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Computerized geochemical modeling of burial diagenesis of the Eocene turbidite reservoir elements：Urucutuca Formation,Espirito Santo Basin,southeastern Brazil passive margin

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Journal of Palaeogeography 2018年第4期7卷 363-377页

作者： marcos antonio klunk Sudipta Dasgupta Rommulo Vieira Conceicao Institute of Isotope Geology Federal University of Rio Grande do SulPorto AlegreBrazil Department of Earth Sciences Indian Institute of Technology (IIT) BombayMumbai India

The computerized geochemical modeling, a useful tool to understand the diagenetic processes influencing the quality of hydrocarbon reservoirs, is performed by using different modules of computer codes based on the thermodynamic and chemical kinetic principles and their associated parameters. As observed in the reservoir lithofacies deposited from the marine sediment-gravity flows, a case study of diagenesis is presented here from the Espírito Santo Basin in southeastern Brazil. The study uses the Geochemist＇s Workbench（GWB～（TM））, PHREEQC～（TM） and TOUGHREACT～（TM） computation packages. The comparison of performances of these packages demonstrates the convergence of results from the software-based geochemical modeling with the petrographic observation of dissolution, albitization, kaolinization, and the precipitation of calcite and dolomite. Moreover, with limited data points, e.g., the sedimentary petrographic data acquired from limited number of boreholes, the computer simulation establishes itself to be a powerful quantitative method estimating the degree and type of diagenetic alteration of turbidite reservoir bodies in contact with a source of saline-water influx associated with salt ***, using the limited petrographic data points, the geochemical computer-simulation method can even be utilized and extrapolated for areas where similar geological context is interpreted but no borehole data are available. Hence, porosity of turbidite reservoir lithofacies can be predicted in relation to the spatial distribution of dissolution, kaolinization, and albitization of feldspars and authigenic carbonate precipitation.

关键词： Sandstone diagenesis Computerized diagenetic modeling Turbidite reservoir GWB PHREEQC TOUGHREACT

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Severe aspiration pneumonia in the elderly

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Journal of Intensive Medicine 2024年第3期4卷 307-317页

作者： Sebastian Ocrospoma marcos I.Restrepo Division of Pulmonary Diseases&Critical Care Medicine University of Texas Health San AntonioSan AntonioTXUSA Section of Pulmonary&Critical Care Medicine South Texas Veterans Health Care SystemSan AntonioTXUSA

The global population is aging at an unprecedented rate,resulting in a growing and vulnerable elderly population in need of efficient comprehensive healthcare services that include long-term care and skilled nursing *** this context,severe aspiration pneumonia,a condition that carries substantial morbidity,mortality,and financial burden,especially among elderly patients requiring admission to the intensive care unit,has attracted greater *** pneumonia is defined as a pulmonary infection related to aspiration or dysphagia in *** episodes of coughing on food or liquid intake,a history of relevant underlying conditions,abnormalities on videofluoroscopy or water swallowing,and gravity-dependent shadow distribution on chest imaging are among the clues that suggest *** with aspiration pneumonia tend to be elderly,frail,and suffering from more comorbidities than those without this ***,we comprehensively address the epidemiology,clinical characteristics,diagnosis,treatment,prevention,and prognosis of severe aspiration community-acquired pneumonia in the elderly to optimize care of this high-risk demographic,enhance outcomes,and minimize the healthcare costs associated with this *** preventive measures and effective management strategies is vital in ensuring the well-being of our aging population.

关键词： Aspiration pneumonia Aged Critical illness Swallowing disorders Frailty Antibacterial agents

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Geotechnical particle finite element method for modeling of soilstructure interaction under large deformation conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第3期14卷 967-983页

作者： Josep Maria Carbonell Lluís Monforte Matteo O.Ciantia marcos Arroyo antonio Gens MECAMAT Group Department of EngineeringFaculty of Science and TechnologyUniversitat de Vic-Universitat Central de Catalunya(UVic-UCC)VicSpain Centre Internacional de Mètodes Numèrics a l'Enginyeria(CIMNE) BarcelonaSpain School of Science and Engineering University of DundeeDundeeUK Universitat Politècnica de Cataluna-BarcelonaTech BarcelonaSpain

