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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate marco badinella martini Corrado Magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodule<3,and 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

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Modeling and optimal control of COVID-19 with comorbidity and three-dose vaccination in Indonesia

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Journal of Biosafety and Biosecurity 2024年第3期6卷 181-195页

作者： Muhammad Abdurrahman Rois Fatmawati Cicik Alfiniyah Santi martini Dipo Aldila Farai Nyabadza Department of Mathematics Faculty of Science and TechnologyUniversitas AirlanggaSurabayaIndonesia Department of Mathematics Universitas Islam Negeri SalatigaSalatigaIndonesia Department of Epidemiology BiostatisticsPopulation and Health PromotionFaculty of Public HealthUniversitas AirlanggaSurabayaIndonesia Department of Mathematics Faculty of Mathematics and Natural SciencesUniversitas IndonesiaDepokIndonesia Department of Mathematics and Applied Mathematics University of JohannesburgAuckland ParkSouth Africa Department of Applied Sciences Emirates Aviation UniversityUnited Arab Emirates

This paper presents and examines a COVID-19 model that takes comorbidities and up to three vaccine doses into *** analyze the stability of the equilibria,examine herd immunity,and conduct a sensitivity analysis validated by data on COVID-19 in *** disease-free equilibrium is locally and globally asymptotically stable whenever the basic reproduction number is less than one,while an endemic equilibrium exists and is globally asymptotically stable when the number is greater than ***,the model incorporates two effective measures,namely public education and enhanced medical care,to determine the most advantageous approach for mitigating the transmission of the *** optimal control model is then determined using Pontryagin’s maximum *** integrated control strategy is the best method for reliably safeguarding the general population against COVID-19 *** evaluations and numerical simulations corroborate this conclusion.

关键词： COVID-19 Comorbidity Stability Herd immunity Optimal control Cost evaluation

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Wunderlich syndrome,an unexpected urological complication in a patient with coronavirus disease 2019(COVID-19):A case report

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Current Urology 2022年第2期16卷 74-76页

作者： Fabrizio Presicce marco martini Francesco Minisola Cristina Falavolti Alessio Filianoti Department of Urology San Filippo Neri HospitalRome00135Italy

We describe the first case of Wunderlich syndrome as a hemorrhagic complication in a patient with severe acute respiratory syndrome coronavirus 2 infection and acute respiratory distress *** possible underlying pathophysiological mechanisms have been extensively *** management included selective angioembolization of the upper polar arterial branches of the left kidney and discontinuation of *** patient was discharged after 18 *** other localizations or local recurrence of bleeding occurred during the *** report suggests a broad spectrum of clinical manifestations in patients with coronavirus disease *** observed in our clinical case,in addition to thrombotic complications,bleeding is a significant cause of morbidity in coronavirus disease 2019 *** studies should determine whether these urological bleeding sequelae are a direct manifestation of the infection or an indirect effect of thromboprophylaxis.

关键词： Bleeding Coagulopathy Coronavirus disease 2019 Interventional radiology Wunderlich syndrome

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Boswellia resin extract and propolis derived polyphenols in patients with type III chronic prostatitis/chronic pelvic pain syndrome:An Italian prospective multicenter study

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Asian Journal of Urology 2022年第2期9卷 139-145页

作者： Fabrizio Presicce Francesco Barrese Andrea Cantiani Alessio Filianoti Domenico Tuzzolo Paolo Di Palma Stefano Lauretti Stefano Brunori marco martini San Filippo Neri Hospital Department of UrologyRomeItaly Sant’Eugenio Hospital Department of UrologyRomeItaly Casa del Sole Clinic Department of UrologyFormiaItaly Fabrizio Spaziani Hospital Department of UrologyFrosinoneItaly Santa Caterina della Rosa Clinic Department of UrologyRomeItaly Villa Stuart Clinic Department of UrologyRomeItaly

