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Open Journal of Pediatrics 2024年第2期14卷 327-337页

作者： Bangoura Mmah Aminata Kolié Ouo Ouo Camara Salématou Hassimiou Baldé Mariama Bangoura Kaba diop mamadou Moustapha Camara Emmanuel Diallo Fatoumata Binta Doukouré mamadou Aliou mamadou Mouctar Sow Bémy Pé Néabey Institut de Nutrition et de Santé de l’Enfant Conakry Guinea Service de Pédiatrie Hô pital National Donka Conakry Guinea Service de Pédiatrie Hô pital National d’Ignace Deen Conakry Guinea

Introduction: The birth of a baby is a moment of joy and celebration. However, the neonatal period is a very delicate phase of life. Neonatal mortality rates remain high in low-income countries. In Guinea, after 20 years, this rate has fallen from 34.2% in 1998 to 32% in 2018. Objective: To identify the main risk factors for neonatal mortality. Methods: This was an observational, analytical case-control study, lasting 6 months from January 1 to June 30, 2019, conducted at the Institut de Nutrition et de la Santé de l’Enfant (INSE) at Donka National Hospital. Results: We collected 242 cases and 242 controls, i.e. a total of 484 records. 748 patients were registered, with 32.35% deaths. 82.86% of deaths occurred in the early neonatal period. Statistical analysis revealed the main risk factors: prematurity (RQ 7.39 95% CI 3.27 - 16.61 p = 0.0000003), hypothermia (RQ 2.29 95% CI 1.51 - 3.46 p = 0.0001), acute fetal distress (RQ 2.13 95% CI 1.33 - 3.43 p = 0.0016), low birth weight (QR 1.91 95% CI 1.12 - 3.24 p = 0.016), home birth (QR 3.26 95% CI 1.25 - 8.46 p = 0.015). Conclusion: Neonatal mortality is a health problem in the INSE neonatology department. To reduce the mortality rate in this referral facility, it is essential to equip it and provide ongoing training for staff.

关键词： Neonatal Mortality INSE Guinea-Conakry

Nutritional Profile of Children with Major Sickle Cell Syndrome at the Centre of Medical and Health Advice of Kipé, Conakry, 2018

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Case Reports in Clinical Medicine 2024年第3期13卷 73-84页

作者： mamadou Aliou Doukoure Ibrahima Sory Diallo M’mah Aminata Bangoura Amadou Oury Toure mamadou Moustapha diop Fatoumata Binta Diallo Mohamed Sama Cherif Thierno Saidou Diallo Saidouba Cherif Camara Abdoulaye Toure Faculty of Health Science and Technology Gamal Abdel Nasser University Conakry Guinea National AIDS Control Programme Ministry of Health Gamal Abdel Nasser University Conakry Guinea

Introduction: Growth is a reflection of a child’s health and nutritional status. Children with sickle cell disease often have slower statural and weight development. The aim of this study was to evaluate the nutritional profile of children with sickle cell disease (SCD) registered in the CEMECO centre database. Methodology: This was a cross-sectional study with simple random sampling of children aged 1 to 16 years registered in the clinic database. Results: We collected information on 208 children, 121 of whom had sickle cell disease and 87 of whom were normal, with a sex ratio of 1.02. The mean age of the sickle cell patients was 8.7 ± 4.4 years, while that of the non-sickle cell patients was 9.5 ± 4 years. Haemoglobin electrophoresis revealed 103 homozygous (SS), 18 double heterozygous (SC, SBetaThal, SE) and 87 normal (AA) and/or sickle cell trait (AS) sickle cell cases. We observed a significant difference in the height/age ratio (P ¥). Conclusion: The results of our study revealed stunted growth in children with sickle cell disease.

