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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da silva Abreu Taysse Holanda Joice Farias do nascimento Henety nascimento Pinheiro Rachel Menezes Castelo Hélcio silva dos Santos Thais Benincá Patrícia da silva Malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Conocarpus erectus L., a plant with a high content of structural sugars, ions and phenolic compounds, shows antioxidant and antimicrobial properties promoted by different organic fractions

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 463-470页

作者： Dayane Kelly Dias do nascimento Santos Weslley Henrique de Oliveira Melo Anastassia Mariáh Nunes de Oliveira Lima Iranildo Joseda Cruz Filho Glaucia Manoella de Souza Lima Tulio Diego da silva Maiara Celine de Moura marcia silva do nascimento Ana Maria Souto Maior Thiago Henrique Napoleao Cristiane Moutinho Lagos de Melo Department of Biochemistry Biosciences Centre Federal University of Pernambuco Department of Antibiotics Biosciences Centre Federal University of Pernambuco Center of Strategic Technologies of the Northeast

Objective: To evaluate the structural and chemical composition of plant and the antioxidant and antimicrobial activities promoted by hexanic, ethanolic and ethyl acetate fractions obtained from leaves of Conocarpus ***: Organic fractions were characterized through UPLC-MS and *** potential was performed through DPPH and molybdenum phosphate *** and antifungal assays were performed in accordance with Clinical and Laboratory Standards Institute ***: The obtained biomass of Conocarpus erectus leaves showed the high presence of glucose(0.45 g/L), cellulose(28.69%), Na(55.126 μg/L) and K(31.163 μg/L).We identified seven compounds in the hexanic and ethyl acetate fractions, and eight compounds in ethanolic ***, phenolic compounds are prevalent in all organic fractions with values of(10.04 ± 0.24),(221.26 ± 1.84),(340.53 ± 0.84) mg/g GAE to hexanic, ethyl acetate and ethanolic fraction, *** results showed a high potential in ethyl acetate fraction(71.82 ± 6.87)% and(10.89 ± 0.05)% in DPPH and molybdenum phosphate techniques, *** ethanolic fraction showed moderate bacteriostatic and bactericidal activity against Staphylococcus aureus and presented a high fungistatic potential for all Candida species ***: Organic fractions obtained from leaves of Conocarpus erectus present antimicrobial and antioxidant properties, and these findings contribute to scientific information for the effectiveness on use of this plant in the development of a phytotherapic compound.

关键词： Combretaceae Phenolic compounds Antimicrobial activity Antioxidant

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History Teacher Training from Decolonial Curriculum Practices to Combat Racism at UniProjeção in the Federal District-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第2期8卷 187-202页

作者： Karoline da silva Ramos Cláudia Pinheiro nascimento Francisca Carla Santos Ferrer Faculty of Philosophy Languages and Human SciencesUniversity of São PauloSão PauloBrazil

This article aims to understand the training process of history undergraduates,to see if there are decolonial curricular practices to combat racism at the Centro Universitário e Faculdade Projeção(UniProjeção)in the Federal District,to understand how coloniality has corroborated the exclusion of different epistemologies and the erasure of different cultures,and how this exclusionary process of coloniality interferes in the training of history *** order to combat this practice,we are looking for alternatives that can break these suppressions carried out by *** this way,we turn to decolonial ideas that aim to break with the logic of *** can conclude that these practices are poorly developed in the institution,so we proposed active problem-based methodology and music as a didactic *** playful educational tools that strengthen the teaching-learning process,they are active agents in the decolonial work of combating racism,and it is essential to train responsible and ethical teachers in the fight against racism and any form of oppression.

关键词： Coloniality Decoloniality Education Curriculum practices Racism

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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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Comparison of Surgical Techniques Used in Treating Acromioclavicular Dislocation in Patients Participating in Sports: A Systematic Review

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Open Journal of Orthopedics 2024年第1期14卷 41-52页

作者： Walter Hugo Brandão nascimento Paulo Renan Matos Sucupira Cunha João Pedro Pimentel Abreu Lethycia Pereira Rosa Kamilly Iêda silva Veigas Rodrigo Martins silva Caetano Orthopedic and Trauma Surgeon Brazilian Army Rio de Janeiro Brazil Orthopedic and Trauma Surgeon S&atildeo Luís Brazil Scholarship Holder National Council for Scientific and Technological Development (CNPq) S&atildeo Luís Brazil School of Medicine Federal University of Maranh&atildeo (UFMA) S&atildeo Luís Brazil Orthopedic and Trauma Surgeon Shoulder and Elbow Surgery Specialist University Hospital of the Federal University of Maranh&atildeo (HUUFMA/EBSERH) S&atildeo Luís Brazil

