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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1396-1401页

作者： Carolina Bernal-Morales Marina Dotti-Boada Alvaro Olate-Perez manuel J.navarro-Angulo Laura Pelegrín Marc Figueras-Roca Institut Clínic d’Oftalmologia(ICOF) Hospital ClínicBarcelona 08028Spain August Pi i Sunyer Biomedical Research Institute(IDIBAPS) Barcelona 08028Spain

AIM:To describe and evaluate the efficacy of Ahmed glaucoma valve implantation(AGV)combined with pars plana vitrectomy(PPV)in a single surgical act for the treatment of advanced neovascular glaucoma(NVG).METHODS:Retrospective observational case series included 51 eyes from 50 patients with severe NVG treated with PPV,AGV,and panretinal photocoagulation and/or cryotherapy in a single surgical act during a 13-year period(2005-2018).Preoperative,intraoperative and postoperative data at day 1 and months 1,3,6,21,and 24 were systematically *** of surgical success was stablished at IOP between 6 and 21 mm Hg with or without topical ***:Main indications for surgery were NVG secondary to proliferative diabetic retinopathy(39.2%)and central retinal vein occlusion(37.3%).Mean(±SD)preoperative IOP was 42.0±11.2 mm Hg decreasing to 15.5±7.1 mm Hg at 12 mo and 15.8±9.1 mm Hg at 24 mo of follow *** incidence of success of IOP control was 76.0%at first postoperative month,reaching 88.3%at 6 *** of successful IOP control at long term was 74.4%at 12 mo and 71.4%at 24 *** evisceration for unsuccessful NVG management was required in 1 case(2.0%).CONCLUSION:Combination of AGV implantation and PPV in a single act may be a suitable option for severe forms of NVG in a case-by-case basis for effective IOP control and a complete panretinal photocoagulation.

关键词： neovascular glaucoma Ahmed valve pars plana vitrectomy panretinal photocoagulation cryotherapy

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice

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International Journal of Oral Science 2020年第1期12卷 31-39页

作者： Angustias Page Ana Bravo Cristian Suarez-Cabrera Raquel Sanchez-Baltasar Marta Oteo Miguel Angel Morcillo MLlanos Casanova Jose CSegovia manuel navarro Angel Ramirez Molecular Oncology Unit.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT)MadridSpain Instituto de Investigación 12 de Octubre i+12 MadridSpain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) MadridSpain Department of Anatomy Animal Production and Veterinary Clinical SciencesLaboratory of Pathology Phenotyping of Genetically Engineered MiceFaculty of Veterinary MedicineUniversity of Santiago de CompostelaLugoSpain Biomedical Applications and Pharmacokinetics Unit Centro de Investigaciones EnergéticasMedioambientales y Tecnológicas(CIEMAT)MadridSpain Hematopoietic Innovative Therapies Division.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)MadridSpain Unidad Mixta de Terapias Avanzadas Fundación Instituto de Investigaciones Sanitarias Fundación Jiménez DíazMadridSpain

Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures that differentiate as teeth. Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog,MAPK and WNT/β-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. In this study, we used genetically modified mice to study the role of IKKβ(a fundamental regulator of NF-κB activity and many other proteins) in oral epithelial cells and odontogenic tissues. Transgenic mice overexpressing IKKβ in oral epithelial cells show a significant increase in immune cells in both the oral epithelia and oral submucosa. They also show changes in the expression of several proteins and mi RNAs that are important for cancer development. Interestingly, we found that overactivity of IKKβ in oral epithelia and odontogenic tissues, in conjunction with the loss of tumour suppressor proteins(p53, or p16 and p19), leads to the appearance of odontogenic tumours that can be classified as ameloblastic odontomas, sometimes accompanied by foci of secondary ameloblastic carcinomas. These tumours show NF-κB activation and increased β-catenin *** findings may help to elucidate the molecular determinants of odontogenic tumourigenesis and the role of IKKβ in the homoeostasis and tumoural transformation of oral and odontogenic epithelia.

