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Antibody engineering: facing new challenges in cancer therapy

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Acta Pharmacologica Sinica 2005年第6期26卷 641-648页

作者： Laura S■NZ ■ngel m CUESTA mana COmPTE Luis ■LVAREZ-VALLINA servicio de Inmunologia Hospital Universitario Puerta de Hterro madrid Spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro madrid Spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro madrid Spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro madrid Spntn

Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as "magic bullets". Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs, radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies.

关键词： immunoglobulin fragments monoclonal antibodies antibody formation gene therapy recombinant proteins biomedical engineering

Types of Irrigation Water and Soil Amendment Affect the Growth and Flowering of Petunia x alkinsiana ‘Bravo Pinc’

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 487-499页

作者： Abdullah m.Algahtani Fahed A.Al-mana Khalid m.Elhindi Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11671Saudi Arabia Department of Vegetable and Floriculture Faculty of AgricultureMansoura UniversityMansoura35516Egypt

Water insufficiency is the hampering feature of crop sustainability,especially in arid and semi-arid ***,the effectual usage of all water resources especially underground brackish water represents the core priority in Saudi *** present study aimed to recognize the influence of different types of water irrigation(tap water as a control,salinized well water,and magnetized salinized well water)with or without soil amendments(soil without any amendment as a control,peat-moss,ferrous sulfate,and peat-moss plus ferrous sulfate)on petunia plant growth and flowering as well as ion *** Petunia plants with saline well water adversely affected growth and flowering as compared to tap water and magnetized saline well ***,plants irrigated with magnetized water showed a significant enhancement in all the studied vegetative and flowering growth parameters as compared to those irrigated with salinized well ***,mineral contents and survival of Petunia plants irrigated with magnetized well water were higher than those irrigated with tap *** with magnetized well water significantly reduced levels of Na+and Cl−ions in leaves of Petunia plants indicating the role of magnetization in alleviating harmful effects of *** conclusion,we recommend the utilization of magnetized saline well water for irrigating Petunia plants either alone or in combination with soil amendments(peat moss plus ferrous sulfate).

关键词： Flowering magnetization petunia saline water soil amendment

Harvesting Energy Via Water movement and Surface Ionics in microfibrous Ceramic Wools

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Energy & Environmental materials 2024年第6期7卷 332-341页

作者： manpreet Kaur Avinash Alagumalai Omid mahian Sameh m.Osman Tadaaki Nagao Zhonglin Wang Research Center for materials Nanoarchitectonics(WPI-mana) National Institute for Materials Science(NIMS)1-1 NamikiTsukuba 305-0044IbarakiJapan Department of Chemical and Petroleum Engineering University of Calgary2500 University Dr.NWCalgaryAB T2N 1N4Canada Department of mechanical Engineering GMR Institute of TechnologyRajamAndhra Pradesh 532127India Faculty of mechanical Engineering and mechanics Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and PipelineNingbo UniversityNingbo 315211China Department of Chemical Engineering Imperial College LondonLondon SW72AZUK Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China Chemistry Department College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Condensed matter Physics Hokkaido UniversitySapporoHokkaido 060-0810Japan School of materials Science and Engineering Georgia Institute of TechnologyAtlanta 30332GAUSA Laboratory on Convective Heat and mass Transfer Tomsk State UniversityTomsk 634045Russia

Due to the push for carbon neutrality in various human activities,the development of methods for producing electricity without relying on chemical reaction processes or heat sources has become highly ***,the challenge lies in achieving microwatt-scale outputs due to the inherent conductivity of the materials and diverting electric *** address this challenge,our research has concentrated on utilizing nonconductive mediums for water-based low-cost microfibrous ceramic wools in conjunction with a NaCl aqueous solution for power *** main source of electricity originates from the directed movement of water molecules and surface ions through densely packed microfibrous ceramic wools due to the effect of dynamic electric double *** occurrence bears resemblance to the natural water transpiration in plants,thereby presenting a fresh and straightforward approach for producing electricity in an ecofriendly *** generator module demonstrated in this study,measuring 12×6 cm^(2),exhibited a noteworthy open-circuit voltage of 0.35 V,coupled with a short-circuit current of 0.51 *** low-cost ceramic wools are suitable for ubiquitous,permanent energy sources and hold potential for use as self-powered sensors and systems,eliminating the requirement for external energy sources such as sunlight or heat.

