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Role of radiomics in the diagnosis and treatment of gastrointestinal cancer

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World Journal of Gastroenterology 2022年第42期28卷 6002-6016页

作者： Qi mao mao-ting zhou Zhang-Ping Zhao Ning Liu Lin Yang Xiao-Ming Zhang Department of Radiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology Panzhihua Central HospitalPanzhihua 617000Sichuan ProvinceChina

Gastrointestinal cancer(GIC)has high morbidity and mortality as one of the main causes of cancer *** risk stratification is critical to guide patient management,but traditional imaging studies have difficulty predicting its biological *** emerging field of radiomics allows the conversion of potential pathophysiological information in existing medical images that cannot be visually recognized into high-dimensional quantitative image *** lesion characterization,therapeutic response evaluation,and survival prediction can be achieved by analyzing the relationships between these features and clinical and genetic *** recent years,the clinical application of radiomics to GIC has increased *** this editorial,we describe the latest progress in the application of radiomics to GIC and discuss the value of its potential clinical applications,as well as its limitations and future directions.

关键词： Gastrointestinal cancer Diagnosis Treatment Radiomics Therapeutic response Hepatocellular carcinoma

A new fabrication method for enhancing the yield of linear micromirror arrays assisted by temporary anchors

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Microsystems & Nanoengineering 2024年第3期10卷 169-180页

作者： Xingchen Xiao ting mao Yingchao Shi Kui zhou Jia Hao Yiting Yu Ningbo Institute of Northwestern Polytechnical University College of Mechanical EngineeringNorthwestern Polytechnical University710072 Xi’anChina Key Laboratory of Micro/Nano Systems for Aerospace(Ministry of Education) Shaanxi Province Key Laboratory of Micro and Nanoelectromechanical SystemsNorthwestern Polytechnical University710072 Xi’anChina

As one of the most common spatial light modulators,linear micromirror arrays(MMAs)based on microelectromechanical system(MEMS)processes are currently utilized in many ***,two crucial challenges exist in the fabrication of such devices:the adhesion of silicon microstructures caused by anodic bonding and the destruction of the suspended silicon film due to residual *** solve these issues,an innovative processing method assisted by temporary anchors is *** approach effectively reduces the span of silicon microstructures and improves the Euler buckling limit of the silicon ***,these temporary anchors are strategically placed within the primary etching areas,enabling easy removal without additional processing *** a result,we successfully achieved wafer-level,high-yield manufacturing of linear MMAs with a filling factor as high as 95.1%.Demonstrating superior capabilities to those of original MMAs,our enhanced version boasts a total of 60 linear micromirror elements,each featuring a length-to-width ratio of 52.6,and the entire optical aperture measures 5 mm×6 *** linear MMA exhibits an optical deflection angle of 20.4°at 110 Vdc while maintaining exceptional deflection flatness and *** study offers a viable approach for the design and fabrication of thin-film MEMS devices with high yields,and the proposed MMA is promising as a replacement for digital micromirror devices(DMDs,by TI Corp.)in fields such as spectral imaging and optical communication.

关键词： mirror exceptional anodic

Cervical aortic arch with aneurysm formation and an anomalous right subclavian artery and left vertebral artery:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3291-3296页

作者： Yao-Kun Wu Qi mao mao-ting zhou Ning Liu Xi Yu Jin-Cheng Peng Yun-Yun Tao Xue-Qin Gong Lin Yang Xiao-Ming Zhang Medical Imaging Key Laboratory of Sichuan Province Nanchong 637000Sichuan ProvinceChina Medical Research Center Department of RadiologyThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND A cervical aortic arch(CAA)refers to a high-riding aortic arch(AA)that often extends above the level of the *** condition is very rare,with an incidence of less than 1/*** SUMMARY A 29-year-old woman was admitted to the otolaryngology department of our hospital for repeated bilateral purulent nasal discharge for the prior 3 *** patient was diagnosed with chronic sinusitis and chronic rhinitis at admission.A preoperative noncontrast chest computed tomography scan showed a high-riding,tortuous AA extending to the mid-upper level of the first thoracic vertebra with local cystic dilatation.A further computed tomography angiography examination showed that the brachiocephalic trunk,left common carotid artery,left vertebral artery(LVA)(slender),and left subclavian artery sequentially branched off of the aorta from the proximal end to the distal end of the *** proximal end of the right subclavian artery(RSCA)was tortuous and *** AA showed tumorlike local expansion,with a maximum diameter of approximately 4 *** consultation with the department of cardiac macrovascular surgery,the patient was diagnosed with left CAA with aneurysm formation and an anomalous RSCA and LVA and was transferred to that *** patient underwent AA aneurysm resection and artificial blood vessel replacement under general anesthesia and cardiopulmonary *** abnormality was found during the 2-mo follow-up after *** A CAA is a rare congenital anomaly of vascular *** present unique case of CAA with aneurysm formation and an anomalous RSCA and LVA enriches existing CAA data.