关键词： Sickle Cell Disease Nutrition Growth Puberty Guinea

Child Victims of Road Traffic Accidents: Epidemiological and Clinical Aspects in the Medical and Surgical Emergency Department of the Donka National Hospital

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Case Reports in Clinical Medicine 2024年第3期13卷 63-72页

作者： Ibrahima Sory Diallo mamadou Moustapha diop Amadou Oury Toure mamadou Aliou Doukouré Aîssata Barry M’mah Aminata Bangoura Mariama Sadjo Diallo Abdoulaye Oumare Diallo Salimatou Hassimiou Camara Thierno mamadou Aliou Touré Ouo Ouo Kolié Mohamed Lamine Diallo Fatoumata Binta Diallo Ibrahima Sory Souaré Institute of Child Nutrition and Health Conakry Guinea Department of Pediatrics Donka National Hospital Conakry Guinea UNICEF-Guinea Community Health Section Conakry Guinea Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: Children involved in road accidents most often suffer head or limb injuries. The severity of these injuries varies according to the age of the child, the type of road user and whether or not protective devices are used. The aim of this study was to carry out a census of admissions and to identify the epidemiological and clinical profile of children involved in road traffic accidents at Donka National Hospital. Methods: This is a descriptive cross-sectional study of children involved in traffic accidents over a 3-month period from September 1 to November 30, 2021. All children admitted to the emergency department for a traffic accident were included in the study. Results: During the study period, 435/530 children (82.1%) were victims of road accidents. Boys accounted for 54.94% of cases, compared with 45.06% for girls. The age group most affected was 12-17 years old (48.97%). October had the highest accident rate (36.4%). Pedestrians are most affected (52.87%). Bicycles and mopeds were involved in 59.77% of accidents. Head injury was the most frequent pathology (33.33%). The study showed that 12.64% of victims were referred to intensive care, pediatric surgery, etc. We recorded 8 cases of death (1.84%). Conclusion: This study highlighted the characteristics, incidence and risk factors for accidents in children admitted to emergency departments. Accident prevention, particularly serious accidents in children, requires more precise knowledge of the factors and circumstances leading to their occurrence.

关键词： Child Accident Public Highway Donka

Neutral stochastic delay partial functional integro-differential equations driven by a fractional Brownian motion

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Frontiers of Mathematics in China 2013年第4期8卷 745-760页

作者： Tomas CARABALLO mamadou Abdoul diop Dpto. Ecuaciones Diferenciales y Analisis Numerico Universidad de Sevilla Apdo. de Correos 1160 41080-Sevilla Spain Universite Gaston Berger de Saint-Louis UFR SAT Departement de Mathematiques 234 Saint-Louis Senegal

This paper deals with the existence and uniqueness of mild solutions to neutral stochastic delay functional integro-differential equations perturbed by a fractional Brownian motion BH, with Hurst parameter H E （1/2, 1）. We use the theory of resolvent operators developed by R. Grimmer to show the existence of mild solutions. An example is provided to illustrate the results of this work.

关键词： Resolvent operator C0-semigroup Wiener process mild solution fractional Brownian motion

Nonparametric estimation for stationary and strongly mixing processes on Riemannian manifolds

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Communications in Mathematics and Statistics 2022年第4期10卷 599-621页

作者： Amour T.Gbaguidi Amoussou Freedath Djibril Moussa Carlos Ogouyandjou mamadou Abdoul diop IMSP Universitéd’Abomey-Calavi(UAC)DangboBenin FAST Universitéd’Abomey-CalaviAbomey-CalaviBenin UniversitéGaston Berger DakarSenegal

In this paper,nonparametric estimation for a stationary strongly mixing and manifoldvalued process(X_(j))is *** this non-Euclidean and not necessarily i.i.d setting,we propose kernel density estimators of the joint probability density function,of the conditional probability density functions and of the conditional expectations of functionals of X_(j)given the past behavior of the *** prove the strong consistency of these estimators under sufficient conditions,and we illustrate their performance through simulation studies and real data analysis.

关键词： Riemannian manifolds Nonparametric estimation Kernel density estimation Stationary and strongly mixing processes Strong consistency

Conjugate Gradient Method to Solve Fluid Structure Interaction Problem

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Applied Mathematics 2017年第4期8卷 444-452页

作者： mamadou diop Ibrahima Mbaye Thies University Thies Senegal Department of Mathematics and Computer Science Thies University Thies Senegal

In this paper, we propose a method to solve coupled problem. Our computational method is mainly based on conjugate gradient algorithm. We use finite difference method for the structure and finite element method for th... 详细信息

关键词： Fluid-Structure Interaction Beam Stokes Finite Element Finite Difference Method Conjugate Gradient Method

How a Cancer Registry Was Set Up in Senegal: An Example to Follow for a Developing Country

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Journal of Cancer Therapy 2023年第9期14卷 382-389页

