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Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

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Bioactive Materials 2022年第2期7卷 153-164页

作者： Lorena Garcia-Hevia Inigo Casafont Jessica Oliveira Nuria Teran Monica L.Fanarraga Juan Gallo manuel Banobre-lopez Advanced(Magnetic)Theranostic Nanostructures Lab.International Iberian Nanotechnology Laboratory Avda.Mestre Jose Veiga s/n4715-330BragaPortugal Grupo de Nanomedicina.Universidad de Cantabria-IDIVAL Herrera Oria s/n39011SantanderSpain

Nowadays,a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective ***,the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical ***,a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient,green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug(doxorubicin)into a natural *** theranostic performance of the final magnetic formulation was validated in vitro and in vivo,in melanoma *** systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy,together with MRI reporting *** application of an alternating magnetic field was found to play a dual role,(i)acting as an extra layer of control(remote,on-demand)over the chemotherapy release and(ii)inducing a local thermal ablation of tumor *** combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes,which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

关键词： Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma

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负载型钌催化剂催化山梨醇氢解制乙二醇(英)

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催化学报 2014年第5期35卷 614-621页

作者： Inmaculada Murillo Leo manuel lopez Granados Jose Luis Garcia Fierro Rafael Mariscal Group of Sustainable Energy and Chemistry Institute of Catalysis and Petrochemistry(CSIC)

Supported Ru catalysts were prepared by wet impregnation to evaluate the role of different oxide supports(Al_2O_3,SiO_2,TiO_2,ZrO_2) in sorbitol hydrogenolysis to glycols.X-ray diffraction,transmission electron microscopy,hydrogen chemisorption,X-ray photoelectron spectroscopy,and NH3temperature-programmed desorption were used to characterize the catalysts,which were active in the hydrogenolysis of *** support affected both the physicochemical properties and catalytic behavior of the supported Ru *** characterization results revealed that the Ru/Al_2O_3catalyst has a high surface acidity,partially oxidized Ru species on the surface,and a higher surface Ru/Al atomic ratio,which gave it the highest selectivity and yield to glycols.

关键词：负载钌催化剂山梨醇过负载二元醇 Ru Al2O3催化剂氢解 X射线光电子能谱透射电子显微镜

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Robust Fiber-Optic Sensor Networks

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Photonic Sensors 2012年第4期2卷 366-380页

作者： Rosa Ana PEREZ-HERRERA Montserrat FERNANDEZ-VALLEJO manuel lopez-AMO Department of Electric and Electronic Engineering Public University of Navarra 31006 Pamplona Spain

The ability to operate despite failure will become increasingly important as the use of optical sensor networks grows, and the amount of sensing information to be handled by a sensor network is increasing, especially for safety and security applications. In this review, the four categories of protection to allow service to be reestablished after a failure （dedicated/shared and line/path） are thoroughly discussed. This paper also presents an overview of the most representative robust fiber-optic sensor systems, discussing their schemes, pros and cons.

关键词： Self-healing robust resilience fiber-optic sensor multiplexing fiber Bragg gratings (FBGs) fiber-optic networks

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Fiber Cavity Ring Down and Gain Amplification Effect

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Photonic Sensors 2016年第4期6卷 324-327页

作者： Susana SILVA Regina MAGALHAES Rosa Ana PEREZ-HERRERA manuel lopez-AMO M. B. MARQUES O. FRAZAO IINESC TEC Rua do Campo Alegre 687 4169-007 Porto Portugal Dept. de Fisica e Astronomia da Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre 687 4169-007 Porto Portugal public University of Navarra Dept. of Electric and Electronic Engineering Campus de Arrosadla Pamplona Spain.

The effect of an erbium-doped fiber amplifier （EDFA） placed inside the fiber ring of a cavity ring down （CRD） configuration is studied. The limitations and advantages of this configuration are discussed, and the study of the ring-down time as a function of the current applied and gain to the EDFA is also presented. In this case, the power fluctuations in the output signal are strongly dependent on the cavity ring-down time with the EDFA gain.

