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Analysis of single nucleotide polymorphisms in the region of ClDN2-MORC4 in relation to inflammatory bowel disease

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World Journal of Gastroenterology 2013年第30期19卷 4935-4943页

作者： Jan Sderman Elisabeth Norén Malin Christiansson Hanna Bragde Raphaele Thiébaut Jean-Pierre Hugot Curt Tysk Colm A O'Morain Miquel Gassull Yigael Finkel Jean-Frédéric Colombel marc lémann Sven Almer Division of Medical Diagnostics Ryhov County Hospital55185 JnkpingSweden Department of Clinical and Experimental Medicine Linkping University58183 LinkpingSweden INSERM U843Université Paris DiderotHpital Robert Debré75019 ParisFrance Université ParisDiderot Sorbonne Paris-Cité UMR84375018 ParisFrance Assistance Publique-Hopitaux de Paris Hopital Robert Debré75019 ParisFrance Division of Gastroenterology Department of MedicineUniversity HospitalSchool of Health and Medical Sciencesrebro University70185 rebroSweden School of Health and Medical Sciences rebro University70185 rebroSweden Department of Gastroenterology Adelaide and Meath HospitalTallaghtDublin 24Ireland Trinity College Dublin College GreenDublin 2Ireland Health Sciences Research Institute Germans Trias i Pujol08916 BadalonaSpain Department of Gastroenterology Sachs' Children's HospitalSdersjukhuset11861 StockholmSweden EPIMAD group Registre EPIMADService d'Epidémiologie et de Santé PubliqueHpital CalmetteCentre Hospitalier Universitaire de Lille59037 LilleFrance Icahn School of Medicine at Mount Sinai New YorkNY 10029United States GETAID group Groupe d'Etude Thérapeutiques des Affections Inflammatoires DigestivesService de gastroentérologieHpital Saint Louis75010 ParisFrance Department of Gastroenterology UHl County Council of stergtland58185 Link pingSweden Division of Gastroenterology Karolinska InstitutetDepartment of Gastroenterology and HepatologyKarolinska university hospital14186 StockholmSweden

AIM:To investigate a possible genetic influence of claudin(ClDN)1,ClDN2 and ClDN4 in the etiology of inflammatory bowel ***:Allelic association between genetic regions of ClDN1,ClDN2 or ClDN4 and patients with inflammatory bowel disease,Crohn's disease(CD)or ulcerative colitis were investigated using both a casecontrol study approach(one case randomly selected from each of 191 Swedish inflammatory bowel disease families and 333 controls)and a family-based study(463 non-Swedish European inflammatory bowel disease-families).A nonsynonymous coding single nucleotide polymorphism in MORC4,located on the same linkage block as ClDN2,was investigated for association,as were two novel ClDN2 single nucleotide polymorphism markers,identified by ***:A single nucleotide polymorphism marker(rs12014762)located in the genetic region of ClDN2 was significantly associated to CD(case-control allelic OR = 1.98,95%CI:1.17-3.35,P = 0.007).MORC4 was present on the same linkage block as this CD *** the case-control approach,a significant association(case control allelic OR = 1.61,95%CI:1.08-2.41,P = 0.018)was found between CD and a nonsynonymous coding single nucleotide polymorphism(rs6622126)in *** association between the ClDN2 marker and CD was not replicated in the familybased *** colitis was not associated to any of the single nucleotide polymorphism ***:These findings suggest that a variant of the ClDN2-MORC4 region predisposes to CD in a Swedish population.

关键词： Crohn’s disease Genetic predisposition Inflammatory bowel disease Single nucleotide polymorphism Tight junctions

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton lisa J Woodhouse Craig S Anderson Sandeep Ankolekar lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey l Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS AlREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Expression of miR‑138 in cryopreserved bovine sperm is related to their fertility potential

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2383-2394页

作者： Albert Salas‑Huetos Jordi Ribas‑Maynou Yentel Mateo‑Otero Carolina Tamargo marc llavanera marc Yeste Unit of Cell Biology Department of BiologyFaculty of SciencesUniversity of GironaGirona 17003Spain. Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaGirona 17003Spain. Department of Nutrition Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA. Consorcio CIBER M.P.Fisiopatologia de la Obesidad y Nutricion(CIBERobn)Instituto de Salud Carlos III(ISCIII)Madrid 28029Spain. Present Address:Unit of Preventive Medicine and Public Health Faculty of Medicine and Health SciencesUniversitat Rovira i VirgiliReus 43201Spain. Department of Animal Selection and Reproduction The Regional Agri-Food Research and Development Service of Asturias(SERIDA)Gijon 33394Spain. Catalan Institution for Research and Advanced Studies(ICREA) Barcelona 08010Spain.

