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Metabolic dysregulation in term infants from SARS-CoV-2-infected mothers

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World Journal of Pediatrics 2023年第9期19卷 912-917页

作者： mari Merce Cascant-Vilaplana Inmaculada Lara-Cantón Victoria Ramos-garcia Alejandro Pinilla-González Álvaro Solaz-García Guillermo Quintás Purificación marín-Reina marta Aguar Laura Torrejón-Rodríguez Máximo Vento Julia Kuligowski maría Cernada Neonatal Research Unit Health Research Institute Hospital La FeUniversity Polytechnic Hospital La FeAvda.Fernando Abril Martorell 10646026ValenciaSpain Leitat Technological Center ValenciaSpain Analytical Unit Health Research Institute La FeValenciaSpain Division of Neonatology University and Polytechnic Hospital La FeValenciaSpain

Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a novel beta coronavirus that causes coronavirus disease 2019(COVID-19),a severe infectious respiratory *** January 2020,the World Health Organization(WHO)d... 详细信息

关键词： mother respiratory acute

Innovation, Competitiveness and Prosperity： A Factor Analysis of Innovation Indicators in Spain

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Management Studies 2018年第5期6卷 375-383页

作者： Antonio garcia-Sanchez David Siles maria de mar Vazquez-Mendez Technical University of Cartagena Cartagena Spain

Competitiveness is a wide concept applied to many fields, especially in economics. The study of tourism competitiveness has been focused on different factors that can enhance the prosperity of a destination. One of these factors is innovation. Innovation makes destination＇s enterprises more advanced and efficient, therefore more productive. Innovation is an enhancer of competitiveness and a generator of prosperity because innovation in every aspect （technology, knowledge, organization, and processes） will provide a better quality of life for the inhabitants of the destination. The incidence of innovation on these concepts is validated by a structural equation model. We measure innovation by a range of indicators and through a factor analysis; we get the most relevant indicators of innovation for the model developed in Spain.

关键词： competitiveness innovation prosperity tourism factors indicators

Anatomical characterization of central, apical and minimal corneal thickness

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 668-672页

作者： Federico Saenz-Frances martha Cecilia Bermúdez-Vallecilla Lara Borrego-Sanz Luis Jaez J osé marìa martinez-de-la-Casa Laura Morales-Fernandez Enrique Santos-Bueso Julián garcia-Sanchez Julián garcia-Feijoo Department of Ophthalmology Hospital Clínico San CarlosUniversidad Complutense de Madrid Instituto de Tecnologìa del Conocimiento Universidad Complutense de Madrid

·AIM: To anatomically locate the points of minimum corneal thickness and central corneal thickness(pupil center) in relation to the corneal apex.·METHODS: Observational, cross-sectional study, 299 healthy volunteers. Thickness at the corneal apex(AT),minimum corneal thickness(MT) and corneal thickness at the pupil center(PT) were determined using the pentacam. Distances from the corneal apex to MT(MD)and PT(PD) were calculated and their quadrant position(taking the corneal apex as the reference) determined:point of minimum thickness(MC) and point of central thickness(PC) depending on the quadrant position. Two multivariate linear regression models were constructed to examine the influence of age, gender, power of the flattest and steepest corneal axes, position of the flattest axis, corneal volume(determined using the Pentacam)and PT on MD and PD. The effects of these variables on MC and PC were also determined in two multinomial regression models.·RESULTS: MT was located at a mean distance of 0.909 mm from the apex(79.4% in the inferior-temporal quadrant). PT was located at a mean distance of 0.156 mm from the apex. The linear regression model for MD indicated it was significantly influenced by corneal volume(B =-0.024; 95% CI:-0.043 to-0.004). No significant relations were identified in the linear regression model for PD or the multinomial logisticregressions for MC and PC.·CONCLUSION: MT was typically located at the inferiortemporal quadrant of the cornea and its distance to the corneal apex tended to decrease with the increment of corneal volume.

