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World Journal of Gastrointestinal Endoscopy 2017年第6期9卷 255-262页

作者： jose mar.a Huguet Patricia Suárez Luis Ferrer-Barceló Lucía Ruiz Ana Monzó Ana Belén Durá Javier Sempere Digestive Disease Department General University Hospital of Valencia46014 ValenciaSpain

Screening for colorectal cancer(CRC) in patients with inflammatory bowel disease(IBD) is recommended by all scientific societies. However, there are differences in the recommendations they make regarding screening and surveillance. We address a series of questions that come up in the daily clinical practice of a physician. The first two questions that are raised are:(1) Who should be offered screening for CRC? and(2) When should the first colonoscopy be performed? The next step is to decide who should undergo endoscopic surveillance and at what intervals they should be performed. Chromoendoscopy is emerging as the recommended endoscopic technique for screening and surveillance. The terminology for describing lesions detected with endoscopy is also changing. The management of visible lesions or non-visible dysplasia is also a motive for the review. We end the review by addressing the followup for endoscopically resected lesions. These questions often cannot be answered easily due to the varying degrees of evidence available; therefore, we have made some general recommendations based on those made by the various guidelines and consensuses. The first screening colonoscopy should be offered 8 years after a IBD diagnosis and we recommend that patients be stratified according to the individual risk for each for endoscopic surveillance intervals.

关键词： Colitis surveillance Colitis screening Chromoendoscopy Colorectal cancer Inflammatory bowel disease

Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés martínez Cáceres jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues jose M Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

Intervention for reducing stigma: Assessing the influence of gender and knowledge

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World Journal of Psychiatry 2013年第2期3卷 18-24页

作者： Francisco martínez-Zambrano Esther García-Morales mar García-Franco jose Miguel Raul Villellas Gemma Pascual Otilia Arenas Susana Ochoa Psychosocial Rehabilitation Ser-vice El Prat Parc Sanitari Sant Joan de DéuEl Prat de Llobregat08918 BarcelonaSpain Mental Health Center El Prat Parc Sanitari Sant Joan de Déu08918 BarcelonaSpain Psychosocial Rehabilitation Services of Baix Llo-bregat Parc Sanitari Sant Joan de Déu08918 BarcelonaSpain Research and Development Unit Parc Sanitari Sant Joan de Déu08918 BarcelonaSpain

AIM: To evaluate the effectiveness in reducing social stigma of an intervention and to assess the influence of gender and ***: The program consisted in providing information and contact with users of mental health in order to reduce social stigma in the school environment. A total of 62 secondary school students(age 14-16 years) were evaluated with the Opinions on Mental Illness(OMI) questionnaire before and after the intervention. The subscales of the OMI were: authoritarianism, interpersonal etiology, benevolence, restrictiveness and negativism. The analysis was performed over the total sample, separating by gender and knowledge of someone with a mental disorder. t-test for repeated measures was used in the statistical ***: All the OMI subscales showed a significant change after the intervention(P < 0.001), except for benevolence. Women presented significant changes in the subscales of authoritarianism and restrictiveness, while men presented changes in negativism and interpersonal etiology rather than restrictiveness(P < 0.001-0.003). Students that knew someone with a mental disorder presented significant changes in authoritarianism, interpersonal etiology, and negativism(P < 0.001-0.003) and students that do not know anyone with a mental disorder improved in restrictiveness and authoritarianism(P < 0.001-0.001). In all the subscales of the instrument the students improved their perception of mental disorders, reducing their levels of ***: The intervention designed to reduce social stigma was effective, especially in the area of authoritarianism. The whole sample showed improved attitudes towards mental illness, although the areas were different depending on gender and knowledge.

关键词： Mental disorders Stigma Intervention Contact Information Schizophrenia Schools

Experimental study on lightweight expanded clay at particle level:Breakage of isolated grains

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1846-1858页

作者： Elías Roces-Alonso jose Estaire Miriam martín-Ruiz Jesús González-Galindo ETS de Ingenieros de Caminos Universidad Politécnica de MadridSpain Laboratorio de Geotecnia CEDEXMadridSpain

In this study,more than 1500 particles of lightweight expanded clay aggregate(LECA)are individually loaded up to breakage,following different patterns of contact(from 2 to 7)using a purpose-built ***,a statistical model for predicting the number of fragments into which a grain breaks as a function of the number of contacts and their diameter is *** number of fragments is found to follow a statistical binomial-type distribution function that depends on the number of *** addition,a model based on Bayesian networks,capable of assessing the number of fragments and their size(measured as normalized weight)as a function of the number of contacts,is *** proposed method is applicable when performing discrete element method(DEM)simulations on granular media in which grain breakage plays a relevant role.

