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High resolution colonoscopy in a bowel cancer screening program improves polyp detection

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World Journal of Gastroenterology 2011年第38期17卷 4308-4313页

作者： Matthew R Banks Rehan Haidry M Adil Butt Lisa Whitley Judith Stein Louise Langmead Stuart L Bloom Austin O' Bichere Sara McCartney Kalpesh Basherdas manuel rodriguez-justo Laurence B Lovat Department of Gastrointestinal Services University College London Hospitals NHS Foundation Trust Department of Histopathology University College London Hospitals NHS Foundation Trust

AIM： To compare high resolution colonoscopy （Olympus Lucera） with a megapixel high resolution system （Pentax HiLine） as an in-service evaluation. METHODS： Polyp detection rates and measures of performance were collected for 269 colonoscopy procedures. Five colonoscopists conducted the study over a three month period, as part of the United Kingdom bowel cancer screening program. RESULTS：There were no differences in procedure duration （x^2 p = 0.98）, caecal intubation rates （x^2 P = 0.67）, or depth of sedation （x^2 P = 0.64）. Mild discomfort was more common in the Pentax group （x^2 p = 0.036）. Adenoma detection rate was significantly higher in the Pentax group （x^2 test for trend P = 0.01）. Most of the extra polyps detected were flat or sessile adenomas. CONCLUSION： Megapixel definition colonoscopes improve adenoma detection without compromising other measures of endoscope performance. Increased polyp detection rates may improve future outcomes in bowel cancer screening programs.

关键词： High resolution colonoscopy Bowel cancerscreening Polyp detection

Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma: A retrospective single centre experience

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World Journal of Gastroenterology 2018年第41期24卷 4698-4707页

作者： David Graham Nejc Sever Cormac Magee William Waddingham Matthew Banks Rami Sweis Hannah Al-Yousuf Miriam Mitchison Durayd Alzoubaidi manuel rodriguez-justo Laurence Lovat Marco Novelli Marnix Jansen Rehan Haidry GI Services University College London Hospital Division of Surgery and Science University College London Gastroenterology Department University Medical Center Ljubljana Department of Metabolism and Experimental Therapeutics University College London

AIM To assess clinical outcomes for submucosal (T1b) oesophageal adenocarcinoma (OAC) patients managed with either surgery or endoscopic eradication *** Patients found to have T1b OAC following endoscopic resection between January 2008 to February 2016 at University College London Hospital were retrospectively analysed. Patients were split into low-risk and high-risk groups according to established histopathological criteria and were then further categorised according to whether they underwent surgical resection or conservative management. Study outcomes include the presence of lymphnode metastases, disease-specific mortality and overall survival. RESULTS A total of 60 patients were included; 22 patients were surgically managed (1 low-risk and 21 high-risk patients) whilst 38 patients were treated conservatively (12 low-risk and 26 high-risk). Overall, lymph node metastases (LNM) were detected in 10 patients (17%); six of these patients had undergone conservative management and LNM were detected at a median of 4 mo after endoscopic mucosal resection (EMR). All LNM occurred in patients with highrisk lesions and this represented 21% of the total high-risk lesions. Importantly, there was no statistically significant difference in tumor-related deaths between those treated surgically or conservatively (P = 0.636) and disease-specific survival time was also comparable between the two treatment strategies (P = 0.376).CONCLUSION T1b tumours without histopathological high-risk markers of LNM can be treated endoscopically with good outcomes. In selected patients, endoscopic therapy may be appropriate for high-risk lesions.

关键词： Oesophageal adenocarcinoma Submucosal invasion T1b Lymph node metastasis Risk prediction Endoscopy

Actinomycosis of the sigmoid colon:A case report

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World Journal of Gastrointestinal Surgery 2009年第1期1卷 62-64页

作者： Antonio Privitera Charanjit Singh Milkhu Vivek Datta manuel rodriguez-justo Alastair Windsor Charles Richard Cohen Department of Surgery University College London Hospitals Histopathology Department Royal Free & University College Medical SchoolRockefeller Building

Abdominal actinomycosis is a chronic suppurative infection caused by Actinomyces *** ileo-cecal region is most commonly affected,while the left side of the colon is more rarely *** infection has a tendency to inf iltrate adjacent tissues and is therefore rarely confined to a single *** may vary from non specif ic symptoms and signs to an acute abdomen.A computed tomography scan is helpful in identifying the inflammatory process and the organs *** also allows visual guidance for percutaneous drainage of abscesses,thus aiding *** is difficult because of the anaerobic character and slow growth of *** is usually normal,but may shows signs of external *** diagnosis is rare and is established only in less than 10% of *** uncomplicated disease,high dose antibiotic therapy is the mainstay of *** is often performed because of a difficulty in *** and antibiotics are required in the case of complicated *** medical and surgical treatment achieves a cure in about 90% of *** authors report a case of sigmoid actinomycosis where diagnosis was made from the histology,and a review of the literature is presented.

