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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： marcus A.Lawson Robert Dantzer Keith W.Kelley College of ACES University of Illinois at Urbana-Champaign USA

Indoleamine 2,3-dioxygenase(IDO) is an intracellular heme enzyme metabolizing tryptophan along the kynurenine *** is evidence that IDO and nitric oxide synthase(NOS) pathways are *** several kinds of cells including murine macrophages,nitric oxide(NO) is a potent inhibitor of IDO,but murine microglial cell lines are *** we tested this hypothesis in primary cultures of microglia from neonatal C57BL/6j *** were activated with IFNγ(1 ng/mL) and LPS(10 ng/mL).This activation was marked by abundant expression of iNOS mRNA and NO production secreted into cells culture *** an identical time-point as iNOS,IDO mRNA and its activity were also significantly *** iNOS inhibitor,L-NIL hydrochloride (30μmol/L) did not affect expressions of iNOS mRNA,IDO mRNA and IDO activity,whereas it fully blocked the ability of IFNγand LPS to induce *** the contrary to the up-regulation of IDO activity,IFNγand LPS induced a reduction in extracellular kynurenine,the first metabolism of IDO catalyzing tryptophan along the kynurenine ***,this reduction of kynurenine in the culture medium was completely blocked by *** explore the mechanism for the reduction in kynurenine,we did cell-free experiments with exogenous kynurenine and *** results were that the level of exogenous kynurenine decreased in the presence not absence of exogenous sodium nitrite(NaNO) after deproteinization with sulfosalicylic acid solution(SSA).These data extend and establish the concept that NO does not affect the expression of IDO mRNA and its activity in primary murine microglia activated by LPS and IFNγ.Furthermore,samples are frequently deproteinized with trichloroacetic acid (TCA) or SSA before kynurenine measurement by *** nitrite degrades kynurenine under SSA condition, we need carefully think about kynurenine’s real concentration measured by HPLC,and draw a reasonable conclusion about the action of NO on IDO when nitri

关键词： nitric oxide kynurenine indoleamine 2,3-dioxygenase lipopolysaccharide interferon-gamma primary microglia

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首次剖宫产术中关闭腹膜与粘连的关系

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 58-59页

作者： Lyell D.j. Caughey A.B. daniels K. 杨晓梅 Department of Obstetrics MC5317 309 Pasteur Drive Stanford CA 94305 United States Dr.

Objective: To evaluate the effect of parietal peritoneal closure at cesarean delivery on adhesion formation. Methods: A prospective cohort study of women undergoing first repeat cesarean delivery was designed. All surgeons were asked immediately after surgery to score the severity and location of adhesions. Patient records were then abstracted to assess prior surgical technique, including parietal peritoneal closure, other attributes of first surgery, and patient characteristics. Exclusion criteria included adhesions, other surgery, or use of permanent suture at the first cesarean, unavailable first postoperative note and course, wound infection or breakdown following first surgery, intervening pelvic surgery, insulin-dependent diabetes mellitus, and steroid-dependent disease. The χ 2 test and multivariable logistic regression were used for statistical comparison and analysis. A total of 128 patients was required to have 80% power to detect a 50% reduction in adhesions when the parietal peritoneum was left open. Results: One hundred seventy-three patients were enrolled. Prior parietal peritoneal closure was associated with significantly fewer dense and filmy adhesions (52% versus 73% , P =.006) and significantly fewer dense adhesions (30% versus 45% , P = .043). When controlling for potential confounding variables, including prior infection, visceral peritoneal closure, rectus muscle closure, payor status, ethnicity, maternal age, gestational diabetes, and labor, parietal peritoneal closure at primary cesarean delivery was 5-fold protective against all adhesions (odds ratio 0.20, 95% confidence interval 0.08-0.49), and 3-fold protective against dense adhesions (odds ratio 0.32, 95% confidence interval 0.13-0.79). Omental-fascial adhesions were decreased most consistently. Conclusion: Parietal peritoneal closure at primary cesarean delivery was associated with significantly fewer dense and filmy adhesions. The practice of nonclosure of the parietal peritoneum at cesa

关键词：剖宫产术壁腹膜手术医师术后粘连病例记录皮质类固醇脏腹膜既往感染前瞻性队列研究失访

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Discovery of novel genetic networks associated with 19 economically important traits in beef cattle

Discovery of novel genetic networks associated with 19 econo...

