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Primary malignant melanoma of the biliary tract: A case report and literature review

World Journal of Clinical Cases 2019年第16期7卷 2302-2308页

作者： soledad Cameselle-garcía José Luis Fírvida Pérez mar.a C Areses Jesús Daniel fernández de Castro Juan Mosquera-Reboredo Jesús garcía-Mata Department of Medical Oncology Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Digestive Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Pathology Hospital San RafaelA Coruna 15009Spain

BACKGROUND Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another *** paper reviews the most important characteristics of MBT cases published in the literature and reports a new *** patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with *** patient remains disease-free 36 mo after the treatment of metastatic lung *** SUMmarY A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical *** resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic *** the suspicion of biliary tract neoplasia,cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of ***-pathological diagnosis was *** intervention,the patient was referred to the Department of Medical Oncology,where a primary origin was excluded in the skin,mucosa,and *** confirmed diagnosis of primary biliary tract *** tomography was performed 12 mo after the procedure revealed several subcentimetric lung *** resection was *** confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract,the patient was started on immunotherapy with *** to treatment was *** patient remains disease-free 36 mo after the treatment of metastatic lung *** The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy.

关键词： Biliary tract Case report Immunotherapy Malignant melanoma

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Enhanced depth OCT imaging of the lamina cribrosa for 24 hours

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 306-309页

作者： Pedro Naranjo Bonilla Rafael Giménez Gómez David Ríos Jiménez mar.a Luísa Varas Fabra mar.a del Carmen Munoz Villanueva Rocío garcía Catalán Pilar Font Ugalde mar.a soledad Poblador fernández JoséLuís Lancho Alonso Josémar.a Gallardo Galera Department of Ophthalmology Reina Sofia University HospitalCordoba 14004Spain Methodological Support to Research Maimonides Institute for Biomedical ResearchReina Sofia University HospitalCordoba 14004Spain Department of Medicine UCO Maimonides Institute for Biomedical ResearchReina Sofia University HospitalCordoba 14004Spain Department of Morphological Sciences Faculty of MedicineCordoba 14004Spain

The lamina cribrosa thickness（LCT） could be affected by dynamic changes in its *** spectral-domainoptical coherence tomography（SD-OCT）,we have studied the behaviour of the laminar region in 14 young subjects over 24 *** changes in LCT were observed,depending on the time at which the measurement was taken,with the maximum thickness being observed at 7.30 p.m.,and the minimum at 7.30 *** finding could suggests a circadian pattern in the LCT thickness in healthy subjects,which could have implications for the classification,diagnosis and prognosis of both normal and glaucomatous subjects.

关键词： lamina cribrosa laminar region glaucoma optical coherence tomography twenty-four-hours

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Bacterial and archaeal communities in saline soils from a Los Negritos geothermal area in Mexico

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Pedosphere 2023年第2期33卷 312-320页

作者： Joseph GUEVARA-LUNA mario HERNÁndez-GUZMÁN Nina MONTOYA-CIRIACO Luc DENDOOVEN marina Olivia FRANCO-HERNÁndez Paulina ESTRADA-DE LOS SANTOS mar.a soledad VÁSQUEZ-MURRIETA Escuela Nacional de Ciencias Biológicas Instituto Politécnico NacionalCiudad de México 11340(Mexico) Laboratory of Soil Ecology CinvestavMexico City 07360(Mexico) Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de Tlaxcala.Carretera Federal Tlaxcala-Puebla km.1.5Tlaxcala 90070(Mexico) Unidad Profesional Interdisciplinaria de Biotecnología Instituto Politécnico NacionalCiudad de México 07340(Mexico)

In recent years,there has been a growing need to understand how salinity affects microbial communities in agricultural *** and bacterial community diversities and structures were investigated by high-throughput sequencing analysis of their 16S rRNA in two arable soils with low electrical conductivity(EC)(2.3 and 2.6 dS m^(-1))and a saline soil(EC=17.6 dS m^(-1)).The dominant bacterial phyla in the soils were Proteobacteria(relative abundance(RA)=46.2%),followed by Acidobacteria(RA=13.1%)and Actinobacteria(RA=10.0%),whereas Serratia(RA=6.0%)and Bacillus(RA=4.0%)were the dominant bacterial *** Nitrososphaera(53.5%)was the dominant archaeal phylotype in the arable soils,whereas Nitrosopumilus(RA=0.4%)dominated in the saline *** archaeal and bacterial community structures were different between the soils and significantly correlated with soil sand,arsenic,barium,and antimony contents,but not with soil salinity.