关键词： Abdominal pain Actinomycosis Gram-positive bacteria Sigmoid colon Sulfur

英国胃肠病学会关于胃癌风险患者的诊断和管理指南

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中华胃肠内镜电子杂志 2020年第2期7卷 49-83页

作者： Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers manuel rodriguez-justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) 伦敦大学学院医院伦敦大学学院医院NHS基金会英国伦敦目标干预研究部伦敦大学学院英国伦敦外科与介入科学部伦敦大学学院生物科学部英国伦敦伦敦大学学院病理学系英国伦敦日本大学医学院医学研究所消化科日本东京板桥区健康集团内镜英国伦敦医学研究委员会癌症中心剑桥大学英国剑桥剑桥大学医院NHS基金会消化科英国剑桥内镜训练和学习中心大阪癌症及心血管疾病医学中心胃肠肿瘤科日本大阪朴茨茅斯大学英国朴茨茅斯转化医学研究所利物浦大学英国利物浦伊拉斯谟大学医学中心荷兰鹿特丹诺丁汉消化疾病中心诺丁汉大学医院英国诺丁汉格洛斯特郡大学细胞病理实验室切尔滕纳姆综合医院英国切尔滕纳姆波尔多葡萄牙肿瘤学研究所消化科葡萄牙波尔多北京大学第三医院消化科北京100191 不详

胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(***,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生... 详细信息

胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(***,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。

关键词：慢性萎缩性胃炎内镜检查内镜黏膜下剥离术恶性贫血常规诊断角切迹早期癌胃肠病学

Characterization of Gromov Hyperbolic Short Graphs

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Acta Mathematica Sinica,English Series 2014年第2期30卷 197-212页

作者： José manuel rodriguez Departamento de Matemticas Universidad Carlos III de MadridAvenida de la Universidad 30

To decide when a graph is Gromov hyperbolic is,in general,a very hard *** this paper,we solve this problem for the set of short graphs（in an informal way,a graph G is r-short if the shortcuts in the cycles of G have length less than r）：an r-short graph G is hyperbolic if and only if S9r（G）is finite,where SR（G）：=sup{L（C）：C is an R-isometric cycle in G}and we say that a cycle C is R-isometric if dC（x,y）≤dG（x,y）＋R for every x,y∈C.

关键词： Short graph Gromov hyperbolicity Gromov hyperbolic graph infinite graphs geodesics

Open avenues for carotenoid biofortification of plant tissues

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Plant Communications 2023年第1期4卷 228-237页

作者： Luca Morelli manuel rodriguez-Concepcion Institute for Plant Molecular and Cell Biology(IBMCP) CSIC-Universitat Polite`cnica de Vale`ncia46022 ValenciaSpain Department of Biology&CESAM&ECOMARE Universidade de Aveiro3810-193 AveiroPortugal

Plant carotenoids are plastidial isoprenoids that function as photoprotectants,pigments,and precursors of apocarotenoids such as the hormones abscisic acid and *** do not produce carotenoids but need to obtain them from their diet as precursors of retinoids,including vitamin *** also provide numerous other health *** attempts to improve the carotenoid profile of different crops have been carried out by manipulating carotenoid biosynthesis,degradation,and/or ***,we will focus on open questions and emerging subjects related to the use of biotechnology for carotenoid *** impressive achievements,new efforts should be directed to extend the use of genome-editing technologies to overcome regulatory constraints and improve consumer acceptance of the carotenoid-enriched *** challenge is to prevent off-target effects like those resulting from altered hormone levels and metabolic *** on biofortification of green tissues should also look for new ways to deal with the negative impact that altered carotenoid contents may have on *** a carotenoid-enriched product has been obtained,additional effort should be devoted to confirming that carotenoid intake from the engineered food is also *** involves ensuring post-harvest stability and assessing bioaccessibility of the biofortified product to confirm that release of carotenoids from the food matrix has not been negatively *** addressing these challenges will ensure new milestones in carotenoid biotechnology and biofortification.

