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Changes of anterior segment parameters after horizontal rectus muscles recession versus resection

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Annals of Eye Science 2020年第1期5卷 15-21页

作者： Amani E.Badawi manal ali kasem Tharwat Mokbel Eman A.Awad Mansoura Ophthalmic Center Faculty of MedicineMansoura UniversityMansouraEgypt

Background:To record the corneal,and anterior chamber depth changes after performing recession versus resection of horizontal recti ***:Consecutive patients who underwent isolated lateral rectus muscle recession or resection February 2014 to January 2015 were prospectively *** error(spherical equivalent);K1,K2,and mean k reading,anterior and posterior corneal elevation;and anterior chamber depth were measured(Pentacam)before,1 month,and 3 months after *** who could not maintain reliable fixation and those with a history of eye surgery were ***-and postoperative measurements were compared by analysis of ***:A total of 36 eyes of 23 patients(average age,16 years)were *** muscle recession was performed in 24 eyes;and resection was performed in 12 *** significant changes in mean keratometry of recession group *** anterior elevation,and central anterior chamber depth were significant when both groups are compared at first month after *** became regressive at the end of the third *** a significant change of central anterior elevation ***:In recession group,the mean K was the only statistically significant variable by the first postoperative *** the both groups,the anterior corneal elevation,and central anterior chamber depth revealed a significant difference by the end of the first postoperative *** 3 months,all parameters showed a statistical insignificant difference between the recession and resection groups except the anterior corneal elevation.

关键词： Strabismus cornea parameters anterior chamber Pentacam

Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed ali Jerah manal Mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam Mohamed ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(P<0.05)with CEWE *** antagonizes 5-HT receptors in isolated rat fundus *** findings indicated that the khat ligands bound to 5-HT2C *** and cathinone levels in rat plasma were ***:Khat extract may suppress appetite by antagonizing the 5-HT *** research is required to understand its mechanism and potential applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

Leptomeningeal metastases in prostate cancer:A review of the current literature

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Current Urology 2024年第3期18卷 159-166页

作者： Umar Durrani kasem Rifai Maha Arshad Awais Paracha Ekamjit Deol Maria Paracha Fatima Waheed Zohair Siddiqui ali Abid Esed Mustafic Wilson Rodriguez Zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA University of Missouri School of Medicine ColumbiaMOUSA University of Virginia CharlottesvilleVAUSA New York Institute of Technology College of Osteopathic Medicine Old WestburyNYUSA Saint Louis University Saint LouisMOUSA Department of Neurology Saint Louis University School of MedicineSaint LouisMOUSA Division of Urology Department of SurgerySaint Louis University School of MedicineSaint LouisMOUSA

Leptomeningeal metastasis/leptomeningeal carcinomatosis(LMC;terms used interchangeably)is an inflammatory complication of primary tumors that involves the spread of the disease to the meninges(specifically the arachnoid and pia maters)and spinal *** the United States,approximately 110,000 new cases are diagnosed each year,and the prognosis is usually *** of LMC include cognitive impairment,cranial nerve dysfunction,ischemic stroke,and *** survival times of untreated and treated LMC are approximately 4–6 weeks and 2–4 months,*** carcinomatoses are usually metastatic cancers that spread to the central nervous *** lung and breast cancers have a clearly defined relationship with LMC,it remains unclear whether prostate cancer(PC)is also directly associated with *** determine whether such association exists,we conducted a PubMed review of the literature on patients with PC with coexisting *** search yielded 23 case reports of patients with preexisting PC who developed *** addition,2 retrospective cohort studies were *** findings were identified in the revised cases and *** first 3 findings were related to the progression of the disease:patients presenting with neurological disease symptoms were in remission from PC for 7 years on average,LMCs tended to occur after other cancer diagnoses,and the disease had already rapidly progressed by the time the symptoms were *** diagnosis,the major finding was that most LMCs were detected by magnetic resonance imaging(which does not detect early dissemination),and it was suggested that single-photon emission computed tomography or positron emission tomography imaging could be used for earlier ***,in terms of treatment,the main finding was that treatment was palliative rather than curative and that prognosis remained poor despite *** the basis of these results,we recommend for individuals with risk facto

