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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors

Chinese Journal of Cancer Research 2024年第2期36卷 124-137页

作者： Jialin Zhang Gengshen Yin Chunmiao Ye man feng Changhua Ji Wenzhong Zhou Fei Wang Lixiang Yu Shuya Huang Zhigang Yu Department of Breast Surgery the Second Hospital of Shandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease Jinan 250033China Department of Pathology the Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031China Department of Pathology the Second Hospital of Shandong UniversityJinan 250033China

Objective: Primary resistance to trastuzumab frequently occurs in human epidermal growth factor receptor 2(HER2)-positive(+) breast cancer patients and remains a clinical challenge. Pyrotinib is a novel tyrosine kinase inhibitor that has shown efficacy in the treatment of HER2+ breast cancer. However, the efficacy of pyrotinib in HER2+ breast cancer with primary trastuzumab resistance is ***: HER2+ breast cancer cells sensitive or primarily resistant to trastuzumab were treated with trastuzumab, pyrotinib, or the combination. Cell proliferation, migration, invasion, and HER2 downstream signal pathways were analyzed. The effects of pyrotinib plus trastuzumab and pertuzumab plus trastuzumab were compared in breast cancer cells in vitro and a xenograft mouse model with primary resistance to ***: Pyrotinib had a therapeutic effect on trastuzumab-sensitive HER2+ breast cancer cells by inhibiting phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) and rat sarcoma virus(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)/extracellular-signal regulated kinase(ERK)pathways. In primary trastuzumab-resistant cells, pyrotinib inhibited cell growth, migration, invasion, and HER2 downstream pathways, whereas trastuzumab had no effects. The combination with trastuzumab did not show increased effects compared with pyrotinib alone. Compared with pertuzumab plus trastuzumab, pyrotinib plus trastuzumab was more effective in inhibiting cell proliferation and HER2 downstream pathways in breast cancer cells and tumor growth in a trastuzumab-resistant HER2+ breast cancer xenograft ***: Pyrotinib-containing treatments exhibited anti-cancer effects in HER2+ breast cancer cells sensitive and with primary resistance to trastuzumab. Notably, pyrotinib plus trastuzumab was more effective than trastuzumab plus pertuzumab in inhibiting tumor growth and HER2 downstream pathways in HER2+ breast cancer with primary resistance

关键词： Breast cancer HER2 pyrotinib trastuzumab primary resistance pertuzumab

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基于判决反馈的VDES解调系统设计与FPGA实现

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兵工学报 2024年第1期45卷 312-318页

作者：孙定柱冯熳狄芳陈鹏东南大学信息科学与工程学院江苏南京211100 三江学院数理部江苏南京210012

甚高频数据交换系统(Very high frequency Data Exchange System,VDES)作为新一代船舶通信系统,具有广阔的应用前景。由于卫星相对船舶的高速运动,VDES中上行应用特定消息(Application-specific Message,ASM)链路会产生较大的多普勒频移... 详细信息

甚高频数据交换系统(Very high frequency Data Exchange System,VDES)作为新一代船舶通信系统,具有广阔的应用前景。由于卫星相对船舶的高速运动,VDES中上行应用特定消息(Application-specific Message,ASM)链路会产生较大的多普勒频移,在接收端仅依靠已知训练序列估计的频偏等信道参数无法满足正确解调的性能要求。为此提出一种基于判决反馈的解调方法,通过分段解调,缩短每次解调的数据长度,提高解调时对频偏的容忍度,并利用每段解调的结果作为下一段未解调数据的导频,估计出当前数据中的信道参数。仿真结果表明,所提算法相较于无反馈相干解调算法性能大大提升。在上述研究的基础上,在可编程逻辑器件上实现了对ASM无导频上行链路的正确解调。

关键词：信号处理甚高频数据交换系统判决反馈可编程逻辑器件

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新型液阻式泵阀冲击特性研究

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流体机械 2024年第8期52卷 54-60页

作者：莫丽何任冯满刘傲西南石油大学机电工程学院成都610500 石油天然气装备技术四川省科技资源共享服务平台成都610500 四川宝石机械专用车有限公司四川广汉618300

为了降低阀芯与阀座冲击应力减小二者间冲击磨损,提出一种液阻式新型泵阀。采用数值仿真方法对泵阀液阻结构参数进行了优化,并仿真计算了阀芯与阀座的冲击速度和泵阀碰撞冲击的压力接触情况。对比分析了液阻泵阀和传统泵阀的运动特征及... 详细信息

