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Emerging role of microRNAs in liver diseases

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World Journal of Gastroenterology 2009年第45期15卷 5633-5640页

作者： Shashi Bala Miguel marcos Gyongyi Szabo Department of Medicine University of Massachusetts Medical School WorcesterMA 01605 United States

MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apopto-sis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules.

关键词： MicroRNA Hepatitis Fatty liver Fibrosis Cirrhosis

Human Interaction Dynamics for Its Use in Mobile Robotics:Impedance Control for Leader-follower Formation

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 696-703页

作者： Daniel Herrera Flavio Roberti marcos Toibero Ricardo Carelli Instituto de Automatica Universidad Nacional de San Juan-CONICET IEEE

A complete characterization of the behavior in human-robot interactions(HRI) includes both: the behavioral dynamics and the control laws that characterize how the behavior is regulated with the perception data. In this way, this work proposes a leader-follower coordinate control based on an impedance control that allows to establish a dynamic relation between social forces and motion error. For this, a scheme is presented to identify the impedance based on fictitious social forces, which are described by distance-based potential *** part of the validation procedure, we present an experimental comparison to select the better of two different fictitious force structures. The criteria are determined by two qualities: least impedance errors during the validation procedure and least parameter variance during the recursive estimation ***, with the best fictitious force and its identified impedance,an impedance control is designed for a mobile robot Pioneer 3AT,which is programmed to follow a human in a structured *** to results, and under the hypothesis that moving like humans will be acceptable by humans, it is believed that the proposed control improves the social acceptance of the robot for this kind of interaction.

关键词： Human modeling human-machine interaction impedance control robot dynamics social robotics

An overview on nucleation theories and models

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Journal of Rare Earths 2019年第10期37卷 1015-1022页

作者： marcos Flavio de Campos Jose Adilson de Castro Department of Mechanical Engineering Federal Fluminense University

Several different models for coercivity are discussed. There are two main situations: i) nanocrystalline magnets, with grain size bellow the single domain particle size, and ii) magnets with grain size above single domain particle size. The described theories and models are general, and can be applied in either NdFeB magnets, SmFeCoCuZr or strontium ferrite magnets. The spring effect observed in isotropic nanocrystalline magnets can be explained with the Stoner-Wohlfarth model. Modifications of the StonerWohlfarth model are necessary to take into account the effect of interaction between grains. When the grain size is above the single domain size, energy considerations show that nucleation should occur at the surface of grains. Nucleation is interpreted as a two-step process, where domain wall displacement occurs for grain size above single domain size, after a nucleus is first formed. The effect of grain size on the coercive field is discussed.

关键词： Coercivity Nucleation Grain size Spring effect Nd-Fe-B Permanent magnet

Niobium in Microalloyed Steels Unchallenged for Its Main Applications

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Journal of Iron and Steel Research International 2011年第S1期18卷 57-65页

作者： Nogueira marcos A Stuart Carneiro Tadeu Companhia Brasileira de Metalurgia e Minerao Technical DirectorSao PauloBrazil Companhia Brasileira de Metalurgia e Minerao Managing DirectorSao PauloBrazil

During the past five decades niobium has emerged as the most important microalloying element in high strength *** first theories to explain its role were presented in the seminal publications of Woodhead,Morrison and *** niobium microalloyed steels are unchallenged for their main *** examples include linepipe for gas transportation,automotive steels used in body-in-white and structural parts,shipbuilding,steel towers and steel structures in civil construction that exhibit better fire resistance and seismic load *** technology for steelmaking helped emphasize the superior overall properties that can be attained with the use of *** linepipe is the best example of cleaner steel with carbon levels below 0.05% manufactured *** niobium microalloyed steels present the optimal balance of strength,toughness,weldability and *** paper describes the evolution of the technology associated with niobium in microalloyed steels,technology that secured its status as the efficient solution to solving today’s challenges:safety,energy efficiency and environmental *** paper also presents evidence that enhances the case that there is a secure,stable,long-term supply of the ferroniobium used to manufacture these steels.