作者： Salif Baldé Sokhna diop Niang Oumar Ba mamadou diop Joliot Curie Institute Aristide Le Dantec Hospital Dakar Senegal Departmentof Internal Medicine Dalal Jamm Hospital Dakar Senegal Department of Internal Medicine Idrissa Pouye Hospital Dakar Senegal

Objectives: Senegal, with the support of WHO, had begun the establishment of a National Cancer Registry in 2009, although it had been at a standstill since 1969;the objective of this work was to test the reliability of data collection tools and feasibility stages necessary for the validation of media before the establishment of a national cancer registry. Methodology: We conducted a non-exhaustive preliminary study over a period of three months from the first of January to 31 March 2010 at four major hospitals in Dakar at the time. Results: Two hundred and eighty-nine cases had been identified: 44% of men (n = 127) and 56% of women (n = 162) with a sex ratio of 0.8. The ages ranged from 20 to 90 years with an average of 50 years. The main diagnostic mode was essentially histological, with 76% of cases (n = 219). The most frequent locations were: ORL (ENT meaning Ear, Nose and Throat) with 25% of cases, liver 7% and bronchopulmonary 4.5% of cases. In men, liver cancer was the most common location and women for cervical cancer with 16%. Squamous cell carcinoma was the most common histological type with 68% of cases followed by adenocarcinoma with 22% of cases. Thirty-eight percent of patients were classified as stage III and IV. A quarter of our patients had received palliative treatment. In contrast, 15 (15%) had received chemotherapy and 4% had received radiotherapy. Data collection was satisfactory. Conclusion: Cancer is a reality in Senegal but it remains underdiagnosed. The materials made it possible to make the cancer registry effective throughout the country.

关键词： Registry Cancer Senegal

Peripheral Neuropathies Revealing Gougerot-Sjögren’s Syndrome: Description of 3 Cases

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Neuroscience & Medicine 2022年第3期13卷 120-125页

作者： Ndiaga Matar Gaye Alassane mamadou diop Khalifa Ababacar Mbaye Serigne Abdou Aziz Fall mamadou Ka Momo Banda Ndiaye Maouly Fall Moustapha Ndiaye Amadou Gallo diop Neuroscience Department Fann Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal

Introduction: Sjögren’s syndrome is an autoimmune epithelitis with various extraglandular signs, among which are neurological, with a variable frequency according to studies. We report three cases of peripheral neuropathy revealing Gougerot-Sjögren’s syndrome, collected in the Neurology Department of the Fann University Hospital in Dakar (Senegal). Observations: The first patient, aged 48 years, presented with a length-dependent sensitivomotor polyneuropathy associated with retrobulbar optic neuritis, with dry eyes and dry mouth noticed by the patient for several years. The second patient, aged 28 years, was admitted to the hospital with chronic generalized paresthesia in the context of xerostomia and xerophthalmia. The results of the clinical examination and the electroeneuromyogram were in favour of pure sensory neuronopathy. The third patient was 32 years old female, with a history of thyroidectomy and acute inflammatory demyelinating polyneuropathy (AIDP), who was seen for acute ascending flaccid tetraplegia with facial diplegia, preceded by diffuse paresthesia. The diagnosis of recurrence of acute demyelinating polyradiculonueropathy was retained in view of the rapidly increasing character of the deficit, the hyperproteinorachy at the lumbar puncture, and the signs of demyelination at the ENMG. The diagnosis of Gougerot-Sjögren’s syndrome in our three patients was established on the basis of the 2016 ACR/EULAR criteria. Indeed, the anti-SSA antibodies (Ro) were positive in our 3 patients with a biopsy of the salivary glands which showed stage 3 in the first patient and stage 4 in the two others. Corticosteroid therapy and immunosuppressive treatment resulted in a favourable clinical evolution on the neurological and general levels. Conclusion: Gougerot-Sjögren’s syndrome is an autoimmune exocrinopathy that may present with peripheral neuropathy, which may precede the diagnosis of Sjögren’s syndrome, be concomitant or occur during the co

关键词： Sjögren’s Syndrome Peripheral Neuropathy Salivary Gland Biopsy Senegal

Carotid Web as a Cause of Ischemic Stroke in Sub-Saharan Africa: A Preliminary Monocentric Descriptive Study of 6 Cases Collected at the Fann Teaching Hospital (Senegal)

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World Journal of Cardiovascular Diseases 2022年第3期12卷 133-139页

