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2020—2021年武汉市596例急性呼吸道感染患者病原谱研究

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实用预防医学 2024年第7期31卷 805-810页

作者：吴奕璇李瑶孔雯骅张祎婕刘满清武汉市疾病预防控制中心湖北武汉430021

目的在新冠感染疫情暴发一年后,明确非药物干预措施下武汉冬季呼吸道感染患者病原谱的构成,为呼吸道感染性疾病的防治提供病原学依据。方法收集2020年12月28日—2021年2月14日武汉8家大型医院发热门诊急性呼吸道感染(acute respiratory ... 详细信息

目的在新冠感染疫情暴发一年后,明确非药物干预措施下武汉冬季呼吸道感染患者病原谱的构成,为呼吸道感染性疾病的防治提供病原学依据。方法收集2020年12月28日—2021年2月14日武汉8家大型医院发热门诊急性呼吸道感染(acute respiratory tract infection,ARTI)病例咽拭子样本,经全自动核酸提取仪提取核酸后,采用实时荧光定量PCR技术进行23种常见呼吸道病原体检测。采用Excel 2016软件对数据进行录入、整理,建立数据库,用SPSS 20.0软件进行统计学分析。结果共收集596例ARTI病例,其中男性335例,女性261例,男女比例1.28∶1。年龄最小患者为5月龄,最大为91岁。23种呼吸道病原体中共13种病原体检出阳性,总阳性率86.24%(514/596),排在前3位的病原体分别为肺炎链球菌(Streptococcus pneumoniae,SPN)占比30.47%(323/1060)、肺炎克雷伯菌(Klebsiella pneumoniae,KPN)占比24.25%(257/1060)和流感嗜血杆菌(Haemophilus influenzae,HIN)占比19.43%(206/1060)。514例检测阳性的病例中混合感染共331例,占比64.40%(331/514),其中细菌之间的混合感染占比54.68%(181/331)高于细菌和病毒的混合感染45.01%(149/331)。331例混合感染病例中,仅检出1例病毒之间的混合感染,占比0.30%(1/331),为人偏肺病毒(human metapneumovirus,HMPV)和呼吸道合胞病毒(respiratory syncytial virus,RSV)共感染。HIN、KPN、SPN、HMPV、RSV、呼吸道腺病毒(respiratory adenovirus,RA)、人博卡病毒(human bocavirus,HBoV)和肠道病毒(human enterovirus,HEV)在不同年龄段的患者中检出率差异有统计学意义,HIN、KPN、SPN、HMPV和RSV在不同体温患者中的检出率差异有统计学意义,不同性别患者之间所有病原体的检出率差异无统计学意义。国家级和非国家级流感监测哨点医院之间A族链球菌(group A streptococcus,GAS)和RSV的检出率差异有统计学意义。结论非药物干预措施下武汉冬季呼吸道病原以SPN、KPN、HIN、HMPV和金黄色葡萄球菌(Staphylococcus aureus,SA)为主。加强对这些病原体的监测和预防是武汉市冬季呼吸道传染病防控的重点。

关键词：急性呼吸道感染非药物干预措施呼吸道病原体病原谱监测与预防

Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice

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Nano Research 2023年第1期16卷 822-833页

作者： Fangcao Lei Zhiqing Huang Qianmin Ou Jiaqi Li manqing liu Lan Ma Lingping Tan Zhengmei Lin Xiaoxing Kou Hospital of Stomatology Sun Yat-sen UniversitySouth China Center of Craniofacial Stem Cell ResearchGuangdong Provincial Key Laboratory of StomatologyGuangzhou 510080China Key Laboratory of Stem Cells and Tissue Engineering(Sun Yat-Sen University) Ministry of EducationGuangzhou 510080China Hospital of Stomatology Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of StomatologyGuangzhou 510055China

Aging skeletons display decreased bone mass,increased marrow adiposity,and impaired bone marrow mesenchymal stem cells(MSCs).Apoptosis is a programmed cell death process that generates a large number of apoptotic vesicles(apoVs).Dysregulated apoptosis has been closely linked to senescence-associated ***,whether apoVs mediate agingrelated bone loss is not *** this study,we showed that young MSC-derived apoVs effectively rejuvenated the nuclear abnormalities of aged bone marrow MSCs and restored their impaired self-renewal,osteo-/adipo-genic lineage differentiation capacities via activating ***,apoptotic young MSCs generated and enriched a high level of Ras-related protein 7(Rab7)into ***,recipient aged MSCs reused apoV-derived Rab7 to restore autolysosomes formation,thereby contributing to autophagy flux activation and MSC ***,systemic infusion of young MSC-derived apoVs enhanced bone mass,reduced marrow adiposity,and recused the impairment of recipient MSCs in aged *** findings reveal the role of apoVs in rejuvenating aging-MSCs via restoring autolysosome formation and provide a potential approach for treating age-related bone loss.

