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Direct ethanol production from rice straw by coculture with two high-performing fungi

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 139-145页

作者： maki TAKANO Kazuhiro HOSHINO Graduate School of Science and Engineering University of Toyama Toyama 930-8555 Japan

To develop efficient and economical direct ethanol production from fine rice straw crashed mechanically, two high-performing fungi, which can secret hyperactive cellulases and/or ferment effectively various sugars, were selected from some strains belong to Mucor circinelloides preserved in our laboratory. The simultaneous saccharification and fermentation （SSF） by coculture with these fungi was investigated. The screening of high- performing fungi resulted in the selection of NBRC 4572 as an ethanol-producing fungus and NBRC 5398 as a cellulase-secreting fungus. The strain 4572 produced ethanol aerobically from glucose and xylose in high yields of 0.420 g/g at 36 h and 0.478 g/g at 60 h, respectively, but secreted fairly low cellulases. On the other hand, the strain 5398 also produced ethanol from glucose in yield of 0.340 g/g though it had a little growth in xylose culture. However, it secreted hyperactive cellulases that are essential for hydrolysis of rice straw in culture and the maximum activities of endo-β-glucanase and β-glucosi- dase were 2.11 U/L and 1.47 U/L, respectively. In SSF of rice straw by coculture with two fungi selected, the ethanol production reached 1.28 g/L after 96 h when the inoculation ratio of the strain 5398 to the strain 4572 was 9.

关键词： Mucor circinelloides ethanol production cellulase secretion SSF coculture rice straw

Antibodies in celiac disease:implications beyond diagnostics

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Cellular & Molecular Immunology 2011年第2期8卷 103-109页

作者： Sergio Caja Markku maki Katri Kaukinen Katri Lindfors Pediatric Research Centre University of Tampere and Tampere University HospitalTampereFinland Medical School University of Tampere and Department of Gastroenterology and Alimentary Tract SurgeryTampere University HospitalTampereFinland

Celiac disease is a multisystemic dietary,gluten-induced autoimmune disorder characterized by the presence of transglutaminase(TG)2 serum *** autoantibodies targeting members of the TG family(TG2,TG3 and TG6)are found deposited in small-bowel mucosa and in extraintestinal tissues affected by the *** autoantibodies against other self-antigens also emerge in untreated celiac disease *** villous atrophy and crypt hyperplasia in small-bowel biopsy samples are still the gold standards in diagnostics,celiac disease-specific antibodies are widely used as diagnostic ***-induced small-bowel mucosal T-cell response is the cornerstone in the pathogenesis of the disorder,but humoral immunity may also play a central *** review article is focused on the autoantibodies that occur in the context of celiac *** article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease.

关键词： antibody celiacdisease diagnostics pathogenesis

Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein

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Science China(Life Sciences) 2011年第8期54卷 770-779页

作者： Masatoshi maki Hironori SUZUKI Hideki SHIBATA Department of Applied Molecular Biosciences Graduate School of Bioagricultural SciencesNagoya University Structural Biology Research Center Photon FactoryInstitute of Materials Structure ScienceHigh Energy Accelerator Research Organization

ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical ***-2 is the most conserved protein among the PEF family members and its homologs are widely found in eukaryotes.X-ray crystal structures of various PEF proteins including ALG-2 have common features:presence of eightα-helices and dimer formation via paired EF5s that are positioned in anti-parallel ***-2 forms a homodimer and a heterodimer with its closest paralog *** calmodulin,a well-known four-EF-hand protein,ALG-2 interacts with various proteins in a Ca2+-dependent fashion,but the binding motifs are completely *** some exceptions,ALG-2-interacting proteins commonly contain Pro-rich regions,and ALG-2 recognizes at least two distinct Pro-containing motifs:PPYP(X) nYP(X,variable;n=4 in ALIX and PLSCR3) and PXPGF(represented by Sec31A) .A shorter alternatively spliced isoform,lacking two residues and designated ALG-2 GF122,does not bind ALIX but maintains binding capacity to Sec31A.X-ray crystal structural analyses have revealed that binding of calcium ions induces the configuration of the side chain of R125 so that it opens Pocket 1,which accepts PPYP,but Pocket 1 remains closed in the case of ALG-2 ***-2 dimer has two ligand-binding sites,each in a monomer molecule,and appears to function as a Ca2+-dependent adaptor protein to either stabilize a preformed complex or to bridge two proteins on scaffolds in systems of the endosomal sorting complex required for transport(ESCRT) and ER-to-Golgi transport.

