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Activity of Salivary 11<i>β</i>-Hydroxysteroid Dehydrogenase Type 2 Becomes the Index for the Continuous Strength Exercise to Prevent Locomotive Syndrome in Japan

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Health 2015年第10期7卷 1352-1356页

作者： Noboru Hasegawa maki Ohara Miyako Mochizuki Department of Health and Medical Sciences Ishikawa Prefectural Nursing University Kahoku Japan Noto-Cho Government Office Health Welfare Section Hosu-Gun Japan Kyoto Bunkyo Junior College Uji Japan

The Japanese Orthopedic Association proposed a concept called locomotive syndrome (LS) to identify middle-aged and older adults at high risk of requiring health care services because of problems with locomotion-associated lower muscle mass. To prevent LS, it is important to increase muscle mass and muscle strength in middle-age by continuous resistance training. A total of 38 men and women were assessed at baseline and 6 months. Body composition, physical strength and salivary cortisol and cortisone were analyzed. The exercise intervention program was performed by individual muscle endurance level. Body weight, muscle weight and basal metabolism were increased after exercise intervention. The 30-second sit-up test and 3-minute walking were increased, and the 10-time sit-to-stand was decreased significantly. This may be related to increase of leg and abdominal muscular strength. The exercise intervention program increased salivary 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activities significantly. These results suggested that 11β-HDS2 became the index for the increase of muscular strength to prevent LS.

关键词： Salivary Cortisol Salivary Cortisone 11β--Hydroxysteroid Dehydrogenase Muscle Weight Strength Exercise

Morphological Feature and Physicochemical Characteristics of Soils under Festuca spp. Dominant Steppe at High Mountain and Mountain of Khuvsgul, Mongolia

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Open Journal of Soil Science 2022年第9期12卷 446-474页

作者： Saruul Narangerel Undarmaa Jamsran maki Asano Kenji Tamura School of Life and Environmental Sciences University of Tsukuba Ibaraki Japan Center for Ecosystem Studies Mongolian University of Life Sciences Ulaanbaatar Mongolia Faculty of Life and Environmental Sciences University of Tsukuba Ibaraki Japan

The morphology, physicochemical, humic substances and micromorphological characteristics of four soil profiles of the steppe dominant by Festuca lenensis (F. lenensis) at the high mountain and mountain of Khuvsgul, Mongolia were studied. Soils were classified as Regosols and Leptosols at high mountain steppe, Leptosols and Cambisols at mountain steppe. On a high mountain, the plant root distribution, OC, N and moisture contents were high due to its high precipitation and low temperature. The soils show immature characteristics with low available nutrients, weakly developed crumb structure, many semi- and undecomposed plant residues, and few little organic pigments with few excrements. The humic acids with immature to degraded characteristics indicate that the climatic condition of high mountains inhibits the soil decomposition process. Due to extremely different landform positions, there a sharp difference was observed between studied soils on high mountain steppe. On the summit with a flat position, the soil of TSO1 showed finer soil texture with higher CEC, exchangeable Mg2+ and humification degree of SOM compared with the soil of TSO2, which located on the steep slope. This confirms that the abrupt changes in landform on high mountain strongly affect the properties of topsoil. On the mountain steppe, the soil contains higher exchangeable Na+, exchangeable K+ and water soluble at topsoil;however, the plant root distribution, OC, N and moisture contents were lower than that of high mountain soil. Because of warmer air and soil temperature in comparison with that of high elevation, active turnover in humic horizon and chemical weathering process lead to higher available nutrients in mountain steppe. The degraded to well humified characteristics of humic acid, moderately developed crumb structure, a higher component of little organic pigment and many intact excrements indicate that the soil decomposition process and biological activit

关键词： Soil Micromorphology Soil Physicochemical Festuca lenensis Mountain Steppe Khuvsgul

Biodegradation of synthetic surfactants by river microorganisms

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Journal of Environmental Sciences 1996年第3期8卷 275-284页

作者： Hideaki maki Kenrou Tokuhiro Yasuhiro Fujiwara Michihiko Ike Kenji Furukawa Masanori Fujita(Department of Environmental Engineering, Faculty of Engineering, Osaka University, 2-1 Yamadaoka,Suita, Osaka 565, Japan) Dept. of Environmental Engineering Faculty of Engineering Osaka University Suita Osaka 565 2-1 Yamadaoka Japan