关键词： Lightweight expanded clay aggregate(LECA) Grain fragmentation Grain breakage Biaxial grain load

Dynamics of the ruminal microbial ecosystem, and inhibition of methanogenesis and propiogenesis in response to nitrate feeding to Holstein calves

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Animal Nutrition 2021年第4期7卷 1205-1218页

作者： Abimael Ortiz-Chura jose Gere Gisela marcoppido Gustavo Depetris Silvio Cravero Claudia Faverin Cesar Pinares-Patino Angel Cataldi d mar.a E.Ceron-Cucchi Institute of Pathobiology CICVyA National Institute of Agricultural TechnologyIPVetUEDD INTA-CONICETHurlinghamC1686Argentina Engineering Research and Development Division National Technological University(UTN)National Scientific and Technical Research Council(CONICET)Buenos AiresC1179Argentina Agricultural Experimental Station of Balcarce National Institute of Agricultural Technology(INTA)BalcarceB7620Argentina Institute of Agrobiotechnology and Molecular Biology IABIMONational Institute of Agricultural Technology(INTA)National Scientific and Technical Research Council(CONICET)HurlinghamC1686Argentina The Agribusiness Group Lincoln UniversityPO Box 85016Lincoln7674New Zealand

It is known that nitrate inhibits ruminal methanogenesis,mainly through competition with hydrogenotrophic methanogens for available hydrogen(H2)and also through toxic effects on the ***,there is limited knowledge about its effects on the others members of ruminal microbiota and their *** this study,we investigated the effects of dietary nitrate inclusion on enteric methane(CH4)emission,temporal changes in ruminal microbiota,and fermentation in Holstein *** animals were maintained in individual pens for 45 *** were randomly allocated to either a control(CTR)or nitrate(NIT,containing 15 g of calcium nitrate/kg dry matter)*** emissions were estimated using the sulfur hexafluoride(SF6)tracer *** microbiota changes and ruminal fermentation were evaluated at 0,4,and 8 h *** this study,feed dry matter intake(DMI)did not differ between dietary treatments(P>0.05).Diets containing NIT reduced CH4 emissions by 27%(g/d)and yield by 21%(g/kg DMI)compared to the CTR(P0.05)but differed with time,and post-feeding(P<0.05).Increases in the concentrations of ruminal ammonia nitrogen(NH3-N)and acetate were observed,whereas propionate decreased at 4 h post-feeding with the NIT diet(P<0.05).Feeding the NIT diet reduced the populations of total bacteria,total methanogens,Ruminococcus albus and Ruminococcus flavefaciens,and the abundance of Succiniclasticum,Coprococcus,Treponema,Shuttlewortia,Succinivibrio,Sharpea,Pseudobutyrivibrio,and Selenomona(P<0.05);whereas,the population of total fungi,protozoa,Fibrobacter succinogenes,Atopobium and Erysipelotrichaceae L7 AE11 increased(P<0.05).In conclusion,feeding nitrate reduces enteric CH4 emissions and the methanogens population,whereas it decreases the propionate concentration and the abundance of bacteria involved in the succinate and acrylate pathways.D

关键词： Methane emission Nitrate Microbiota Ruminal fermentation

A Comparative Study on Efficacy of Fludrocortisones versus Glucocorticoids and Vasodilators in the Treatment of Idiopathic Sensorineural Cochlear Hearing Loss

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 115-123页

作者： Daniel López-Campos Daniel López-Aguado Eugenia M.Campos-Banales jose Luis de Serdio-Arias mar García-Sáinz ENT Service University Hospital of the Canary IslandsTenerifeSpain Department of Otorhinolaryngology La Laguna UniversityTenerifeSpain ENT Service University Hospital Nuestra Senora de CandelariaTenerifeSpain Pharmacology and Pharmacotherapy Service University Hospital of the Canary IslandsTenerifeSpain

