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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI mamta BISHNOI NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP SINGH TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

Pichia as yeast cell factory for production of industrially important bio-products:Current trends,challenges,and future prospects

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生物质资源与工程(英文) 2023年第2期8卷 108-124页

作者： Akansha Shrivastava mamta Pal Rakesh Kumar Sharma Department of Biosciences Manipal University JaipurJaipur 303007India Sardar Swaran Singh National Institute of Bio-Energy Jalandhar 144601India

Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and *** a variety of biotechnological production hosts,a few specific genera of yeast have proven *** developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these *** this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia ***-edge solutions involving genetic and process engineering have also been ***,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like *** processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关键词： Natural product Pichia Non-conventional yeast Biosynthesis System biology Synthetic biology

An incremental learning approach for the text categorization using hybrid optimization

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International Journal of Intelligent Computing and Cybernetics 2019年第3期12卷 333-351页

作者： mamta Kayest Sanjay Kumar Jain Department of Computer Engineering National Institute of Technology KurukshetraKurukshetraIndia

Purpose–Document retrieval has become a hot research topic over the past few years,and has been paid more attention in browsing and synthesizing information from different *** purpose of this paper is to develop an effective document retrieval method,which focuses on reducing the time needed for the navigator to evoke the whole document based on contents,themes and concepts of ***/methodology/approach–This paper introduces an incremental learning approach for text categorization using Monarch Butterfly optimization–FireFly optimization based Neural Network(MB–FF based NN).Initially,the feature extraction is carried out on the pre-processed data using Term Frequency–Inverse Document Frequency(TF–IDF)and holoentropy to find the keywords of the ***,cluster-based indexing is performed using MB–FF algorithm,and finally,by matching process with the modified Bhattacharya distance measure,the document retrieval is *** MB–FF based NN,the weights in the NN are chosen using MB–FF ***–The effectiveness of the proposed MB–FF based NN is proven with an improved precision value of 0.8769,recall value of 0.7957,F-measure of 0.8143 and accuracy of 0.7815,***/value–The experimental results show that the proposed MB–FF based NN is useful to companies,which have a large workforce across the country.

关键词： Text categorization Monarch butterfly optimization Neural network Holoentropy,Cluster-based indexing Data mining

A Real-Time Integrated Face Mask Detector to Curtail Spread of Coronavirus

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Computer Modeling in Engineering & Sciences 2021年第5期127卷 389-409页

作者： Shilpa Sethi mamta Kathuria Trilok Kaushik Department of Computer Applications J.C.Bose University of Science and TechnologyFaridabad121102India R&D Department Samsung India Pvt.Ltd.Noida210301India

Effective strategies to control COVID-19 pandemic need high attention to mitigate negatively impacted communal health and global economy,with the brim-full horizon yet to *** the absence of effective antiviral and limited medical resources,many measures are recommended by WHO to control the infection rate and avoid exhausting the limited medical *** mask is among the non-pharmaceutical intervention measures that can be used as barrier to primary route of SARS-CoV2 droplets expelled by presymptomatic or asymptomatic *** of discourse on medical resources and diversities in masks,all countries are mandating coverings over nose and mouth in public *** contribution of public health,the aim of the paper is to devise a real-time technique that can efficiently detect non mask faces in public and thus enforce to wear *** proposed technique is ensemble of one stage and two stage detectors to achieve low inference time and high *** took ResNet50 as a baseline model and applied the concept of transfer learning to fuse high level semantic information in multiple feature *** addition,we also propose a bounding box transformation to improve localization performance during mask *** experiments are conducted with three popular baseline models namely ResNet50,AlexNet and *** explored the possibility of these models to plug-in with the proposed model,so that highly accurate results can be achieved in less inference *** is observed that the proposed technique can achieve high accuracy(98.2%)when implemented with ***,the proposed model can generate 11.07%and 6.44%higher precision and recall respectively in mask detection when compared to RetinaFaceMask detector.

关键词： Face mask detection transfer learning COVID-19 object recognition image classification

Design and simulation of nanoscale double-gate TFET/tunnel CNTFET

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Journal of Semiconductors 2018年第4期39卷 34-38页

作者： Shashi Bala mamta Khosla Department of Electronic and Communication Engineering Dr B R Ambedkar Natrional Institute of Technology Jalandhar-144011 India

A double-gate tunnel field-effect transistor （DG tunnel FET） has been designed and investigated for various channel materials such as silicon （Si）, gallium arsenide （GaAs）, alminium gallium arsenide （A1xGa1-xAs） and CNT using a nano ViDES Device and TCAD SILVACO ATLAS simulator. The proposed devices are com- pared on the basis of inverse subthreshold slope （SS）, ION/IoFF current ratio and leakage current. Using Si as the channel material limits the property to reduce leakage current with scaling of channel, whereas the A1xGa1-xAs based DG tunnel FET provides a better ION/IOFF current ratio （2.51 × 10^6） as compared to other devices keeping the leakage current within permissible limits. The performed silmulation of the CNT based channel in the double-gate tunnel field-effect transistor using the nano ViDES shows better performace for a sub-threshold slope of 29.4 mV/dec as the channel is scaled down. The proposed work shows the potential of the CNT channel based DG tunnel FET as a futuristic device for better switching and high retention time, which makes it suitable for memory based circuits.