关键词： ALG-2 calcium penta-EF-hand X-ray crystal structure protein-protein interaction membrane trafficking

Machining Robot with Vibrational Motion and 3D Printer-like Data Interface

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International Journal of Automation and computing 2018年第1期15卷 1-12页

作者： Fusaomi Nagata Keigo Watanabe maki K. Habib Department of Mechanical Engineering Faculty of Engineering Tokyo University of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda 756-0884 Japan Department of Intelligent Mechanical Systems Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology Okayama University 3-1-1 Tsushima-naka Kita-ku Okayama 700-8530 Japan American University 113 Kasr E1 Eini Street Cairo 11511 Egypt

In this paper, a vibration motion control is proposed and implemented on a foamed polystyrene machining robot to suppress the generation of undesirable cusp marks, and the basic performance of the controller is verified through machining experiments of foamed polystyrene. Then, a 3 dimensional （3D） printer-like data interface is proposed for the machining robot. The 3D data inter- face enables to control the machining robot directly using stereolithography （STL） data without conducting any computer-aided man- ufacturing （CAM） process. This is done by developing a robotic preprocessor that helps to remove the need for the conventional CAM process by directly converting the STL data into cutter location source data called cutter location （CL） or cutter location source （CLS） data. The STL is a file format proposed by 3D systems, and recently is supported by many computer aided design （CAD）/CAM soft- waxes. The STL is widely used for rapid prototyping with a 3D printer which is a typical additive manufacturing system. The STL deals with a triangular representation of a curved surface geometry. The developed 3D printer-like data interface allows to directly control the machining robot through a zigzag path, rectangular spiral path and circular spiral path generated according to the information included in STL data. The effectiveness and usefulness of the developed system are demonstrated through actual machining experiments.

关键词： Computer integrated manufacturing machining robot computer aided design (CAD)/computer-aided manufacturing(CAM) cutter location (CL) data vibrational motion stereolithography (STL) data preprocessor 3 dimensional (3D) printer-likedata interface.

Comparison of electronic structure between monolayer silicenes on Ag(111)

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Chinese Physics B 2015年第8期24卷 120-124页

作者： Chun-Liang Lin Ryuichi Arafune maki Kawai Noriaki Takagi Department of Advanced Materials Science Graduate School of Frontier ScienceThe University of Tokyo International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science

√√The electronic structures of monolayer silicenes(4 × 4 and■ ×■R13.9o) grown on Ag(111) surface are studied by scanning tunneling spectroscopy(STS) and density functional theory(DFT) calculations. While both phases have similar electronic structures around the Fermi level, significant differences are observed in the higher energy unoccupied *** DFT calculations show that the contributions of Si 3pz orbitals to the unoccupied states are different because of their different buckled configurations.

关键词： silicene electronic structure STM DFT

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Topos and Identity

世界建筑 1993年第1期 20-22页

作者： Fumihiko maki

I have before me now a booklet entitled A New Wave of Japanese Architecture. It served as the catalogue of a 1978 exhibition of 11 Japanese architects—the youngest was then in his thirties and the oldest in his early fifties—that was held at the Institute for Architecture and Urban Studies then headed by Peter Eisenman. Kenneth Frampton’s introduction, an account of how the Japanese architectural scene in the late 1970s looked from the outside, is rather accurate and interesting.