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中国畜牧兽医学会第七届养牛学分会2009年学术研讨会

作者： jennifer j.Michal Tyler F.daniels Tanja Kunej Charles T.Gaskins jan R.Busboom Leeson j.Alexander Raymond W.Wright Michael D.MacNeil Department of Animal Sciences Washington State UniversityPullmanWA 99164-6351 USDA-ARS Fort Keogh Livestock and Range Research LaboratoryMiles CityMT 59301

Quantitative or complex traits are determined by the combined effects of many loci,and are affected by genetic networks or molecular *** the present study,we genotyped a total of 138 mutations,mainly single nucleotide polymorphisms derived from 71 functional genes on a Wagyu x Limousin reference *** hundred forty six F animals were measured for 5 carcass,6 eating quality and 8 fatty acid composition traits.A total of 2,280 single marker-trait association runs with 120 tagged mutations selected based on the HAPLOVIEW analysis revealed 144 significant associations(P<0.05),but 50 of them were removed from the analysis due to the small number of animals(≤9) in one genotype group or absence of one genotype among three *** remaining 94 single-trait associations were then placed into three groups of quantitative trait modes(QTMs) with additive,dominant and overdominant *** significant markers and their QTMs associated with each of these 19 traits were involved in a linear regression model analysis,which confirmed single-gene associations for 4 traits,but revealed two-gene networks for 8 traits and three-gene networks for 5 *** genetic networks involving both genotypes and QTMs resulted in high correlations between predicted and actual values of performance,thus providing evidence that the classical Mendelian principals of inheritance can be applied in understanding genetic complexity of complex *** present study also indicated that carcass, eating quality and fatty acid composition traits rarely share genetic ***,marker-assisted selection for improvement of one category of these traits would not interfere with improvement of another.

关键词： Quantitative traits quantitative trait modes genetic networks beef cattle

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加勒比岛屿的森林火灾

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AMBIO－人类环境杂志 2008年第7期37卷 459-465页

作者： A.marcus j.Robbins Claus-Martin Eckelmann Maya Quinoes 梁虹联合国粮农组织(FAO) 波多黎各圣胡安国际热带林业研究所

本文概述了加勒比岛屿的林火情况。资料来自于地方管理报告和公开发布的地区性中分辨率成像光谱仪(MODIS)卫星活动火产品(active fire products)。土地管理报告的林火数量和MODIS林火信息资源管理系统数据中的起火点之间具有显著差异。... 详细信息

本文概述了加勒比岛屿的林火情况。资料来自于地方管理报告和公开发布的地区性中分辨率成像光谱仪(MODIS)卫星活动火产品(active fire products)。土地管理报告的林火数量和MODIS林火信息资源管理系统数据中的起火点之间具有显著差异。这些差异的原因还有待深入研究。虽然加勒比地区林火统计数据普遍缺乏,但大体观察表明:林火主要发生在干旱森林(年均降水量500～1000 mm)。这些也是人类定居点最多的地方。低地乔木和山地森林的降水量较多(每年1000mm以上),不易发生林火,但林火在特别干旱的年份也可能发生。加勒比地区大部分干旱森林生态系统属于火敏感型生态系统,但加勒比地区(古巴、多米尼加共和国和巴哈马)松林为火依赖性生态系统。在火敏感型生态系统中,通常火灾失控燃烧有利于外来入侵物种的扩散。2005～2006年,联合国粮农组织制定了加勒比地区火灾管理合作战略。这一区域战略旨在鼓励生态环境类似的国家之间密切合作,以加强加勒比地区的火灾管理网络。该战略鉴别了一系列旨在加强加勒比地区的野火管理能力的研究、培训和管理活动。

关键词：森林火灾岛屿森林生态系统中分辨率成像光谱仪加勒比地区信息资源管理系统外来入侵物种地方管理

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沉积型铀矿床的磁化率测井

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世界核地质科学 1985年第1期 61-65页

作者： j.H.Scott j.j.daniels R.L.Reynolds R.L.Seeley 刘家瑾

美国地质调查局曾在三个产铀区,即得克萨斯州南部,怀俄明州泡德河盆地以及新墨西哥州圣胡安盆地作过钻孔磁化率测量的研究。本文再次证实,在沉积铀矿区内铀与磁性的铁钛矿物之间存在着一般的负相关关系。在上述三个地区中,对铀矿床形成... 详细信息

美国地质调查局曾在三个产铀区,即得克萨斯州南部,怀俄明州泡德河盆地以及新墨西哥州圣胡安盆地作过钻孔磁化率测量的研究。本文再次证实,在沉积铀矿区内铀与磁性的铁钛矿物之间存在着一般的负相关关系。在上述三个地区中,对铀矿床形成有影响的地下水蚀变或破坏了普遍存在的碎屑磁性矿物。在铀矿勘探中可以利用这种负相关关系。它还有助于研究沉积铀矿床的古水文学与古地球化学。

关键词：磁化率铀矿化铀矿床沉积型盆地地质构造测井测井曲线砂岩碎屑岩地下水怀俄明州磁性矿物新墨西哥州新墨西哥

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Analysis of Sentinel Lymph Node Biopsy on Clear Cell Sarcoma Treatment