Four kinds of widely used synthetic surfactants and polyethylene glycol (PEG) which corresponds to the hydrophilic moieties of polyoxyethylene-type nonionic surfactants were subjected to a complete biodegradation test using microorganisms from relatively unpolluted river waters (the TOC-Handai method). Sodium dodecyl sulfate (SDS), alcohol ethoxylate (AE) and PEG were mineralized by most of the microorganisms used as inocula, irrespective of differences in their degradation rates, which is in agreement with their biodegradabilities confirmed so far by other *** degradable surfactants were, however, not completely degraded by some river microorganisms. Among the surfactants tested, SDS was degraded most rapidly by microorganisms of each river in the same manner but the degradation rates of AE and PEG differed considerably according to the inoculum sampling station. Sodium linear alkylbenzensulfonate (LAS) and nonylphenol ethoxylate (NPE). which are known to be recalcitrant molecules, were not degraded completely by microorganisms of any of the river waters within the testing period; degradation of the former rarely proceeded , while that of the latter ceased leaving the well-known intermediates. The residual metabolites of NPE generated by biodegradation, which were analyzed by high-performance liquid chromatography and gas chromatography/mass spectrometry, revealed that this surfactant was transformed to carboxylated metabolites, nonylphenoxy acetic acid (NP1EC)and [(nonylphenoxy)ethoxy] acetic acid (NP2EC) exclusively.

关键词： biodegradation surfactants river microorganisms TOC

Remission endpoints in ulcerative colitis: A systematic review

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World Journal of Meta-Analysis 2017年第4期5卷 85-102页

作者： maki Jitsumura Rory Frederick Kokelaar Dean Anthony Harris Colorectal Department Singleton Hospital Abertawe Bro Morgannwg University Health Board

AIM To summarize the current consensus on the defnition of remission and the endpoints employed in clinical *** bibliogragraphic search was performed from 1946 to 2016 sing online databases （National Library of Medicine’s PubMed Central Medline, OVID SP MEDLINE, OVID EMBASE, the Cochrane Library and Conference Abstracts） with key words：（“ulcerative colitis”） AND （“ulcerative colitis endoscopic index of severity” OR “UCEIS”） AND （“remission”） as well as （“ulcerative colitis”） AND （“ulcerative colitis disease activity index”） OR “UCDAI” OR “UC disease activity index” OR “Sutherland index”） AND （“remission”）.RESULTSThe search returned 37 and 116 articles for the UCEIS and UCDAI respectively. For the UCEIS, 12 articles were cited in the final analysis of which 9 validation studies have been identified. Despite the UCEIS has been more extensively validated in all three aspects （validity, responsiveness and reliability）, it has been little employed to monitor disease in randomised clinical trials. For the UCDAI, 37 articles were consider-ed for the final analysis. Although the UCDAI is only partially validated, 29 randomised clinical trials were acknowledged to use the UCDAI to determine endpoints and disease remission, though no clear protocol was *** the UCEIS has been more widely validated than the UCDAI, it has not been refected in the moni-toring of disease activity in clinical trials. Conversely, the UCDAI has been used in numerous large clinical trials to defne their endpoints and disease remission, however, it is challenging to determine the best possible outcomes due to a lack of homogeneity of the clinical trial protocols. Before determining a gold standard index, international agreement on remission is urgently needed to advance patient care.

关键词： Ulcerative colitis Remission Ulcerative colitis endoscopic index of severity Ulcerative disease activity index

Plasma Levels of Growth Arrest Specific Protein (Gas6) and the Soluble Form of Its Tyrosine Kinase Receptor Axl (sAxl) in Patients with Hepatocellular Carcinoma

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Journal of Cancer Therapy 2013年第2期4卷 632-639页

作者： Soichiro Uehara Katsuhiro Gotoh Hiroshi Handa Yoshiyuki maki Department of Internal Medicine and Gastroenterology Hizirigaoka Hospital Hunaoka Japan Primary Cell Co. Ltd. Sapporo Japan.

The aim of this study was to determine the plasma levels of vitamin K-dependent protein growth arrest-specific protein 6 (Gas6) and its soluble receptor Axl (sAxl) in patients with hepatocellular carcinoma (HCC), acute hepatitis (AH), fulminant hepatitis(FH), chronic hepatitis (CH), and liver cirrhosis (LC) and to determine whether Gas6 and sAxl can be used as biomarkers. Immunoassys were used to measure levels of plasma Gas6 and sAxl in 40 patients with HCC, 13 patients with AH, 3 patients with FH, 7 patients with LC, and 20 healthy normal adult controls (NC). Furthermore, urinary γ-carboxyglutamic acid (Gla) was measured by high performance liquid chromatography. We have addressed this issue by conducting a cross-sectional study to determine whether plasma Gas6 and sAxl levels are associated with DCP, urinary γ-Gla, and liver functions in humans. Levels of Gas6, sAxl, and γ-Gla were significantly higher in HCC as compared to those in NC, and they were significantly positive correlated. Gas6/sAxl molar ratios in HCC were significantly higher than in NC, but those ratios in AH, FH, and LC were significantly lower in NC. Furthermore, Gas6/sAxl molar ratios in HCC increased significantly in comparison with those AH and LC. The increase of Gas6, sAxl and Gas6/sAxl molar ratio were correlated with the progression and poor prognosis of HCC. Thus, Gas6 and sAxl may be useful biomarkers for HCC.

