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Factors influencing the drug release from calcium phosphate cements

Bioactive Materials 2022年第1期7卷 341-363页

作者： marco fosca Julietta V.Rau Vuk Uskokovi Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere 10000133RomeItaly I.M.Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia Advanced Materials and Nanobiotechnology Laboratory TardigradeNano LLCIrvineCA 92604United States

Thanks to their biocompatibility,biodegradability,injectability and self-setting properties,calcium phosphate cements(CPCs)have been the most economical and effective biomaterials of choice for use as bone void *** have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone,including primarily antibiotics and growth *** review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 *** chemical,compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been *** doing so,the effects of(i)the chemistry of the matrix,(ii)porosity,(iii)additives,(iv)drug types,(v)drug concentrations,(vi)drug loading methods and(vii)release media have been distinguished and discussed *** specificities of in vivo release of drugs from CPCs have been reviewed,*** the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical *** goal of this review has been to shed light on these fundamental correlations.

关键词： Calcium phosphate cements Drug release Release rate Antibiotics release Bone fillers

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In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

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Bioactive Materials 2021年第10期6卷 3383-3395页

作者： Iulian V.Antoniac Aurora Antoniac Eugeniu Vasile Camelia Tecu marco fosca Viktoriya G.Yankova Julietta V.Rau University Politehnica of Bucharest 313 Splaiul Independentei StreetDistrict 6060042BucharestRomania Academy of Romanian Scientists 54 Splaiul Independentei StreetDistrict 5050094BucharestRomania Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere10000133RomeItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8Build.2Moscow119991Russia

New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous *** inspiration from basic composition of the mammalian bones,composed of collagen,apatite and a number of substitution ions,among them magnesium(Mg2+),in this work,novel composite scaffolds composed of collagen(10%)-hydroxyapatite(HAp)(90%)and collagen(10%)-HAp(80%)-Mg(10%)were *** lyophilization was used for composites *** insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive *** HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen *** samples were tested for degradation in Simulated Body Fluid(SBF)solution by soaking for up to 28 *** release of Mg from collagen(10%)-HAp(80%)-Mg(10%)composite during the period of up to 21 days was attested,this composite being characterized by a decreased degradation rate with respect to the composite without *** developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.

关键词： Composite Collagen Hydroxyapatite Magnesium Scaffold Hard tissue regeneration Scaffold degradation

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Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive Materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi marco fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“M.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of Metallurgy and Materials Science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-Medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured Materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

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Quality control methods in musculoskeletal tissue engineering:from imaging to biosensors

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Bone Research 2021年第4期9卷 473-493页

作者： Daniele Zuncheddu Elena Della Bella Andrea Schwab Dalila Petta Gaia Rocchitta Silvia Generelli Felix Kurth Annapaola Parrilli Sophie Verrier Julietta V.Rau marco fosca Margherita Maioli Pier Andrea Serra Mauro Alini Heinz Redl Sibylle Grad Valentina Basoli AC Research Institute Davos Clavadelerstrasse 87270 DavosSwitzerland Regenerative Medicine Technologies Lab Ente Ospedaliero Cantonale(EOC)Via Tesserete 466900 LuganoSwitzerland Department of Medical Surgical and Experimental SciencesUniversity of SassariViale San Pietro 43/b07100 SassariItaly Centre Suisse d'Electronique et de Microtechnique Bahnhofstrasse 17302 LandquartSwitzerland Center for X-ray Analytics Empa-Swiss Federal Laboratories for Materials Science and TechnologyUberlandstrasse 1298600 DubendorfSwitzerland lstituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133 RomeItaly Sechenov First Moscow State Medical University Trubetskaya 8build.2119991 MoscowRussian Federation Department of Biomedical Sciences University of SassariViale San Pietro 43/b07100 SassariItaly Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA trauma research center DonaueschingenstraBe 131200 ViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria

Tissue engineering is rapidly progressing toward clinical *** the musculoskeletal field,there has been an increasing necessity for bone and cartilage *** the promising translational potential of tissue engineering approaches,careful attention should be given to the quality of developed constructs to increase the real applicability to *** a general introduction to musculoskeletal tissue engineering,this narrative review aims to offer an overview of methods,starting from classical techniques,such as gene expression analysis and histology,to less common methods,such as Raman spectroscopy,microcomputed tomography,and biosensors,that can be employed to assess the quality of constructs in terms of viability,morphology,or matrix deposition.A particular emphasis is given to standards and good practices(GXP),which can be applicable in different ***,a classification of the methods into destructive,noninvasive,or conservative based on the possible further development of a preimplant quality monitoring system is *** in musculoskeletal tissue engineering have not yet been used but have been proposed as a novel technology that can be exploited with numerous advantages,including minimal invasiveness,making them suitable for the development of preimplant quality control systems.

关键词： skeletal starting spite

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