关键词： ceramic microfibers energy harvesting power generation self-powered systems water evaporation

Game changer:How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis mana

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World Journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio m Caballero-mateos Guillermo Arturo Cañadas-de la Fuente Department of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain Department of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancements in the treatment landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of Janus kinase(JAK)-signal transducer and activator of transcription *** novel agents offer a paradigm shift in UC management by targeting key signaling pathways involved in inflammatory *** approved JAK inhibitors(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to modulate immune responses and gene expression,potentially revolutionizing the treatment algorithm for *** trials have demonstrated the efficacy of JAKis in inducing and maintaining remission,presenting viable options for patients who have failed conventional ***-world data support the use of JAKis not only as first-line treatments but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of JAKis have broadened the possibilities in the management strategies of UC,offering timely relief for patients with active disease and facilitating personalized treatment *** safety concerns,including cardiovascular risks and infections,ongoing research and post-marketing surveillance will continue to refine our understanding of the risk-benefit profile of JAKis in UC management.

关键词： Ulcerative colitis Janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

Effect of Graphene Nanoribbons (TexasPEG) on locomotor function recovery in a rat model of lumbar spinal cord transection

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Neural Regeneration Research 2018年第8期13卷 1440-1446页

作者： C-Yoon Kim William K. A. Sikkema Jin Kim Jeong Ah Kim James Walter Raymond Dieter Hyung-min Chung Andrea mana James m. Tour Sergio Canavero Department of Stem Cell Biology School of Medicine Konkuk University Seoul Korea Department of Laboratory Animal medicine College of Veterinary Medicine Seoul National University Seoul Korea Department of Chemistry Department of Materials Science and NanoEngineering and The NanoCarbon Center Rice University Houston TXUSA Biomedical Omics Group Korea Basic Science Institute Cheongju-si Chungbuk Korea Research Service Hines Veterans Administration Hospital Hines IL USA HEAVEN/GEmINI International Collaborative Group Turin Italy

A sharply transected spinal cord has been shown to be fused under the accelerating influence of membrane fusogens such as polyethylene glycol （PEG）（GEmINI protocol）. Previous work provided evidence that this is in fact possible. Other fusogens might improve current results. In this study, we aimed to assess the effects of PEGylated graphene nanoribons （PEG-GNR, and called ＂TexasPEG＂ when prepared as lwt% dispersion in PEG600） versus placebo （saline） on locomotor function recovery and cellular level in a rat model of spinal cord transection at lumbar segment 1 （L1） level. In vivo and in vitro experiments （n -- 10 per experiment） were designed. In the in vivo experiment, all rats were submitted to full spinal cord transection at L1 level. Five weeks later, behavioral assessment was performed using the Basso Beattie Bresnahan （BBB） locomotor rating scale. Immunohistochemical staining with neuron marker neurofilament 200 （NF200） antibody and astrocyt- ic scar marker glial fibrillary acidic protein （GFAP） was also performed in the injured spinal cord. In the in vitro experiment, the effects of TexasPEG application for 72 hours on the neurite outgrowth of SH-SYSY cells were observed under the inverted microscope. Results of both in vivo and in vitro experiments suggest that TexasPEG reduces the formation of glial scars, promotes the regeneration of neurites, and thereby contributes to the recovery of locomotor function of a rat model of spinal cord transfection.