关键词： cornealthickness anatomy glaucoma

A procedure to assess the spatial variability in the importance of abiotic factors affecting distributions： the case of world freshwater fishes

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Current Zoology 2018年第5期64卷 549-557页

作者： Ana M. MANJARRES-hernandez Castor GUISANDE Emilio garcia-ROSELLO Patricia PELAYO-VILLAMIL Jacinto GONZALEZ-DAcOSTA Juirgen HEINE Luis GONZALEZ VILAS Carlos GRANADO-LORENClO Santiago R. DUQUE Jorge M. LOBO alnstituto Amazonico de Investigaciones-IMANI Universidad Nacional de Colombia Leticia A.A. 215 Colombia 910001 Facultad de Ciencias del mar Universidad de Vigo Vigo 36310 Spain Departamento de Informatica Edificio Fundicien Universidad de Vigo Vigo 36310 Spain Grupo de Iciologia Universidad de Antioquia Medellin Colombia 050010 eDepartamento de Biologia Vegetal y Ecologia Facultad de Biologia Universidad de Sevilla Sevilla 41080 Spain Departamento de Biogeografia y Cambio Global Museo Nacional de Ciencias Naturales (CSIC) Calle de Jose Gutierrez Abascal 2 Madrid 28006 Spain

Understanding the factors shaping species＇ distributions is a key longstanding topic in ecology with unresolved issues. The aims were to test whether the relative contribution of abiotic factors that set the geographical range of freshwater fish species may vary spatially and/or may depend on the geographical extent that is being considered. The relative contribution of factors, to discriminate between the conditions prevailing in the area where the species is present and those existing in the considered extent, was estimated with the instability index included in the R pack- age SPEDInstabR. We used 3 different extent sizes： 1） each river basin where the species is present （local）; 2） all river basins where the species is present （regional）; and 3） the whole Earth （global）. We used a data set of 16,543 freshwater fish species with a total of 845,764 geographical records, together with bioclimatic and topographic variables. Factors associated with tempera- ture and altitude show the highest relative contribution to explain the distribution of freshwater fishes at the smaller considered extent. Altitude and a mix of factors associated with temperature and precipitation were more important when using the regional extent. Factors associated with precipitation show the highest contribution when using the global extent. There was also spatial variability in the importance of factors, both between species and within species and from region to region. Factors associated with precipitation show a clear latitudinal trend of decreasing in importance toward the equator.

关键词： anisotropic predictors environmental data selection geographical background non-stationary predictors

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas maria A.garcia-Lopez Jose M.Olano Gabriel Sanguesa-Barreda Miguel garcia-Hidalgo Susana Gomez-Gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio garcia-Gonzalez Laura Lozano-Lopez Paula garcia-Gonzalez Ana I.garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

Effect of caffeine in the intraventricular hemorrhage of the preterm newborn

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Neural Regeneration Research 2023年第9期18卷 1942-1943页

作者： Pilar Alves-martinez Monica garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Biomedical Research and Innovation Institute of Cádiz(INiBICA)Research Unit Puerta del Mar University Hospital University of CadizCadizSpain

There are around 15 million preterm newborns(PT) eve ry year(Atienza-Navarro et al., 2020).With these figures in mind,prematurity represents a major health problem worldwide and it is a leading cause of infant mortality,accounting for up to 35%of all deaths among newborns(Atienza-Navarro et al.,2020) and up to 18% of the deaths among children under 5 years of age.

关键词： newborn infant deaths

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2

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Journal of Molecular Cell Biology 2014年第4期8卷 299-311页

作者： Lucia garcia-Guerra Rocio Vila-Bedmar marta Carrasco-Rando marta Cruces-Sande Mercedes martin Ana Ruiz-Gomez mar Ruiz-Gomez margarita Lorenzo Sonia Fernandez-Veledo Federico Mayor Jr. Cristina Murga Iria Nieto-Vazquez Department of Biochemistry and Molecular Biology II School of Pharmacy Complutense University 28040 Madrid Spain CIBER de Diabetes y Enfermedades Metab61icas Asociadas (CIBERDEM) 08017 Barcelona Spain Instituto de Investigaciones Biomedicas Alberto Sols (CSIC-UAM) 28029 Madrid Spain CIBER de enfermedades neurodegenerativas (CIBERNED) 28049 Madrid Spain Departament of Molecular Biology and Centro de Biologia Molecular Severo Ochoa (CSIC-UAM) 28049 Madrid Spain Instituto de Investigacion Sanitaria la Princesa 28006 Madrid Spain Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) 28049 Madrid Spain Hospital Universitari de Tarragona Joan XXIII. IISPV. Universitat Rovira i Virgili 43007 Tarragona Spain