Objective:To assess the efficacy and safety of a treatment regimen based on rectal administration of Boswellia resin extract and propolis derived polyphenols in patients with type IIIa and type IIIb chronic prostatitis and chronic pelvic pain syndrome(CP/CPPS).Methods:Patients with type IIIa and type IIIb CP/CPPS received one rectal suppository a day for 15 days per month for 3 consecutive *** were evaluated with National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI),the International Prostate Symptom Scores(IPSS),International Index of Erectile Function(IIEF),four-glass test,uroflowmetry,and prostate-specific antigen assessments at baseline and at Week 4,and Week *** endpoints were improvement in pain domain of NIH-CPSI and improvement of NIH-CPSI total *** outcomes included improvement of micturition and quality of life(QoL)domains of NIH-CPSI ***:A total of 61 males were *** adverse events were *** improvements from baseline to Day 30 were reported for NIH-CPSI total score(mean difference:-9.2;p<0.01),NIH-CPSI pain domain(mean difference:-5.5;p<0.01),NIH-CPSI micturition domain,NIH-CPSI QoL domain,and IPSS total score(mean difference:-5.6;p<0.01).No significant changes from baseline in terms of IIEF score or maximum flow rate were *** final follow-up(Day 90),further significant improvements in terms of NIH-CPSI total score(mean difference:-12.2;p<0.01),NIH-CPSI pain domain(mean difference:-6.6;p<0.01),NIH-CPSI micturition domain,NIH-CPSI QoL domain,and IPSS total score were ***:Rectal administration of Boswellia resin extract and propolis derived polyphenols is well tolerated and delivers a significant symptomatic improvement in most patients with type IIIa and type IIIb CP/CPPS.

关键词： Boswellia serrata Chronic prostatitis Chronic pelvic pain syndrome Propolis Treatment

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Cold acclimation increases Asian citrus psyllid Diaphorina citri (Hemiptera: Liviidae) survival during exposure to freezing temperatures

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Insect Science 2022年第2期29卷 531-538页

作者： Xavier martini Kathi Malfa Dara Stockton Monique JRivera Department of Entomology and Nematology North Florida Research and Education CenterQuincyFloridaUSA USDA-ARS U.S.Pacific Basin Agricultural Research CenterHiloHawaiiUSA Department of Entomology University of CaliforniaRiversideCaliforniaUSA

The Asian citrus psyllid,Diaphorina citri,is the vector of the pathogenic bacteria that causes Huanglongbing,the most devasting disease affecting citrus *** cultivation of citrus tends to expand northward,the tolerance of psyllids to freezing temperatures needs to be *** mortality of *** to cold temperature has been previously studied,much less is known regarding the acclimation potential of psyllids to cold *** first evaluated cold resistance of *** depending on color morph and ***,we compared mortality of *** at−4°C for 10 hours between unacclimated psyllids,psyllids that were gradually acclimated to cold over 1 or 2 weeks,and psyllids intermittently acclimated also for 1 or 2 *** did not find major differences in cold resistance between color morphs and *** found that after 1 week of gradual acclimation,the survival of psyllids at−4°C increased to 86%,compared to 20%in the control *** did not increase after the second week of gradual *** intermittent acclimation improved survival compared to the control group,it was less effective than gradual acclimation with a survival at 30%and 70%after 1 and 2 weeks of acclimation,respectively,although this difference with gradual acclimation was not significant at week *** data show that gradual cold acclimation allows *** to survive brief periods below *** may serve as a mechanism responsible for increasing northern establishment of this pest.

关键词： cold acclimation cold hardy citrus cold resistance citrus greening Diaphorina citri overwintering

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The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： Francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti Francesco Montorsi Felix K.H.Chun Shahrokh F.Shariat Alessandro Antonelli Giovanni Guano Guglielmo Mantica marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

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Deep Representation Learning for Sarcasm Detection in Twitter using Attention Mechanism

Deep Representation Learning for Sarcasm Detection in Twitte...

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作者： ANDRIANARISOA TOJO martini 大连理工大学

学位级别：硕士

情感分析是自然语言处理中一个非常活跃的研究领域。近来,互联网上出现了许多包含用户评论的文本资源:互联网用户的想法、论坛、社交网络、消费者调查等。考虑到数据的丰富性,自动综合多个观点对于获得对即定主题情感的概述变得至关重... 详细信息

