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Peritoneal carcinomatosis from advanced ovarian cancer: To treat or not to treat ethical issues suggested by a case study

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World Journal of Obstetrics and Gynecology 2014年第1期3卷 14-20页

作者： Mirco Nacoti Elena Colombetti maria Simonetta Spada Marco Ceresoli Luca Ansaloni Gianmariano Marchesi Luca Lorini Davide Corbella Federico Coccolini Anesthesia and Intensive Care Department Papa Giovanni XXIII Hospital 24127 Bergamo Italy Centre for Bioethics Università Cattolica del Sacro Cuore di Milano 20121 Milan Italy Clinical Psychology Unit Papa Giovanni XXIII Hospital 24127 Bergamo Italy General Surgery Departement Papa Giovanni XXIII Hospital 24127 Bergamo Italy

This article provides a brief description of an epithelial ovarian cancer （EOC） case （stage Ⅳ） treated with the association of complete CytoReductive Surgery and hy-pertermic intraPEritoneal chemotherapy （HIPEC）. The use of HIPEC in EOC makes theoretic sense in view of the high rates of recurrence following standard treat-ment, but there are no randomized clinical trial to date and HIPEC for these patients still represents a radical treatment where the choice of no treatment may be acceptable since defnitive cure is unlikely. We reviewed the entire decision making process considering the risk/beneft of the procedure in term of mortality/morbidity, the quality of life and the psychological profile of the patient 1 year after surgery. The platform World Health Organization-International Classification of Function-ing, Disability and Health that permits evaluation of the person in relation to the psycho-social context is pre-sented. A person-centred approach and assessment of health-related quality-of-life and disability in EOC survi-vors are of central importance for decision making.

关键词： Advanced epithelial ovarian cancer Perito-neal carcinomatosis Platform World Health Organiza-tion-International Classifcation of Functioning Disability and health Ethical issues Hyperthemic intraperitoneal chemotherapy Health related quality of life

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HS-SPME/GC-MS Analysis of VOC and Multivariate Techniques Applied to the Discrimination of Brazilian Varieties of Mango

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American Journal of Analytical Chemistry 2014年第3期5卷 157-164页

作者： Clícia maria de Jesus Benevides Marcos de Almeida Bezerra Pedro Afonso P. Pereira Jailson Bittencourt de Andrade Departamento de Ciências da Vida Universidade do Estado da Bahia (UNEB) Salvador Brazil Instituto de Química Universidade Federal da Bahia (UFBA) Salvador Brazil Laboratório de Química Analítica Universidade Estadual do Sudoeste da Bahia (UESC) Jequié Brazil

The present study analyzed the volatile compounds of three mango varieties (Tommy Atkins, Rosa and Espada) using the static headspace technique with SPME coupled to CG-MS. Multivariate methodologies, such as factorial design and response surface methodology, were used to optimize the conditions of adsorption and desorption of these substances. The data were evaluated by using principal components analysis (PCA) and hierarchical grouping analysis, in order to visualize grouping tendencies of volatile compounds. Thirty-seven volatile compounds belonging to different chemical classes, such as esters, terpenes, alcohols and others, were tentatively identified in the three varieties of mango. Amongst them, twenty-three presented chromatographic peaks with relative areas larger than 2%. The multivariate analysis made it possible to visualize the grouping tendencies of the mango samples, according to the presence of their respective volatile substances, and enabled the identification of the groups of substances responsible for the discrimination among the three varieties.

关键词： Mango Volatiles Multivariate Techniques HS-SPME/GC-MS Chemometrics

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Factorial analysis of the effect of sugarbeet vinasses on agroecological indices in horticultural field

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Journal of Agricultural Science and Technology 2009年第8期3卷 31-39页

作者： Miguel Angel Diez-Rojo Jose Antomo Lopez-Perez maria Rosa Gonzalez-Lopez Ana Piedra Buend Antonio Bello Gonzalo Almendros Centro de Ciencias Medioambientales CSIC Madrid 28006 Spain Centro de Experimentacion Agraria de Marchamalo Consejeria de Agricultura de Castilla-La Mancha Guadalajara 19180 Madrid Spain

The impact on soil of applying sugarbeet vinasses （V） was analyzed through a field experiment in horticulture greenhouse, arranged in a 23 factorial design. Two levels of three independent variables--application of V, use of polyethylene cover （PC） on the soil. and soil depth （D）---on various dependent variables were studied. Vinasses favoured crop yield and reduced the number of Meloidogyne incognita juveniles in soil. The concentrations ofN. P and K increased with the interaction VxD, with PC also increasing N concentration. The amounts of humic acids and humin decreased with D; fulvic acid concentration increased with V, but decreased with the interaction VxPC. Soil physical factors were improved mainly with D and V. Aromaticity of humic acid-like fractions increased ~＇itb V. In general, V showed significant effects mainly on the topsoil, suggesting low leaching risks. The results indicate that the levels of the independent factors improving a group of variables were not the same that those contributing to another group. Therefore, their best combination should be determined for each scenario to achieve optimum agroecological performance.

