Clinical Evaluation after Introduction of Stem Cell Supernatant Biocell Shot 65 by Electroporation
Clinical Evaluation after Introduction of Stem Cell Supernatant Biocell Shot 65 by Electroporation作者机构：Division of Life Science and Engineering School of Science and Engineering Tokyo Denki University Saitama Japan Suzuki Plastic Surgery Clinic Kyoto Japan Yokogawa Dermatological Clinic Kochi Japan Pure Code Inc. Osaka Japan
出 版 物：《Journal of Cosmetics, Dermatological Sciences and Applications》 (化妆品、皮肤病及应用期刊（英文）)
年 卷 期：2021年第11卷第1期
页 面：58-70页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Clinical Evaluation Stem Cell Skin Treatment
摘 要：Objectives: The objective of this study is clinical evaluation after introduction of stem cell supernatant Biocell Shot 65 by electroporation. Background: There is a clinical report of psoriasis treatment by umbilical cord blood-derived stem cells, in which there was a beneficial result. These clinical results are the result of cord blood-derived cell growth factors. The umbilical cord blood-derived stem cell culture supernatant contains a high amount of TGF-β, PDGA, etc., and promotes wound healing. In addition, we suppose that the supernatant has the esthetic effect of improving skin condition, thus, we planned to make a clinical evaluation. However, it is difficult to set judgement criteria, and human judgement tends to be subjective. Therefore, in this study, as a new clinical evaluator, we used an AI skin diagnostic device with learning function. Methods: Stem cell culture supernatant Biocell Shot 65 was used as an introduction solution. After it was applied to the full faces of four patients, electroporation with BeBe pinocchio DM-5 SUPER DX Plus promoted infiltration deep in the keratinized layer. The patients were all healthy women in their forties. This procedure was performed every two weeks for three months. Wrinkles, fine lines around eyes, stains, pores, and 4V, which is considered as one diagnostic criteria, were eva
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