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Antimicrobial activity of water and acetone extracts of some Eucomis taxa

Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 892-895页

作者： malgorzata mizielińska Piotr Salachna Magdalena Ordon Lukasz Lopusiewicz Center of Bioimmobilisation and Innovative Packaging Materials Faculty of Food Sciences and Fisheries West Pomeranian University of Technology Szczecin Department of Horticulture West Pomeranian University of Technology Szczecin

Objective: To evaluate the antibacterial and antifungal properties of acetone and water extracts of selected Eucomis ***: The bulbs of Eucomis bicolor, Eucomis comosa(E. comosa) and E. comosa cv. were dried and examples from each experimental treatment were ground separately into powder. Each sample was divided into two groups with equal amounts of powder,and respectively extracted with water and a 70% solution of aqueous acetone. The crude water extracts were then filtered through a 0.2 mm filter. The 70% aqueous acetone extracts were next concentrated at 40C. After the evaporation of the acetone, the samples were additionally filtered through a 0.2 mm filter. The antibacterial and antifungal activities of the extracts against chosen microorganisms were then ***: The results of the study demonstrated that the water and acetone extracts of Eucomis bulbs have an influence on the viability of Staphylococcus aureus and Bacillus atrophaeus strains. In the case of mediums containing E. comosa and E. comosa ***, a decrease in the number of gram-positive bacteria was dependent on the extract concentration. The best results were obtained in the case of the 25% extracts. The water and acetone extracts of Eucomis bulbs did not cause a decrease in the number of Escherichia coli cells. Additionally, antifungal activity against Aspergillus niger, Botrytis cinerea, Stachybotrys chartarum, Mucor circinelloides and Rhizopus oryzae cells were also not ***: The tested gram-negative and fungi microorganisms show resistance towards acetone and water extracts of Eucomis bulbs. The highest activity is found in the case of Aspergillus clavatus, Staphylococcus aureus and Bacillus atrophaeus strains,which shows water and acetone extracts of 25%.

关键词： Antibacterial Antifungal Medicinal plants Pineapple lily

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Should mitral valve prolapse be considered as one of the risk factors for open angle glaucoma? A preliminary observation

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 346-351页

作者： Ewa Grudzińska malgorzata Peregud-Pogorzelska Daniel Zaborski Monika Modrzejewska Second Department of Ophthalmology Pomeranian Medical UniversitySzczecin 70-111Poland Department of Cardiology Pomeranian Medical UniversitySzczecin 70-111Poland Laboratory of Biostatistics West Pomeranian University of TechnologySzczecin 71-270Poland

AIM:To assess the incidence of mitral valve prolapse in patients with newly diagnosed primary open angle ***:The study included 12 patients without any other comorbidities or taking any general or local *** patient underwent a full ophthalmological examination with visual field assessment and optical computed tomography of the macula and optic nerve *** Doppler ultrasound was performed to exclude impaired blood flow in this region and transthoracic echocardiography with assessment of the function and morphology of the heart ***:In the study group,mitral valve prolapse was found in seven patients(58.3%),while mitral valve regurgitation in 11 patients(91.7%).One case of normal pressure glaucoma and four cases of juvenile glaucoma were *** were also other risk factors for glaucoma:myopia(58.3%),migraine headaches(41.7%),a positive family history of glaucoma(16.7%).CONCLUSION:Mitral valve prolapse could be indicated as a new risk factor for *** seems reasonable to conduct screening tests for glaucoma in patients with mitral valve prolapse in the course of echocardiography.

关键词： ultrasonography Doppler echocardiography heart valves mitral valve insufficiency

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ON A CURVATURE CHARACTERIZATION OF RICCI-PSEUDOSYMMETRIC HYPERSURFACES

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Acta Mathematica Scientia 2004年第3期24卷 361-375页

作者： malgorzata Glogowska Department of Mathematics Agricultural University of Wroclaw Grunwaldzka S3 50-357 Wroclaw POLANDhe author presents a curvature characterization of Ricci-pseudosymmetric hypersurfaces in semi-Riemannian space forms Nsn+1(c) n>4.

The author presents a curvature characterization of Ricci-pseudosymmetric hypersurfaces in semi-Riemannian space forms Nsn+1(c), n>4.

关键词： Ricci-pseudosymmetric manifold pseudosymmetric manifold hypersurface Cartan hypersurface Clifford torus

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Hepatitis C virus infection in children in the era of directacting antiviral

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World Journal of Gastroenterology 2018年第24期24卷 2555-2566页

作者： malgorzata Pawlowska malgorzata Sobolewska-Pilarczyk Krzysztof Domagalski Department of Paediatric Infectious Diseases and Hepatology Faculty of MedicineCollegium MedicumNicolaus Copernicus University Centre For Modern Interdisciplinary Technologies Nicolaus Copernicus University

Hepatitis C virus(HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral(DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C.