关键词： Niobium in Microalloyed Steels Unchallenged for Its Main Applications

Genetic and epigenetic control of transfer cell development in plants

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Journal of Genetics and Genomics 2016年第9期43卷 533-539页

作者： Jing Yuan Perry Bateman Jose Gutierrez-marcos State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences School of Life Sciences University of Warwick

The inter-cellular translocation of nutrients in plant is mediated by highly specialized transfer cells （TCs）. TCs share similar functional and structural features across a wide range of plant species, including location at plant exchange surfaces, rich in secondary wall ingrowths, facilitation of nutrient flow, and passage of select molecules. The fate of endosperm TCs is determined in the TC fate acquisition stage （TCF）, before the structure features are formed in the TC differentiation stage （TCD）. At present, the molecular basis of TC development in plants remains largely unknown. In this review, we summarize the important roles of the signaling molecules in different development phases, such as sugars in TCF and phytohormones in TCD, and discuss the genetic and epigenetic factors, including TC-specific genes and endogenous plant peptides, and their crosstalk with these signaling molecules as a complex regulatory network in regulation of TC develonment in olants.

关键词： Transfer cells Differentiation Signals and genes network

Long-term Regional Dynamic Sea Level Changes from CMIP6 Projections

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Advances in Atmospheric Sciences 2021年第2期38卷 157-167页

作者： Bruno FERRERO marcos TONELLI Fernanda MARCELLO Ilana WAINER University of São Paulo São Paulo 05508120Brazil

Anthropogenic climate forcing will cause the global mean sea level to rise over the 21st ***,regional sea level is expected to vary across ocean basins,superimposed by the influence of natural internal climate ***,we address the detection of dynamic sea level(DSL)changes by combining the perspectives of a single and a multimodel ensemble approach(the 50-member CanESM5 and a 27-model ensemble,respectively,all retrieved from the CMIP6 archive),under three CMIP6 projected scenarios:SSP1-2.6,SSP3-7.0 and *** ensemble analysis takes into account four key metrics:signal(S),noise(N),S/N ratio,and time of emergence(ToE).The results from both sets of ensembles agree in the fact that regions with higher S/N(associated with smaller uncertainties)also reflect earlier *** DSL signal is projected to emerge in the Southern Ocean,Southeast Pacific,Northwest Atlantic,and the *** common for both sets of ensemble simulations show that while S progressively increases with increased projected emissions,N,in turn,does not vary substantially among the SSPs,suggesting that uncertainty arising from internal climate variability has little dependence on changes in the magnitude of external *** changes are greater and quite similar for the scenarios SSP3-7.0 and SSP5-8.5 and considerably smaller for the SSP1-2.6,highlighting the importance of public policies towards lower emission scenarios and of keeping emissions below a certain threshold.

关键词： dynamic sea level CMIP6 sea level rise signal-to-noise time of emergence

Selection of Bacillus thuringiensis strains in citrus and their pathogenicity to Diaphorina citri (Hemiptera: Liviidae) nymphs

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Insect Science 2020年第3期27卷 519-530页

作者： Silvia de Oliveira Dorta Juliana Balbinotte Rose Monnerat Joao roberto Spotti Lopes Tatiane da Cunha Odimar Zanuzo Zanardi Marcelo Pedreira de Miranda marcos Antonio Machado Juliana de Freitas-Astua Programs de Pos-Graduagao em Microbiologia Agricola Escola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Laboratorio de Biotecnologia Centro de Citricultura Sylvio MoreiraInstituto Agronomico de CampinasCordeiropolisSPBrazil Laboratorio de Insetos Vetores de Fitopatdgenos Departamento de Entomologia e AcarologiaEscola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Embrapa Recursos Geneticos e Biotecnologia BrasiliaDFBrazil Fundo de Defesa da Citricultura(Fundecitrus) AraraquaraSPBrazil Embrapa Mandioca e Fruticultura Cruz das AlmasBABrazil Laboratdrio de Bioquimica Fitopatoldgica Instituto BioldgicoSao PauloSPBrazil

Bacillus thuringiensis(Bt)toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic *** discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap‐sucking insects,such as the Asian citrus psyllid Diaphorina citri Kuwayama(Hemiptera:Liviidae),a vector of“Candidatus Liberibacter spp.,”associated with citrus huanglongbing(HLB).In this study,translocation of endophytic Bt strains in citrus seedlings inoculated with Bt suspension delivered by soil‐drench,and their systemic pathogenicity to *** nymphs were *** pathogenicity of three wild‐type Bt strains against *** third‐instar nymphs was *** the 10 recombinant strains tested(each of them harboring a single cry or cyt gene),3 can be highlighted,causing 42%–77%and 66%–90%nymphal mortality at 2 and 5 d after inoculation,*** isolation of Bt cells from young citrus shoots and dead nymphs,and PCR performed with specific primers,confirmed the involvement of the Bt strains in the psyllid *** is the first report showing the translocation of Bt strains from citrus seedling roots to shoots and their potential to control *** nymphs that fed on these soil‐drench inoculated *** Bt strains that caused the highest mortality rates have the potential to be used as bioinsecticides to control *** and the identified genes can be used for the production of transgenic Bt citrus.

