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中华高血压杂志 2016年第3期24卷 299-299页

作者： Van Der Bruggen CE Happé CM Dorfmüller P Trip P Spruijt OA Rol N Hoevenaars F Houweling AC Girerd B marcus jt Mercier O Humbert M Handoko ML Van Der Velden J Vonk Noordegraaf A Bogaard HJ Goumans MJ de Man FS 刘莉叶鹏

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴... 详细信息

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴或不伴BMPR2突变的PAH患者的右心室功能进行评估。方法与结果：纳入原发性或家族性PAH患者95例进行基因筛选,结果示28例患者存在BMPR2突变,67例无突变。应用右心导管术和心脏核磁共振检测。

关键词：骨形态发生蛋白受体基因突变肺动脉高压患者 hypertension 受体2 receptor arterial

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Cell Wall Biology： Perspectives from Cell Wall Imaging

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Molecular Plant 2011年第2期4卷 212-219页

作者： Kieran J.D. Lee Susan E. marcus J. Paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK

Polysaccharide-rich plant cell walls are important biomaterials that underpin plant growth, are major repositories for photosynthetically accumulated carbon, and, in addition, impact greatly on the human use of plants. Land plant cell walls contain in the region of a dozen major polysaccharide structures that are mostly encompassed by cellulose, hemicelluloses, and pectic polysaccharides. During the evolution of land plants, polysaccharide diversification appears to have largely involved structural elaboration and diversification within these polysaccharide groups. Cell wall chemistry is well advanced and a current phase of cell wall science is aimed at placing the complex polysaccharide chemistry in cellular contexts and developing a detailed understanding of cell wall biology. Imaging cell wall glycomes is a challenging area but recent developments in the establishment of cell wall molecular probe panels and their use in high throughput procedures are leading to rapid advances in the molecular understanding of the spatial heterogeneity of individual cell walls and also cell wall differences at taxonomic levels. The challenge now is to integrate this knowledge of cell wall heterogeneity with an understanding of the molecular and physiological mechanisms that underpin cell wall properties and functions.

关键词： Cell structure cell walls fluorescence imaging development cell wall imaging polysaccharides

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Cell Wall Microstructure Analysis Implicates Hemicellulose Polysaccharides in Cell Adhesion in Tomato Fruit Pericarp Parenchyma

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Molecular Plant 2009年第5期2卷 910-921页

作者： Jose J. Ordaz-Ortiz Susan E. marcus J. Paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT United Kingdom

Methods developed to isolate intact cells from both unripe and ripe tomato fruit pericarp parenchyma have allowed the cell biological analysis of polysaccharide epitopes at the surface of separated cells. The LM7 pectic homogalacturonan epitope is a marker of the junctions of adhesion planes and intercellular spaces in parenchyma systems. The LM7 epitope persistently marked the former edge of adhesion planes at the surface of cells separated from unripe and ripened tomato fruit and also from fruits with the Cnr mutation. The LM 11 xylan epitope was associated, in sections, with cell walls lining intercellular space but the epitope was not detected at the surface of isolated cells, being lost during cell isolation. The LM15 xyloglucan epitope was present at the surface of cells isolated from unripe fruit in a pattern reflecting the former edge of cell adhesion planes/intercellular space but with gaps and apparent breaks. An equivalent pattern of LM15 epitope occurrence was revealed at the surface of cells isolated by pectate lyase action but was not present in cells isolated from ripe fruit or from Cnr fruit. In contrast to wild-type cells, the LM5 galactan and LM21 mannan epitopes occurred predominantly in positions reflecting intercellular space in Cnr, suggesting a concerted alteration in cell wall microstructure in response to this mutation. Galactanase and mannanase, along with pectic homogalacturonan-degrading enzymes, were capable of releasing cells from unripe fruit parenchyma. These observations indicate that hemicellulose polymers are present in architectural contexts reflecting cell adhesion and that several cell wall polysaccharide classes are likely to contribute to cell adhesion/cell separation in tomato fruit pericarp parenchyma.

关键词： Cell walls fruit development tomato cell adhesion cell separation polysaccharide.

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