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Analysis of PTEN Methylation Pattern by Pyrosequencing in Renal Cell Carcinoma

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journal of Cancer Therapy（癌症治疗） 2020年第12期

作者： Eurico Cleto Ribeiro de Campos Marcos Gonçalves Adriano júnior marcus Rivabem Winheski Renan Martins Ademar Lopes

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Bárány协会:“颈性头晕”的观点

神经损伤与功能重建 2023年第12期18卷 691-696页

作者：王钰茹(译) 邢玥(译) 冯宇菲(译) 凌霞(译) 隋汝波(审校) 杨旭(审校) Barry M.Seemungal Yuri Agrawal Alexander Bisdorff Adolfo Bronstein Kathleen E.Cullen Peter j.Goadsby Thomas Lempert Sudhir Kothari Phang Boon Lim Måns Magnusson Hani j.marcus Michael Strupp David Susan L.Whitney 航天中心医院(北京大学航天临床医学院)神经内科锦州医科大学附属第一医院神经内科北京大学第一医院神经内科帝国理工学院脑科学系前庭神经病学中心约翰·霍普金斯大学医学院耳鼻喉头颈外科学系 Emile Mayrisch医疗中心神经内科约翰·霍普金斯大学医学院生物医学工程、神经科学和耳鼻喉科-头颈外科系英国伦敦国王学院和美国加州大学洛杉矶分校 Schlosspark-Klinik医院神经内科浦那医院与研究中心帝国理工学院哈默史密斯医院心内科隆德大学&Skane大学医院耳鼻咽喉科和临床科学部英国伦敦国立神经病学与神经外科医院神经外科路德维希马克西米利安大学神经病学系与德国眩晕和平衡障碍中心匹兹堡大学健康与康复科学学院物理治疗系

本文介绍了Bárány协会分类监督委员会(COCS)对颈性头晕(有时也称为颈性眩晕)的观点。这些内容首先由多个领域的专家进行了初步审查,之后由Bárány协会COCS进行进一步审定。基于当前已发表的文献,Bárány协会COCS认为,自身运动的错觉... 详细信息

本文介绍了Bárány协会分类监督委员会(COCS)对颈性头晕(有时也称为颈性眩晕)的观点。这些内容首先由多个领域的专家进行了初步审查,之后由Bárány协会COCS进行进一步审定。基于当前已发表的文献,Bárány协会COCS认为,自身运动的错觉(眩晕-旋转感或其他)与颈部病理和(或)颈部疼痛症状(通过影响颈椎、软组织结构或颈神经根)之间机制的关联尚缺乏证据支持。当头颈部联合运动诱发出现旋转的错觉时,其原因可能是尚未确诊的常见前庭疾病(如偏头痛或BPPV),也可能是较少见的中枢性前庭疾病(包括急性起病的危急状况,例如椎动脉夹层伴后循环卒中以及极其罕见的椎动脉压迫综合征)。同时,COCS指出,迄今为止,偏头痛(包括前庭性偏头痛)为颈部疼痛和前庭症状同时出现的最常见原因。而且,在几乎所有前庭疾病中,头部运动常会导致患者症状的加重,推测在这些前庭疾病患者中常见颈部肌肉紧张度的增加(因果关系尚不清楚)可能与头部运动减少有关。此外,还存在一些尚未探索的理论机制问题,如颈部疼痛可能促发血管迷走反射、心脏抑制反射继而通过晕厥前机制导致短暂的定向障碍和(或)失衡。COCS提出还有一些少见的案例,如那些颈部肌肉痉挛伴模糊的空间定向障碍和(或)失衡感的患者是否确实存在颈部本体感觉受损机制,值得进一步深入研究。展望未来,通过严格纳入和排除标准,以减少敏感性而增加特异性的方法进行研究对象的选择,进一步采用双盲、安慰剂对照的研究方案将更为理想。为进一步促进“颈性头晕/眩晕”的研究,在进行设计机制和治疗的对照研究时,亦应考虑到那些重要的混杂因素相关问题。基于此,目前的Bárány COCS并未提出用于研究之外的临床初步诊断标准。相信随着新的研究证据的不断积累,这一观点将可能会发生改变。