Introduction and Objectives: The idiopathic sensorineural cochlear hearing loss is one of the most frequent human sensory deficits and there is no specific drug therapy for it. The possible hearing recovery is related with the reestablishment of normal ionic homeostasis of the endolymph controlled by the mineralocorticoid as could be demonstrate experimentally. The purpose of this clinical trial was to confirm the efficacy of mineralocorticoids to the recovery of hearing level in patients suffering idiopathic sensorineural hearing loss (SNHL) against the glucocorticoids and vasodilator drugs. Material and Methods: The research lasted three months and involved 90 patients allocated into four different groups: Placebo group, consisted of 20 patients (10 men and 10 women);the group consisting of 22 patients treated with glucocorticoid therapy (12 men and 10 female);the group treated with mineralocorticoid therapy encompassed 26 patients (13 males and 13 females) and the group of vasodilators formed by 22 patients (12 men and 10 women). The level of hearing loss was estimated by the tests Liminal Tone Audiometry (LTA) and Auditory Brainstem Response (ABR). Results: The main features in this research were overall better response in improving the hearing level with the mineralocorticoid therapy. This improvement in hearing levels was greater in women than in men, and a higher response was found in the left ear regardless of patient’s gender. Conclusions: The hearing gain was significantly superior in the mineralocorticoids group followed by the glucocorticoids group whereas the response to vasodilators was lesser and with no statistical significance.

关键词： Idiopathic Sensorineural Cochlear Hearing Loss(ISNCHL) Liminal Tonal Audiometry(LTA) Auditory Brainstem Response(ABR)

Four Cases of X-Linked Hypophosphatemic Rickets, Clinical Description and Genetic Testing

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Open Journal of Genetics 2014年第1期4卷 40-45页

作者： David Vila-Pérez Sílvia marín-del-Barrio Jordi Vila-Cots jose Antonio Camacho-Díaz marcos Morey Lourdes Loidi Department of Endocrinology Hospital Sant Joan de Déu Barcelona Spain Department of genomics Fundación Pública Galega de Medicina Xenómica Santiago de Compostela Spain Department of Nephrology Hospital Sant Joan de Déu Barcelona Spain

One of the major causes of congenital hypophosphatemic rickets is the X-linked hypophosphatemic rickets (XHR), due to a defect on PHEX gene. The XHR increases the renal elimination of phosphate, that condition leads a defective mineralization of bones and also affects the growth in children. Clinical diagnosis should be suspected in children with signs of rickets and hypophosphatemia with normal calcium levels. We describe clinical characteristics and genetic results of four patients diagnosed and treated in our Nephrology Section. All patients have a “de novo” XHR as none familiars are affected. Early diagnosis should be suspected before the bone deformities have been submitted and the growth would have been impaired.

关键词： Rickets X-Linked Hypophosphatemic Rickets XHR PHEX Gene

Mercury in Canned Tuna in *** Light Tuna Really Light?

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Food and Nutrition Sciences 2013年第7期4卷 48-54页

作者： Montserrat González-Estecha mar.a Josémartínez-García Manuel Fuentes-Ferrer Andrés Bodas-Pinedo Alfonso Calle-Pascual Josémar.a Ordóñez-Iriarte Cristina Fernández-Pérez Nieves martell-Claros MiguelÁngel Rubio-Herrera Emilia Gómez-Hoyos JoséJesús Guillén-Pérez Trace Element Unit and Laboratory Medicine Department Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Universidad Politécnica CartagenaSpain Universidad Camilo jose Cela MadridSpain Department of Epidemiology Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Department of Pediatrics Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Department of Endocrinology Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Consejería de Sanidad y Consumo MadridSpain Hypertension Unit Instituto de Investi-gación SanitariaHospital Clínico San CarlosMadridSpain Publich Health Department CartagenaSpain Universidad de Murcia MurciaSpain