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journal of Cancer Therapy 2020年第12期11卷 785-792页

作者： Eurico Cleto Ribeiro de Campos Marcos Gonçalves Adriano júnior marcus Rivabem Winheski Ricardo Poroski Diego Sanches Robson Menezes Leal Marcela Cavalcanti Emanuela Benevides Poyer Renan Martins Department of Melanoma and Soft Tissue Sarcoma from Prevent Senior Sao Paulo Group Sao Paulo Brasil Oncology Surgical Department of Evangélico Mackenzie University Hospital Curitiba Paraná Department of Pathology Neopath Curitiba Paraná Brasil Department of Clinical Oncology from Evangélico Mackenzie University Hospital Ponta Grossa State University Paraná Brasil

Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds to a less than 1% of all sarcomas and is a high degree neoplasm with propensity to disseminate to regional lymph nodes. Regional lymphadenectomies have a controversial impact on sarcomas treatment and survival, even though those patients have higher local recurrence and lower survival. So, sentinel lymph node biopsy must be one option for better regional staging to STS with higher propensity to lymph node commitment. The authors demonstrate two cases of CCS submitted to surgery through compartmental resection associated with the sentinel lymph node biopsy. A literature review about soft tissue sarcoma and lymph node sentinel biopsy is shown as an initial experience of two cases.

关键词： Clear Cell Sarcomas Soft Tissue Sarcoma Sentinel Biopsy

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Bárány协会:“颈性头晕”的观点

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神经损伤与功能重建 2023年第12期18卷 691-696页

作者：王钰茹(译) 邢玥(译) 冯宇菲(译) 凌霞(译) 隋汝波(审校) 杨旭(审校) Barry M.Seemungal Yuri Agrawal Alexander Bisdorff Adolfo Bronstein Kathleen E.Cullen Peter j.Goadsby Thomas Lempert Sudhir Kothari Phang Boon Lim Måns Magnusson Hani j.marcus Michael Strupp David Susan L.Whitney 航天中心医院(北京大学航天临床医学院)神经内科锦州医科大学附属第一医院神经内科北京大学第一医院神经内科帝国理工学院脑科学系前庭神经病学中心约翰·霍普金斯大学医学院耳鼻喉头颈外科学系 Emile Mayrisch医疗中心神经内科约翰·霍普金斯大学医学院生物医学工程、神经科学和耳鼻喉科-头颈外科系英国伦敦国王学院和美国加州大学洛杉矶分校 Schlosspark-Klinik医院神经内科浦那医院与研究中心帝国理工学院哈默史密斯医院心内科隆德大学&Skane大学医院耳鼻咽喉科和临床科学部英国伦敦国立神经病学与神经外科医院神经外科路德维希马克西米利安大学神经病学系与德国眩晕和平衡障碍中心匹兹堡大学健康与康复科学学院物理治疗系

本文介绍了Bárány协会分类监督委员会(COCS)对颈性头晕(有时也称为颈性眩晕)的观点。这些内容首先由多个领域的专家进行了初步审查,之后由Bárány协会COCS进行进一步审定。基于当前已发表的文献,Bárány协会COCS认为,自身运动的错觉... 详细信息

本文介绍了Bárány协会分类监督委员会(COCS)对颈性头晕(有时也称为颈性眩晕)的观点。这些内容首先由多个领域的专家进行了初步审查,之后由Bárány协会COCS进行进一步审定。基于当前已发表的文献,Bárány协会COCS认为,自身运动的错觉(眩晕-旋转感或其他)与颈部病理和(或)颈部疼痛症状(通过影响颈椎、软组织结构或颈神经根)之间机制的关联尚缺乏证据支持。当头颈部联合运动诱发出现旋转的错觉时,其原因可能是尚未确诊的常见前庭疾病(如偏头痛或BPPV),也可能是较少见的中枢性前庭疾病(包括急性起病的危急状况,例如椎动脉夹层伴后循环卒中以及极其罕见的椎动脉压迫综合征)。同时,COCS指出,迄今为止,偏头痛(包括前庭性偏头痛)为颈部疼痛和前庭症状同时出现的最常见原因。而且,在几乎所有前庭疾病中,头部运动常会导致患者症状的加重,推测在这些前庭疾病患者中常见颈部肌肉紧张度的增加(因果关系尚不清楚)可能与头部运动减少有关。此外,还存在一些尚未探索的理论机制问题,如颈部疼痛可能促发血管迷走反射、心脏抑制反射继而通过晕厥前机制导致短暂的定向障碍和(或)失衡。COCS提出还有一些少见的案例,如那些颈部肌肉痉挛伴模糊的空间定向障碍和(或)失衡感的患者是否确实存在颈部本体感觉受损机制,值得进一步深入研究。展望未来,通过严格纳入和排除标准,以减少敏感性而增加特异性的方法进行研究对象的选择,进一步采用双盲、安慰剂对照的研究方案将更为理想。为进一步促进“颈性头晕/眩晕”的研究,在进行设计机制和治疗的对照研究时,亦应考虑到那些重要的混杂因素相关问题。基于此,目前的Bárány COCS并未提出用于研究之外的临床初步诊断标准。相信随着新的研究证据的不断积累,这一观点将可能会发生改变。