关键词： biomarkers of liver injury adolescents epidemiology direct-acting antiviral Hepatitis C virus non-invasive methods children

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WNT/β-catenin signaling in hepatocellular carcinoma:The aberrant activation,pathogenic roles,and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 727-746页

作者： Anna Gajos-Michniewicz malgorzata Czyz Department of Molecular Biology of Cancer Medical University of LodzLodz 92-215Poland

Hepatocellular carcinoma(HCC)is a liver cancer,highly heterogeneous both at the histopathological and molecular *** arises from hepatocytes as the result of the accumulation of numerous genomic alterations in various signaling pathways,including canonical WNT/β-catenin,AKT/mTOR,MAPK pathways as well as signaling associated with telomere maintenance,p53/cell cycle regulation,epigenetic modifiers,and oxidative *** role of WNT/β-catenin signaling in liver homeostasis and regeneration is well established,whereas in development and progression of HCC is extensively ***,we review recent advances in our understanding of how WNT/β-catenin signaling facilitates the HCC development,acquisition of stemness features,metastasis,and resistance to *** outline genetic and epigenetic alterations that lead to activated WNT/β-catenin signaling in *** discuss the pivotal roles of CTNNB1 mutations,aberrantly expressed non-coding RNAs and complexity of crosstalk between WNT/β-catenin signaling and other signaling pathways as challenging or advantageous aspects of therapy development and molecular stratification of HCC patients for treatment.

关键词： Cancer stem cells CTNNB1 mutations Liver cancer Non-coding RNA Tumor heterogeneity

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Sorption Properties of Hard Coals with Regard to Gases Present in the Mine Atmosphere

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Journal of Earth Science 2017年第1期28卷 124-130页

作者： agnieszka dudzińska Mines Ventilation Department Central Mining Institute 40-166 Katowice Poland

In this study, the sorption capacities of hard coals with reference to gases present in the mine atmosphere： carbon dioxide, methane, ethane, ethene, propane, propene, carbon monoxide and hydrogen were examined. For laboratory tests, 4 samples of hard coals collected from exploitable coal seams were selected. Among considered gases the mostly sorbed is carbon dioxide, in slightly smaller amounts are sorbed unsaturated hydrocarbons： ethene and propene. Their large sorption results from i.a. interactions of ？ electrons in the double bond between carbon atoms in the ethene or propene molecules with energetic centers of the coal surface. The amounts of the sorbed saturated hydrocarbons： ethane and propane are small, which is probably related to the adsorption mechanism of their sorption by coals. In the smallest amounts are sorbed hydrogen and carbon monoxide, the values of their sorption being maximum 5% of hard coals sorption capacity in relation to carbon dioxide. Based on the experiments it was found that the largest amounts of gases are sorbed by lowrank, highly porous coals with high oxygen content. The process of sorption of unsaturated hydrocarbons： ethene and propene can lead to a reduction in concentration of those gases in the mine atmosphere and thus may affect correctness of the self-heating phenomenon assessment.

关键词： coal sorption gas.

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NO_(x) control for high-ash coal-fired power plants in India

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Clean Energy 2019年第1期3卷 24-33页

作者： malgorzata Wiatros-Motyka IEA Clean Coal Centre Apsley House176 Upper Richmond RoadLondonSW152SHUnited Kingdom

Many countries have strict emission limits for nitrogen oxides(NO_(x));thus NO_(x) control systems are widely *** has recently introduced NO_(x) emission limits,which require that pollution control technologies must be installed on most coal-fired ***,operational experience with NO_(x) control systems in India is limited to primary measures ***,Indian coals have a high level of inherent ash,which is also highly erosive and can influence the behaviour of some NO_(x) control systems and thus affect the selection *** measures for NO_(x) control from coal-fired power plants include low NO_(x) burners(LNBs),overfire air systems(OFA),fuel reburning,flue gas recirculation,fuel biasing,low excess air and combustion *** NO_(x) control includes selective catalytic reduction,selective non-catalytic reduction and multi-pollutant control *** of primary measures(LNBs and OFA)in India has been recommended to take place during next-scheduled plant outages;for many plants this could occur by ***,control strategies for individual plants will be needed to ascertain the appropriateness of installing post-combustion technologies or various combinations of NO_(x) control *** installation of secondary NO_(x) controls is not expected before test results from secondary controls on selected Indian power plants units are known.

