Therapeutic targets in the pancreatic adenocarcinoma microenvironment: past challenges and opportunities for the future
作者机构：Helen Diller Family Comprehensive Cancer CenterUniversity of California San FranciscoSan FranciscoCA 94158USA
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2021年第7卷第1期
页 面：448-465页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pancreatic cancer PDAC tumor microenvironment pancreatic stroma
摘 要：Pancreatic ductal adenocarcinoma(PDAC)remains a leading cause of cancer-related mortality,with cytotoxic chemotherapy still the mainstay of *** effective therapeutic agents alone,successful drug delivery is *** PDAC,the tumor microenvironment represents a physical barrier that limits in vivo drug delivery and *** this review,we highlight therapeutic targets in the tumor microenvironment,focusing on past challenges and opportunities for the *** discussed include the Hedgehog pathway,angiogenesis,hyaluronic acid,cancer-associated fibroblasts and associated cytokines,among *** the obstacles in successfully recapitulating promising lab results to practice-changing clinical results,many important lessons have been learned to improve clinical trial design within a highly engaged and motivated scientific *** collaborative efforts and the collective optimism will continue to propel the momentum forward to overcome these barriers and ultimately improve patient outcomes.
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