关键词： agricultural soil compositional approach microbial community mud volcano soil salinity soluble anion

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Administration of selected probiotic mixture improves body weight gain and meat fatty acid composition of creole goats

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Food Bioscience 2022年第5期49卷 188-195页

作者： Natalia Taboada mar.a fern´andez Salom Alicia C´ordoba Silvia N.Gonz´alez soledad L´opez Alzogaray Carina Van Nieuwenhove Instituto de Ciencia y Tecnología de los Alimentos Facultad de Agronomía y AgroindustriasUniversidad Nacional de Santiago del EsteroAv.Belgrano 1912(S)CP 4200Santiago del EsteroArgentina Instituto Multidisciplinario de Salud Tecnología y Desarrollo IMSaTeD(UNSE-CONICET)Ruta Nacional N◦9 km 1125 S/NVilla El Zanj´onCP4206Santiago del EsteroArgentina Instituto Nacional de Tecnología Agropecuaria Campo Experimental Francisco CantosRuta Nacional 9 km.11084206La AbritaSantiago del EsteroArgentina Instituto de Biotecnología Farmaceútica y Alimentaria(INBIOFAL-CONICET) Av.Kirchner 1900CP 4000Tucum´anArgentina Centro de Referencia para Lactobacilos(CERELA-CONICET) Laboratorio de Ecofisiología Tecnol´ogicaChacabuco 1454000Tucum´anArgentina f Facultad de Ciencias Naturales Instituto Miguel Lillo Universidad Nacional de Tucum´anMiguel Lillo 2054000Tucum´anArgentina

This work aimed to determine the effect of native probiotic administration on body weight gain, nutritional characteristics and fatty acid profile of meat of creole goats. Equally distributed forty postweaned goats (75 days old) divided into control (n=20) and probiotic (n=20) groups were fed ad libitum for 60 days with native pasture and commercial diet. Lactobacillus reuteri DDL19, Lactobacillus alimentarius DDL48, Enterococcus faecium DDE39, and Bifidobacterium bifidum DDBA mixed culture (108 CFU/ml, 1:1:1:1 ratio) were daily orally delivered to the probiotic group. At the end of the study, muscle samples (Longissimus dorsi, LD, and Bicep femoris, BF) were analyzed for their chemical composition (protein, fat, moisture, pH, water-holding capacity, cholesterol) and fatty acid profile. Probiotic supplementation significantly increased body weight gain, reduced the incidence of diarrhea and improved the fatty acid profile of goat meat. Probiotic-fed animals exhibited increased monounsaturated and polyunsaturated fatty acids and a significant decrease in saturated fatty acid content. Conjugated linoleic acid content was significantly higher in probiotics than in the control group (P < 0.05). Muscles from probiotics-treated goats showed healthier lipid indexes and a significant decrease in the n-6/n-3 ratio (~2.50), atherogenic (~0.30) and thrombogenic (~0.75) indexes. In addition, increases in desirable fatty acids (~79.40 g/100 g of FAME) and nutritional value index (~2.86) were observed compared to control groups. The native mix probiotic could be used as growth promoters to reduce the antibiotics, and to improve its derived-foods.

关键词： Probiotic Creole goat Goat meat Fatty acid profile Health lipid index

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The reaction electronic flux in chemical reactions

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Science China Chemistry 2011年第12期54卷 1982-1988页

作者： CERON mar.a Luisa ECHEGARAY Eleonora GUTIRREZ-OLIVA soledad HERRERA Barbara TORO-LABB Alejandro Laboratorio de Química Teorica Computacional(QTC) Facultad de Química Pontificia Universidad Catolica de Chile

The mechanism of a chemical reaction can be characterized in terms of chemical events that take place during the *** events are bond weakening/breaking and/or bond strengthening/*** reaction electronic flux(REF),a concept that identifies and rationalizes the electronic activity taking place along the reaction coordinate,has emerged recently as a powerful tool for characterizing the mechanism of chemical reactions.A quantitative theory introducing new descriptors for characterizing reaction mechanisms is presented in detail and three illustrative examples are *** nucleophilic substitution reactions the REF indicates that bond breaking or forming events may be leading the electronic activity whereas in the methanol decomposition reaction by copper oxide,the REF allows to discover that consecutive electronic reductions of copper together with bond breaking processes control the course of the reaction.