关键词： Asian citrus psyllid Citrus sinensis Cry toxins endophytic Bt huanglongbing young shoots

Efficacy of soy protein concentrate replacing animal protein supplements in mucosa-associated microbiota, intestinal health, and growth performance of nursery pigs

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Animal Nutrition 2023年第3期14卷 235-248页

作者： Zixiao Deng marcos Elias Duarte Sung Woo Kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

This study investigated the effects of using soy protein concentrate (SPC) to replace animal protein supplements on mucosa-associated microbiota,intestinal health,and growth performance of nursery ***-six newly weaned pigs (BW=6.4±0.6 kg) were allotted to 5 treatments in a randomized complete block *** were fed for 35 d in 3 phases (P;1,2,3) for 10,12,13 d,*** treatments were:(1) basal diet with fish meal (P1:4%,P2:2%,and P3:1%),poultry meal (P1:10%,P2:8%,and P3:4%),and blood plasma (P1:4%,P2:2%,and P3:1%),where SPC replacing none (NC);(2) basal diet with SPC replacing fish meal (RFM);(3) basal diet with SPC replacing poultry meal (RPM);(4) basal diet with SPC replacing blood plasma (RBP);and (5) basal diet with SPC replacing all animal protein supplements (PC).Growth performance was recorded for each *** were euthanized on d 35 to collect jejunal mucosa and tissue to evaluate intestinal health and microbiota,and ileal digesta to measure apparent ileal digestibility (AID) of *** were analyzed using the MIXED procedure of ***,RFM,RPM,and RBP did not affect growth performance,whereas PC decreased (P<0.05) ADG and *** RPM increased (P<0.05) Prevotella stercorea and decreased (P<0.05) Helicobacter *** PC decreased (P<0.05) ***,whilst increasing (P<0.05) Prevotella copri,Propionibacterium acnes,and Pelomonas *** RFM tended to increase (P=0.096) immunoglobulin A in the *** PC tended to decrease (P=0.078) jejunal crypt cell *** were no differences in the villus height,AID of nutrients,intestinal inflammation,and intestinal oxidative stress among *** conclusion,SPC can replace fish meal,poultry meal,or blood plasma individually without affecting growth performance and intestinal health,and AID of nutrients of nursery *** SPC replacing poultry meal benefitted intestinal health by reducing *** and increasing ***,SPC replac

关键词： Blood plasma Fish meal Intestinal health Nursery pigs Poultry meal Soy protein concentrate

In situ characterizations of solid-solid interfaces in solid-state batteries using synchrotron X-ray techniques

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Carbon Energy 2021年第5期3卷 762-783页

作者： marcos Lucero Shen Qiu Zhenxing Feng School of Chemical Biologicaland Environmental EngineeringOregon State UniversityCorvallisOregonUSA

The solid-solid electrode-electrolyte interface represents an important component in solid-state batteries(SSBs),as ionic diffusion,reaction,transformation,and restructuring could all take *** these processes strongly influence the battery performance,studying the evolution of the solid-solid interfaces,particularly in situ during battery operation,can provide insights to establish the structure-property relationship for *** X-ray techniques,owing to their unique penetration power and diverse approaches,are suitable to investigate the buried interfaces and examine structural,compositional,and morphological *** this review,we will discuss various surface-sensitive synchrotron-based scattering,spectroscopy,and imaging methods for the in situ characterization of solid-solid interfaces and how this information can be correlated to the electrochemical properties of *** goal is to overview the advantages and disadvantages of each technique by highlighting representative examples,so that similar strategies can be applied by battery researchers and beyond to study similar solid-solid interface systems.

关键词： in situ characterizations solid-state battery solid-solid interface synchrotron X-ray