关键词： Cervical aortic arch Aortic aneurysm Aortic anomaly Computed tomography angiography Haughton classification Case report

Socioeconomic Impact and Response Strategies to the Multifaceted Respiratory Illness Outbreak in Northern China:Beyond Influenza A and Mycoplasma Pneumoniae

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China CDC weekly 2024年第36期6卷 934-938页

作者： Xi Wang Rongfeng zhou ting Li Shuai Du Ayan mao Wuqi Qiu Hongzhou Lu Institute of Medical Information Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhen CityGuangdong ProvinceChina.

This study examines the socioeconomic and public health effects of a recent respiratory illness outbreak in northern China,focusing on Beijing following the lifting of coronavirus disease 2019(COVID-19)*** analyzes the implications of increased influenza A(H3N2)and Mycoplasma pneumoniae cases on urban health systems and economic *** mixed-methods study integrated a review of academic and governmental literature,a quantitative analysis of public health data,and a qualitative assessment of response *** indicate a significant increase in respiratory illnesses in late 2023,prompting a proactive response from health authorities that involved expanded hospital capacity and intensified ***,including resource limitations and public health fatigue,persisted,affecting response *** outbreak management was achieved through immediate health responses,although the event highlighted the need for improved infrastructure,surveillance,and policy *** emphasize the importance of international collaboration and comprehensive preparedness plans to strengthen global health security for future epidemics.

关键词： intensified lifting prompt

On Stability Discrimination of Limit Cycles for Piecewise Smooth Systems

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1785-1803页

作者： mao An HAN Xia Yu zhou School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004P.R.China

This paper is concerned with the problem of stability discrimination of limit cycles for piecewise smooth *** first establish the Poincaré map near a periodic orbit,and deduce the first order derivative of the map for general piecewise smooth systems on the ***,we obtain a sufficient condition for determining the stability of limit cycles for these systems.

关键词： Piecewise smooth system limit cycle stability

Adhesion Performances Between Two Orthotropic Solids Influenced by Temperature Increment

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Acta Mechanica Solida Sinica 2024年第3期37卷 430-443页

作者： Qing-Hui Luo Yue-ting zhou School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China

The classical adhesive contact models belong to isothermal adhesion theories,where the effect of temperature on adhesion was ***,a number of experimental results indicated that the adhesion behaviors can be significantly affected by *** this paper,the two-dimensional non-slipping anisothermal adhesion behaviors between two orthotropic elastic cylinders are investigated within the framework of the Johnson-Kendall-Roberts *** stated problem is reduced to the coupled singular integral equations by virtue of the Fourier integral transform,which are solved analytically with the analytical function *** closed-form solutions for the stress fields in the presence of thermoelastic effect are *** stable equilibrium state of contact system is determined by virtue of the Griffith energy *** effect of temperature difference on adhesion behaviors between orthotropic solids is *** is found that the difference between the oscillatory and non-oscillatory solutions increases with increasing the degree of anisotropy of orthotropic *** oscillatory solution cannot be well approximated by the non-oscillatory solution for the orthotropic materials with relatively high anisotropy.

关键词： Adhesive contact Non-slipping JKR model Temperature Griffith energy balance

Perturbation of autophagy pathways in murine alveolar macrophage by 2D TMDCs is chalcogen-dependent

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Journal of Environmental Sciences 2024年第1期135卷 97-107页

作者： Xiaofei zhou Weitao Jin Rui Zhang Xuan mao Jianbo Jia Hongyu zhou College of Science&Technology Hebei Agricultural UniversityHuanghua 061100China Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China

Increasing risks of incidental and occupational exposures to two-dimensional transition metal dichalcogenides(2D TMDCs)due to their broad application in various areas raised their public health *** the composition-dependent cytotoxicity of 2D TMDCs has been well-recognized,how the outer chalcogenide atoms and inner transition metal atoms differentially contribute to their perturbation on cell homeostasis at non-lethal doses remains to be *** the present work,we compared the autophagy induction and related mechanisms in response to WS_(2),NbS_(2),WSe_(2)and Nb Se_(2)nanosheets exposures in MH-S murine alveolar *** these 2D TMDCs had comparable physicochemical properties,overall cytotoxicity and capability in triggering autophagy in MH-S cells,but showed outer chalcogen-dependent subcellular localization and activation of autophagy ***,WS_(2)and NbS_(2)nanosheets adhered on the cell surface and internalized in the lysosomes,and triggered m TOR-dependent activation of ***,WSe_(2)and Nb Se_(2)nanosheets had extensive distribution in cytoplasm of MH-S cells and induced autophagy in an m TOR-independent ***,the 2D TMDCs-induced perturbation on autophagy aggravated the cytotoxicity of respirable benzo[a]*** findings provide a deeper insight into the potential health risk of environmental 2D TMDCs from the perspective of homeostasis perturbation.

