Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia
Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia作者机构：Centre for Tumour BiologyBart’s Cancer InstituteLondon EC1M 6BQUnited Kingdom Research Department of General SurgeryUniversity College LondonLondon WC1E 6BTUnited Kingdom Department of PathologyUniversity College LondonLondon WC1E 6BTUnited Kingdom
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第15期
页 面：4453-4456页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Medical Research Council, MRC, (MC_PC_13036) Medical Research Council, MRC
主 题：Squamous carcinoma oesophagus Barrett's oesophagus Radiofrequency ablation Squamous cell cancer High grade dysplasia
摘 要：Barrett’s oesophagus(BO)is a usually indolent condition that occasionally requires endoscopic *** ablation(RFA)is an effective endoscopic treatment for high grade dysplasia(HGD)and intramucosal cancer in *** has a good efficacy,durability and safety profile although complications can *** we describe a case of RFA in a patient with high grade *** the response to treatment was initially very good with the development of neosquamous epithelium,the patient very rapidly developed a squamous cell cancer of the oesophagus confirmed on radiology,histology and *** sequencing confirmed that the original HGD and the squamous cell cancer(SCC)were derived from separate clonal *** report highlights the fact that SCC of the oesophagus has been noted after endoscopic ablation for BO previously and suggest that ablation of BO may encourage the clonal expansion of cells carrying carcinogenic mutations once a dominant clonal population has been eradicated.
维普期刊数据库