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Transcriptome and Metabolic Profiling Provides Insigh into Betalain Biosynthesis and Evolution in Mirabilis jalapa

Molecular Plant 2018年第1期11卷 189-204页

作者： Guy Polturak Uwe Heinig Noam Grossman maor battat Dena Leshkowitz Sergey Malitsky liana Rogachev~ and Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of Science 234 Herzl Street Rehovot 7610001 Israel Bioinformatics Unit Life Sciences Core Facilities Weizmann Institute of Science 234 Herzl Street Rehovot 7610001 Israel

Betalains are tyrosine-derived pigments that occur solely in one plant order, the Caryophyllales, where they largely replace the anthocyanins in a mutually exclusive manner. In this study, we conducted multi-species transcriptome and metabolic profiling in Mirabilisjalapa and additional betalain-producing species to identify candidate genes possibly involved in betalain biosynthesis. Among the candidates identified, betalainrelated ytochrome P450 and glucosyltransferase-type genes, which catalyze tyrosine hydroxylation or （hydroxy）cinnamoyl-glucose formation, respectively, were further functionally characterized. We detected the expression of genes in the flavonoid/anthocyanin biosynthetic pathways as well as their metabolite intermediates in betalain-accumulating M. jalapa flowers, and found that the anthocyanin-related gene ANTHOCYANIDIN SYNTHASE （MjANS） is highly expressed in the betalain-accumulating petals. However, it appears that MjANS contains a significant deletion in a region spanning the corresponding enzyme active site. These findings provide novel insights into betalain biosynthesis and a possible explanation for how anthocyanins have been lost in this plant species. Our study also implies a complex, non-uniform history for the loss of anthocyanin production across betalain producers, previously assumed to be strictly due to diminished expression of anthocyanin-related genes.

关键词： betalain anthocyanin caryophyllales plant pigment biosynthesis secondary metabolism

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Effect of the transcutaneous electrical stimulation system on esophageal-acid exposure in patients non-responsive to once-daily proton-pump inhibitor:proof-of-concept study

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Gastroenterology Report 2021年第4期9卷 323-328,I0002页

作者： Ram Dickman Sigal Levy Tsachi Tsadok Perets maor Hazani-Pauker Doron Boltin Hemda Schmilovitz-Weiss Issa Nidal Matan Siterman Dan Carter Ronnie Fass Rachel Gingold-Belfer Department of Gastroenterology Rabin Medical CenterBeilinson CampusesPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Statistics Education Unit Academic College of Tel Aviv-YafoTel Aviv-YafoIsrael Department of Surgery B Rabin Medical CenterHasharon CampusPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Division of Gastroenterology and Hepatology Chaim Sheba Medical CenterRamat Gan and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Division of Gastroenterology and Hepatology Metrohealth Medical CenterClevelandOHUSA

Background:Gastroesophageal reflux disease(GERD)is a common ***,≤35%of GERD patients fail the standard dose of proton-pump-inhibitor(PPI)*** to the high prevalence and low satisfaction rate with treatment failure,there is an unmet need for new *** aim was to evaluate whether the use of the transcutaneous electrical stimulation system(TESS)can reduce esophageal-acid exposure in GERD patients unresponsive to standard-dose ***:We enrolled 10 patients suffering from heartburn and regurgitation with an abnormal esophageal-acid exposure(off PPIs)who failed standard-dose *** the placement of a wireless esophageal pH capsule,all patients were treated with *** primary end point was the reduction in the baseline(pretreatment)24-hour percent total time pH<4 and/or DeMeester score by 50%.Results:Seven GERD patients(five females and two males,aged 49.3610.1 years)completed the *** baseline,the mean percent total time pH<4 was *** TESS,the mean percent total time pH<4 dropped to 5.563.4,4.562.6,3.762.9,and 4.462.5 on Days 1,2,3,and 4,*** baseline,the mean DeMeester score was *** TESS,the mean DeMeester score dropped to 15.869.2,13.266.8,11.269.4,and 12.066.8 on Days 1,2,3,and 4,***:TESS is a safe and potentially effective modality in reducing esophageal-acid exposure in GERD patients unresponsive to standard-dose PPI.A larger and prospective controlled study is needed to verify these preliminary results.

关键词： gastroesophageal reflux disease transcutaneous electrical stimulation system proton-pump inhibitor

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Synergistic beneficial vascular effects of a non-psychotropic cannabinoid-A potential novel strategy in cardiovascular therapy

Synergistic beneficial vascular effects of a non-psychotropi...

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11th International Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia, Shanghai-Suzhou 2006

作者： Yehoshua maor Ruth Gallily Michal Horowitz Raphael Mechoulam Department of Natural Products and Medicinal Chemistry School of Pharmacy The LautenbergCenter for General and Tumor Immunology Department of Physiology School of Dental Medicine The Hebrew University Jerusalem 91120 - Israel Department of Natural Products and Medicinal Chemistry School of Pharmacy

Cannabinoids exert numerous biological activities including the well-known psychotropic and cardiovascular effects. Most of the effects are caused by the activation of two receptors, CB1 and CB2. Most of the vascular effects are known to be mediated by CB1 receptors. Attempts to separate the hypotensive action of Δ9-THC from its psychotropic properties have been only partial successful. However, a novel pharmacological target (Abn-CBD sensitive receptor) was shown to be present in the endothelium of peripheral blood vessels. This putative receptor

关键词： CBG DMH Synergistic beneficial vascular effects of a non-psychotropic cannabinoid-A potential novel strategy in cardiovascular therapy

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原来如此

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天天爱学习（五年级） 2017年第31期 20-21页

作者： Tahel maor

在沙发上钓鱼，拿仙人掌当气球，和自己的影子比赛转呼啦圈，鲜花开在大象的尾巴上……放飞想象，就可以发现一个不一样的世界！

关键词：仙人掌尾巴鲜花

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微积分

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作者： (美)毛尔(maor Eli)

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平均值的统一处理——基于一有启发性的几何模型

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中学教研(数学) 1981年第2期 36-41页

作者： BLI maor 王宗尧美国威斯康星大学

在“数学教师”杂志的一篇文章中(Ercolano1973),作者要人们注意两个正数的调和平均值及其对这两个数的算术平均值和几何平均值的关系.他说明了如何用几何方法构造出这些平均值,但是人们仍希望对这样一个平均值能有一个解释或例子.事实... 详细信息

在“数学教师”杂志的一篇文章中(Ercolano1973),作者要人们注意两个正数的调和平均值及其对这两个数的算术平均值和几何平均值的关系.他说明了如何用几何方法构造出这些平均值,但是人们仍希望对这样一个平均值能有一个解释或例子.事实上,除了 a 和b 的算术平均值外,那些完全不明白为什么要引入其他的平均值的学生,对这些平均值的理解看来是模糊的.

关键词：统一处理数学教师 HR 长方形平方根启发性几何模型

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