The possibilities of the particle finite element method(PFEM)for modeling geotechnical problems are increasingly *** is a numerical approach to solve large displacement and large strain continuum problems that are beyond the capabilities of classical finite element method(FEM).In PFEM,the computational domain is reconfigured for optimal solution by frequent remeshing and boundary *** inherits many concepts,such as a Lagrangian description of continuum,from classic geomechanical *** familiarity with more popular numerical methods facilitates learning and *** work focuses on G-PFEM,a code specifically developed for the use of PFEM in geotechnical *** article has two *** first is to give the reader an overview of the capabilities and main features of the current version of the G-PFEM and the second is to illustrate some of the newer developments of the code.G-PFEM can solve coupled hydro-mechanical static and dynamic problems involving the interaction of solid and/or deformable *** constitutive models for geomaterials are available,including features,such as structure and destructuration,which result in brittle *** solutions are robust,solidly underpinned by numerical technology including mixedfield formulations,robust and mesh-independent integration of elastoplastic constitutive models and a rigorous and flexible treatment of contact *** novel features presented in this work include the contact domain technique,a natural way to capture contact interactions and impose contact constraints between different continuum bodies,as well as a new simplified formulation for dynamic impact *** code performance is showcased by the simulation of several soil-structure interaction problems selected to highlight the novel code features:a rigid footing insertion in soft rock,pipeline insertion and subsequent lateral displacement on over-consolidated clay,screw-pile pull-out and the dyn

关键词： Particle finite element method(PFEM) Structured soils Nonlocal elastoplasticity Contact domain method Soil penetration problems

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Integral Representation Formulas Related to the Lamé–Navier System

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Acta Mathematica Sinica,English Series 2020年第12期36卷 1341-1356页

作者： Ricardo ABREU-BLAYA Juan BORY-REYES marcos antonio-HERRERA-PELáEZ José María SIGARRETA-ALMIRA Facultad de Matemáticas Universidad Autónoma de GuerreroGuerreroMéxico Instituto Politécnico Nacional SEPI-ESIME-ZAC CD-MXMéxico

The paper provides integral representations for solutions to a certain first order partial differential equation natural arising in the factorization of the Lamé–Navier system with the help of Clifford analysis *** representations look like in spirit to the Borel–Pompeiu and Cauchy integral formulas both in three and higher dimensional setting.

关键词： Lamésystem Clifford analysis Dirac operator

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Impact,economic evaluation,and sustainability of integrated vector management in urban settings to prevent vector-borne diseases:a scoping review

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Infectious Diseases of Poverty 2018年第1期7卷 830-843页

作者： Jorge marcos-marcos antonio Olry de Labry-Lima Silvia Toro-Cardenas Marina Lacasaña Stephanie Degroote Valery Ridde Clara Bermudez-Tamayo Public Health Research Group University of AlicanteAlicanteSpain Andalusian School of Public Health GranadaSpain Biomedical Research Centre Network for Epidemiology and Public Health(CIBERESP) MadridSpain Biomedical Research Centre(ibs.GRANADA) GranadaSpain Public Health Research Institute(IRSPUM) University of MontrealMontrealQuebecCanada IRD(French Institute for Research on Sustainable Development) CEPED(IRD-Universite Paris Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:The control of vector-borne diseases(VBD)is one of the greatest challenges on the global health *** and uncontrolled urbanization has heightened the interest in addressing these challenges through an integrated vector management(IVM)*** aim was to identify components related to impacts,economic evaluation,and sustainability that might contribute to this integrated approach to VBD *** body:We conducted a scoping review of available literature(2000-2016)using PubMed,Web of Science,Cochrane,CINAHL,Econlit,LILACS,Global Health Database,Scopus,and Embase,as well as Tropical Diseases Bulletin,WHOLIS,WHO Pesticide Evaluation Scheme,and Google *** terms and free-text terms were used.A data extraction form was used,including TIDieR and *** and CHEERS were used to evaluate *** the 42 documents reviewed,30 were focused on dengue,eight on malaria,and two on *** than a half of the studies were conducted in the *** used a quantitative descriptive approach(n=21),followed by cluster randomized controlled trials(n=11).Regarding impacts,outcomes were:a)use of measures for vector control;b)vector control;c)health measures;and d)social *** reduced breeding sites,the entomology index,and parasite *** were heterogeneous,with variable magnitudes,but in all cases were favourable to the *** of IVM impacts on health outcomes was very limited but showed reduced *** outcomes were improved abilities and capacities,empowerment,and community *** economic evaluation,only four studies performed an economic analysis,and intervention benefits outweighed *** was dependent on illness *** results provided key elements to analyze sustainability in terms of three dimensions(social,economic,and environmental),emphasizing the implementation of a community-focused eco-bio-social ***:IVM has an impact on redu

关键词： Vector-borne diseases Integrated vector management Urban health Intervention Scoping review

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H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression

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World Journal of Gastroenterology 2008年第6期14卷 884-891页

作者： Valeska Portela Lima marcos antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst Departament of Pathology and Forensic Federal University of Ceará State Brazil Saint House of Mercy in Fortaleza Brazil

AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

关键词： Gastric carcinoma Helicobacter pylori Epstein-Barr virus, p53, Bax, Bcl-2, c-Myc

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Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility

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Asian Journal of Andrology 2004年第1期6卷 59-65页

作者： Nicolás Garrido marcos Meseguer Carlos Simon antonio Pellicer José Remohi Instituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Department of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia Spain

Oxidative stress is a common condition suffered by biological systems in aerobic conditions. Human semen also has its own molecular guard against the free radicals created by normal respiratory process or from immune reactions. The equilibrium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy. The paper is a systematic review of publications that evaluate oxidative stress in semen. The Cochrane Library, Medline (1966-2003), Embase (1988-2003), SciSearch (1981-2003) and the conference papers were searched. When sperm samples from fertile and infertile males were analyzed, some of the mechanisms that determine the oxidative stress level were found to be impaired while others were unaltered. In conclusion, the literature as a whole provides contradictory findings and it is necessary to carry out more work to identify all the enzymatic and non-enzymatic systems involved in oxidative stress in the ejaculate, in order to develop new diagnostic systems and therapeutic strategies for combating detrimental free radical imbalance in the semen.

关键词： oxidative stress antioxidants semen spermatozoa male fertility

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Mortality Trends for Neglected Tropical Diseases in the State of Sergipe,Brazil,1980-2013

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Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： marcos antonio Costa de Albuquerque Danielle Menezes Dias Lucas Teixeira Vieira Carlos Anselmo Lima Angela Maria da Silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information System of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of Sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,Schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,Schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of Sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:Schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

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The effect of the infection within the individual host on its propagation in the population

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Infectious Disease Modelling 2018年第1期3卷 345-361页

作者： Franciane Azevedo marcos Amaku Francisco antonio Bezerra Coutinho Luis Fernandez Lopez Eduardo Massad Faculdade de Engenharia da Computaçaoe Engenharia Eletrica Universidade Federal do Sul e Sudeste do ParaMarabaPABrazil Faculdade de Medicina Universidade de Sao Pauloe LIM01-HCFMUSPAv.Dr.Arnaldo 455Sao PauloSP01246-903Brazil Faculdade de Medicina Veterinariae Zootecnia Universidade de Sao PauloSao PauloSP05508-270Brazil London School of Hygiene and Tropical Medicine LondonUK Escola de Matematica Aplicada Fundaçao Getúlio VargasRio de JaneiroBrazil College of Natural and Life Sciences The University of DerbyDerbyUK

We consider nested or multiscale models to study the effect of the temporal evolution of the disease within the host in the population dynamics of the disease,for one and two infectious *** assumed a coupling between the within-host infection rate and the between-host transmission *** age of infection within each individual in a population affects the probability of transmission of the disease to a susceptible host and this will affect the temporal evolution of the disease in the host *** analyze the infection within the host,we consider bacterial-like and viral-like *** the model for two infectious agents,we found that,when strain 2 has a basic reproduction number R02 greater than the basic reproduction number R01 of strain 1,strain 2 replaces strain 1 in the ***,if R02>R01 but the values are closer,the replacement does not occur immediately and both strains can coexist for a long *** applied the model to a scenario in which patients infected with the hepatitis C virus(HCV)are cleared of HCV when super-infected with the hepatitis A virus(HAV).We compared the time for the replacement of HCV by HAV in the population considering instantaneous and noninstantaneous replacement within the *** model developed can be generalized for more than two infectious agents.

关键词： Nested model Multiscale model Within-host infection Between-host transmission Infectious disease

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A SIMPLE DEVICE TO MONITOR SEDIMENT YIELD FROM GULLY EROSION

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International Journal of Sediment Research 2005年第3期20卷 90-94页

作者： antonio Jose Teixeira GUERRA,marcos FIGUEIREDO Senior Lecturer in Physical Geography Federal University of Rio de Janeiro Av. Canal de Marapendi 1100 apto. 608 Bloco 2 Barra da Tijuca-CEP Rio de Janeiro Rio de Janeiro 22.631-050 Brazil Lecturer in Physical Geography State University of Mato Grosso

The focus of this paper is the design and use of a simple device to determine sediment yield from gullies. The simplicity and low cost makes this device especially useful when resources are limited. In this study, it was used to measure sediment yield at a site called An?o Gully, in a study area in Cáceres municipality (15o 57’ S and 57o 31’ W, Mato Grosso State, Brazil). This gully is located 28 kilometres from the center of the town, Cáceres, and was easy to reach during and immediately after storm events to make measurements with this device.

关键词： Gully erosion Sediment yield Gully monitoring Simple device

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