关键词： aggregate stability. biodisinfestation humic acid meloidogyne soil organic matter sugarbeet vinasses

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CDX2 Overexpression in Barrett’s Esophagus and Esophageal Adenocarcinoma

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Journal of Cancer Therapy 2014年第7期5卷 657-663页

作者： Leandro Almeida Streher Vinicius Campos Guilherme da Silva Mazzini Marcelo Binato Luise Meurer maria Isabel Edelweiss Richard Ricachenevsky Gurski Gastrointestinal Surgery Department Hospital de Clínicas de Porto Alegre Porto Alegre Brazil School of Medicine Universidade Federal do Rio Grande do Sul Porto Alegre Brazil

Background: Patients with Barrett’s esophagus have an increased risk of developing esophageal adenocarcinoma. Our purpose was to determine CDX2 expression in esophageal mucosa and establish a correlation between this marker and the progression of disease. Methods: We analyzed biopsies and surgical specimens from 150 patients who were divided into five groups according to histopathological diagnosis: G1, normal mucosa (n = 29);G2, esophagitis (n = 19);G3, columnar epithelium without intestinal metaplasia (n = 26);G4, Barrett’s esophagus (n = 32), and G5, adenocarcinoma (n = 44). Immuno-histochemical determination of CDX2 expression was considered positive in the presence of nuclear staining. Results: No CDX2 expression was detected in the G1 or G3 groups;5% of G2, 62.5% of G4 and 70.5% of G5 patients were CDX2 positive. There was a statistically significant difference between the G4 and G5 groups compared to the G1, G2 and G3 (p < 0.05). Conclusions: CDX2 expression was observed among patients with Barrett’s esophagus and adenocarcinoma compared to other groups. CDX2 was not expressed in the phases preceding Barrett’s esophagus, but there was no linear correlation between CDX2 expression and metaplasia-adenocarcinoma progression.

关键词： CDX2 Barrett’s Esophagus Intestinal Metaplasia Esophageal Adenocarcinoma Immunohistochemistry

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Are There Age-Related Differences in the In-Hospital Treatment of Victims from Out-of-Hospital Cardiac Arrest?

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International Journal of Clinical Medicine 2015年第6期6卷 431-438页

作者： Martin Christ Katharina Isabel von Auenmueller Irini maria Breker Jeanette Liebeton Michael Brand Jan Peter Noelke Hans-Joachim Trappe Department of Cardiology and Angiology Ruhr-University Bochum Bochum Germany

Objective: Hardly anything is known about reasons for age-related differences in surviving out-of-hospital cardiac arrest (OHCA) with worse surviving rates in elderly. Methods: 204 victims from OHCA who were admitted in our hospital between January 1st 2008 and December 31st 2013 were identified. According to their mean age (69.1 ± 14.2 years) we classified those patients (pts) who were younger than mean age minus standard deviation (SD) as young, and those victims from OHCA who were older than mean age plus SD as old. Results: Young victims from OHCA (n = 32 pts) presented more often with an initial shockable rhythm than the elderly (n = 38 pts) (50.0% vs. 21.1%;p = 0.014), received more often coronary angiography (71.9% vs. 18.4%;

关键词： Out-of-Hospital Cardiac Arrest Mild Therapeutic Hypothermia Coronary Angiography Resuscitation Elderly

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Diagnostic neuroradiology for the interventional neuroradiologist

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World Journal of Radiology 2013年第11期5卷 386-397页

作者： Vitor Mendes Pereira maria Isabel Vargas Ana Marcos Philippe Bijlenga Ana Paula Narata Sven Haller Karl-Olof Lvblad Service Neuro-diagnostique et Neuro-interventionnel Geneva University Hospitals Service de Neurochirurgie HUG Geneva University Hospitals

In order to further improve the impact of the continuously evolving neurointerventional techniques, the interventional neuroradiologist needs to have at his disposal more powerful techniques to image the central nervous system. With the recent development of diagnostics techniques that are computed tomography and magnetic resonance based we are now able to assess not just morphology, but also physiology, physiopathology and function. This review discusses the place of diagnostic techniques in the evaluation that the interventional neuroradiologist hast to make when confronted with patients. We provide an overview of current techniques for the brain and spine.

