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Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia

World Journal of Cardiology 2012年第10期4卷 296-301页

作者： Aimé Bonny Antonio De Sisti manlio f márquez Richard megbemado franoise Hidden-Lucet Guy fontaine Hpital Pitié-Salpêtrière Unité de Rythmologie47-83 Boulevard de l'Hpital75651 ParisFrance Instituto Nacional de Cardiología Ignacio Chávez Departamento de ElectrofisiologíaJuan Badiano 1Col.Sección ⅩⅥ14080 Mexico CityMexico Hpital Saint Camille Service de Cardiologie2 Rue des Pères Camilliens94366 Bry-sur MarneFrance

We report three cases of sustained monomorphic ventricular tachycardia(VT) in the setting of coronary artery disease,resistant to beta-blockers in two patients and to amiodarone in all,successfully terminated by low doses of intravenous(IV) *** was the first manifestation of coronary artery disease in one patient,whereas the other two patients had a previous history of myocardial infarction and were recipients of an implantable cardioverter-defibrillator(ICD).One of these two patients experienced an arrhythmic *** had hemodynamic instability at the time of epinephrine administration.A single slow administration of IV epinephrine(0.5 to 1 mg administered over 30 to 60 s) restored sinus rhythm after 30-90 s with only minor side *** the ICD patient with recurrent VT and several cardioversions due to transformation of VT to ventricular fibrillation,epinephrine injection led to the avoidance of further *** potentially harmful,low doses of IV epinephrine used alone or in combination with beta-blocker treatment and electrical cardioversion may be an alternative effective therapy for sustained monomorphic VT refractory to *** role of epinephrine in the termination of VT should be studied further,especially in patients pre-treated with amiodarone in combination with beta-blockers.

关键词： Ventricular tachycardia Epinephrine Cardiopulmonary resuscitation Ischemic heart disease Coronary artery disease Amiodarone

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Correlation between thoracic aorta 18f-natrium fluoride uptake and cardiovascular risk

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World Journal of Radiology 2016年第1期8卷 82-89页

作者： francesco fiz Silvia morbelli matteo Bauckneht Arnoldo Piccardo Giulia ferrarazzo Alberto Nieri Nathan Artom manlio Cabria Cecilia marini marco Canepa Gianmario Sambuceti Nuclear medicine Department of Health ScienceUniversity of Genoa and IRCCS San Martino-IST Nuclear medicine Unit Galliera Hospital Clinic of Internal medicine 1 Department of Internal MedicineUniversity of Genoa School of Medicine CNR Institute of molecular Bioimaging and Physiology milan section of Genoac/o Nuclear Medicine Cardiovascular Unit Department of Internal MedicineUniversity of Genoa

AIm: To investigating the relationship between thoracic and cardiac 18f-Natrium-fluoride (18f-Naf) uptake, as a marker of ongoing calcification and cardiovascular risk ***: Seventy-eight patients (44 females, mean age 63, range 44-83) underwent whole body 18f-Naf positron emission tomography/computed tomography. Cardiovascular risk (CVR) was used to divide these patients in three categories: Low (LR), medium (mR) and high risk (HR). 18f-Naf uptake was measured by manually drawing volumes of interest on the ascending aorta, on the aortic arch, on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool, to obtain target-to-background ratio (TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic ***: A significant difference in whole thoracic aorta TBR was detected between HR and LR (1.84 ± 0.76 vs 1.07 ± 0.3, P mR and HR-LR (1.4 ± 0.4, P ficance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta (P myocardial uptake provided an effective CVR classes stratification (P ment (R = 0.75), in comparison with the aortic arch and the ascending segment (R = 0.55 and 0.53, respectively).CONCLUSION: fluoride uptake within the thoracic aorta wall effectively depicts patients’ risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination.

关键词： Positron emission tomography/computed tomography 18f-Natrium fluoride Plaque imaging Cardiovascular risk profile Thoracic aorta

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