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作者： margaret Mitchell[]

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Combating Climate Change Through Scratch Card Waste Management

地学前缘 2009年第S1期16卷 99-100页

作者： margaret Akinyi Demba Minai Okach Joshua Environmental Science Intervarsity Environmental Network Unite for Climate(A Unicef Initiative)MESA-Mainstreaming Environmental Sustainability in African Universities(A UNEP Initiative)

One of the most challenging anthropogenic activities that have driven climate change off the edge is *** human populations have exerted a lot of pressure on natural forests due to the increased demand of resources—one of which is *** example of this effect is the increased usage of mobile phone scratch cards made out of paper that most of the population in Africa use to top-up

关键词： deforestation climate change recycling paper scratch-cards students

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Medical therapy for nephrolithiasis:State of the art

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Asian Journal of Urology 2018年第4期5卷 243-255页

作者： Igor Sorokin margaret S.Pearle Department of Urology University of MassachusettsWorcesterMAUSA Department of Urology UT Southwestern Medical CenterDallasTXUSA Charles and Jane Pak Center for Mineral Metabolism and Bone Research UT Southwestern Medical CenterDallasTXUSA

The prevalence of nephrolithiasis is increasing *** and implementing medical therapies for kidney stone prevention are critical to prevent recurrences and decrease the economic burden of this *** and pharmacologic therapies require understanding on the part of the patient and the prescribing practitioner in order to promote *** into occupational exposures and antibiotic use may help uncover individual risk ***-up is essential to assess response to treatment and to modify treatment plans to maximize therapeutic benefit.

关键词： Medical management Kidney stones Medical therapy Pharmacology Nephrolithiasis

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Therapeutic targets in the pancreatic adenocarcinoma microenvironment: past challenges and opportunities for the future

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 448-465页

作者： Erica S.Tsang margaret A.Tempero Helen Diller Family Comprehensive Cancer Center University of California San FranciscoSan FranciscoCA 94158USA

Pancreatic ductal adenocarcinoma(PDAC)remains a leading cause of cancer-related mortality,with cytotoxic chemotherapy still the mainstay of *** effective therapeutic agents alone,successful drug delivery is *** PDAC,the tumor microenvironment represents a physical barrier that limits in vivo drug delivery and *** this review,we highlight therapeutic targets in the tumor microenvironment,focusing on past challenges and opportunities for the *** discussed include the Hedgehog pathway,angiogenesis,hyaluronic acid,cancer-associated fibroblasts and associated cytokines,among *** the obstacles in successfully recapitulating promising lab results to practice-changing clinical results,many important lessons have been learned to improve clinical trial design within a highly engaged and motivated scientific *** collaborative efforts and the collective optimism will continue to propel the momentum forward to overcome these barriers and ultimately improve patient outcomes.

关键词： Pancreatic cancer PDAC tumor microenvironment pancreatic stroma

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The Gothic and death

The Gothic and death

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作者： Davison Carol margaret

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LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma

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Genes & Diseases 2023年第1期10卷 254-266页

作者： Xiang Chen margaret Clement MJohn Hicks Poonam Sarkar MWaleed Gaber Tsz-Kwong Man Department of Pediatrics Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Department of Pathology Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Dan L.Duncan Comprehensive Cancer Center 7200 Cambridge StreetHoustonTX 77054USA Texas Children's Cancer and Hematology Centers 1102 Bates StHoustonTX 77030USA

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric *** the use of chemotherapy and surgery,metastasis remains to be the leading cause of death in patients with *** have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in *** this study,we further show that lysyl oxidase(LOx)expression was associated with p27 *** is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter;however,its role in osteosarcoma is still ***,we performed both in vitro and in vivo analyses to dissect the role of Lox in *** result of our survival analysis indicated that Lox expression significantly correlated with a poor outcome in osteosarcoma with or without controlling for the initial metastasis status(P<0.05).Functionally,we found that higher LoX expression promoted osteosarcoma cell proliferation,migration,and invasiveness in vitro and produced a higher number of mice with pulmonary metastases in an orthotopic xenograft mouse ***,phospho-FAK was increased in osteosarcoma cells with high LOX *** results further showed that FAK inhibition significantly reduced tumor cell proliferation and migration in vitro as well as LoX-mediated metastasis in ***,our findings suggest that there is a novel link between p27 mislocalization and LOX *** plays a pivotal role in osteosarcoma metastasis by upregulating FAK *** inhibition may constitute a promising therapeutic strategy to reduce the development of metastasis in osteosarcoma with Lox overexpression.