关键词： Neuroradiology Brain Imaging Magnetic resonance Interventional radiology

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Trends in Wind-Power Desalination for Water Supply

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Journal of Environmental Protection 2019年第6期10卷 807-820页

作者： Fabrícia de S. Moreira Adelaide maria de S. Antunes Marcos Aurélio V. de Freitas Program of Engineering of Chemical and Biochemical Processes School of Chemistry Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Nacional de Propriedade Industrial (INPI) Rio de Janeiro Brazil Energy Planning Program COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Water scarcity is a threat for mankind and its symptoms have been aggravated by several factors such as climate change effects, increase in population and accelerated urbanization. Among the alternatives of water supply, the desalination has become one of the most sustainable solutions to provide freshwater. However, the process of desalination requires high quantities of energy and the use of renewable energy sources can make the technology affordable for regions characterized by fresh-water scarcity where the supply from electricity is not accessible. In this context, wind power can be singled out because of the constant innovations and progress of the wind power industry, which grows rapidly worldwide. This study aims to use patent applications for the technological forecasting of wind-powered desalination in order to analyse its innovation potential. China is the leader country in the technological development of this field, accounting for almost 80% of patent applications in the last 17 years. The patents analysis showed that innovations are being developed to combine the wind power, mainly, with Reverse Osmosis technology. This study also shows the immense potential of integrating of these two technologies as a strategic alternative for remote regions affected by a lack of freshwater and with no electricity access.

关键词： Water Scarcity Desalination Wind Energy Technological Trends Patent Applications

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Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal Bruno Lima Rodrigues Marina Moreira de Castro Alan Sidnei Corrêa Martins Dante Orsetti Silva Araújo Luis Eduardo Miani Gomes Michel Gardere Camargo maria de Lourdes Setsuko Ayrizono Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(P<0.0001),and in 44%,there was an increase of≥2 g/dL in a single *** addition,86%of the patients showed an increase in serum iron(P<0.0001)and ferritin(P=0.0008)and 50%in transferrin saturation(P=0.01).The serum iron levels at baseline showed a negative association with the ileal and colonic CD and use of biologics and a positive association with patients who developed CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

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Chronic hepatitis C:This and the new era of treatment

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World Journal of Hepatology 2016年第2期8卷 92-106页

作者： Gaetano Bertino Annalisa Ardiri maria Proiti Giuseppe Rigano Evelise Frazzetto Shirin Demma mariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta Bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone mariano Malaguarnera Emanuele Bertino Michele Malaguarnera Hepatology Unit-Department of Clinical and Experimental Medicine University of Catania95123 CataniaItaly Internal Medicine Unit ARNAS Civic Hospital90142 PalermoItaly Research Centre“La Grande Senesce” University of Catania95100 CataniaItaly Department of Biomedical Sciences University of Catania95100 CataniaItaly Faculty of Pharmacy University of Catania95123 CataniaItaly Occupational Medicine Unit Department of Clinical and Experimental MedicineUniversity of Catania95100 CataniaItaly Department of Surgical Sciences Organ Transplantation and Advanced TechnologiesUniversity of Catania95100 CataniaItaly Gastroenterology Unit Acireale Hospital95024 AcirealeCataniaItaly

Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects.

关键词： Direct-acting antiviral agents Nucleosideinhibitors Boceprevir Sofosbuvir Telaprevir HepatitisC Simeprevir Daclatasvir Ledipasvir Faldaprevir Ritonavir Ombitasvir Dasabuvir

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Color of Corn Grains and Carotenoid Profile of Importance for Human Health

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American Journal of Plant Sciences 2014年第6期5卷 857-862页

作者： Sara de Almeida Rios maria Cristina Dias Paes Wilton Soares Cardoso Aluízio Borém Flávia França Teixeira Embrapa Western Amazon ManausBrazil Embrapa Maize and Sorghum Sete LagoasBrazil Federal Institute of Education Science and Technology of the Espírito SantoIFESVenda Nova do ImigranteBrazil Federal University of Vicosa VicosaBrazil

The increasing on the levels of carotenoids in staple foods of broad human consumption is one of the strategies of food biofortification programs, mainly due to the importance of these compounds to human health on the prevention of vitamin A deficiency. Maize is a major staple food due to its high consumption in regions where problems of Vitamin A deficiency are of great relevance. Maize biofortification programs have made progress in determining the amounts of carotenoids in grain of thousands of accesses. This work aimed at studying the influence of the color of the grains in the profile of carotenoids in four different Brazilian genotypes. The selection of ears within the same genotype was based on a color scale, considering the lighter (lightest yellow) in one group and the most colorful (darkest orange) in another group. Significant interactions (p 0.05) between the color of the grains and the genotypes for all the variables were detected in addition to genetic variability for both groups (lightest yellow and darkest orange). The colored ears of corn showed a high level of total carotenoids (TC) and fractions in RS 535 and RS 445, and the colorful ears of genotype RS 535 showed 300% more α + β carotenes (μg·g-1) in relation to lighter of this same material. The results of this study showed the influence of genotype on the grain color and content of carotenoids, indicating that breeders have the flexibility to make selection of some genotypes based on grain color, reducing cost and time compared to laboratory methods used for the screening of genetic materials.

关键词： Carotenes Zea mays Vitamin A Genetic Variability Biofortification

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