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Eye and Vision 2016年第1期3卷 263-282页

作者： Katie L.Pennington margaret m.deangelis Department of Ophthalmology John A.Moran Eye CenterUniversity of UtahSalt Lake CityUTUSA

Age-related macular degeneration(AmD)is the leading cause of irreversible blindness in adults over 50 years ***,epidemiological,and molecular studies are beginning to unravel the intricate mechanisms underlying this complex disease,which implicate the lipid-cholesterol pathway in the pathophysiology of disease development and *** of the genetic and environmental risk factors associated with AmD are also associated with other complex degenerative diseases of advanced age,including cardiovascular disease(CVD).In this review,we present epidemiological findings associating AmD with a variety of lipid pathway genes,cardiovascular phenotypes,and relevant environmental *** a number of studies showing significant associations between AmD and these lipid/cardiovascular factors,results have been mixed and as such the relationships among these factors and AmD remain *** is imperative that researchers not only tease out the various contributions of such factors to AmD development but also the connections between AmD and CVD to develop optimal precision medical care for aging adults.

关键词： Atherosclerosis Hypertension Retina Statins Stroke Cholesterol Obesity BmI Antioxidants Genetic association

Emerging roles of circular RNAs in retinal diseases

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Neural Regeneration Research 2022年第9期17卷 1875-1880页

作者： Aneliya Hanineva Karen Sophia Park Joshua J.Wang margaret m.deangelis michael H.Farkas Sarah X.Zhang Department of Ophthalmology and Ross Eye Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA Research Service Veterans Administration Western New York Healthcare SystemBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA

Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the *** research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal *** this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just *** knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and ***,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular ***,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

关键词： age-related macular degeneration circular RNA diabetic retinopathy glaucoma microRNA proliferative vitreoretinopathy retina

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

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Journal of molecular Cell Biology 2017年第6期9卷 516-532页

作者： maximilian J. Gerhardt Joseph A. marsh margaux morrison Andrius Kazlauskas Arogya Khadka Stephan Rosenkranz margaret m. deangelis magali Saint-Geniez Sarah melissa P. Jacobo Department of Ophthalmology Harvard Medical School The Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary Boston MA 02114 USA Department III of Internal medicine Cologne University Heart Center Center for Molecular Medicine University of Cologne 50931 Cologne Germany mRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh EH4 2XU UK Department of Ophthalmology and Visual Sciences University of Utah and John A. Moran Eye Center Salt Lake City UT 84132 USA

High temperature requirement A1 （HtrA1） belongs to an ancient protein family that is linked to various human disorders. The pre- cise role of exon 1-encoded N-terminal domains and how these influence the biological functions of human HtrAZ remain elusive. In this study, we traced the evolutionary origins of these N-terminal domains to a single gene fusion event in the most recent common ancestor of vertebrates. We hypothesized that human HtrA1 is impticated in unfotded protein response. ｜n highly secre- tory cells of the retinal pigmented epithelia, endoplasmic reticulum （ER） stress upregulated HtrA1. HtrA1 co-localized with vimen- tin intermediate filaments in highly arborized fashion. Upon ER stress, HtrA1 tracked along intermediate filaments, which collapsed and bundled in an aggresome at the microtubule organizing center. Gene silencing of HtrA1 altered the schedule and amplitude of adaptive signaling and concomitantly resulted in apoptosis. Restoration of wild-type HtrA1, but not its protease inactive mutant, was necessary and sufficient to protect from apoptosis. A variant of HtrA1 that harbored exon 1 substitutions dis- played reduced efficacy in rescuing cells from proteotoxicity. Our results illuminate the integration of HtrA1 in the toolkit of mam- malian cells against protein misfolding and the implications of defects in HtrA1 in proteostasis.