关键词： reaction mechanisms chemical potential conceptual DFT reaction electronic flux (REF)

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Alternatives of Small-Scale Biorefineries for the Integrated Production of Xylitol from Sugarcane Bagasse

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Journal of Renewable Materials 2018年第2期6卷 139-151页

作者： Nicolás M.Clauser soledad Gutiérrez mar.a C.Area fernando E.Felissia mar.a E.Vallejos Materials Institute of Misiones(IMAM) National University of Misiones–National Council of Scientific and Technical Research(UNaM–CONICET)1552 Félix de Azara St.(3300)PosadasMisionesArgentina Faculty of Engineering University of the Republic(UDeLaR)565 Julio Herrera y Reissig St.(11700)MontevideoUruguay

Small-scale biorefinery from sugarcane bagasse offers new possibilities to the sugar and ethanol *** aim of this study was to evaluate the feasibility of a small-scale biorefinery for the production of xylitol from sugarcane *** liquid fraction from the autohydrolysis treatment was selected as the source of sugars for xylitol and two scenarios were analyzed for the residual solid:ethanol or pellet production.A technical-economic analysis of alternatives was *** internal rate of return(IRR)was used to compare the selected *** highest IRR values were obtained when processing 70,000 dry tons per year of *** results showed promising prospects for a small-scale biorefinery with capacities above 20,000 dry tons per year(xylitol and pellets),and above 50,000 dry tons per year(xylitol and ethanol).

关键词： Biorefinery sugarcane bagasse xylitol ethanol pellets

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Solanum lycopersicum: Novelties for Climate Factors and Its Agronomic Management for High Yields

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World Journal of Engineering and Technology 2022年第3期10卷 605-612页

作者： Víctor garcía-Gaytán soledad garcía-Morales Ana V. Coria-Téllez Fanny Hernández-Mendoza Janet mar.a León-Morales El Colegio de Michoacán La Piedad México Profesor Investigador Mejoramiento Integral de Plantas a Través de la Genética y Nutrición Vegetal La Piedad México (CONACYT) Centro de Investigación y Asistencia en Tecnología y Diseñ o del Estado de Jalisco Zapopan México Coordinación Académica Región Altiplano Oeste Universidad Autónoma de San Luis Potosí San Luis Potosí México

The intensive production of vegetables such as tomatoes depends on various strategies to achieve high *** of this manuscript is to provide scientific and technological strategies for the intensive production of tomato or other vegetables in mega-production factories. However, with the advancement of knowledge, new improvements in the strategies will be incorporated. We have carried out research related to growth and yield variables in S. Lycopersicum. From this research we have worked on the intensive production of this noble vegetable at an industrial level. The results obtained are improvements in the production system. The improvements include the selection of the appropriate variety, germination and development of seedlings in a certified nursery. Trans-plantation in soil or hydroponics. The conditions of nutrient applications from the irrigation head system. The ventilation system and monitoring of climatic factors both day and night (temperature and relative humidity). Monitoring of macro- and micronutrients in the plant system, including Ca, K, Fe, and Zn. Soil fertility analyzes should include: primary and secondary macronutrients (ppm), organic matter (OM), EC, pH, bulk density (BD), and cation exchange capacity (CEC). The nutritional diagnosis to confirm ranges of sufficiency. As a tool in plant nutrition programs, foliar application can include biostimulants and growth regulators. The foregoing can be considered strategies for the integral management of the tomato crop.

关键词： Integrated Management Climate Factors Plant Nutrition Growth Regulators

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Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination

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Pedosphere 2017年第3期27卷 511-526页

作者： Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES mar.a de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNndez Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG mar.a soledad VSQUEZ-MURRIETA Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas Prolongación Carpio y Plan de Ayala s/n Col.Santo Tomás Del.Miguel Hidalgo Ciudad de México

Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria （PGPR） for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting （PGP） traits, including production of siderophores and indol-3-acetic acid （IAA）. Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizoba^teria were also resistant to high levels of heavy metals （including As as a metalloid）（up to 480 mmol L-1 As（V）, 24 mmol L-1 Pb（II）, 21 mmol L-1 Cu（II）, and 4.5 mmol L-1 Zn（II））. Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay. The inoculation of Brassica nigra seeds with Microbacteriurn sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1, and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L-1 Zn（II）. The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals.