Introduction: The acromioclavicular joint is a superficial diarthrodial joint that surrounds the medial articular facet of the acromion and the distal portion of the clavicle. Due to its anatomy and biomechanics, it is highly susceptible to trauma and in young men who play contact sports, acromioclavicular dislocation is common. This article aimed to systematically review the literature and compare the surgical techniques used in the treatment of acromioclavicular dislocation in patients who practice sports. Methods: This systematic review was conducted according to the International Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Eligible studies for this systematic review included articles in English or Spanish published between 2013 and 2023, which mention the occurrence of acromioclavicular dislocation during sports practices. Additionally, only studies that addressed the surgical treatment of acromion-clavicular dislocation and contained original data on the topic were included. Results: We found 144 eligible studies after searching the LILACS and PubMed databases. Based on the inclusion and exclusion criteria and the reviewers’ consensus, we selected four studies for the systematic review. 133 patients with AC joint displacement were evaluated. Mean Age: approximately 31.90 years. 81.92 of these injuries occurred during sports practice. Surgical Procedures Used: titanium plates fixation (49 patients), arthroscopy (24), single tunnel technique (30) and coracoid sling technique (30). The results of the visual analog scale and Constant-Murley scores varied between the techniques used. Twenty-two complications after surgical treatment were identified. Conclusion: A significant variability of operative techniques can be used in the surgical approach of acromioclavicular dislocation, such as arthroscopy, single tunnel, coracoid sling and titanium plates. Although it presented excellent functional results compared to the other three tech

关键词： Acromioclavicular Joint Shoulder Dislocation Surgical Procedure Postoperative Complications Postoperative Care

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Comparison between Care Strategies for Patients with Osteoarthritis of the Hands Based on the Use of Joint Protection, Assistive Technology and Exercises

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Open Journal of Orthopedics 2024年第7期14卷 295-311页

作者： Daniele dos Santos Scarcella Talita Dias da silva Victoria Yanara Hernandes da silva Maria Cândida de Miranda Luzo Selma Lancman marcia Uchoa de Rezende Carlos Bandeira de Mello Monteiro Instituto de Ortopedia e Traumatologia Hospital das Clnicas HCFMUSP Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Programa de Ps-Graduao em Cincias da Reabilitao Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Escola de Artes Cincias e Humanidades Universidade de So Paulo So Paulo Brazil

Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. Purpose: To assess whether a group of people with hand osteoarthritis (hOA) who received different types of treatment improved their function after two years of follow-up. Method: The entire sample (n = 97) underwent three follow-up assessments regarding anthropometric parameters of the upper limbs and ability to perform functional activities. Subsequently, the sample was divided into two groups for the intervention periods, called the First Period (n = 73) and the Second Period (n = 24);the First Period kept the same protocol with orientations, and the Second Period went to an intervention with orientation strength exercises and use of orthosis. Findings: In the separate analysis of the three questions of the DASH pain module, no differences were found between the assessment moments for groups of guidelines, treatment, or symptoms. Significant effects were observed for F(2, 162) = 3.5, p = 0.033, η2 = 0.04, and interaction for moments and intervention F(2, 162) = 4.3, p = 0.016, η2 = 0.05. Implications: It can be concluded that only guidance treatment does not benefit patients with hand osteoarthritis. In contrast, guidance, exercise, and orthosis treatment can significantly improve the disease.

关键词： Hand Osteoarthritis Hand Deformities Occupational Therapy

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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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A remote sensing approach to estimate the load bearing capacity of soil

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Information Processing in Agriculture 2024年第1期11卷 109-116页

作者： Italo Rômulo Mendes de Souza Edson Eyji Sano Renato Paiva de Lima Anderson Rodrigo da silva Statistics and Geoprocessing Laboratory Instituto Federal GoianoGeraldo Silva Nascimento RoadKm 2.575790-000 UrutaíGoiásBrazil Embrapa Cerrados BR-020 RoadKm 18Mailbox 0822373310-970 PlanaltinaDFBrazil Department of Soil Science ‘Luiz de Queiroz’College of AgricultureUniversity of São PauloAv.Pádua Dias235-AgronomiaPiracicabaSP 13418-900Brazil

