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增生性多中心网状组织细胞增生症合并子宫内膜乳头状浆液性癌

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 13-14页

作者： malik m.K. Regan L. Robinson-Bostom L. 崔荣 Department of Dermatology Brown Medical School Rhode Island Hospital-APC 10 593 Eddy St Providence RI 02903 United States Dr

multicentric reticulohistiocytosis (mRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although mRH is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of mRH with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of endometrial carcinoma. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki- 67. Treatment of endometrial carcinoma resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of mRH.

关键词：多中心网状组织细胞增生症组织细胞增生性疾病子宫内膜乳头状浆液性癌子宫内膜癌疾病恶化皮肤活检肿瘤性疾病 Ki-67 肿瘤相关关节症状

Treatment Initiation among Patients with multidrug Resistant Tuberculosis in Bhopal District, India

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Journal of Tuberculosis Research 2017年第4期5卷 237-242页

作者： Hemant Deepak Shewade Arun m. Kokane Akash Ranjan Singh manoj Verma malik Parmar Sanjay Singh Chahar manoj Tiwari Sheeba Naz Khan mukesh Nagar Sanjai Kumar Singh Pradeep Kumar mehra Ajay m. V. Kumar International Union against Tuberculosis and Lung Disease (The Union) South-East Asia Office New Delhi India Department of Community medicine and Family medicine All India Institute of Medical Sciences (AIIMS) Bhopal India State TB cell Department of Health and Family Welfare Bhopal India World Health Organization Country Office in India New Delhi India International Union against Tuberculosis and Lung Disease (The Union) Paris France

Revised national tuberculosis control programme in India has limited co-hort-wise information about what happens to patients diagnosed with multidrug resistant TB (mDR-TB). We determined the pre-treatment loss to follow-up (non-initiation of treatment by programme within 6 months of diagnosis) and time from diagnosis to treatment initiation in Bhopal district, central India (2014). Pre-treatment loss to follow-up was 13% (0.95 CI: 7%, 23%), not significantly different from the national estimates (18%) and median time to initiate treatment was seven days, lower than that reported elsewhere in the country. Bhopal was performing well with reference to time to treatment initiation in programmatic settings.

关键词： multidrug-Resistant Tuberculosis Operational Research Pre-Treatment Attrition Diagnosis and Treatment Pathway Initial Loss to Follow-Up

Comparison of Radial Basis Function Neural Network and Response Surface methodology for Predicting Performance of Biofilter Treating Toluene

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Journal of Software Engineering and Applications 2012年第8期5卷 595-603页

作者： Sharvari C. Deshmukh J. Senthilnath Rashmi m. Dixit Sameena N. malik Ram A. Pandey Atul N. Vaidya Subbaramajois N. Omkar Sandeep N. mudliar Department of Aerospace Engineering Indian Institute of Sciences Bangalore India Environmental Biotechnology Division National Environmental Engineering and Research Institute Nagpur India Solid Waste management Division National Environmental Engineering and Research Institute Nagpur India

Biofiltration is emerging as a promising cost effective technique for the Volatile Organic Compounds (VOCs) removal from industrial waste gases. In the present investigation a comparative modeling study has been carried out using Radial Basis Function Neural Network (RBFN) and Response Surface methodology (RSm) to predict and optimize the performance of a biofilter system treating toluene (a model VOC). Experimental biofilter system performance data collected over a time period by daily measurement of inlet VOC concentration, retention time, pH, temperature and packing moisture content was used to develop the mathematical model. These independent variables acted as the inputs to the mathematical model developed using RSm and RBFN, while the VOC removal efficiency was the biofilter system performance parameter to be predicted. The data set was divided into two parts: 60% of data was used for training phase and remaining 40% of data was used for the testing phase. The average % error for RSm and RBFN were 7.76% and 3.03%, and R2 value obtained were 0.8826 and 0.9755 respectively. The results indicated the superiority of RBFN in the prediction capability due to its ability to approximate higher degree of nonlinearity between the input and output variables. The optimization of biofilter parameters was also done using RSm to optimize the biofilter performance. RSm being structured in nature enabled the study of interaction effect between the independent variables on biofilter performance.