In Spain, certain population-based studies have shown high blood mercury (Hg) levels due to the high consumption of fish. Some studies have stated that one of the most consumed fish in Spain is canned tuna. Different Spanish organisms consider that it is safe to consume canned tuna as it supposedly has a low mercury content, particularly in so-called light tuna. However, in Spain light tuna is mainly yellowfin and bigeye tuna, while in other countries it is mainly skipjack tuna. This study analyzed 36 cans of the most popular brands in Spain and examined the influence of the type of tuna, packaging medium (olive oil, sunflower seed oil, water or marinade), different brands, prices and expiration dates. Mercury concentrations (mg/kg) were measured by atomic absorption spectrometry and thermal decomposition amalgamation. The medians observed were (mg/kg): light tuna: 0.314;IQR: 0.205 - 0.594, white tuna: 0.338;IQR: 0.276 - 0.558, skipjack: 0.311;IQR: 0.299 - 0.322, frigate tuna: 0.219;IQR 0.182 - 0.257 and mackerel: 0.042;IQR 0.029 -?0.074. We found statistically significant differences between white tuna, light tuna and mackerel (p = 0.004);light tuna and mackerel (p = 0.002) and white tuna and mackerel (p = 0.006). However, we found no differences between white tuna and light tuna, or among packaging medium, brands, prices or expiration dates. The limit of 0.500 mg/kg of mercury in canned tuna was exceeded by the following percentages of the cans: 33.3% of light tuna, 16.7% of white tuna, and 0% of Skipjack, frigate tuna and mackerel. The mercury content of the cans of Spanish light tuna that were analyzed was variable and high. The results of this study indicate that stricter regulation of Hg in canned tuna is necessary. Until then, it is safer to recommend that vulnerable populations such as children and pregnant women consume canned mackerel, which has a markedly lower mercury content.

关键词： Mercury Canned Tuna Spain

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas mar.a A.Garcia-Lopez jose M.Olano Gabriel Sanguesa-Barreda Miguel Garcia-Hidalgo Susana Gomez-Gonzalez Roberto Lopez-Rubio jose M.Fernandez-Palacios Ignacio Garcia-Gonzalez Laura Lozano-Lopez Paula Garcia-Gonzalez Ana I.Garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

Thedual pathogenesisofpenileneoplasia: The heterogeneous morphology of human papillomavirus-relatedtumors

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Asian Journal of Urology 2022年第4期9卷 349-358页

作者： Alcides Chaux Diego F.Sanchez mar.a jose Fernandez-Nestosa Sofia Canete-Portillo Ingrid M.Rodriguez Giovanna A.Giannico Antonio L.Cubilla Department of Scientific Research School of Postgraduate Studies Norte UniversityAsuncionParaguay InstitutodePatologiae Investigacion AsuncionParaguay Polytechnic School National University of AsuncionSan LorenzoParaguay Department of Pathology University of Alabama at BirminghamBirminghamALUSA School of Medicine National University of AsuncionSan LorenzoParaguay Department of Pathology Microbiologyand ImmunologyVanderbilt University Medical CenterNashvilleTNUSA

Objective:Penile neoplasia,usually of squamous histogenesis,is currently classfied into human papillomavirus(HPV)-related or-dependent and non-HPV-related or-indepen *** are distinct morphological differences among the two *** research studies on penile cancer from Northern countries showed that the presence of HPV is corre lated with a better prognosis than virus negative people,while studies in Southern countries had not confirmed,perhaps due to differences in staging or ***:We focused on the description of the *** carcinomas of the *** approach was to describe common clinical features followed by the pathological features of each entity or subtype stressing the characteristics for differential diagnosis,HPV genotypes,and prognostic features of the invasive *** structure was followed for penile intraepithelial neoplasia,except for prognosis because of the scant evidence ***:Most of HPV-related lesions can be straightforwardly recognized by routine hematoxylin and eosin stains,but in some cases surrogate p16 immunohistochemical staining or molecular methods such as in situ hybridization or polymerase chain reaction can be ***,there are eight tumor invasive variants associated with HPV,as follows:basaloid,warty,warty-basaloid,papillary basaloid,clear cell,medullary,lymphoepithelioma-like,and giant condylomas with malignant ***:This review presents and describes the heterogeneous clinical,morphological,and genatypic features of the HPV-related subtypes of invasive and non-invasive penile neoplasia.

关键词： Penile neoplasia Squamous cell carcinoma Human papillomavirus Carcinoma in situ Penile intraepithelial neoplasia