Preconsolidation pressure(σp)of soil can be considered as an indicator of the Load Bearing Capacity(LBC),which is the tolerated surface pressure before compaction,often caused by the traffic of agricultural *** this pioneering study,a remote sensing approach was introduced to estimate LBC throughσp from soils of the“Rio Preto”Hydrographic Basin,Bahia State,Brazil,in a monthly time lapse from 2016 to ***,σp is measured by a laborious and time demanding laboratory analysis,making it unfeasible to map large *** innovative methodology of this work consists of combining active–passive satellite data on soil moisture and pedotransfer functions of clay content and water matric potential to obtain geo-located estimates ofσ*** were analysed under different classes of soil use,land cover and slope;95%confidence intervals were built for the time series of mean values of LBC for each *** overall seasonal variation in LBC estimates is similar in areas with annual crops,grasslands and natural vegetation,and flat areas are less affected by soil moisture variations over the year(between seasons).LBC decreased,in general,at about 0.5%a year in flat ***,these areas demand attention,since they occupy 86%of the Basin and are mostly subjected to agricultural soil management and surface pressure by heavy machinery.

关键词： Soil compaction SMAP Preconsolidation stress Brazilian Cerrado

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Challenges in Implementing DVI Best Practice Guidelines Due to the Brumadinho Disaster

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Forensic Medicine and Anatomy Research 2024年第1期12卷 1-12页

作者： Reinaldo Moreira silva Bruno Diniz Sander Morais Carlos Danilo Ruas silva Elza Cristina Lopes de Oliveira Fernando Pereira Macedo Giovanni Vitral Pinto Guadalupe Dell’Arret Coutinho Higgor Gonçalves dornelas João Luiz silva Moreira Laila Evangelista de Almeida Fernandes marcia Lobão Iannini Patrícia Siqueira Valéria Rosalina Dias e Santos Sordaini Maria Caligiorne Instituto de Criminalística Polícia Civil de Minas Gerais Belo Horizonte Brazil

The broke of a tailings dam from Vale S.A. destroyed a gigantic area killing 270 persons in Brumadinho/Brazil. Organizing activities after a mass disaster is a complex process that requires the involvement of many people and resources in the laboratory. To DNA identification of the victims, a daunting work had to be made by DNA laboratory staff in a collaborative effort with many partners. Efforts to implement good practice guidelines in Disaster Victim Identification (DVI) have revealed several important aspects that need to change in the forensic DNA laboratory. This article highlights the challenges of implementing DVI best practice guidelines in resource-poor settings, but with professionals from different sectors engaged in the same goal of briefly identifying victims and helping families and society.

关键词： Disaster Victim Identification DNA Brumadinho

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Identification of victims of the collapse of a mine tailing dam in Brumadinho

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Forensic Sciences Research 2022年第4期7卷 580-589页

作者： Ricardo Moreira Araújo Yara Vieira Lemos Erlon Dias do nascimento Anna Helena silva Paraizo Alberto Julius Alves Wainstein Ana Paula Drummond-Lage Faculty of Medical Sciences of Minas Gerais Belo HorizonteBrazil Instituto Médico Legal AndréRoquette Belo HorizonteBrazil Corpo de Bombeiros Militar de Minas Gerais Juiz de ForaBrazil

The collapse of the B1 Dam of VALESAmining company in Brumadinho,Minas Gerais,Brazil was the largest humanitarian disaster and occupational accident in the country’s history,and it posed challenges regarding the management and identification of multiple *** evaluated the impact of the iron ore tailings on the victims’*** examined the scientific identification of the victims and the dynamics of the disaster over the 1st year after it *** also determined the socio-demographic profiles of the *** this retrospective,cross-sectional study,we investigated the expert reports of the victims’biological remains from 25 January 2019 to 25 January *** analysed the socio-demographic data,identification methods,identification status,identification time,and necroscopic *** the study period,259 of 270 victims were identified,and 603 biological materials were analysed;among them,86.2%were body parts and 13.8%were whole *** the total cases registered that year,476(78.9%)were submitted during the first 10 weeks after the *** ridge analysis accounted for 67.9%of primary identifications and DNAanalysis did so for 91.6%of re-identification *** dismemberment was 3.4 times greater among mine workers than among community *** males accounted for the greatest number of victims(P<0.001).Polytraumatic injury was the prevalent single cause of *** examination revealed the occurrence of asphyxia in 7%of *** higher number of fatalities and greater dismemberment among employees than with community residents underlines the occupational dangers in the mining industry and clarifies the dynamics of the *** the initial weeks after the dam collapsed,friction ridge analysis was the most appropriate method for ***,DNAanalysis became the most-used technique for identification and re-identification owing to the great volume of body parts and decomposed biological ***

关键词： Disasters victim identification tailings mining legal medicine developing countries man-made disasters traumatic amputation

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