Background MicroRNAs(miRNAs)are small,single-stranded,non-coding RNA molecules of 22–24 nucleotides that regulate gene *** the last decade,miRNAs have been described in sperm of several mammals,including *** is known that miRNAs can act as key gene regulators of early embryogenesis in mice and humans;however,little is known about the content,expression,and function of sperm-borne miRNAs in early bovine *** this study,total sperm RNA was isolated from 29 cryopreserved sperm samples(each coming from a separate bull)using a RNeasy kit and treatment with DNase *** concentration and purity were determined through an Epoch spectrophotometer and an Agilent *** expression of 10 candidate miRNAs in bovine sperm(bta-miR-10a,bta-miR-10b,bta-miR-138,bta-miR-146b,bta-miR-19b,bta-miR-26a,bta-miR-34a,bta-miR-449a,bta-miR-495 and btamiR-7),previously identified in testis and/or epididymis,was evaluated with *** cel-miR-39-3p was used as a spike-in exogenous *** mann–Whitney tests were run to evaluate which miRNAs were differentially expressed between bulls with high fertility[HF;non-return rates(NRR)ranging from 39.5 to 43.5]and those with subfertility(SF;NRR ranging from 33.3 to 39.3).Several sperm functionality parameters(e.g.,viability,membrane stability or oxygen consumption,among others)were measured by multiplexing flow cytometry and oxygen sensing *** RNA concentration and purity(260/280 nm ratio)(mean±SD)from the 29 samples were 99.3±84.6 ng/μl and 1.97±0.72,*** results confirmed the lack of RNA from somatic *** terms of the presence or absence of miRNAs,and after applying the livak method,8 out of 10 miRNAs(bta-miR-10b,-138,-146b,-19b,-26a,-449a,-495,-7)were consistently detected in bovine sperm,whereas the other two(bta-miR-10a,and-34a)were ***,the relative expression of one miRNA(bta-miR-138)in sperm was significantly lower in the SF than in the HF gr

关键词： Bovine Fertility miRNAs Sperm

学历与一生的收入:德国最新的有关调查统计(上)

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应用型高等教育研究 2017年第4期2卷 83-88页

作者： marc Piopiunik Franziska Kugler ludger Wβmann 陈颖 ifo研究所教育经济学中心德国慕尼黑81679 路德维希-马克西米利安-慕尼黑大学德国慕尼黑80539 奥斯纳布吕克应用科学大学

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的居民年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,对不同受教育程度... 详细信息

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的居民年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,对不同受教育程度人群进行分类并计算他们之间终生收入的差异。研究结果表明,在整个职业生涯中,每一个较高的学历都会带来多出22%到64%的收入。但是,地域、性别,特别是职业培训和大学教育的不同专业也是影响收入差距的重要因素,例如医学和社会工作之间的差异就很大。

关键词：教育教育收益职业教育高等教育

学历与一生的收入德国最新的有关调查统计(下)

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应用型高等教育研究 2018年第1期3卷 57-64页

作者： marc Piopiunik Franziska Kugler ludger Woβmann 陈颖(翻译) ifo研究所教育经济学中心德国慕尼黑81679 路德维希-马克西米利安-慕尼黑大学德国慕尼黑80539 奥斯纳布吕克应用科学大学

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,根据不同受教育程度计... 详细信息

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,根据不同受教育程度计算人们终生收入的差异。我们的研究结果表明,在整个职业生涯中,每一个较高的学历都会带来多出22%到64%的收入。但是,地域、性别、特别是不同专业也是影响收入差距的重要因素,例如医学和社会工作之间的差异就很大。

关键词：教育教育收益职业教育高等教育

Spatio-Temporal Analysis of Climate Change Impact on Future Wind Power Potential in Burundi (East Africa)

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American Journal of Climate Change 2019年第2期8卷 237-262页

作者： Manirakiza Célestin lawin Agnidé Emmanuel lamboni Batablinlè Niyongendako marc Institute of Mathematics and Physical Sciences University of Abomey-Calavi Porto-Novo Benin laboratory of Applied Hydrology National Institute of Water University of Abomey-Calavi Abomey-Calavi Benin