关键词： apoptotic vesicles mesenchymal stem cells(MSCs) autolysosome formation Ras-related protein 7(Rab7) aging

北部湾表层沉积物中重金属与放射性元素/核素的分布、风险、源解析与环境研究启示

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广西科学 2024年第3期31卷 565-580页

作者：许泽钺刘鳗卿何贤文周花珑黄美琴管永精何华刘志勇郭凯行卢颖何佶蔓韦湫阳广西壮族自治区辐射环境监督管理站广西南宁530222 广西大学物理科学与工程技术学院广西相对论天体物理重点实验室广西南宁530004 苏州大学放射医学及交叉学科研究院放射医学与辐射防护国家重点实验室江苏苏州215123

本研究对北部湾表层沉积物中的重金属(Hg、Cr、Zn、As、Cd、Ni、Cu、Pb)和放射性核素(238 U、232 Th、210 Pb、239+240 Pu)进行全面分析,以评估其环境风险并考察其作为环境指示物的有效性。结果表明,除了局部地区的Cr浓度超出《海洋沉... 详细信息

本研究对北部湾表层沉积物中的重金属(Hg、Cr、Zn、As、Cd、Ni、Cu、Pb)和放射性核素(238 U、232 Th、210 Pb、239+240 Pu)进行全面分析,以评估其环境风险并考察其作为环境指示物的有效性。结果表明,除了局部地区的Cr浓度超出《海洋沉积物质量》(GB 18668-2002)中的第一类指标外,其他重金属浓度均低于第一类指标。放射性核素的环境风险评估显示238 U和232 Th属于第二级(安全级别),而210 Pb和239+240 Pu尚缺乏评估标准。研究发现部分重金属和放射性元素/核素呈现出“T”型分布,指向多样化的污染源和传输机制。结果显示放射性元素/核素在海洋环境监测和管理中具有独特的源相示踪潜力,海洋放射性研究可作为交叉学科为海洋环境保护和污染综合治理研究提供新的启示。

关键词：北部湾表层沉积物重金属放射性核素环境风险评估空间分布环境研究启示

High Power 940 nm Al-free Active Region Laser Diodes and Bars with a Broad Waveguide

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Chinese Journal of Lasers 2002年第1期11卷 10-14页

作者： FANG Gaozhan XIAO Jianwei MA Xiaoyu XU Zuntu ZHANG Jinming TAN manqing liu Zongshun liu Suping FENG Xiaoming (Institute of Semiconductors, The Chinese Academy of Sciences, National Engineering Research Center for Optoelectronics Devices, Beijing Institute of Semiconductors The Chinese Academy of Sciences National Engineering Research Center for Optoelectronics Devices 北京 100083

The 940 nm Al-free active region laser diodes and bars with a broad waveguide were designed and fabricated. The stuctures were grown by metal organic chemical vapour deposition. The devices show excellent performances. The maximum output power of 6.7 W in the 100 μm broad-area laser diodes has been measured, and is 2.5 times higher than that in the Al-containing active region laser diodes with a narrow waveguide and 1.7 times higher than that in Al-free active region laser diodes with a narrow waveguide. The 19% fill-factor laser diode bars emit 33 W, and they can operate at 15W with low degradation rates.

关键词： laser diode bar waveguide Al-free

Influence of axial stress on rockburst in deep tunnels: insight from model experiment

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Journal of Mountain Science 2024年第10期21卷 3536-3551页

作者： YAN Yaofeng XIA Yuanyou HUANG Jian LIN manqing liu Xiqi YAN Minjia ZHANG Hongwei School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan 430070China School of Resources and Safety Engineering Wuhan Institute of TechnologyWuhan 430074China Key Laboratory of Geotechnical and Structural Engineering Safety of Hubei Province School of Civil EngineeringWuhan UniversityWuhan 430000China China Railway 11th Bureau Group Fourth Engineering Co. Ltd.Wuhan 430074China School of Resource and Environment Sciences Wuhan UniversityWuhan 430000China

Frequent rockburst disasters in deep-buried engineering projects severely impact construction. To explore the influence of axial stress on rockburst in deep-buried tunnels, large-scale true triaxial rockburst experiments were conducted under four different axial stress ratio conditions (ηt, axial loading stress/vertical loading stress) using a self-developed true triaxial loading device under the condition of "pre-loading before excavation". The influence of axial stress on the rockburst process and failure characteristics in deep tunnels was studied using a combination of real-time video monitoring, rockburst debris sieving, and acoustic emission monitoring. The results indicate: (1) all four specimens subjected to different axial stress ratio loading conditions exhibited three stages of macroscopic failure: small particle ejection, flake spalling, and large fragment ejection. Ultimately, "V"-shaped notches appeared on both sides of the tunnel. (2) The failure stress, fragment volume, and fragment size distribution of the rockburst specimens exhibited a clear two-stage failure characteristic with increasing axial stress ratio. In the lower axial stress ratio stage (ηt ≤ 0.7), the increase in the axial stress ratio enhances lateral confinement, thereby increasing the crack initiation strength of the surrounding rock, inhibiting crack formation and propagation, and thus suppressing damage to the surrounding rock of the tunnel. In the higher axial stress ratio stage (ηt > 0.7), the increase in axial stress ratio makes the Poisson effect of the surrounding rock more pronounced, promoting the generation and propagation of cracks along the tunnel axis direction, thereby promoting damage to the surrounding rock. (3) Based on the analysis of acoustic emission parameters (fracture properties), it can be concluded that in the lower axial stress ratio stage (ηt ≤ 0.7), an increase in the axial stress ratio leads to a higher proportion of shear fracture in rockburst damage. Co