关键词：颈性颈源性颈部头晕眩晕前庭

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53例女性梭形细胞脂肪瘤

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临床与实验病理学杂志 2018年第5期34卷 544-544页

作者： Ko j S daniels B Emanuel P O 赵芳魏建国浙江省绍兴市中心医院妇产科绍兴312030 浙江省绍兴市人民医院病理科绍兴312000

梭形细胞脂肪瘤（SCL）最常发生于上背部和颈部,80%～90%为男性患者。由于特殊的男性好发倾向,诊断女性SCL时常常表示迟疑。作者推测女性SCL可能有不同的临床表现。在过去11年中,作者单位一共诊断了395例SCL。

关键词：梭形细胞脂肪瘤 SCL 发病年龄

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Search for two-neutrino double-beta decay of 136Xe to the 01+excited state of136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 5-13页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.daniels L.Darroch S.j.Daugherty j.Davis S.Delaquis A.Der Mesrobian-Kabakian R.De Voe j.Dilling A.Dolgolenko M.j.Dolinski j.Echevers W.Fairbank jr. D.Fairbank j.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen j.Hoessl P.Hufschmidt M.Hughes A.Iverson A.jamil C.jessiman M.j.jewell A.johnson A.Karelin L.j.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.Mac Lellan T.Mc Elroy T.Michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson j.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado j.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel j.-L.Vuilleumier M.Wagenpfeil j.Watkins M.Weber L.j.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler EXO-200 Collaboration Physics Department McGill University Erlangen Centre for Astroparticle Physics (ECAP) Friedrich-Alexander-University Erlangen-Nürnberg Physics Department Carleton University King Abdulaziz City for Science and Technology Department of Physics Duke University and Triangle Universities Nuclear Laboratory (TUNL) Physics Department University of Illinois Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre “Kurchatov Institute” a division of National Research Center “Kurchatov Institute” Department of Physics University of South Dakota Department of Physics and Astronomy University of Kentucky SLAC National Accelerator Laboratory TRIUMF Institute of High Energy Physics Witmem Technology Co. Ltd. Department of Physics Laurentian University Also at SNOLAB Physics Department Colorado State University Department of Physics and Physical Oceanography University of North Carolina at Wilmington Physics Department and CEEM Indiana University Carleton University Commissariat àl’Energie Atomique et auxénergies alternatives Physics Department Stanford University Department of Physics Drexel University University of California Amherst Center for Fundamental Interactions and Physics Department University of Massachusetts Technische Universit?t München Physikdepartment and Excellence Cluster Universe Qventus Department of Physics University of Virginia Physics Department University of Maryland Department of Physics at the University of California Department of Physics and Astronomy University of Alabama Wright Laboratory Department of Physics Yale University Department of Physics Princeton University IBS Center for Underground Physics Physics Department University of California SNOLAB Department of Physics and Astronomy Stony Brook University SUNY SCIPP University of California Institute for Experimental Physics Hamburg University Department of Physics and Astronomy Iowa State University Kellogg Lab Caltech LHEP Albert Einstein Center University of Ber

A new search for two-neutrino double-beta(2vββ) decay of136Xe to the 01+excited state of136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase Ⅱ dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2vββ decay to the 01+state of136Ba is 2.9 × 1024yr using a total136Xe exposure of 234.1 kg *** statistically significant evidence for 2vββ decay to the 01+state is observed,leading to a lower limit of T1/22v(0+→01+)>1.4×1024yr at 90% confidence level,improved by 70% relative to the current world’s best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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湿空气环境对铝合金da/dN和j1c的影响

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东北大学学报(自然科学版) 1983年第1期 89-94+130页

作者：曾梅光 H.L.marcus 美国得克萨斯大学材料科学与工程系教授

湿空气促进铝合金疲劳裂纹生长和增加合金的脆性。对于不同热处理的合金,影响也是不同的。腐蚀疲劳降低铝合金的断裂韧性j;,而j;降低的百分数随真空和湿空气中da/dN的增加而增加。

关键词：铝合金湿空气疲劳裂纹断裂韧性轻有色金属合金破断韧性力学强度 j1c da/dN

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