This paper assessed climate change impact on future wind power potential across highlands and western lowlands of Burundi. Hourly observed and MERRA-2 data were considered for the historical period 1980-2016, and a Multi-model ensemble for future projections data of eight selected Regional Climate Models under RCP 4.5 and RCP 8.5 over the periods 2019-2040 and 2071-2100 was used. Variability and trend analysis were adopted using standardized index and mann-Kendall’s test, respectively while wind power density (WPD) in quartiles was adopted for changes distribution. As results, diurnal wind speeds (WS) were higher from 9:00 AM to 2:00 PM, while monthly wind speeds reached the maximum during summer time. An increasing trend in WPD was detected all over the studied area. Over the period 2019-2040, the lowest WPD change is projected at Northern Highlands (NHl) under RCP 4.5 with 28.04 W·m−2 while the highest WPD change of 47.35 W·m−2 is projected under RCP 8.5 at Southern Imbo plain (SIP). As for the period 2071-2100, the highest change is expected at SIP under RCP 8.5 with 152.39 W·m−2 while the minimum change of 83.96 W·m−2 is projected under RCP 4.5 at NHl. The findings showed that areas nearby the lake Tanganyika are expected to have high positive WDP changes.

关键词： Burundi Wind Power Changes Future Climate

Trauma Activation and Substance Use in an Urban Trauma Center

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Surgical Science 2021年第3期12卷 53-66页

作者： Derek Titus Areta Kowal-Vern John Porter marc R. Matthews Philomene Spadafore Sydney Vail College of Osteopathic Medicine of the Pacific-Northwest Lebanon USA Department of Research Valleywise Health Medical Center Phoenix USA Arizona Burn Center Valleywise Health Medical Center Phoenix USA Department of Physical Medicine & Rehabilitation Valleywise Health Medical Center Phoenix USA Department of Surgery Valleywise Health Medical Center Phoenix USA

Background: Alcohol and drug screens in trauma patients are endorsed by the American College of Surgeons Committee on Trauma. The objective was to determine the characteristics and frequency of alcohol and poly-drug combinations in patients triaged by Trauma Team Activation (TTA) codes. Methods: A retrospective study of a level I hospital trauma registry was initiated with 14,972 patients of whom 7028 (47%) were Substance Users (SU). There were 10,369 TTA patients: 5396 (52%) were SU, and 4603 (31%) non-TTA patients, of whom 1632 (35.5%) were SU. Inclusion criteria were: age ≥14 years old, blood alcohol level and Urine Drug Screen (UDS) documentation, Injury Severity Score (ISS), TTA code, hospital charges and length of Hospitalization (lOS). Statistical analyses were performed with one-way ANOVA, Maximum likelihood chi squared, and mann-Whitney U tests. Results: The median ISS was 5 for both groups. TTA patients were younger than non-TTA patients (median 33 years versus 41 years). Mortality was significantly higher for TTA (4.7%) than for non-TTA (0.7%) patients. From 2010-2013 to 2014-2018, all substance users had a significant decrease in alcohol only use (58.0% to 42.0%) with an increase in single drug (42.0% to 58.0%) and poly-drug use (36.9% to 63.1%), p ll SU patients (TTA and non-TTA), the major single drugs used were opiates (19.9%), cannabinoids (THC) (15.2%), benzodiazepines (7.7%), amphetamines (6.6%), and cocaine (2.5%). The major poly-drugs were: opiates/THC (4.7%), opiates/benzodiazepines (4.6%), THC/amphetamines (3.1%), THC/benzodiazepines (2.2%). Conclusions: By trauma activation code designation, the TTA group had most of the positive alcohol and drug screens in this study. Since the change in mandated opioid prescription practices in 2014, this study showed increased poly-drug use (two to six-drug combinations) in urban trauma patients between 2014-2018. Op

关键词： Drugs Alcohol Trauma

卒中医疗体系之急诊医疗服务的实施策略美国心脏协会／美国卒中协会急诊医疗服务体系专家组和卒中委员会的政策声明

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国际脑血管病杂志 2008年第7期16卷 481-498页

作者： Joe E. Acker Ⅲ Arthur M. Pancioli Todd J. Crocco marc K. Eckstein Edward C. Jauch Hollynn larrabee Neil M. Meltzer William C. Mergendahl John W. mann Susanne M. Premiss Charles Sand Jeffrey l. Saver Brian Eigel Brian R. Gilpin Mark Schoeberl Penelope Solis JoAnne R. Bailey Katie B. Horton Steven K. Stranne 曹勇军(译) 李瑞霞(译) 刘建芳(译) 刘春风(译) 不详苏州大学附属第二医院神经内科 215004

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，突出显示了急诊医... 详细信息

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，突出显示了急诊医疗服务（emergency medical services，EMS）机构和急诊医疗服务体系（emergency medical services systems，EMSS）在优化卒中医疗中的关键作用。

关键词：急诊医疗服务体系美国心脏协会卒中协会医疗体系委员会专家组死亡原因急性卒中