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Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers

Acta Pharmacologica Sinica 2005年第4期26卷 447-452页

作者： Márcio Goncalves de SOUSA Juan Carlos YUGAR-TOLEDO marcelo rubira Sílvia Elaine FERREIRA-MELO Rodrigo PLENTZ Deise BARBIERI Fernanda CONSOLIM-COLOMBO Maria Cláudia IRIGOYEN Heitor MORENO Jr Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil

Aim:To compare the acute effects of ascorbic acid on vasodilation of veins andarteries in ***:Twenty-six healthy non-smokers and 23 healthy moder-ate smokers were recruited in this *** dorsal hand vein compliance tech-nique and flow-mediated dilation were ***-response curves to bradykininand sodium nitroprusside were constructed to test the endothelium-dependentand-independent relaxation before and after acute infusion of ascorbic ***:Smokers had an impaired venodilation with bradykinin compared withnon-smokers(68.3%±13.2% vs 93.7%±20.1%,respectively;P<0.05).Ascorbic acidadministration in the dorsal hand vein significantly increased the venodilationwith bradykinin in smokers(68.3%±13.2% vs 89.5%±6.3% before and after infusion,respectively;P<0.05)but not in non-smokers(93.7%±20.1% vs 86.4%±12.4% be-fore and after infusion,respectively).Similarly,the arterial response in smokershad an impaired endothelium-dependent dilation compared with that in non-smok-ers(8.8%±2.7% vs 15.2%±2.3%,respectively;P<0.05)and ascorbic acid restoredthis response in smokers(8.8%±2.7% vs 18.7%±6.5% before and after infusion,respectively;P<0.05),but no difference was seen in non-smokers(15.2%±2.3% vs14.0%±4.4% before and after infusion,respectively).The endothelium-indepen-dent dilation did not differ in both the groups *** important hemody-namic change was detected using the Portapress ***:Smokershad impaired endothelium-dependent vasodilation responsiveness in both arte-rial and venous *** acid restores this responsiveness in smokers.

关键词： ascorbic acid vasodilation vascular endothelium arterioles venules dorsal hand vein flow-mediated dilation

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