关键词： ER stress unfolded protein response RPE HtrA1 multi-domain protein evolution proteostasis

mandated health insurance increases rates of elective knee surgery

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World Journal of Orthopedics 2019年第2期10卷 81-89页

作者： Daniel Kim Woo Do Shahein Tajmir Brandon mahal Joe deangelis Arun Ramappa Radiation Oncology Massachusetts General Hospital Harvard Medical School Department of Surgery Madigan Army Medical Center Radiology Massachusetts General Hospital Harvard Medical School Department of Orthopaedic Surgery Beth Israel Deaconess Medical Center Harvard Medical School

BACKGROUND The recent federal ruling to against Affordable Care Act(ACA), specifically the mandate requiring people to buy insurance, has once again brought the healthcare reform debate to the spotlight. The ACA increased the number of insured Americans through the development of subsidized healthcare plans and health insurance exchanges. Insurance-based differences in the rate of upper extremity elective orthopaedic surgery have been described before and after healthcare reform in massachusetts, where a similar mandate was put into place years before the ACA was passed. However, no comprehensive study has evaluated insurance-based differences of knee elective surgery before and after *** To investigate how an individual mandate to purchase health insurance affects rates of knee *** A retrospective review was performed within an orthopaedic surgery department at a tertiary-care, academic medical center in massachusetts. The rate of elective knee surgery performed before and after the healthcare reform(2005-2006 and 2007-2010, respectively) was calculated. The patients were categorized by insurance type(Commonwealth Care, medicare, medicaid, private insurance,Workers' Compensation, TriCare, and Uninsured). Using χ2 testing, differences in rates of surgery between the pre-reform and post-reform period and among insurance subgroups were *** Rate of surgery increased in the post-reform period(pre-reform 8.07%(95%CI:7.03%-9.11%), post-reform 9.38%(95%CI: 8.74%-10.03%)(P = 0.04) and was statistically significant. When the insurance groups and insurance types were compared, the rates of surgery are not significantly different before or after *** The increase in the rate of elective knee surgery in the post-reform period suggests that health care reform in massachusetts has been successful in decreasing the uninsured population and may increase health care *** is a hypothesis generating study that suggests furthe

关键词： Healthcare reform Elective surgery Lower extremity Affordable Care Act Orthopaedic surgery

Simulation for Astroparticle Experiments and Planetary Explorations：Tools and Applications

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International Conference on Computing in High Energy and Nuclear Physics 2001年第1期 341-344页

作者： A.deangelis A.Brunengo 等 UniversitadiUdineandINFNSezionediTrieste Italy） INFNSezionediGenova Italy

We present a set of tools and general-pupose applications for the simulation of astrophysics and astroparticle experiments,concerning both physics and radiation background *** addrss the speific requirements of various typical astroparticle detectors:new-generation X-and γ-ray detectors on satellites,underground detectors for astroparticle experiments and solar system explorations.

关键词：宇宙物理学宇宙粒子探测宇宙模拟

Identification of Oblate Band in Odd-Odd ^184Au

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Chinese Physics Letters 2004年第5期21卷 799-801页

作者：张玉虎王华磊 G.deangelis N.marginean A.Gadea D.R.Napoli m.Axiotis C.Rusu T.martinez 周晓红郭文涛柳敏良雷祥国郭应祥许甫荣 InstituteofmodernPhysics ChineseAcademyofSciencesLanzhou730000 GraduateSchool ChineseAcademyofSciencesBeijing100039 IstitutoNazionalediFisiscaNucleare LaboratoriNazionalidiLegnaroLegnaroItaly Hahn-meitner-Institut BerlinGermany DepartmentofTechnicalPhysicsandmOEKeyLaboratory PekingUniversityBeijing100871

High-spin states in 184Au have been populated via the 149Sm(29Si, 4nγ) 184Au reaction at a beam energy of 140meV. Three- or higher-fold γ-ray coincidences have been measured using the multidetector array of GASP. A rotational band built on the 11− oblate πh11/2−1⊗νi13/2−1 structure has been newly observed, similar to those reported in 186−194Au. This result extends the knowledge of shape coexistence to the currently lightest odd–odd Au isotope.