关键词： Rockburst experiments Axial stress ratio Failure characteristics Fracture properties

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废弃墨粉的再生机理及工艺(英文)

仪器仪表学报 2004年第Z2期25卷 60-61,79页

作者：刘漫青刘树果湛江惠能墨业有限公司湛江524022

将被废弃的激光打印机或复印机用墨粉进行再生,首先用清洗、干燥、分选等方法对废墨粉进行处理,再按传统生产墨粉的工艺,经预混、混炼、粉碎、分级、外添等重新制作新品种的墨粉粉体。再生后的不同品种的墨粉,它用在激光打印机或复印机... 详细信息

将被废弃的激光打印机或复印机用墨粉进行再生,首先用清洗、干燥、分选等方法对废墨粉进行处理,再按传统生产墨粉的工艺,经预混、混炼、粉碎、分级、外添等重新制作新品种的墨粉粉体。再生后的不同品种的墨粉,它用在激光打印机或复印机上,同原厂制造的墨粉一样优异。

关键词：再生废弃墨粉工艺

Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3457-3475页

作者： manqing Tang Zhijie Zhang Ping Wang Feng Zhao Lin Miao Yuming Wang Yingpeng Li Yunfei Li Zhonggao Gao College of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic *** tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable *** survive shear stress,resist anoikis,evade immune surveillance,and thwart *** comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their *** signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in ***,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet *** innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and *** review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.

关键词： CTCs Anoikis Platelet Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting Nanomedicines

用超临界流体溶喷技术制造墨粉的构想(英文)

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仪器仪表学报 2004年第Z2期25卷 56-59页

作者：刘漫丹刘漫青刘树果华东理工大学自动化研究所上海200237 湛江惠能墨业有限公司湛江524022

提出了用CO2 超临界流体作溶剂,采用溶喷技术制造复印机用或激光打印机用墨粉的方法。利用超临界流体对有机材料的强溶解性能,将树脂、颜料及电荷控制剂等全部或部分溶解在 CO2 超临界流体中,用搅拌方法使未溶部分均匀悬浮在含有溶质的... 详细信息

提出了用CO2 超临界流体作溶剂,采用溶喷技术制造复印机用或激光打印机用墨粉的方法。利用超临界流体对有机材料的强溶解性能,将树脂、颜料及电荷控制剂等全部或部分溶解在 CO2 超临界流体中,用搅拌方法使未溶部分均匀悬浮在含有溶质的超临界流体中,然后用瞬间喷雾方法获得墨粉粒子。依此方法制造的墨粉,形貌近似于球形,具粒度均匀、无表面污染等优点,与传统的机械法及化学聚合法相比,具有节能、节水、无环境污染、生产成本低等优点,将成为大规模生产墨粉的新方法。

关键词： CO2超临界流体墨粉溶解喷雾工艺方法

高等教育中外合作办学对我国经济增长影响的实证研究

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北京大学教育评论 2023年第2期21卷 101-119,191页

作者：李锋亮刘漫卿闵维方清华大学教育研究院北京100084 北京大学教育学院北京100871

本文以中外合作办学为分析对象,采用我国1997—2019年的省级面板数据,通过固定效应模型和门槛回归模型检验高等教育对外开放与经济增长之间的关系。实证结果发现:高等教育中外合作办学规模与省际经济发展水平之间呈现显著正相关关系,高... 详细信息

本文以中外合作办学为分析对象,采用我国1997—2019年的省级面板数据,通过固定效应模型和门槛回归模型检验高等教育对外开放与经济增长之间的关系。实证结果发现:高等教育中外合作办学规模与省际经济发展水平之间呈现显著正相关关系,高等教育中外合作办学机构规模和办学项目规模均对经济增长有显著促进效应;本科和研究生教育阶段的中外合作办学规模对省际经济增长的影响存在差异,中外合作办学规模对经济增长的影响存在地区差异;考虑门槛模型后,中外合作办学规模与经济增长之间呈现非单调、非线性的关系。根据实证发现,本文建议为进一步促进高等教育阶段教育对外开放,我国应进一步扩大中外合作办学规模,调整区域中外合作办学资源配置结构,丰富中外合作办学形式,并对经济社会发展较为落后的省份和农村地区进行经济扶持和人才调配。

关键词：教育对外开放高等教育中外合作办学经济增长

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