关键词： Leptomeningeal carcinomatosis Prostate cancer Prostate cancer metastasis

Correlation between Wnt Signalling Inhibitors (Dickkopf-1 & Sclerostin) and the Intimal Medial Thickness in Children on Maintenance Hemodialysis

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Open Journal of Nephrology 2024年第3期14卷 397-412页

作者： manal Abd El-Salam Mohamed Hamdi ali Nadia Youssef Riad Rasha Abd El Samad Fawaz Shima Mohamed Department of Pediatrics Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Tbilisi State Medical University Tbilisi Georgia Department of Clinical Pathology National Heart Institute Cairo Egypt Department of Radiology Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt

Background: Wnt signalling inhibitors (Dickkopf-1 and Sclerostin) signalling play a role in vascular development and may contribute to calcification. Aim: To investigate the association between Dickkopf-1 and sclerostin serum concentrations in children undergoing maintenance hemodialysis with intimal medial thickness and peak systolic velocity of the main arteries. Patients and Methods: A study was conducted on 40 children undergoing maintenance hemodialysis and controls of the same age and sex. The study measured the initial medial thickness (IMT) and peak systolic velocity (PSV) of the main vessels (carotid, ulnar, and femoral). Dickkopf-1 and sclerostin serum levels in both groups were assessed, and a routine investigation was performed. Results: The findings indicate that the levels of serum Dickkopf-1 and Sclerostin were significantly higher in the hemodialysis group 2540.65 (2215.4 - 2909.2 pg/ml) and 1.17 (0.85 - 2.03 ng/ml)respectively (P = 0.001), compared to their control group it was 1110.45 (885.45 - 1527.65 pg/ml) and 0.28 (0.25 - 0.32 ng/ml)) respectively P = 0.001. Additionally, there was a significant increase in intima-media thickness (IMT) with a decrease in peak systolic velocity (PSV) in the main blood vessels, including the carotid, ulnar, and femoral arteries. A significant correlation was also observed between Dickkopf-1 and sclerostin levels and IMT of the carotid, ulnar, and femoral arteries. Conclusion: Wnt signalling inhibitors (Dickkopf-1 and Sclerostin) exert effects beyond the bone and significantly contribute to early vascular calcification in pediatric patients undergoing maintenance hemodialysis.

关键词： Wnt Signalling Vascular Calcification Hemodialysis Children

Medical clowning in hospitalized children:a meta‑analysis

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World Journal of Pediatrics 2023年第11期19卷 1055-1061页

作者： Rim kasem ali Sliman Noam Meiri Giora Pillar Department of Pediatrics Carmel Medical CenterCarmel Hospital7 Michal St.3436212 HaifaIsrael Technion Faculty of Medicine HaifaIsrael

Background Medical clowning has been proven effective in reducing pain,anxiety,and stress in many sporadic,usually small-scale *** meta-analysis aims to evaluate the efficiency of medical clowns in reducing pain and anxiety in hospitalized pediatric patients and their parents in different medical *** A thorough literature search was conducted from different databases,and only randomized controlled trials(RCTs)were included with children aged 0 to 18 years old.A total of 18 studies were included,and statistical analysis was performed on the combined *** A total of 912 children(14 studies)showed significantly reduced anxiety when procedures were performed with a medical clown compared with the controls(−0.76 on anxiety score,P<0.001).Preoperative anxiety was lower in 512 children(nine studies)with clown interventions than in the controls(−0.78,P<0.001).The pain scale was completed by 338 participants(six studies),indicating a trend toward reduced pain during procedures performed while the clown was acting compared to controls(−0.49,P=0.06).In addition,medical clown significantly(−0.52,P=0.001)reduced parental anxiety in 489 participants in ten studies;in six of the ten studies,with a total of 380 participants,medical clown significantly reduced parental preoperative anxiety(P=0.02).Conclusion Medical clowns have substantial positive and beneficial effects on reducing stress and anxiety in children and their families in various circumstances in pediatrics.