关键词： Gamma rays

Relationship Between Vegetation Restoration and Soil microbial Characteristics in Degraded Karst Regions: A Case Study

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Pedosphere 2011年第1期21卷 132-138页

作者： WEI Yuan YU Li-Fei ZHANG Jin-Chi YU Yuan-Chun D. L. deangelis School of Resources and Environmental management Guizhou College of Finance and Economics Guiyang 550004 (China) College of Forestry Guizhou University Guiyang 550025 (China) College of Forest and Environment Nanjing Forestry University Nanjing 210037 (China) Department of Biology University of Maimi P. O. Box 249118 Coral Gables FL 33124 (USA)

The mechanism of vegetation restoration on degraded karst regions has been a research focus of soil science and ecology for the last *** an attempt to preferably interpret the soil microbiological characteristic variation associated with vegetation restoration and further to explore the role of soil microbiology in vegetation restoration mechanism of degraded karst regions,we measured microbial biomass C and basal respiration in soils during vegetation restoration in Zhenfeng County of southwestern Guizhou Province,*** community level physiological profiles(CLPP) of the soil microbial community to were estimated determine if vegetation changes were accompanied by changes in functioning of soil microbial *** results showed that soil microbial biomass C and microbial quotient(microbial biomass C/organic C) tended to increase with vegetation restoration,being in the order arboreal community stage > shrubby community stage > herbaceous community stage > bare land *** trend was found in the change of basal respiration(BR).The metabolic quotient(the ratio of basal respiration to microbial biomass,qCO 2) decreased with vegetation restoration,and remained at a constantly low level in the arboreal community *** of the CLPP data indicated that vegetation restoration tended to result in higher average well color development,substrate richness,and functional *** utilization of specific substrate guilds was highest in the arboreal community *** component analysis of the CLPP data further indicated that the arboreal community stage was distinctly different from the other three *** conclusion,vegetation restoration improved soil microbial biomass C,respiration,and utilization of carbon sources,and decreased qCO 2,thus creating better soil conditions,which in turn could promote the restoration of vegetation on degraded karst regions.

关键词： basal respiratory community level physiological profile functional diversity metabolic quotient microbial biomass C

Interaction between salinity intrusion and vegetation succession:A modeling approach

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Theoretical & Applied mechanics Letters 2013年第3期3卷 1-8页

作者： Su Yean Teh Hock Lye Koh Donald L.deangelis mike Turtora School of mathematical Sciences Universiti Sains MalaysiaPenang 11800Malaysia UCSI University No.1UCSI HeightsJalan Menara GadingTaman ConnaughtKuala Lumpur 56000Federal Territory of Kuala Lumpur U.S.Geological Survey and University of miami Coral GablesFlorida 33124USA U.S.Geological Survey GainesvilleFlorida 32605USA

Predicting potential changes in groundwater salinity in low-lying coastal regions due to climate change is important, where coastal vegetation is abundant, succession competition between halophytes and glycophytes plays a significant role in the salinity budget. Sea level rise enhances salinity intrusion, contributing an additional dimension to vegetation competition. A new simulation model known as mangrove-hardwood hammock model coupled with saturated-unsaturated transport （mANTRA） has recently been developed by the authors to simulate groundwater salinity regimes in the presence of vegetation competition, subject to climate change. mANTRA is based upon linking two existing Unites States geological survey （USGS） simulation models known as mangrove-hardwood hammock model （mANHAm） and saturated-unsaturated transport （SUTRA）. mANHAm simulates the evolution of vegetation succession subject to changing groundwater salinity. SUTRA simulates saturated and unsaturated transport of solutes and salinity in groundwater given sea salinity. mANTRA improves the simulation robustness to simultaneously simulate groundwater hydrology, salinity and coastal vegetation succession subject to sea level rise. Some simulation results will be presented to demonstrate the impact of sea level rise on coastal vegetation succession and groundwater salinity.

关键词： salinity intrusion groundwater vegetation succession mANTRA climate change