关键词： Cavity ring down EDFA multimode laser optical fibers.

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Simulation, Construction and Characterization of a Piezoelectric Transducer Using Rexolite as Acoustic Matching

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材料科学与工程（中英文B版） 2013年第4期3卷 208-213页

作者： Israel Sanchez Dominguez Pedro Acevedo Contla manuel Recuero lopez Demetrio Fabian Garcia Nocetti Polytechnic University of Madrid School of Industrial Engineering Madrid Spain National Autonomous University of Mexico lnstitutito Research in Applied Mathematics and Systems Mexico City Mexico

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Irrigation of Romaine Lettuce (Lactuca sativa)Using Wastewater Treated byNon-Conventional Technologies

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World Journal of Engineering and Technology 2017年第5期5卷 1-11页

作者： manuel Enrique lopez Sepulveda Santiago Gutierrez Ruiz Antonio Lineiro Bullon Jose Maria Quiroga Alonso Department of Environmental Technologies(Av Republica Saharaui S/N Faculty of Marine and Environmental Sciences(CASEM)CP11510 Puerto RealCadizSpain

The aim of this study was to assess the capacity for reuse of wastewater treated in stabilisation ponds and subsequently reclaimed by means of different filtration systems at pilot scale. An analysis of filtered water showed turbidity values of below 5 NTU, a total suspended solids (TSS) content of 7 mg/l, and Escherichia coli values of up to 1.6 log CFU/100 ml. These results fall within the parameters stipulated in RD 1620/2007 Spanish Water Reuse Regulations governing the reuse of reclaimed wastewater for agricultural purposes. The water reclaimed by means of filtration systems was used to irrigate Romainelettuce (Lactuca sativa longifolia), comparing growth with that of the same variety irrigated with water from the supply network. The results showed a mean difference in lettuce growth of up to 300% in favour of the crop irrigated with reclaimed water.

关键词： Reclamation, Reutilisation, Small Communities, Intermittent Sand Filters,Infiltration-Percolation, Stabilisation Ponds, Artificial Wetlands

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Heritage risk index:A multi-criteria decision-making tool to prioritize municipal historic preservation projects

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Frontiers of Architectural Research 2020年第2期9卷 403-418页

作者： Jonathan Ruiz-Jaramillo Carmen Munoz-Gonzalez Maria Dolores Joyanes-Diaz Eduardo Jimenez-Morales Jose manuel lopez-Osorio Roberto Barrios-Perez Carlos Rosa-Jimenez Department of Art and Architecture School of ArchitectureUniversidad de MalagaMalaga 29071Spain

The current pressure on the built historical heritage requires a global evaluation to develop strategies for its preservation.A combined vision of the state of conservation of architectural heritage is essential to highlight the vulnerabilities of the structure from which harmonized measures can be proposed for its *** study proposes a multi-criteria analysis methodology that considers a qualitative and quantitative approach to organize the global conservation state of heritage buildings hierarchically.A global index can be determined on the basis of the generation of an interoperable data matrix by defining a set of indicators to assess different components of a *** index describes the risk with respect to the stability,safety,and habitability of the *** methodology aims to achieve the state of the building in an integral way by obtaining a simple and objective index that enables efficient comparison among different *** application of this methodology to a historic area allows creating a hierarchical map of risk to stablish priorities for intervention and enable a sustainable and critical management and planning over the actions of maintenance,conservation,and *** this way,a holistic vision of the complex reality of built heritage and the urban landscape is obtained to identify critical areas of priority intervention.