关键词： Anxiety Medical clown Pain Pediatric patients

Attribute Reduction for Information Systems via Strength of Rules and Similarity Matrix

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Computer Systems Science & Engineering 2023年第5期45卷 1531-1544页

作者： Mohsen Eid Tamer Medhat manal E.ali Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Electrical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Physics and Engineering Mathematics Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt

An information system is a type of knowledge representation,and attribute reduction is crucial in big data,machine learning,data mining,and intelligent *** are several ways for solving attribute reduction problems,but they all require a common *** selection of features in most scientific studies is a challenge for the *** working with huge datasets,selecting all available attributes is not an option because it frequently complicates the study and decreases *** the other side,neglecting some attributes might jeopardize data *** this case,rough set theory provides a useful approach for identifying superfluous attributes that may be ignored without sacrificing any significant information;nonetheless,investigating all available combinations of attributes will result in some ***,because attribute reduction is primarily a mathematical issue,technical progress in reduction is dependent on the advancement of mathematical *** the focus of this study is on the mathematical side of attribute reduction,we propose some methods to make a reduction for information systems according to classical rough set theory,the strength of rules and similarity matrix,we applied our proposed methods to several examples and calculate the reduction for each *** methods expand the options of attribute reductions for researchers.

关键词： Rough set reduction strength of rules similarity matrix

Breeding Enrichment of Genetic Variation of Grain Yield and Its Attributes in Bread Wheat under Drought Stress and Well Irrigation

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Phyton-International Journal of Experimental Botany 2022年第12期91卷 2699-2717页

作者： Dina Swelam Abdel Hamid Salem manal Hassan Mohammed ali Wheat Research Department Agricultural Research CenterGiza12619Egypt Agronomy Department Faculty of AgricultureZagazig UniversityZagazig44519Egypt

Drought stress(DS)is one of the most critical environmental abiotic stresses for wheat production in the arid *** of high-yielding genotypes tolerant to DS can play a significant role in mitigation the negative impacts associated with *** the present study,generation means analysis(GMA)was used to study the performance of two crosses under well irrigation(WI)and deficit irrigation[cross I(Line 44×Shandweel-1)and cross II(Line 20×Sakha 93)].Significant differences were observed for days to heading(DH),days to maturity(DM),plant height(PH),spike length(SL),number of spikes per plant(NS/P),number of grains per spike(NG/S),thousand-grain weight(TGW),grain yield per plant(GY/P),and proline content(PC)in the six populations of the two crosses within each irrigation *** II had early maturity and the highest PC,NS/P,TGW,and GY/P regardless of the irrigation *** I showed positive significant relative heterosis and heterobeltiosis for GY/P under the two irrigation *** inheritance of characters of cross I revealed additive,dominant,and epistatic effects,which varied with trait and *** genetic effects predominated in DH,SL,and PC,while non-additive were found in DM,NS/P,NG/S,and GY/***-sense heritability estimates(h^(2) n)were high for DH and PC,moderate to high for PH and SL,moderate for DM,NG/S,NS/P,and TGW,and low for GY/*** on different drought indices the populations BC_(1),BC_(2),F_(1),and P1 of cross II and BC1 of cross I were more tolerant to drought ***,PC,TGW and DH can be used as selection indicators to improve wheat for drought tolerance in early generations and other yield components traits in late *** second cross(Line 20×Sakha 93)shows promise and is of interest to a drought tolerance breeding program,where wheat breeders can use recombinant breeding strategies to construct desirable drought stress *** and path coefficient revealed that TGW and PC were the main

关键词： Drought generation mean analysis heterosis heritability wheat

Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis:In vitro and in vivo study