关键词：颈性颈源性颈部头晕眩晕前庭

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波兰华沙国家体育场

城市环境设计 2013年第7期 174-177页

作者：福尔克温·玛格胡贝特·尼恩霍夫马库斯费斯德 Krystian Trela marcus Bredt

2012年,乌克兰和波兰共同承办了欧洲杯足球锦标赛。新建华沙波兰国家体育场的国际建筑设计竞赛于2007年举行。gmp国际建筑设计有限公司作为方案设计者与j.S.K.建筑设计事务所和施莱希伯格曼(schlaichbergermannundpartner)工程师事务所... 详细信息

2012年,乌克兰和波兰共同承办了欧洲杯足球锦标赛。新建华沙波兰国家体育场的国际建筑设计竞赛于2007年举行。gmp国际建筑设计有限公司作为方案设计者与j.S.K.建筑设计事务所和施莱希伯格曼(schlaichbergermannundpartner)工程师事务所共同组成的设计团队赢得了项目的设计委托。

关键词：波兰

长效局麻药减轻FMLP诱导的大鼠急性肺损伤的作用

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麻醉与镇痛 2012年第3期8卷 52-57页

作者： marcus T. Schley, MD Matthias Casutt, MD Christoph Haberthar, PhD Martin Dusch, MD Roman Rukwied, PhD Martin Schmelz, MD, PhD joachim Schmeck, MD,PhD Guido K. Schupfer, MD, PhD , Christoph j, Konrad, MD, PhD 徐妍君(译) 李士通(校) Department of Anaesthesiology and Operative Intensive Care Medicine Kantonsspital Lucerne Switzerland Department of Anaesthesiology and Intensive Care Medicine University of Heidelberg Heidelberg Germany Department of Anaesthesiology University of Mainz Mainz Germany 不详

背景内皮素-1（endothelin-1，ET-1）可介导肺部疾病，是一个强有力的血管收缩药。与血栓素A2一起参与了肺水肿的形成。利多卡因和甲哌卡因可以缓解肺动脉压的升高以及肺水肿的进展。我们利用增加肺动脉压、促使ET—1释放的实验模型验... 详细信息

背景内皮素-1（endothelin-1，ET-1）可介导肺部疾病，是一个强有力的血管收缩药。与血栓素A2一起参与了肺水肿的形成。利多卡因和甲哌卡因可以缓解肺动脉压的升高以及肺水肿的进展。我们利用增加肺动脉压、促使ET—1释放的实验模型验证普鲁卡因、布比卡因、罗哌卡因的作用。方法用Krebs-Henseleit羟乙基淀粉缓冲液灌注大鼠离体肺脏，测量肺动脉压及肺脏质量，加入10^-1-10^7mg／kg浓度的布比卡因、罗哌卡因、普鲁卡因，用免疫酶标技术检测ET-1水平，放射免疫法检验血栓素A2水平，用N-甲酰-甲硫氨酰．亮氨酰苯丙氨酸（FMLP）来激活人多形核中性粒细胞。结果与对照组（P〈0．05）相比，治疗组布比卡因、罗哌卡因、普鲁卡因明显减轻了肺动脉压的升高（P〈0．05），导致肺脏质量的减轻。除了普鲁卡因，在剂量为10^-3-10^-6mg／kg的范围中，长效局麻药布比卡因、罗哌卡因（P〈0．05）降低了ET-1的水平，降低炎症发生率，且不影响肺结构。结论布比卡因、罗哌卡因能缓解FMLP诱导的肺动脉压升高，减轻肺水肿，减少ET-1释放。利多卡因和甲哌卡因能更有效地缓解肺动脉压升高以及肺水肿形成，但是长效局麻药能通过抑制ET-1的释放增强抗炎能力。

关键词：急性肺损伤长效局麻药 FMLP 减轻大鼠 ET-1水平多形核中性粒细胞布比卡因

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持续服用哌甲酯治疗注意力缺陷多动症

世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 22-22页

作者： marcus S.C. Kemner j.E. Olfson M. 平智广 New York State Psychiatric Institute Department of PsychiatryCollege of Physicians and Surgeons of Columbia University 1051 Riverside Dr New York NY 10032 United StatesDr.

