Roberto Corazza Department of Internal Medicine Celiac CentreS. Matteo Hospital FoundationUniversity of Pavia27100 PaviaItaly

Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one-third of adult patients with celiac disease, and it may predispose to a higher risk of infections by encapsulated bacteria and thromboembolic and autoimmune complications, particularly when celiac patients have concomitant pre-malignant and malignant complications (refractory celiac disease, ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma). However, the clinical management of patients with celiac disease does not take into account the evaluation of splenic function, and in patients with high degree of hyposplenism or splenic atrophy the prophylactic immunization with specific vaccines against the polysaccharide antigens of encapsulated bacteria is not currently recommended. We critically re-evaluate clinical and diagnostic aspects of spleen dysfunction in celiac disease, and highlight new perspectives in the prophylactic management of infections in this condition.

关键词： Hyposplenism Memory B cell Pitted red cell Pneumococcal vaccine Splenic atrophy

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