为了降低阀芯与阀座冲击应力减小二者间冲击磨损,提出一种液阻式新型泵阀。采用数值仿真方法对泵阀液阻结构参数进行了优化,并仿真计算了阀芯与阀座的冲击速度和泵阀碰撞冲击的压力接触情况。对比分析了液阻泵阀和传统泵阀的运动特征及冲击应力结果,并搭建试验台架对仿真模型结果进行验证。结果表明,在阀芯下落阶段,带液阻结构的泵阀的回落速度明显小于传统泵阀,传统泵阀阀芯与阀座相接触的速度达到了0.118 m/s,而带液阻结构泵阀的阀芯与阀座相接触的速度仅为传统泵阀的1/6左右,约为0.02 m/s;带液阻结构的泵阀只发生了1次碰撞,而传统泵阀发生了2次碰撞,在碰撞时,带液阻结构的泵阀阀芯与阀座上的最大接触应力约为260 MPa,而传统泵阀第1次碰撞为190 MPa,第2次为270 MPa;液阻式泵阀能明显降低阀芯与阀座相接触的速度,降低冲击应力,从而减小泵阀的冲击磨损。研究结果可为液阻式泵阀的设计和应用提供参考。

关键词：压裂泵泵阀优化分析数值仿真液体阻尼冲击应力

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“互联网+”背景下大学英语语音缩微课堂教学模式探究——以兰州工商学院为例

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林区教学 2024年第2期 75-78页

作者：满凤兰州工商学院兰州730000

随着“互联网+”战略的不断深化,信息技术与教育的深度融合为大学英语语音教学创造了新的教学生态。作为英语语言能力发展前提的语音教学无疑是大学英语教学中的重要任务。然而,大学英语教学长期注重读写能力的提升而忽视了听说能力和... 详细信息

随着“互联网+”战略的不断深化,信息技术与教育的深度融合为大学英语语音教学创造了新的教学生态。作为英语语言能力发展前提的语音教学无疑是大学英语教学中的重要任务。然而,大学英语教学长期注重读写能力的提升而忽视了听说能力和语音意识的培养,严重制约了学生英语综合能力的提高。基于大学英语听说教学的现状,结合线上线下教学优势,短时高效的语音缩微课堂成为改变大学英语语音教学失衡现状、全面提升学生英语应用能力的有效途径。

关键词：大学英语语音教学缩微课堂互联网+

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基于5G物联网的智慧安全帽方案及分析

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智能建筑与智慧城市 2024年第5期 39-41页

作者：满运锋河南省通信工程局有限责任公司

如何高效、精准地保障施工作业人员的安全和企业防护用品信息智能统计,强化以人为本的安全保护意识,是目前各级通信施工企业关注的重点。文章从建设、使用和维护等角度,介绍5G模式下,作为承担施工现场安全重要设施之一的智慧安全帽的方... 详细信息

如何高效、精准地保障施工作业人员的安全和企业防护用品信息智能统计,强化以人为本的安全保护意识,是目前各级通信施工企业关注的重点。文章从建设、使用和维护等角度,介绍5G模式下,作为承担施工现场安全重要设施之一的智慧安全帽的方案设计及普及应用情况,通过物联网技术、云计算技术、5G移动互联网技术和相关传感产品,帮助运营商和通信施工企业第一时间发现人员、环境等异常状态,为及时应急响应创造条件。同时通过实际应用模型和商用情况,进一步阐述该模式下理论和实用成果在5G其他领域的发展前景。

关键词：智慧安全帽安全保护意识 5G

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人教版初中《英语》(Go for it!)八年级(下)Unit 6 An old man tried to move the *** A 1a-2c跨学科主题学习课教学设计与反思

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英语教师 2024年第12期24卷 33-36页

作者：冯满吴晓威(指导) 吉林省教育学院吉林长春130000

授课对象:八年级学生。一、课例背景。本课例由吉林省初中英语教研员冯满执教,授课时长为45分钟。《义务教育课程方案(2022年版)》(以下简称《方案》)提出,义务教育课程要加强课程内容与学生经验、社会生活的联系,注重培养学生在真实情... 详细信息

授课对象:八年级学生。一、课例背景。本课例由吉林省初中英语教研员冯满执教,授课时长为45分钟。《义务教育课程方案(2022年版)》(以下简称《方案》)提出,义务教育课程要加强课程内容与学生经验、社会生活的联系,注重培养学生在真实情境中运用知识解决问题的能力,开展跨学科主题学习,强化课程协同育人功能。

关键词：义务教育课程主题学习协同育人真实情境课例《英语》授课对象解决问题的能力

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Numerical Simulation of Innovative Operation of Blast Furnace Based on Multi-Fluid Model

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Journal of Iron and Steel Research International 2006年第6期13卷 8-15页

作者： CHU man-sheng YANG Xue-feng SHEN feng-man YAGI jun-ichiro NOGAMI Hiroshi Institute of Ferrous Metallurgy Northeastern University Shenyang 110004 Liaoning China School ofResource Processing and Bio-Engineering Central South University Changsha 410083 Hunan China Institute of Multidiseiplinary Research for Advanced Materials Tohoku University Sendal 980-8577 Japan