关键词： Focal adhesion kinase Lysyl oxidase Metastasis Osteosarcoma

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Emma: Intermediate (Macmillan Readers)

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2005年

作者： Jane Austen, margaret Tarner...

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The Internet for Nurses and Allied Health Professionals 3

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丛书名： Health Informatics

2002年

作者： margaret J. A. Edwards

ISBN: (数字)9781461300274

ISBN: (纸本)9780387952369

New and expanded to reflect changes on the Internet, especially the explosive growth of the World Wide Web, this best-selling book is primer to the Internet for those who have little or no computer experience and a time-saving guide to resources for the more experienced surfer. In plain language it describes the Internet, how it works, and how to use various Internet tools. In addition, it provides an extensive listing of health-related Internet resources accompanied by reviews and descriptions - not just URLs - of dozens of health-related topics. From the online "American Journal of Nursing" to the "Virtual Nursing Centre," this third edition contains hundreds of new sites, as well as an expanded section devoted to the use of search engines. The reader will find this directory a treasure trove of information resources available for health care professionals on the Internet. When you need to have up-to-the-minute information at your fingertips, when you need to know about the latest changes in health care reform - that's when you discover the real power of the Internet. It allows you to exchange information with peers around the world instantly, giving you the knowledge edge to keep your nursing or health care practice professional and progressive.

关键词： Nursing Health Informatics

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Optimal allocation of watershed management cost among different water users

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Ecological Economy 2006年第3期2卷 245-250页

作者： Wang Zanxin margaret M. Calderon Department of Business Administration Jiangsu Polytechnic University Changzhou 213164 P. R. China Institute of Renewable Natural Resources University of the Philippines Los Banos the Philippines

The issue of water scarcity highlights the importance of watershed management. A sound watershed manage- ment should make all water users share the incurred cost. This study analyzes the optimal allocation of watershed management cost among different water users. As a consumable, water should be allocated to different users the amounts in which their marginal utilities (MUs) or marginal products (MPs) of water are equal. The value of MUs or MPs equals the water price that the watershed manager charges. When water is simultaneously used as consumable and non- consumable, the watershed manager produces the quantity of water in which the sum of MUs and/or MPs for the two types of uses equals the marginal cost of water production. Each water user should share the portion of watershed management cost in the percentage that his MU or MP accounts for the sum of MUs and/or MPs. Thus, the price of consumable water does not equal the marginal cost of water production even if there is no public good.

关键词： Consumable Non-consumable Optimal allocation Watershed management cost

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High-level expression of recombinant IgG1 by CHO K1 platform

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Frontiers of Chemical Science and Engineering 2015年第3期9卷 376-380页

作者： Ningning Xu Jianfa Ou Al-Karim (AI) Gilani Lufang Zhou margaret Liu Department of Chemical and Biological Engineering The University of Alabama Tuscaloosa AL 35294 USA Departments of Medicine and Biomedical Engineering The University of Alabama at Birmingham Birmingham AL 35294 USA

The Chinese Hamster Ovary （CHO K1） cell was used to express a targeted anti-cancer monoclonal antibody by optimizing the platform of the construction of production cell line in this study. The adherent CHO K1 was first adapted to suspension culture in chemical defined medium. Then the glutamine synthetase （GS） vector was applied to construct a single plasmid to overexpress a monoclonal antibody IgG1. Post transfection, the produc- tion of cell pool was optimized by glutamine-free selection and amplification using various concentrations of methio- nine sulfoximine. The best cell pool ofCHO K1/IgG1 was used to screen the top single clone using the limiting dilution cloning. Finally, a high IgG1 production of 780 mg/L was obtained from a batch culture. This study demonstrated that the construction of high producing cell line, from gene to clone, could be completed within six month and the gene amplification improved protein production greatly.

关键词： Chinese hamster ovary (CHO) monoclonal antibody IgG1 amplification cell line development

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