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 243-252页

作者： Enas M.ali manal A.Alfwuaires Gehan M.Badr Department of Biological Sciences Faculty of ScienceKing Faisal UniversityP.O.Box 380Al-Ahsa 31982Saudi Arabia Department of Botany and Microbiology Faculty of ScienceCairo UniversityCairo 12613Egypt Department of Zoology Faculty of ScienceAin Shams UniversityCairo11566Egypt

Objective:To characterize the antifungal activity of methanolic leaf extract of Calotropis gigantea alone or in combination with amphotericin B against invasive pulmonary aspergillosis in ***:GC/MS was used for analysis of active constituents of Calotropis gigantea *** germination assay and broth micro-dilution method were used to determine antifungal potential of Calotropis gigantea/amphotericin B against Aspergillus *** mice were randomly assigned into 5 groups:group 1 was neutropenic(control);group 2 was infected with Aspergillus fumigatus;group 3 was infected with Aspergillus fumigatus,and treated with Calotropis gigantea extract;group 4 was infected with Aspergillus fumigatus and treated with amphotericin B;group 5 was infected with Aspergillus fumigatus and treated with both Calotropis gigantea extract and amphotericin *** lung tissues were histopathologically *** burden and gliotoxin concentration were evaluated in lung ***,superoxide dismutase,and malondialdehyde content were determined in lung ***,tumor necrosis factor-alpha,interleukin-1,and interleukin-17 were also estimated by the sandwich enzyme-linked immuno-sorbent ***:Calotropis gigantea/amphotericin B had a minimum inhibitory concentration and minimum fungicidal concentration of 80 and 160μg/mL,respectively,for Aspergillus ***,Calotropis gigantea/amphotericin B significantly reduced lung fungal burden by 72.95%and inhibited production of gliotoxin in lung tissues from 6320 to 1350μg/g *** gigantea/amphotericin B reduced the oxidative stress of the lung via elevating the activity of antioxidant enzymes and decreasing the levels of lipid *** activity and the production of pro-inflammatory cytokines were also significantly *** electron microscopy revealed deteriorations in the hyphae ultrastructure in Calotropis gigantea/amphotericin B trea

关键词： Aspergillus fumigatus Antifungal Invasive pulmonary aspergillosis Calotropis gigantea Amphotericin B Mice

Mathematical Morphology View of Topological Rough Sets and Its Applications

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Computers, Materials & Continua 2023年第3期74卷 6893-6908页

作者： Ibrahim Noaman Abd El Fattah El Atik Tamer Medhat manal E.ali Department of Mathematics Faculty of Science and Arts in Al-MandaqAl-Baha UniversityKingdom of Saudi Arabia Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Electrical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Physics and Engineering Mathematics Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt

This article focuses on the relationship between mathematical morphology operations and rough sets,mainly based on the context of image retrieval and the basic image correspondence *** morphological procedures and set approximations in rough set theory have some clear *** initiatives have been made to connect rough sets with mathematical *** significant publications have been written in this *** attempt to show a direct connection between mathematical morphology and rough sets through relations,a pair of dual operations,and neighborhood *** sets are used to suggest a strategy to approximatemathematicalmorphology within the general paradigm of soft computing.A single framework is defined using a different technique that incorporates the key ideas of both rough sets and mathematical *** paper examines rough set theory from the viewpoint of mathematical morphology to derive rough forms of themorphological structures of dilation,erosion,opening,and *** newly defined structures are applied to develop algorithm for the differential analysis of chest X-ray images from a COVID-19 patient with acute pneumonia and a health *** algorithm and rough morphological operations show promise for the delineation of lung occlusion in COVID-19 patients from chest *** foundations of mathematical morphology are covered in this *** that,rough set theory ideas are taken into account,and their connections are ***,a suggested image retrieval application of the concepts from these two fields is provided.

关键词： Mathematical morphology rough set theory topological spaces COVID-19