G protein-coupled receptor kinase 2 （GRK2） is an important serine/threonine-kinase regulating different membrane receptors and intraceUular proteins. Attenuation of Drosophila Gprk2 in embryos or adult flies induced a defective differentiation of somatic muscles, loss of fibers, and a flightless phenotype. In vertebrates, GRK2 hemizygous mice contained less but more hypertrophied skeletal muscle fibers than wild-type littermates. In C2C12 myoblasts, overexpression of a GRK2 kinase-deficient mutant （K220R） caused precocious differentiation of ceUs into immature myotubes, which were wider in size and contained more fused nuclei, while GRK2 overexpression blunted differentiation. Moreover, p38MAPK and Akt pathways were activated at an earlier stage and to a greater extent in K220R-expressing cells or upon kinase downregulation, while the activation of both kinases was impaired in GRK2-overexpressing cells. The impaired differentiation and fewer fusion events promoted by enhanced GRK2 levels were recapitulated by a p38MAPK mutant, which was able to mimic the inhibitory phosphorylation of p38MAPK by GRK2, whereas the blunted differentiation observed in GRK2-expressing clones was rescued in the presence of a constitutively active upstream stimulator of the p38MAPK pathway. These results suggest that balanced GRK2 function is necessary for a timely and complete myogenic process.

关键词： GRK2 p38MAPK Akt skeletal muscle myogenesis

Dynamic Modeling, Testing, and Stability Analysis of an Ornithoptic Blimp

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Journal of Bionic Engineering 2011年第4期8卷 375-386页

作者： John Dietl Thomas Herrmann Gregory Reich Ephrahim garcia Sibley School of Mechanical and Aerospace Engineering Cornell University Ithaca New York USA Air Force Research Laboratory Wright-Patterson AFB OH 45433-7542 USA

In order to study omithopter flight and to improve a dynamic model of flapping propulsion, a series 0f tests are conducted on a flapping-wing blimp. The blimp is designed and constructed from mylar plastic and balsa wood as a test platform for aerodynamics and flight dynamics. The blimp, 2.3 meters long and 420 gram mass, is propelled by its flapping wings. Due to buoyancy the wings have no lift requirement so that the distinction between lift and propulsion can be analyzed in a flight platform at low flight speeds. The blimp is tested using a Vicon motion tracking system and various initial conditions are tested including accelerating flight from standstill, decelerating from an initial speed higher than its steady state, and from its steady-state speed but disturbed in pitch angle. Test results are used to estimate parameters in a coupled quasi-steady aerodynamics/Newtonian flight dynamics model. This model is then analyzed using Floquet theory to determine local dynamic modes and stability. It is concluded that the dynamic model adequately describes the vehicle＇s nonlinear behavior near the steady-state velocity and that the vehicle＇s linearized modes are akin to those of a fixed-wing aircraft.

关键词： omithopter blimp flight dynamics stability analysis

Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients

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World Journal of Hepatology 2020年第11期12卷 1076-1088页

作者： Teresa Broquetas Montserrat garcia-Retortillo Miquel Mico Lidia Canillas marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose hernandez Xavier Bessa JoseA Carrion Department of Gastroenterology Liver SectionHospital del Mar Medical Research InstituteBarcelona 08003Spain Departament of de Medicina Universitat Autònoma de BarcelonaBarcelona 08003Spain Laboratori de Referencia de Catalunya El Prat de LlobregatBarcelona 08820Spain

BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)*** To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs *** Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in *** B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were *** with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were *** and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six *** loss rate was evaluated in both *** events were recorded in both *** kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression *** Sixty-five patients were enrolled,61%receiving tenofovir and 33%***-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA *** matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not ***(22%)patients discontinued Peg-IFN due to adverse *** HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA *** The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to N

关键词： Chronic hepatitis B Hepatitis B e antigen-negative Hepatitis B surface antigen Hepatitis B core-related antigen Pegylated-interferon Nucleos(t)ids analogues©The Author(s)2020.Published by Baishideng Publishing Group Inc.All rights reserved