关键词： nerve regeneration spinal cord transfection spinal cord fusion GEmINI TexasPEG graphene nanoribbons

Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury

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Cellular & molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ryota Sakai minako Ito Kyoko Komai mana Iizuka-Koga Kazuhiko matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki masato Kubo Akihiko Yoshimura Department of microbiology and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan medical Institute of Bioregulation Kyushu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chemotherapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological Science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

Pharmacotechnical and Chemical Study of Paracetamol Sold in Kinshasa-DR Congo: Comparative Quality Assessment of Five Brands

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Open Journal of Applied Sciences 2022年第4期12卷 501-516页

作者： Jocelyn K. mankulu Eben-Ezer K. Ive Eugene m. Kagheni Timothy m. mavanga Daniel O. Opota Didi K. mana Laboratory of Drugs Analysis and Quality Control and Diets Survey (LACOmEDA) Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo Central Research Laboratory Catholic University of Graben Butembo Democratic Republic of the Congo Laboratory Pharmaceutics and Solid Forms (Tests Division) Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo

Paracetamol/Acetaminophen was assessed in different 5 brands comparatively to study its physicochemical and pharmaceutical parameters. We also evaluated the similarity among those brands. Widely used as an antipyretic and analgesic agent to cure fever and pain, the therapeutic efficacy of this product depends on both physicochemical and pharmaceutical qualities which include its conformity to standard specifications according to the active ingredient dosage in the formulation. This research work aimed to assess comparatively 5 paracetamol brands tablet form sold in the Democratic Republic of the Congo (particularly in Kinshasa), on their physicochemical and pharmaceutical tests conformities compared to the standard specifications. Based on tests, we evaluated the uniformity of weight, disintegration time, friability, crushing strength (hardness), and the active ingredient dosage per brand. The tests were performed using the SotaxTm apparatus according to standard methods following the pharmacopoeia protocols. And according to the performed tests, only the fifth brand of Paracetamol coded P5 did not satisfy the friability test. About the hardness test, we have also observed the unconformity of three brands (P1, P2, and P3) while both P4 and P5 satisfied the test. This leads us to conclude that among all the studied brands, only P5 satisfy to all the tests either pharmacotechnically or chemically (identification and dosage). And this study allowed us to re-examine the equivalence concept between several princeps (original brand) with their generics since that similarity depends on many parameters that need to be improved during the manufacturing process including in-process analysis in all the phases of preparation to evaluate the rate of either active ingredient or inactive ingredient because each component can affect seriously the final pharmaceutical formulation quality.

关键词： Quality Control Paracetamol Pharmacotechnical Chemical Study

Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases

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World Journal of Stem Cells 2016年第9期8卷 288-296页

作者： Taro Tsujimura mana Idei masahiro Yoshikawa Osamu Takase Keiichi Hishikawa Department of Advanced Nephrology and Regenerative medicine Division of Tissue EngineeringUniversity of Tokyo Hospital

The gene encoding bone morphogenetic protein-7(BmP7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of BmP7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BmP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to provide them with competence to respond to differentiation cues, each relying on distinct signaling pathways. Intriguingly, in the adult organ, BmP7 has been implicated in protection against and regeneration from injury. Exogenous administration of recombinant BmP7 to animal models of kidney diseases has shown promising effects in counteracting inflammation, apoptosis and fibrosis evoked upon injury. Although the expression pattern of BmP7 has been well described, the mechanisms by which it is regulated have remained elusive and the processes by which the secretion sites of BmP7 impinge upon its functions in kidney development and diseases have not yet been assessed. Understanding the regulatory mechanisms will pave the way towards gaining better insight into the roles of BmP7, and to achieving desired control of the gene expression as a therapeutic strategy for kidney diseases.

关键词： Bone morphogenetic protein-7 Therapeutics Kidney Development Nephron progenitor cells Disease Regeneration Chromatin conformation Gene expression Gene regulation

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海外英语 2006年第4期 4-5页

作者： mana Solavn 王海强

　　She stood at the front of the room, hands on hips, and faced us all as if we were prisoners."Keep in mind that I'm the boss,"she said. "You will do as you are told, and if you don't, I'll make your lives miserabl... 详细信息

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