关键词： high-ash coal NO_(x)controls SCR SNCR low NO_(x)burners overfire air India emission standards

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Emissions of fluorides from welding processes

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Journal of Environmental Sciences 2015年第11期27卷 179-183页

作者： malgorzata Szewczynska Emilia Pagowska Krystyna Pyrzynska Department of Chemical and Aerosol Hazards Central Institute for Labour Protection-National Research Institute Faculty of Chemistry University of Warsaw

The levels of fluoride airborne particulates emitted from welding processes were investigated. They were sampled with the patented IOM Sampler, developed by J. H Vincent and D. Mark at the Institute of Occupational Medicine（IOM）, personal inhalable sampler for simultaneous collection of the inhalable and respirable size fractions. Ion chromatography with conductometric detection was used for quantitative analysis. The efficiency of fluoride extraction from the cellulose filter of the IOM sampler was examined using the standard sample of urban air particle matter SRM-1648 a. The best results for extraction were obtained when water and the anionic surfactant N-Cetyl-N-N-Ntrimethylammonium bromide（CTAB） were used in an ultrasonic bath. The limits of detection and quantification for the whole procedure were 8 μg/L and 24 μg/L, respectively The linear range of calibration was 0.01–10 mg/L, which corresponds to 0.0001–0.1 mg of fluorides per m3 in collection of a 20 L air sample. The concentration of fluorides in the respirable fraction of collected air samples was in the range of 0.20–1.82 mg/m3, while the inhalable fraction contained 0.23–1.96 mg/m3 of fluorides during an eight-hour working day in the welding room.

关键词： Fluorides Particle size distribution Welding processes

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Developmental Toxicity in Mice Following Paternal Exposure to Di-N-Butyl-Phthalate (DBP)

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Biomedical and Environmental Sciences 2011年第5期24卷 569-578页

作者： malgorzata M.DOBRZY ska Ewa J.TYRKIEL Krzysztof A.PACHOCKI Department of Radiation Protection and Radiobiology National Institute of Public Health-National Institute of Hygiene00-791 WarsawPoland Department of Environmental Toxicology National Institute of Public Health-National Institute of Hygiene00-791 WarsawPoland

Objective The aim of the present study was to investigate the effects of paternal Di‐N‐butyl‐phthalate （DBP） exposure pre‐ and postnatally on F1 generation offspring,and prenatally on F2 generation *** Male mice were exposed to either 500 mg/kg or 2 000 mg/kg of DBP for 8 weeks,and mated with non‐exposed ***‐quarters of the females were sacrificed a day prior to parturition,and examined for the number of living and dead implantations,and incidence of gross *** from the remaining females were assessed for developmental markers,growth parameters,as well as sperm quantity and *** There were no changes in the fertility of parents and in intrauterine development of the *** of DBP‐exposed males demonstrated growth‐*** paternal exposure to 500 mg/kg bw of DBP,there were almost twice the number of males than females born in the F1 generation.F1 generation females had a 2.5‐day delay in vaginal *** exposure to 2 000 mg/kg bw of DBP increased the incidence of sperm head malformations in F1 generation males;however,there were no changes in the fertility and viability of foetuses in the F2 *** Paternal DBP exposure may disturb the sex ratio of the offspring,delay female sexual maturation,and deteriorate the sperm quality of F1 generation males.

关键词： Di‐n‐butyl phthalate Paternal exposure Pre‐ and postnatal effects Male‐mediated developmental toxicity

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Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis – with impact on gastrointestinal tract

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World Journal of Gastroenterology 2021年第39期27卷 6590-6600页

作者： Izabela Berdowska malgorzata Matusiewicz Department of Biochemistry and Immunochemistry Wroclaw Medical UniversityWroclaw 50-368Lower SilesiaPoland

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)seems to employ two routes of entrance to the host cell;via membrane fusion(with the cells expressing both angiotensin converting enzyme 2(ACE2)and transmembrane peptidase/serine subfamily member 2/4(TMPRSS2/4))or via receptor-mediated endocytosis(to the target cells expressing only ACE2).The second mode is associated with cysteine cathepsins(probably cathepsin L)involvement in the virus spike protein(S protein)proteolytic *** furin might activate the virus S protein enabling it to enter *** tract(GIT)involvement in SARS-CoV-2 infection is evident in a subset of coronavirus disease 2019(COVID-19)patients exhibiting GIT symptoms,such as diarrhea,and presenting viral-shedding in *** the abundance and co-localization of ACE2 and TMPRSS2 in the lower GIT(especially brush-border enterocytes),these two receptors seem to be mainly involved in SARS-CoV-2 invasion of the digestive ***,in vitro studies have demonstrated the virions capability of infection and replication in the human epithelial cells lining ***,also furin and cysteine cathepsins(cathepsin L)might participate in the activation of SARS-CoV-2 spike protein contributing to the virus invasiveness within ***,cathepsin L(due to its involvement in extracellular matrix components degradation and remodeling,the processes enhanced during SARS-CoV-2-induced inflammation)might be responsible for the dysregulation of absorption/digestion functions of GIT,thus adding to the observed in some COVID-19 patients symptoms such as diarrhea.

关键词： COVID-19 SARS-CoV-2 Angiotensin converting enzyme 2 Transmembrane peptidase/serine subfamily member 2/4 Cathepsin L Gastrointestinal tract

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