情感分析是自然语言处理中一个非常活跃的研究领域。近来,互联网上出现了许多包含用户评论的文本资源:互联网用户的想法、论坛、社交网络、消费者调查等。考虑到数据的丰富性,自动综合多个观点对于获得对即定主题情感的概述变得至关重要。该研究对于希望了解客户对其产品的反馈意见的公司,以及希望查询关于产品或旅行的评论的人来说都很有吸引力。在过去的十年里,推特已经变得很流行,并且成为许多人日常生活的一部分。在该论文中,笔者研究了Twitter消息中的讽刺检测。尽管大多数关于讽刺检测的研究都强调词汇、句法或语用特征的使用。这些特征通常通过比喻手段来表达,如单词、表情符号和感叹号。在本文中,作者将注意力机制与深度神经模型相结合,并将其与目前最先进的特征工程方法进行了比较,探索深度学习在讽刺检测任务中的应用。作者还建立了一个关于讽刺存在的tweet手动注释数据集。因为递归神经网络(RNN)模型通常不能囊括其最终的所有重要信息隐藏状态,作者重点关注机制的影响,首先通过与长期短期记忆(LSTM)结合探究,然后与双向长期短期记忆(BLSTM)结合探究找出句子中的每个单词的相对作用。结果表明,基于注意机制下的LSTM模型的F1score为0.91,基于注意机制下的BLSTM模型的F1score为0.90,与现有模型相比具有较强的竞争力。

关键词：情感分析 Twitter 讽刺深度学习注意机制长期短期记忆

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Landscape and land use in southern Hainan Island,China

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Chinese Science Bulletin 2001年第S1期46卷 102-104页

作者： ZHANG Yongzhan martini I.Peter GE Chendong ZHU Dakui State Pilot Laboratory of Coast&Island Development Nanjing UniversityNanjing 210093China Department of Land Resource Science University of GuelphGuelphONCanadaNIG 2W1

According to the landscape/land use relation of southern Hainan Island, four main zones are considered: the mountain and high hill zone, the inner coastal zone, the shoreline zone and the marine zone. The economic boo... 详细信息

关键词： landscape land use southern Hainan Island.

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Clinical challenges of glycemic control in the intensive care unit:A narrative review

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World Journal of Clinical Cases 2022年第31期10卷 11260-11272页

作者： Roshni Sreedharan Adriana martini Gyan Das Nida Aftab Sandeep Khanna Kurt Ruetzler Anesthesiology Institute Cleveland ClinicClevelandOH 44195United States

Glucose control in patient admitted to the intensive care unit has been a topic of much debate over the past 20 *** harmful effects of uncontrolled hyperglycemia and hypoglycemia in critically ill patients is well *** a large clinical trial in 2001 demonstrated significant mortality and morbidity benefits with tight glucose control in this patient population,the results could not be replicated by other ***“Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation”trial in 2009 established that tight glucose control was not only of no benefit,but in fact harmful due to the significant risk of *** current guidelines suggest a moderate approach with the initiation of intravenous insulin therapy in critically ill patients when the blood glucose level is above 180 mg/*** most important factor that underpins glycemic management in intensive care unit patients is the consequent prevention of *** glucose monitoring strategies and insulin protocols need to be implemented in order to achieve this goal.

关键词： Diabetes management Intensive care unit Anesthesiology

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Coastal plain evolution in southern Hainan Island,China

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Chinese Science Bulletin 2001年第S1期46卷 90-96,125页

作者： WANG Ying martini I.Peter ZHU Dakui ZHANG Yongzhan TANG Wenwu Key Laboratory of Coast&Island Development of Ministry of Education of China Dept.of Geo&Ocean SciencesNanjing UniversityNanjing 210093China Department of Land Resource Science University of GuelphGuelphON.Canada

The coast of southern Hainan Island is characterized by wide sandy embayments, which consist of ( i) drowned valleys bounded by steep bedrock hills and only locally receiving sediments, and embayments of various dimensions covered either by (ii) alluvial-deltaic deposits or by (iii) sands of coastal beach ridges/barriers and associated elongated lagoons. During the late Tertiary-Pleistocene the area has experienced isostatic and eustatic movements associated with neotectonics and climatic changes. Such history isrecorded in terraces at various altitudes (SO, 40, 20 m asl) and sequences of coastal sand ridges/baymouth bars. The Holocene variations in sea level and climate are recorded in the dated coastal ridges, coral reef and beachrock. Conditions suitable for reef development started about 8000 a BP. The GPR profiles also show that the internal structures of the sand ridges have composite nature being formed by several superimposed secondary ridges.

关键词： sand barrier system coral reef sea level change south- ern Hainan Island.

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