关键词： Historic city State of conservation Risk index Intervention priority Architectural heritage

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Recirculating chemohyperthermia as a treatment for non-muscle invasive bladder cancer:Current and future perspectives

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World Journal of Clinical Urology 2017年第2期6卷 34-39页

作者： Javier Flores-Carbajal Alejandro Sousa-Escandón Daniel Sousa-Gonzalez Silvia Rodriguez Gomez manuel lopez Saavedra M Elia Fernandez Martinez Comarcal Hospital of Monforte

About 75% of all bladder cancer diagnosed are non-muscle invasive bladder cancer(NMIBC), recurring over 50% of them after transurethral resection of the bladder tumor. In order to prevent recurrences, adjuvant intravesical chemotherapy with mitomycin C and immunotherapy with bacillus Calmette-Gu-érin(BCG) is traditionally used. Unfortunately, many patients relapse after receiving these treatments and a significant proportion of them require surgery. After a one-to-three years BCG maintenance, the risk for progression at 5 years was 19.3% for T1G3 tumors. Many new treatment approaches are being investigated to increase the effectiveness of adjuvant intravesical therapy. One of the developing treatments for intermediate and high-risk NMIBC is the combination of intravesical chemotherapy and hyperthermia, called chemohyperthermia. This article provides a review of the mechanism of action, current status and indications, results and future perspectives.

关键词： Bladder cancer Thermotherapy Non-muscle invasive Chemohyperthermia Recirculating Intravesical chemotherapy Treatment Mechanism of action

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Quiksilver威尼斯大道旗舰店——585BOARDRIDERS

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中国建筑装饰装修 2012年第7期 136-141页

作者： Tatiana Barhar Sarai Grenell manuel lopez Augusta Quirk Principals Minna Guillermo

由VERDEGO事务所设计的新概念店落成于洛杉矶中心、颇具波希米亚风同时又是板类运动流行地的威尼斯大道。这里毗邻威尼斯海滩,

关键词：威尼斯旗舰店洛杉矶事务所海滩

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Open Journal of Respiratory Diseases 2012年第2期2卷 17-24页

作者： manuel lopez-Meseguer Río Aguilar Carles Bravo Víctor Monforte Laura Dos Carmen P. Simeon Enric Domingo Antonio Roman Cardiology Department Hospital Universitari de Bellvitge Hospitalet de Llobregat Spain Cardiology Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain Department of Physiology Universitat Autonòma de Barcelona Barcelona Spain Internal Medicine Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain Respiratory Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain

Background: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are serious diseases with similar pathophysiologic aspects. The prognosis of patients with these conditions is highly uncertain, particularly incident cases. Methods: A Cox proportional hazards model was applied to a group of 85 patients (81% women, mean age 52 (18 - 82) years) with PAH (80%) and non-surgical CTEPH (20%) to evaluate risk factors for mortality. The following variables were included in the model: age, etiology, baseline 6-minute walk test (6 mWT), cardiac index, and improvement in the 6 mWT following initiation of first medical treatment. Results: In the multivariate analysis, the response to treatment, assessed by an improvement on the 6 mWT, was the most relevant prognostic factor in these patients (RR, 4.832 (95% CI, 1.888 - 12.364);p = 0.001). The remaining variables studied in this model had less influence on the prognosis: age > 50 years (RR, 0.744 (95% CI, 0.26 - 2.133);p = 0.582);etiology of connective tissue disease-associated PAH (RR, 3.145 (95% CI, 0.995-9.946);p = 0.051) or CTEPH (RR, 0.654 (95% CI, 0.179 - 2.387);p = 0.521) with respect to idiopathic PAH;baseline 6 mWT (RR, 1.173 (95% CI, 0.599 - 4.895);p = 0.315);or cardiac index (RR, 2.295 (95% CI, 0.793 - 6.642);p = 0.125). Conclusions: There is a high degree of uncer-tainty regarding the prognosis of PAH and CTEPH at the start of appropriate treatment. Our results support the idea that the initial treatment response is of paramount importance as prognostic factor in these patients.

关键词： Pulmonary Arterial Hypertension Chronic Thromboembolic Pulmonary Hypertension Survival Risk Factors

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