作者： Ndiaga Matar Gaye Alassane mamadou diop Adjaratou Dieynabou Sow Abdoul Salam Soumaré Didier Smadja Moustapha Ndiaye Sokhna Ba Amadou Gallo diop Neurology Department Fann Teaching Hospital Dakar Senegal Stroke Unit Centre Hospitalier Sud-Francilien Corbeil-Essones France Radiology Department Fann Teaching Hospital Dakar Senegal

Introduction: Carotid web (CW), a rare and probably unknown arterial cause of ischemic stroke (IS), is commonly reported in young black patients, although most of the published cases resided in a non-African country. We describe the features of the first six Senegalese cases diagnosed at the Neurology Department of the Fann Teaching Hospital in Dakar. Patients and Method: It was a preliminary retrospective and prospective study conducted at the Neurology department of Fann teaching hospital (Dakar-Senegal). The symptomatic CW diagnosis was based on angioCT-scan of the neck arteries. The National Institute of Health Stroke Scale (NIHSS) and the modified-Rankin Scale (mRS) were used to assess the severity of the IS and the functional disability after the event, respectively. Results: CW was causing a left sylvian infarction in 4 patients. The mean age of the patients at the IS diagnosis was 41 ± 6 years with a sex ratio of 1. The mean time to diagnosis of CW was 13 months. Smoking (1/6), hypertension (1/6), and obesity (1/6) were the main vascular risk factors. The mean LDL cholesterol level was 1.52 g/L ± 0.49. The mean initial NIHSS was 15 ± 6 (8-22). Half of the patients had a severe infarction (NIHSS ≥ 15). For secondary prevention, half of the patients were treated with aspirin and the other half with acenocoumarol. After 18 months ± 17 of follow-up, the mean mRS score was 2 ± 1 (1-3). Conclusion: CW is an unknown cause of IS in young black patients. An early and appropriate multidisciplinary management could help to reduce the risk of recurrences.

关键词： Carotid Web Sub-Saharan Africa Senegal AngioCT-Scan Acenocoumarol

Retinoblastoma: Socio-Demographic, Clinical and Therapeutic Aspects in the Hemato-Oncology Unit of the Department of Pediatrics of Donka National Hospital, Guinea

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Open Journal of Pediatrics 2020年第3期10卷 561-569页

作者： Aïssata Barry mamadou M. diop mamadou A. Doukoure Emmanuel Camara Saliou B. Diallo Narcisse V. Gateu Tadjom Fatoumata Barry Hasmiou Dia Boubacar Togo mamadou P. Diallo Department of Pediatrics National Hospital Donka Conakry Guinea Department of Pediatrics Ignace Deen Hospital Conakry Guinea Departmentof Pediatrics Gabriel Toure Hospital Bamako Mali Medical and Health Counseling Center Conakry Guinea

Introduction: Retinoblastoma is one of the pediatric malignancies and its treatment is still challenging. The objective of this study was to highlight the sociodemographic, clinical, and therapeutic aspects of retinoblastoma at the Donka Paediatric Haematology/Oncology unit in Donka university hospital, Guinea, and thereby highlight the conditions of this malignancy in this country. Methods: This was a retrospective study over 3 years (January 1, 2017 to December 31, 2019). The study population was all retinoblastoma patients who were treated in this unit. Socio-demographic, clinical, and therapeutic data were analyzed. Results: Out of 210 pediatric patients followed up for cancer in this unit during the period, retinoblastoma accounted for 46 (22%). The patient age at diagnosis was 35.17 months (range: 3 - 132 months). At admission, metastases were observed in 16 patients (35%): 14 with brain metastases and 2 with lymph node metastases. Preoperative chemotherapy was employed in 38 (83%), tumor resection was performed in 20 patients (43%), and postoperative chemotherapy was performed in 19 patients. As for the prognosis, remission in 9, death in 14, and treatment discontinuation in 15. Only one patient had health insurance (2%). Conclusion: In this region of Guinea, retinoblastoma is the most common ocular tumor in children. Its diagnosis is easy: strabismus and leukocoria are the early signs of retinoblastoma. The prognosis depends on how early the diagnosis is made. Physicians, care-givers, and family members should be aware of the nature of this malignancy and social education/message as such is necessary.

关键词： Retinoblastoma Leukocoria Chemotherapy Enucleation