关键词： IKKβ tumour suppressor

Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

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Neural Regeneration Research 2019年第11期14卷 1851-1857页

作者： Fernando Lucas-Ruiz Caridad Galindo-Romero David García-Bernal María Norte-Munoz Kristy T. Rodríguez-Ramírez manuel Salinas-navarro Jose E. Millán-Rivero manuel Vidal-Sanz Marta Agudo-Barriuso Grupo de Oftalmologia Experimental Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Talmologia Universidad de MurciaMurciaSpain Unidad de Terapia Celular y Trasplante Hematopoyetico Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Medicina Interna Universidad de MurciaMurciaSpain

Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e.,Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.

关键词： stem cells adipose stem cells umbilical cord bone marrow Wharton's jelly optic nerve axotomy neuroprotection

Transcatheter aortic valve implantation in very elderly patients： immediate results and medium term follow-up

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Journal of Geriatric Cardiology 2015年第4期12卷 340-345页

作者： Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas manuel F Jimenez-navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís Area del Corazón Hospital Universitario Central de Asturias Av. Roma Oviedo Asturias Spain Department of Cardiology Hospital Universitario Virgen de la Victoria Campus de Teatinos Málaga Spain Department of Cardiology Complejo Hospitalario Universitario de Santiago de Compostela Travesla da Choupana A Coru a Spain

Objective To evaluate immediate transcatheter aortic valve implantation （TAVI） results and medium-term follow-up in very elderly pa- tients with severe and symptomatic aortic stenosis （AS）. Methods This multicenter, observational and prospective study was carried out in three hospitals. We included consecutive very elderly （〉 85 years） patients with severe AS treated by TAVI. The primary endpoint was to evaluate death rotes from any cause at two years. Results The study included 160 consecutive patients with a mean age of 87 ± 2.1 years （range from 85 to 94 years） and a mean logistic EuroSCORE of 18.8% ± 11.2% with 57 （35.6%） patients scoring 〉 20%. Procedural success rate was 97.5%, with 25 （15.6%） patients experiencing acute complications with major bleeding （the most frequent）. Global mortality rate during hospitalization was 8.8% （n = 14） and 30-day mortality rate was 10% （n = 16）. Median follow up period was 252.24± 232.17 days. During the follow-up period, 28 （17.5%） patients died （17 of them due to cardiac causes）. The estimated two year overall and cardiac survival rates using the Kaplan-Meier method were 71% and 86.4%, respectively. Cox proportional hazard regression showed that the variable EuroSCORE ≥ 20 was the unique vari- able associated with overall mortality. Conclusions TAVI is safe and effective in a selected population of very elderly patients. Our findings support the adoption of this new procedure in this complex group of patients.

关键词： Aortic stenosis High surgical risk Transcatheter aortic valve Very elderly patients

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恒山风景名胜区游客中心

建筑创作 2011年第11期 64-67页

作者： manuel navarro Jorge Gonzalez

中国的快速发展对建筑提出新的需求。在具有地域性和历史文脉背景下营建,对知识和经验的要求,远远超出普通的城市建筑。营建这个项目的目的是促进一处历史遗迹旅游业的发展,特别是它受到现存的北魏时期(公元386-534)恒山悬空寺寺庙文物... 详细信息

中国的快速发展对建筑提出新的需求。在具有地域性和历史文脉背景下营建,对知识和经验的要求,远远超出普通的城市建筑。营建这个项目的目的是促进一处历史遗迹旅游业的发展,特别是它受到现存的北魏时期(公元386-534)恒山悬空寺寺庙文物建筑的制约。另外附近还有一个即将用来发展水上休闲活动的大坝。在本方案中,建筑的目的关注于如何利用大坝海拔最低点和最高点之间的距离。这种特性提供了发挥使之与众不同的独特潜力。台阶,成为创建一个竖向漫步的场所的理由。这个长廊要有别于它周围的建筑,因为周围的建筑对特色定义并不明确,需要找寻一种新的途径,以代替复制传统古建筑形式,来接近历史遗迹与记忆的认同感。