关键词： bioinoculants endemic plants mine railings pH phytoremediation salinity

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Emerging bisphenol a replacements(colour developers)in indoor dust from Spain

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Emerging Contaminants 2019年第1期5卷 168-172页

作者： mar.a Jesús Duenas-Mas Ana Ballesteros-Gomez soledad Rubio Department of Analytical Chemistry Institute of Fine Chemistry and NanochemistryMarie Curie Building AnnexCampus of RabanalesUniversity of Cordoba14071CordobaSpain

Bisphenol A(BPA)and replacements,such as bisphenol S(BPS)and F(BPF)and other substitutes(BPSMAE,D-8 and TGSA)have been recently reported in thermal *** this study,BPA,BPS,BPF;BPS-MAE,D-8 and TGSA were analysed in indoor dust collected in Spain from different microenvironments(living rooms,bedrooms,cars and offices).Levels were compared with those reported in our previous study(shops and other public microenvironments,where frequent use of thermal paper is expected).We investigated the differences between microenvironments,possible correlations between compounds and estimated the ingestion ***-MAE,D-8 and TGSA were present at levels up to 529,128 and 356 ng g^-1,respectively,in all the *** highest levels were measured in cars.

关键词： Bisphenol A Bisphenol F Bisphenol S BPS-MAE D-8 TGSA Indoor dust

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Arsenic and chromium resistance mechanisms in the Micrococcus luteus group

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Pedosphere 2023年第4期33卷 600-611页

作者： Ivan ARROYO-HERRERA Brenda ROMÁN-PONCE Rafael BUSTAMANTE-BRITO Joseph GUEVARA-LUNA Erika Yanet TAPIA-garcÍA Violeta LARIOS-SERRATO Nannan ZHANG Paulina ESTRADA-DE LOS SANTOS En Tao WANG mar.a soledad VÁSQUEZ-MURRIETA Escuela Nacional de Ciencias Biológicas Instituto Politécnico NacionalCiudad de México 11340(Mexico) Universidad Politécnica del Estado de Morelos Jiutepec 62550(Mexico) Centro de Ciencias Genómicas Universidad Autónoma de MéxicoCuernavaca 62210(Mexico) CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilisation&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041(China)

High arsenic(As)and chromium(Cr)concentrations are currently receiving attention because of their negative effects on the environment and human *** inhabiting contaminated environments have developed resistance mechanisms against the toxicity of these ***,members of the bacterial genus Micrococcus have been isolated from different toxic metal-contaminated environments;however,knowledge concerning its resistance mechanisms to As and Cr toxicity remains *** luteus strains(An24,Mh,NE2TL6,and NE2TTS4)were isolated from the endosphere and soil of two heavy metal-contaminated sites in Mexico to identify differences in the resistance mechanisms by the *** *** strains were resistant to As(As^(3+)and As^(5+)),chromate,dichromate,cobalt,copper,nickel,and *** analysis indicated that the heavy metal-resistant strains(An24,Mh,NE2TL6,and NE2TTS4)could be assigned to the *** group and had more heavy metal-resistant genes(transporters,chaperones,and enzymes)compared to reference strains of the *** group,*** NCTC 2665^(T)and Micrococcus endophyticus JCM 16951^(T).The resistant bacteria were able to biotransform As^(3+)and As^(5+)through a carbon source-dependent *** biotransformation of As5+was potentially carried out in the cytoplasm through a thioredoxin-dependent pathway,which may be coupled with biosorption.A qualitative analysis of organic acids(OAs)identified a change in the OA profile of the metal-resistant strains that was As-or *** genomic and phenotypic findings suggest that the four *** group strains evaluated in the current study have developed resistance mechanisms that may enable their survival in contaminated sites.

关键词： arsenophore biosorption genome analysis heavy metal-resistant strain immobilization organic acid pollutant

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