关键词： VOC Toluene Biofilter Response Surface methodology Radial Basis Function Neural Network

Identification of DNA markers for Cotton Leaf Curl Disease (CLCD) in Cotton (Gossypium hirsutum L. )

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棉花学报 2002年第S1期14卷 17-17页

作者： mehboob-ur-RAHmAN N.ASLAm m.ASIF T.A.malik K.A.malik Y.ZAFAR National Institute for Biotechnology and Genetic Engineering(NIBGE) PO Box 577 Jhang Road FaisalabadPakistanNational Institute for Biotechnology and Genetic Engineering(NIBGE) PO Box 577Jhang Road FaisalabadPakistanNational Institute for Biotechnology and Genetic Engineering(NIBGE) PO Box 577Jhang Road FaisalabadPakistanDepartment of Plant Breeding & Genetics(PBG)University of Agriculture Faislolbad PakistanNational Institute for Biotechnology and Genetic Engineering(NIBGE) PO Box 577Jhang Road FaisalabadPakistanNational Institute for Biotechnology and Genetic Engineering(NIBGE) PO Box 577Jhang Road FaisalabadPakistan

Epidemic of cotton leaf curl virus disease(CLCD)was the compelling factor to devise newstrategies in cotton breeding programs *** evaluation of cotton genotypesagainst the CLCD resistance is difficult,expensive and ti... 详细信息

关键词： Cotton Gossypium cotton breeding greenhouse consuming expensive devise programs populations

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累及肛门的寻常型天疱疮

世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 5-6页

作者： malik m. El Tal A.-E.-K. Ahmed A.R. 纪泛扑 Center for Blistering Diseases New England Baptist Hospital70 Parker Hill AvenueBostonMA 02120United States.Dr

INTRODUCTION: Anal involvement in patients with pemphigus vulgaris has rarely been reported. We report 16 pemphigus vulgaris patients with anal involvement. mETHODS: We retrospectively reviewed the clinical data on 16 patients treated at a tertiary dermatology referral center. RESULTS: Of 16 patients with anal involvement of pemphigus vulgaris, ten were female and six were male. The mean age of onset was 56 (range, 37-82) years. All patients had involvement of pemphigus vulgaris at multiple sites, including oral involvement. Recurrent episodes of anal pemphigus vulgaris were noted in nine (56 percent) patients, with a mean of 2.4 recurrences (range, 1-11). In all patients, pemphigus vulgaris was controlled with systemic and local therapy. Long-term follow-up for a mean of 53 (range, 4-188) months indicated that no long-term sequela occurred because of anal involvement. CONCLUSIONS: Anal involvement in pemphigus vulgaris is not very common and generally occurs in patients with severe disease. With appropriate topical and systemic therapy, patients have full recovery with no sequelae.

关键词：寻常型天疱疮远期后遗症发病年龄临床资料一所

Assessment of Biochemical and Antioxidative Status in Patients Suffering from Dengue Fever

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Journal of Huazhong University of Science and Technology(medical Sciences) 2015年第3期35卷 411-418页

作者： mahmood Rasool Arif malik Khalid mahmud Khan muhammad Saeed Qureshi Beenish Shabbir Sara Zahid muhammad Asif Abdul manan Sana Rashid Saima Rubab Khan Hafiz muhammad Arsalan Rabail Alam mahwish Arooj mahmood Husain Qazi Adeel Gulzar Ahmed Chaudhary Adel mohammed Abuzenadah mohammed Hussain Al-Qahtani Sajjad Karim Center of Excellence in Genomic medicine Research Faculty of Applied Medical SciencesKing Abdulaziz University Institute of molecular Biology and Biotechnology the University of Lahore Fatima Jinnah medical College Sir Gangaram Hospital Lahore Institute of molecular Biology and Biotechnology the University of Lahore Department of Biotechnology and Informatics BUITEMS Quetta 87300 Pakistan Center for Research in molecular medicine the University of Lahore KACST Technology Innovation Center in Personalized medicine King Abdulaziz University Center of Excellence in Genomic medicine Research Faculty of Applied Medical Sciences King Abdulaziz University

Summary：A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever（DF） by evaluating biochemical and oxidative status of patients. ELISA Ig m antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever（DHF） and dengue shock syndrome（DSS） showed significant difference. Significant increases in serum alanine amino transferase（ALT）（P=0.000）, aspartate amino transferase（AST）（P=0.000）, alkaline phosphatase（ALP）（P=0.000）, malondialdehyde（mDA） along with significant decreases in total protein（TP）（P=0.000）, reduced glutathione（GSH）（P=0.000）, superoxide dismutase（SOD）, catalase（CAT）（P=0.000）, and sialic acid contents（P=0.016） were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants（r=0.656, P=0.016）. In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.