A multi-fluid blast furnace model was simply introduced and was used to simulate several innovative ironmaking operations. The simulation results show that injecting hydrogen bearing materials, especially injecting natural gas and plastics, the hydrogen reduction is enhanced, and the furnace performance is improved simultaneously. Total heat input shows obvious decrease due to the decrease of heat consumption in direct reduction, solution loss and silicon transfer reactions. If carbon composite agglomerates are charged into the furnace, the temperature of thermal reserve zone will obviously decrease, and the reduction of iron-bearing burden materials will be retarded. However, the efficiency of blast furnace is improved just due to the decrease in heat requirements for solution loss, sinter reduction, and silicon transfer reactions, and less heat loss through top gas and furnace wall. Finally, the model is used to investigate the performance of blast furnace under the condition of top gas recycling together with plastics injection, cold oxygen blasting and carbon composite agglomerate charging. The lower furnace temperature, extremely accelerated reduction rate, drastically decreased CO2 emission and remarkably enhanced heat efficiency were obtained by using the innovative operations, and the blast furnace operation with superhigh efficiency can be realized.

关键词： blast furnace innovative ironmaking technology multi-fluid blast furnace model

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体验式教学融入线上线下结合的“大学生心理健康教育”课程的改革探索

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吉林工程技术师范学院学报 2024年第5期40卷 81-88页

作者：冯缦刘燕杨馥聪甘肃农业大学甘肃兰州730070

本文介绍了体验式教学融入线上线下结合的“大学生心理健康教育”课程的课程准备、教学实施、效果评价、反思展望等情况,证实了“体验式教学+线上线下结合”的教学模式能够推动学生自主学习,实现“知、情、意、行”四个方面的教学目标,... 详细信息

本文介绍了体验式教学融入线上线下结合的“大学生心理健康教育”课程的课程准备、教学实施、效果评价、反思展望等情况,证实了“体验式教学+线上线下结合”的教学模式能够推动学生自主学习,实现“知、情、意、行”四个方面的教学目标,是顺应时代需求、符合心理发展规律的教学改革探索。

关键词：心理健康课程体验式教学模式信息技术网络学习

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Characterization of suspended solids and particle-bound heavy metals in a first flush of highway runoff

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1567-1575页

作者： Fa-hui NIE Tian LI Hai-feng YAO man feng Guang-kai ZHANG State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China Institute of Environment Engineering Research East China Jiaotong University Nanchang 330013 China

To investigate the dynamic characteristics of total suspended solids (TSS) and their particle-bound heavy metals in a first flush, the runoff sampling together with its flow rate measuring was conducted for three rainfall events at outfalls of highway in Shanghai from June to September 2007. Field samples were analyzed to determine the concentrations of TSS and particle-bound heavy metals, such as Zn, Pb, and Cu. Results show that the wash off behavior of TSS under varying runoff rate condition can be explained by different antecedent dry weather period (ADWP). Contribution of fine fraction (45 μm). When the runoff flow increased obviously, a significant contribution of the coarse fraction was observed for a certain rainfall events with long antecedent dry weather condition. The changes of total metals concentration and particle-bound metal concentrations were strongly dependent on the TSS variation. TSS was generally well correlated with most particulate-bound heavy metals. Of the heavy metals, the concentration of Zn was found considerably high and that of Pb was significantly low at North Zhongshan 2 Road, in Shanghai, China, but they are still within the range reported in the literature. Fluctuation of heavy metal contents in the coarse fraction during a first flush period was more significant compared with that in the fine fraction. The results will assist in the development of effective control strategies to minimize heavy metals and solids in highway runoff.

关键词： Heavy metals Highway runoff First flush Suspended solids (SS)

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Numerical Analysis of Blast Furnace Performance Under Charging Iron-Bearing Burdens With High Reducibility

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Journal of Iron and Steel Research International 2007年第2期14卷 13-19页

作者： CHU man-sheng GUO Xian-zhen SHEN feng-man YAGI Jun-ichiro NOGAMI Hiroshi Institute of Ferrous Metallurgy Northeastern University Shenyang 110004 Liaoning China Ironmaking Plant Anyang Steel Company Limited Anyang 455004 Henan China Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai 980-8577 Japan

The reducibility of iron-bearing burdens was emphasized for improving the operation efficiency of blast furnace. The blast furnace operation of charging the burdens with high reducibility has been numerically evaluated using a multi-fluid blast furnace model. The effects of reaction rate constants and diffusion coefficients were investigated separately or simultaneously for clarifying the variations of furnace state. According to the model simulation results, in the upper zone, the indirect reduction of the burdens proceeds at a faster rate and the shaft efficiency is enhanced with the improvement under the conditions of interface reaction and intra-particle diffusion. In the lower zone, direct reduction in molten slag is restrained. As a consequence, CO utilization of top gas is enhanced and the ratio of direct reduction is decreased. It is possible to achieve higher energy efficiency of the blast furnace, and this is represented by the improvement in productivity and the decrease in consumption of reducing agent. The use of high-reducibility burdens contributes to a better performance of blast furnace. More efforts are necessary to develop and apply highreducibility sinter and carbon composite agglomerates for practical application at a blast furnace.

关键词： blast furnace iron-bearing burden reducibility multi-fluid model 3-interface shrinking core model

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