关键词： biofortification biotechnology carotenoids plastidial isoprenoids vitamin A

Factors affecting the spatial distribution and breeding habitat of an insular cliff-nesting raptor community

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Current Zoology 2018年第2期64卷 173-181页

作者： Beneharo rodriguez Airam rodriguez Felipe SIVERIO manuel SIVERIO Canary Islands' Ornithology and Natural History Group (GOHNIC) La Malecita s/n 38480 Buenavista del NorteTenerife Canary Islands Spain Department of Evolutionary Ecology Estacion Biologica de DoSana (CSIC)Avda. Americo Vespucio s/n Seville 41092 Spain

The specific spatial distribution and habitat association--strongly influenced by environmental fac- tors or competitive interactions--are major issues in ecology and conservation. We located and georeferenced nesting sites of five cliff-nesting raptors （Egyptian vulture Neophron percnopterus [a locally extinct species], common buzzard Buteo buteo, osprey Pandion haliaetus, common kes- trel Falco tinnunculus, Barbary falcon Falco peregrinus pelegrinoides）, and common raven Corvus corax on one of the most biodiverse hotspot within the Canary Islands （Teno, Tenerife）. We used generalized linear models to evaluate the factors affecting abundance, richness, and intra- and interspecific interactions. Raptor abundance increased with slope, shrub-covered area, and habitat diversity, and decreased with altitude, and forested and grassed areas. Richness increased with slope and decreased with altitude. Threatened species （osprey, Barbary falcon, and raven） occu- pied cliffs farther away from houses and roads, and more rugged areas than the non-threatened species. The models suggested that the probability of cliff occupation by buzzards, falcons, and rav- ens depended only on inter-specific interactions. Buzzard occupation increased with the distance to the nearest raven and kestrel nests, whereas falcons and ravens seek proximity to each other. Teno holds between 75% and 100% of the insular breeding populations of the most endangered species （osprey and raven）, indicating the high conservation value of this area. Our study suggests that the preservation of rugged terrains and areas of low human pressure are key factors for raptor conservation and provide basic knowledge on the community structure and habitat associations to develop appropriated management actions for these fragile island populations.

关键词： Canary Islands competitive interactions human disturbances habitat threatened species.

Plant geranylgeranyl diphosphate synthases: every (gene) family has a story

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aBIOTECH 2021年第3期2卷 289-298页

作者： M.Victoria Barja manuel rodriguez-Concepcion Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UAB Bellaterra08193 Barce-lonaSpain Institute for Plant Molecular and Cell Biology(BMCP) CSIC-Universitat Politecnica de Valencia46022 ValenciaSpain

Plant isoprenoids(also known as terpenes or terpenoids)are a wide family of primary and secondary metabolites with multiple *** particular,most photosynthesis-related isoprenoids(including carotenoids and chlorophylls)as well as diterpenes and polyterpenes derive from geranylgeranyl diphosphate(GGPP)produced by GGPP synthase(GGPPS)enzymes in several cell *** genomes typically harbor multiple copies of differentially expressed genes encoding GGPPS-like *** sequence comparisons allow to identify potential GGPPS candidates,experimental evidence is required to ascertain their enzymatic activity and biologi cal ***,functional analyses of the full set of potential GGPPS paralogs are only available for a handful of plant *** we review our current knowledge on the GGPPS families of the model plant Arabidopsis thaliana and the crop species rice(0ryza sativa),pepper(Capsicum annuum)and tomato(Solanum lycopersicum).The results indicate that a major determinant of the biological role of particular GGPPS paralogs is the expression profile of the corresponding genes even though specific interactions with other proteins(including GGPP-consuming enzymes)might also contribute to *** some species,however,a single GGPPS isoforms appears to be responsible for the production of most if not all GGPP required for cell *** the mechanisms regulating GGPPS activity in particular cell compartments,tissues,organs and plant species will be very useful for future metabolic engineering approaches aimed to manipulate the accumulation of particular GGPP-derived products of interest without negatively impacting the levels of other isoprenoids required to sustain essential cell functions.

关键词： Geranylgeranyl diphosphate GGPP GGPP synthase Isoprenoid Isoprenyl transferase

Wavelet-based deconvolution of ultrasonic signals in nondestructive evaluation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1748-1756页

作者： HERRERA Roberto Henry OROZCO Rubén rodriguez manuel Department of Informatics University of Cienfuegos Cienfuegos 59430 Cuba CEETI Central University of Las Villas Santa Clara 54830 Cuba Department of Physics Central University of Las Villas Santa Clara 54830 Cuba

In this paper, the inverse problem of reconstructing reflectivity function of a medium is examined within a blind deconvolution framework. The ultrasound pulse is estimated using higher-order statistics, and Wiener filter is used to obtain the ultrasonic reflectivity function through wavelet-based models. A new approach to the parameter estimation of the inverse filtering step is proposed in the nondestructive evaluation field, which is based on the theory of Fourier-Wavelet regularized deconvolution (ForWaRD). This new approach can be viewed as a solution to the open problem of adaptation of the ForWaRD framework to perform the convolution kernel estimation and deconvolution interdependently. The results indicate stable solutions of the esti- mated pulse and an improvement in the radio-frequency (RF) signal taking into account its signal-to-noise ratio (SNR) and axial resolution. Simulations and experiments showed that the proposed approach can provide robust and optimal estimates of the reflectivity function.

关键词： Blind deconvolution Ultrasonic signals processing Wavelet regularization