关键词： dengue fever alanine amino transferase aspartate amino transferase malondialdehyde superoxide dismutase catalase

Isolate a Gene for Velvet Hairiness in Cotton(Gossypium hirsutum L.)by map-based Cloning

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棉花学报 2002年第S1期14卷 25-25页

作者： mehboob-ur-RAHmAN m.A.I.ALI S.A.RANDNAWA T.A.malik K.A.malik Y.ZAFAR National Institute for Biotechnology and Genetic Engineering(NIBGE)PO Box 577 Jhang Road FaisalabadPakistan Department of Plant Breeding&Genetics(PBG) University of Agriculture Faisalabad Pakistan

Cotton crop is prone to many insect *** dense pubescence(pilose/velvet hairy),one of the important elements of defenseumbrella confers in built resistance againstseveral insect *** present research wasconducted to iso... 详细信息

关键词：图位克隆陆地棉绒毛 insect pests present research

以芳香胺玻璃为载体的固定化的胆固醇脂酶和胆固醇氧化酶

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生物工程学报 2002年第2期18卷 155-161页

作者： Vomalik S.Singh 等 BiochemistryResearchLaboratory DepartmentofBio－SciencesM.D.UniversityRohtak－24001（Haryana）India

Cholesterol esterase (Cease) from bovine pancreas and cholesterol oxidasc (COD) from Bravibacterium recombinant type have been innobilized individually and co-immobilized onto arylamine glass (pore diameter 55nm) through the process of diazotization. Cease and COD retained 92.65% and 85.54% of the initial activity with conjugation yields of 7.2 mg/g and 8.3mg/g support respectively when imnobilized individually on arylamine glass beads, but retained 89.58% of the initial activity with a conjugation yield of 2.9 mg/g support when co-immobilized on the same support. The effects of pH, temperature, time of incubation, substrate concentration, serum inorganic salts & metabolites, thermal stability, storage stability in cold and reusability on the immobilized enzymes were studied and compared with those of free enzymes. The analytic use of both individually immobilized and co-immobilized enzymes in discrete analysis of total and free cholesterol in serum is demonstrated.

关键词：胆固醇胆固醇脂酶胆固醇氧化酶固定化芳香胺玻璃血清胆固醇测定载体

围术期不良事件对麻醉医师的影响：一项全国性调查结果

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麻醉与镇痛 2013年第2期9卷 1-8页

作者： Farnaz m. Gazoni Peter E. Amato Zahra m. malik marcel E.Durieux, 荆建敏(译) 郭政(校) Department of Anesthesiology University of Virginia Health System Charlottesville Virginia 不详

背景大多数麻醉医师在他们的职业生涯中至少会经历一次围术期不良事件。然而，这些事件所产生的情绪反应及其对于麻醉医师短期和长期工作能力的影响，人们知道的还很少。在这项研究中，我们调查了围术期不良事件的发生率及其后果对美国... 详细信息

背景大多数麻醉医师在他们的职业生涯中至少会经历一次围术期不良事件。然而，这些事件所产生的情绪反应及其对于麻醉医师短期和长期工作能力的影响，人们知道的还很少。在这项研究中，我们调查了围术期不良事件的发生率及其后果对美国麻醉医师的影响。方法我们给美国麻醉医师协会随机挑选出来的1200名成员发放了自填问卷。参加者会收到一封推进信，还有2份调查表，2份提醒明信片，还有一份小额现金奖励。659名医师（56％）完成了调查表。结果84％的受访者在他，她的职业生涯中都曾经历过一次围术期的患者意外死亡或严重损伤。问及到“最令人难忘”的围术期不良事件的情绪影响时。70％以上的人有内疚感、焦虑，88％的人对事件耿耿于怀，需要时间从事件中恢复情绪，19％的人承认自己从未完全恢复。12％的人想过要换一个职业。67％的受访者认为在事件发生的后续4小时内，他们不能为患者提供服务，但只有7％的人得到休假。结论一个围术期不良事件可能对当事医师造成深刻和持久性的情绪影响，这类事件的余波可能影响他／她为患者提供服务的能力。

关键词：美国麻醉医师协会不良事件围术期调查结果职业生涯工作能力情绪反应情绪影响