关键词： band-to-band tunneling (BTBT) double gate (DG) silicon (Si) gallium arsenide (GaAs) aluminum gallium arsenide (AlxGa1 xAs) tunnel field effect transistor (FET) carbon nanotube (CNT)

Natural and artificial small RNAs:a promising avenue of nucleic acid therapeutics for cancer

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Cancer Biology & Medicine 2017年第3期14卷 242-253页

作者： Sunny Yadav mamta Shekhawat Devashree Jahagirdar Nilesh Kumar Sharma Cancer and Translational Research Lab Dr.D.Y Patil Biotechnology&Bioinformatics InstituteDr.D.Y.Patil VidyapeethPune 411033MaharashtraIndia

Since the failure of traditional therapy, gene therapy using functional DNA sequence and small RNA/DNA molecules(oligonucleotide) has become a promising avenue for cancer treatment. The discovery of RNA molecules has impelled researchers to investigate small regulatory RNA from various natural and artificial sources and determine a cogent target for controlling tumor progression. Small regulatory RNAs are used for therapeutic silencing of oncogenes and aberrant DNA repair response *** their advantages, therapies based on small RNAs exhibit limitations in terms of stability of therapeutic drugs, precisionbased delivery in tissues, precision-based intercellular and intracellular targeting, and tumor heterogeneity-based responses. In this study, we summarize the potential and drawbacks of small RNAs in nucleic acid therapeutics for cancer.

关键词： Cancer drug targeting gene intracellular therapeutics tumor heterogeneity

Radiation effect on temperature distribution in three-dimensional Couette flow with suction or injection

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Applied Mathematics and Mechanics(English Edition) 2007年第3期28卷 309-316页

作者： Bhupendra Kumar Sharma mamta Agarwal R.C.Chaudhary Department of Mathematics University of RajasthanJaipur-302004India

A theoretical analysis of three-dimensional Couette flow with radiation effect on temperature distribution has been analysed, when the injection of the fluid at the lower stationary plate is a transverse sinusoidat one and its corresponding removal by constant suction through the upper porous plate is in uniform motion. Due to this type of injection velocity, the flow becomes three-dimensional. The effect of Prandtl number, radiation parameter and injection parameter on rate of heat transfer has been examined by the help of graphs. The Prandtl number has a much greater effect on *** distribution than the injection or radiation parameter.

关键词： Couette flow three-dimensional heat transfer radiation incompressible

Compact model for ballistic single wall CNTFET under quantum capacitance limit

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Journal of Semiconductors 2016年第10期37卷 48-55页

作者： Amandeep Singh mamta Khosla Balwinder Raj Department of Electronics & Communication National Institute of Technology Jalandhar Punjab India

This paper proposes a compact model for carbon nanotube field effect transistor（CNTFET） based on surface potential and conduction band minima. The proposed model relates the I–V characteristics to chirality under quantum capacitance limit. C–V characteristics have been efficiently modelled for different capacitance models which are used to find the relationship between CNT surface potential and gate voltage. The role of different capacitances is discussed and it has been found that the proposed circuit compact model strictly follows quantum capacitance limit. The proposed model is efficiently designed for circuit simulations as it denies self-consistent numerical simulation. Furthermore, this compact model is compared with experimental results. The model has been used to simulate an inverter using HSPICE.

关键词： carbon nanotube(CNT) device modelling ballistic CNTFET quantum capacitance

Changes in organic structure and mineral phases transformation of coal during heat treatment on laboratory scale

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International Journal of Coal Science & Technology 2016年第4期3卷 418-428页

作者： Vivek Mishra mamta Sharma Sanchita Chakravarty Amit Banerjee CSIR - National Metallurgical Laboratory Jamshedpur 831007 India

Structural changes due to coalification and oxidation influence the coal quality, geochemically and petrologically. Understanding of the coal structures helps to predict the behaviour of coal at various processes. The objective of this paper is to study the changes in organic structure and mineral phase transformation during combustion. Different density fractions were generated and then heated at different temperatures from 200 to 1000 ℃. Petrography, Fourier transform infrared spectroscopy （FTIR） and X-ray diffraction （XRD） were carried out on all the density fractions aimed to accomplish this objective. Here, through petrography, it was observed that the vitrinite and liptinite macerals disappear at higher temperature while porous inertinite is seen. The inertinite structure is exposed which is assumed by the presence of -OH and C-O-C stretches with the aromatic nucleus （CH） and three to four adjacent H from FTIR spectra. Moreover, it can be concluded that aliphatic groups get collapsed at high temperature. In case of inorganic matter, through XRD and FTIR, it is also revealed that with increasing temperature, clay minerals converted into elemental oxides. Hence, this study is suggesting that the structures of coal are altered by the degree of contact metamorphism.

关键词： Coal Heat treatment Oxidation Petrography FTIR XRD