To compare the continuity of methylphenidate hydrochloride (MPH) therapy among youth Medicaid beneficiaries treated for attention-deficit/ hyperactivity disorder with immediate-release (IR) or extended-release (ER) MPH formulations. Method: An analysis was conducted of statewide California Medicaid claims (2000- 2003) focusing on children and adolescents, ages 6 to 17 years, who started ER-MPH or IR-MPH treatment for attention-deficit/hyperactivity disorder. The study cohorts were limited to youth who had not filled a prescription for MPHs, amphetamines, pemoline, or atomoxetine for 6 months preceding the index prescription and remained eligible for Medicaid benefits for the following 12 months. The study groups were compared with respect to background demographic traits and clinical characteristics. Mean and median duration of MPH treatment episodes were defined to terminate if a gap of 30 or more days occurred from the end of the last prescription supply to the start of the next prescription. Survival time ratios were used to assess treatment duration controlling for group differences in background characteristics. Results: As compared with patients initiating IR-MPH treatment, patients initiating ER-MPH treatment had a significantly longer mean estimated duration of treatment (ER-MPH, 140.3 days [95% confidence interval (CI), 136.3- 144.4 days] vs IR-MPH, 103.4 days [95% CI, 101.3- 103.4 days]). Similar results were found in analyses stratified by patient age, race/ethnicity, and sex. Controlling for group differences in age, sex, race/ethnicity, coprescribed psychotropic medications, other treated mental disorders, case management, managed care participation, and seasonal effects, ER-MPH treatment initiation was associated with an average 37% longer duration of treatment than IR-MPH treatment (survival time ratio, 1.37 [95% CI, 1.32- 1.42]). Among patients treated with ER-MPH, treatment initiation with an osmotic release oral system MPH (Concerta)- was associate

关键词：注意力缺陷哌甲酯利他林控释剂苯丙胺匹莫林精神兴奋药持续时间背景特征救助计划

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Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第A期 8-8页

作者： Anne Eckert Susanne Hauptmann Isabel Scherping jessica Meinhardt Virginie Rhein Stefan Dr?se Ulrich Brandt marcus F?ndrich Walter E.Müller jürgen G?tz

We recently provided evidence for a mitochondrial dysfunction in P301 l tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301 L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301 L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

关键词： Alzheimer’s disease Amyloid aggregates Amyloid β-peptide Amyloid toxicity Fibrils Frontotemporal dementia Globulomer Mitochondria oligomer Protein aggregation respiration tau transgenic mice

Oligomeric and fibrillar species of β-amyloid(A β 42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第99期 1-1页

作者： Anne Eckert Susanne Hauptmann Isabel Scherping jessica Meinhardt Virginie Rhein Stefan Dr?se Ulrich Brandt marcus F?ndrich Walter E.Müller jürgen G?tz

We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

Theoretical Analysis of the Kinetics Electron Transport at Solid/Solid Processes

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journal of Physical Science and Application 2016年第1期6卷 212-220页

作者： Hadi j. M. A1-Agealy Department of Physics College of Education for pure Science Baghdad University Baghdad Iraq

The kinetics of electron transmission at solid/solid interface system are investigation and studied using a simple model that derives depending on the quantum consideration. A two quantum state for donor state ｜αn 〉 and acceptor state ｜αA 〉 are supposed. marcus-Hush semi classical continuum levels theory adapted to evaluated the energies for orientation before transfer. The probability of transmission of electron is calculated to investigation the kinetics of transfer. Our result for calculation of rate constant of electron transfer shows a good agreement with experiment data.

关键词： Kinetics electron transport theoretical Analysis.

Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： Gerie j.Glas janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello Gamma de Abreu Ignacio Martin-Loeches Paolo Pelosi Folke Sjoerg jan M.Binnekade Berry Cleffken Nicole P.juffermans Paul Knape Bert G.Loef David P.Mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro Marc jeschke jeffrey Lipman Matthieu Legrand johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho joa Manoel Silva junior Cintia M.C.Grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu jeanne Morgane Bacus Maite Chaussard marcus Lehnhardt Bassem Daniel Mikhail jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting marcus j.Schultz LAMiNAR investigators Academic Medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ jAN PALFIjN GENT Watersportlaan 5–9000 Gent–Belgium ABC Medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl Gustav Carus Dresden 01307Germany St james University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden Maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands Martini Hospital GroningenNT 9728The Netherlands University of Texas Medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive Care Research Centre.Monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece Middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 ICUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressuresjority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： Mechanical ventilation Inhalation trauma Lung-protective Critical care