关键词：历史遗迹史迹遗存建筑周围

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龙城双塔

建筑创作 2011年第11期 68-71页

作者： Jorge Gonzalez manuel navarro 梁洁欣

这两座分别为40层和23层的高层塔楼位于太原市汾河西岸。最高的办公塔楼被精心切割,以引入一个从街道而来的新视点,避免通常塔楼的完整形态。小一些的精品酒店塔楼的幕墙经过造型处理以显现内部生活,泳池和露台等室内外空间形成一系列... 详细信息

这两座分别为40层和23层的高层塔楼位于太原市汾河西岸。最高的办公塔楼被精心切割,以引入一个从街道而来的新视点,避免通常塔楼的完整形态。小一些的精品酒店塔楼的幕墙经过造型处理以显现内部生活,泳池和露台等室内外空间形成一系列特征。这些元素最终使塔楼在太原市天际线中创造了独有的轮廓。连接双塔的水平部分是可容纳展览、餐饮、休闲设施等多功能的广场。本设计摒弃典型的高层塔楼模式,以融合于城市的摩天楼替代孤立的塔楼。

关键词：双塔高层塔楼太原市

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禅居

建筑创作 2011年第11期 72-75页

作者： manuel navarro Jorge Gonzalez 刘冬冬

此项目受五台山佛教寺庙高僧委托,设计一处用于修行悟禅的新场所。首要的任务是确认能够定义佛教生活本质的功能和审美价值。由此生成这些核心品质最适合的表达方式,赋予对时间、场所感受的优先权。即使缺少一些建筑语汇的范例,设计依... 详细信息

此项目受五台山佛教寺庙高僧委托,设计一处用于修行悟禅的新场所。首要的任务是确认能够定义佛教生活本质的功能和审美价值。由此生成这些核心品质最适合的表达方式,赋予对时间、场所感受的优先权。即使缺少一些建筑语汇的范例,设计依然忠于虔诚信徒的本质精神。方案需要与很多重要的文脉对话,从现状场地的结构到历史上人们认为的佛教修行冥想空间应该的长相。不同尺度的隐喻清晰表露;建构景观视图的框架:交通流线逐步引领进入令人欢愉的境界;有克制地运用混凝土、木材和纸门等材料构件:每一个节点清晰表达佛教美学的纯净。

关键词：效果图佛教释教立面

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene navarro-Lobato Mariam Masmudi-Martín manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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多功能综合体

建筑创作 2011年第11期 55-63页

作者： manuel navarro Jorge Gonzalez 曹玺甘宁马刚李青松刘冬冬

从古罗马开始,中庭就被用作为房屋中心引入光线和空气的孔洞。在北京王府井大街上,本方案意在创造一个人工的,充满无限体验可能性的容器。本项目从对社会的、城市的、建筑学建构的空间条件思考入手。为创造一个城市化的片段,大量程序被... 详细信息

从古罗马开始,中庭就被用作为房屋中心引入光线和空气的孔洞。在北京王府井大街上,本方案意在创造一个人工的,充满无限体验可能性的容器。本项目从对社会的、城市的、建筑学建构的空间条件思考入手。为创造一个城市化的片段,大量程序被处理,与之对应的功能和行为形成有效的关联事物。这个片段可以包涵整个世界。这个想法基于运用项目任务书所需的零售、酒店、公寓总面积建造总共5个立面,以形成内部共享空间。中空系统部分的轮廓为体块引入日光和与周围环境交流的视线。向东700m,中国传统建筑群紫禁城,恰好诠释了创造一个被围合的核心的可能性——创造自己的世界、自己的视角。

关键词：概念图

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建筑与周围区域的互动

设计家 2012年第5期 8-9页

作者：马努·纳瓦罗(manuel navarro) LATITUDE STUDIO(纬度建筑)设计事务所

《设计家》：在您近期的设计实践中，您最关注哪部分？对此，产生了怎样的思考？

关键词：建筑设计实践建筑设计建筑环境