关键词： Gas6 Soluble Axl (sAxl) Receptor Tyrosine Kinase γ-Carboxyglutamic Acid (γ-Gla) Vitamin K Hepatocellular Carcinoma (HCC)

Problems Associated with Non-Ergot Dopamine Agonist Maintenance Therapy in Patients with Advanced Parkinson’s Disease

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Advances in Parkinson's Disease 2019年第3期8卷 35-41页

作者： Makoto Shiraishi Futaba maki Naoshi Sasaki Yasuhiro Hasegawa Department of Neurology St. Marianna University School of Medicine Kawasaki City Kanagawa Japan

Non-ergot dopamine agonists have become popular for treating motor complications associated with long-term use of levodopa-containing drugs. We conducted a retrospective study in which we identified clinical problems related to use of non-ergot dopamine agonists. The study included 38 patients with Parkinson’s disease (PD) who suffered the wearing-off phenomenon and had thus been under non-ergot dopamine receptor agonist therapy for 1 - 2 years. Some presented with problems such as major symptoms of PD (30.3%), psychiatric symptoms (24.2%), and postural dysfunction (21.2%). Comparison between two different non-ergot drugs showed the levodopa dosage to be greater among patients taking ropinirole than among those taking pramipexole. In patients with advanced PD, various problematic symptoms can develop early after administration of a non-ergot dopamine agonist to treat the wearing-off phenomenon, necessitating identification and treatment of such symptoms on a patient-to-patient basis.

关键词： Parkinson’s Disease Non-Ergot Dopamine Agonist Wearing-Off Ropinirole Pramipexole

Reduction effect of bacterial counts by preoperative saline lavage of the stomach in performing laparoscopic and endoscopic cooperative surgery

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World Journal of Gastroenterology 2014年第42期20卷 15763-15770页

作者： Hirohito Mori Hideki Kobara Takaaki Tsushimi Shintaro Fujihara Noriko Nishiyama Tae Matsunaga maki Ayaki Tatsuo Yachida Joji Tani Hisaaki Miyoshi Asahiro Morishita Tsutomu Masaki Departments of Gastroenterology and Neurology Facultyof Medicine Kagawa University Department of Gastroenterological Surgery Ehime Rosai Hospital

AIM: To investigate the effects of gastric lavage with 2000 mL of saline in laparoscopic and endoscopic cooperative surgery.

关键词： Laparoscopic and endoscopic cooperative surgery Systemic gastric lavage Disinfection Bacterial counts Duodenal balloon occlusion

干旱区蒸发与水分平衡的研究——以新疆吐鲁番为例

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干旱区资源与环境 1993年第Z1期7卷 197-200页

作者： Mingyuan DU Taichi maki 热带农业研究中心边际土地研究室日本

1.引言了解蒸发和水分平衡特征对干旱区农业的持续发展十分重要。根据气象资料,中国干旱区蒸发皿测得的蒸发量是降水量的10到150倍(Du,1993)。以新疆吐鲁番(40°56′N,89°12′E,34.5m)为例,图1给出了温度,皿蒸发量和降水量的年度变化(... 详细信息

1.引言了解蒸发和水分平衡特征对干旱区农业的持续发展十分重要。根据气象资料,中国干旱区蒸发皿测得的蒸发量是降水量的10到150倍(Du,1993)。以新疆吐鲁番(40°56′N,89°12′E,34.5m)为例,图1给出了温度,皿蒸发量和降水量的年度变化(日平均,最高和最低)。吐鲁番年降水量只有16mm,而皿蒸发量却达2838mm。

关键词：干旱区蒸发水分平衡

浆纸纤维原料的来源与消耗——热带阔叶杂木作为浆纸纤维来源的供应正在下降

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中华纸业 2004年第8期25卷 57-59页

作者： Petteri Pihlajmaki Hannu Hytonen Jaakko Pyry Jaakko Pyry

通过对全球纸和纸板需求量和产量的预测,阐述了浆纸纤维原料的供应来源和需求消耗,其中产于印度尼西亚的热带阔叶杂木作为造纸纤维来源的供应正在下降,在浆纸生产中所起的作用并不重要。

关键词：浆纸纤维原料来源消耗热带阔叶杂木印度尼西亚造纸工业