关键词： Chalcogen group Autophagy pathway Cell function Endosomal escape Inhalation toxicity

Combined proteomic and metabolomic studies on the liver of Amur sturgeon Acipenser schrenckii under titanium dioxide nanoparticle exposure

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Journal of Oceanology and Limnology 2024年第3期42卷 1001-1015页

作者： zhou zhou ting LIU Jie KONG Zhenxing ZHAO Junquan ZHU Key Laboratory of Aquacultural Biotechnology Ministry of Educationand Key Laboratory of Marine Biotechnology of Zhejiang ProvinceCollege of Marine SciencesNingbo UniversityNingbo 315000China Guizhou Fisheries Research Institute Guizhou Academy of Agriculture SciencesGuiyang 550000China

Nanomaterials,particularly titanium dioxide nanoparticles(TiO_(2)-NPs),are extensively utilized across various ***,their environmental release has raised concerns regarding their potential ecological and environmental *** reproductive toxicity of TiO_(2)-NPs in fish species has attracted considerable attention,yet conflicting research outcomes have been *** investigated the effects of TiO_(2)-NPs exposure on the liver of juvenile Amur sturgeon Acipenser schrenckii using label-free proteomic and untargeted metabolomic *** experiment included a control group and three groups exposed to different concentrations of TiO_(2)-NPs(low,TL;medium,TM;high,TH).Compared to the control group,9,19,and 25 proteins and 35,73,and 158 metabolites were differentially expressed in the TH,TM,and TL TiO_(2)-NP-exposed groups,*** differentially expressed genes(DEGs)were enriched in the Kyoto Encyclopedia for Genes and Genomes(KEGG)pathways related to glycolysis and ***,among the 126 correlated proteins,the most enriched pathways were associated with endocytosis and protein processing in the endoplasmic ***,syringic acid was significantly downregulated across all three TiO_(2)-NP-exposed *** obtain a comprehensive overview of the TiO_(2)-NP-induced expression changes,a co-regulated network of proteins and metabolites associated with TiO_(2)-NPs exposure was *** to TiO_(2)-NPs led to enrichment and alteration of pathways related to immune responses,including endocytosis,protein processing in the endoplasmic reticulum,and peroxisome proliferator-activated receptor(PPAR)*** conclusion,our findings indicate that exposure to TiO_(2)-NPs might disrupt glucose metabolism and induce immune responses,thus contributing to our understanding of the environmental impacts of nanomaterials and highlighting the need for further research and development of potential mitigation strategies.

关键词： TiO_(2)-nanoparticle exposure proteomics metabolomics glucose metabolism immune response

Engineering classification recycling of spent lithium-ion batteries through pretreatment:a comprehensive review from laboratory to scale-up application

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Rare Metals 2024年第3期43卷 915-941页

作者： Shu-Xuan Yan You-zhou Jiang Xiang-Ping Chen Lu Yuan ting-ting Min Yu Cao Wan-Li Peng Tao zhou Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410083China School of Public Policy and Management Tsinghua UniversityBeijing 100084China China Nonferrous Metal Industry's Foreign Engineering and Construction Co. LtdBeijing 100029China

The lithium-ion batteries(LIBs)have been widely equipped in electric/hybrid electric vehicles(EVs/HEVs)and the portable electronics due to their excellent electrochemical ***,a large number of retired LIBs that consist of toxic substances(e.g.,heavy metals,electrolytes)and valuable metals(e.g.,Li,Co)will inevitably flow into the waste stream,and their incineration or landfill treatment will cause severe risks to ecosystem and human *** sustainable and efficient treatment or recycling of valuable resources from spent LIBs should be fully recognized for environmental and resource *** one of the most important processes for spent LIBs recycling,the pretreatment is an indispensable step,which is directly related to the subsequent metal extraction and separation *** considerable progresses have been made regarding the pretreatment technologies,there are few summarized reports concerning critical processes of spent LIBs recycling,especially combination of currently available recycling technologies with industrialized applications during ***,comprehensive review of the current prevailing pretreatment technologies in laboratory to existing scale-up applications is quite necessary to reveal cutting-edge development in the field of *** this review,the current pretreatment technologies are systematically categorized and introduced,along with critical *** review focused on the various options for pretreatment processes itself,instead of general spent LIBs recycling technologies without the focused topics that have been sophisticatedly reviewed by previous ***,the deactivation,discharge,dismantling,separation,liberation of active material and electrolyte treatment have been summarized with the in-depth discussion of the technology development and current status of each ***,current states of industrial development are also reviewed and discussed for the development of

关键词： Spent lithium-ion batteries(LIBs) Recycling Pretreatment Valuable metals Cutting-edge technologies Industrialized application