关键词： Topos and Identity

Cognitive changes associated with ADT： a review of the literature

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Asian Journal of Andrology 2012年第2期14卷 232-238页

作者： Rhoda J Jamadar Mary J Winters Pauline M maki Center for Cognitive Medicine Department of Psychiatry university of Illinois at Chicago Chicago IL 60612 USA Department of Psychology University of Illinois at Chicago Chicago IL 60612 USA

The use of androgen deprivation therapy （ADT） has increased since the early 1990s after early detection efforts and greater use of the prostate-specific antigen （PSA） test. Although ADT is associated with favorable clinical outcomes, ADT has been associated with an increased risk for cardiovascular disease, increased serum cholesterol, triglycerides, insulin resistance, body mass index and fat body mass. Here we review findings from 11 clinical studies examining the effects of ADT on cognition as measured by standardized tests in cognitive domains such as verbal and spatial memory. Most of these studies have important limitations, including small sample sizes, suboptimal control groups and baseline group differences in confounding factors. Despite these limitations, the best designed studies, those comparing patients on ADT to healthy controls, generally suggest that spatial memory might be especially sensitive to the effects of ADT. Critically, to date there is only one study involving random assignment of ADT versus close clinical observation. That study revealed a decrease in verbal memory with ADT, but was limited in sample size and did not include a measure of spatial memory. A recent observational study revealed no substantial evidence of cognitive impairment with ADT, even in the domain of verbal memory. Like the randomizedstudy, however, this large observational study lacked a measure of spatial memory. Overall, the studies with the best controls suggest a potential negative impact of ADT on spatial memory, and perhaps verbal memory, and a need for continued investigation of the impact of ADT on cognition, particularly in these two cognitive domains.

关键词： androgen deprivation therapy cognition prostate cancer

Microstructural Evolution of Pearlite in Eutectoid Fe-C Alloys during Severe Cold Rolling

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Journal of Materials Science & Technology 2005年第1期21卷 25-27页

作者： WantangFU YiXIONG JunZHAO YongLI T.Furuhara T.maki KeyLab.ofMetastableMater.Sci.&Tech.YanshanUniversity Qiuhuangdao066004China//Dept.ofMater.Sci.andEng.KyotoUuiversityKyoto606-8501Japan KeyLab.ofMetastableMater.Sci.&Tech.YanshanUniversity Qiuhuangdao066004China Dept.ofMater.Sci.andEng. KyotoUuiversityKyoto606-8501Japan

The microstructural evolution of pearlite during severe cold rolling in Fe-0.8C binary alloy and Fe-1Mn-0.8C ternary alloys was investigated by using SEM, TEM and XRD etc. The results show that the deformed pearlite consists of irregularly bent lamella, coarse lamella with shear-band and fine lamella. As the rolling reduction increases, the proportion of fine lamella increases. The strong plastic deformation, amorphization and dissolution of cementite take place during the severe cold rolling. The maximum carbon content in ferrite reaches 0.15 mass% after 90% cold rolling.

关键词： Pearlite Severe cold rolling Microstructural evolution Dissolution Amorphization Fe-C alloy

GATA4 mutations are uncommon in patients with 46,XY disorders of sex development without heart anomaly

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Asian Journal of Andrology 2018年第6期20卷 629-631页

作者： maki Igarashi Kentaro Mizuno Masafumi Kon Satoshi Narumi Yoshiyuki Kojima Yutaro Hayashi Tsutomu Ogata maki Fukami Department of Molecular Endocrinology National Research Institute for Child Health and Development Tokyo 157-8535 Japan Department of Nephro-Urology Nagoya City University Graduate School of Medical Sciences Nagoya 467-8601 Japan Department of Urology Fukushima Medical University Fukushima 960-1295 Japan Department of Pediatrics Hamamatsu University School of Medicine Hamamatsu 431-3192 Japan

Dear Editor, Disorders of sex development （DSDs） are a group of conditions in which chromosomal, gonadal, or anatomical sex is atypical.1 DSD in genetic males （46,XY DSD） primarily results from impaired androgen production or action or perturbed genital morphogenesis？ The current understanding of the genetic basis of 46,XY DSD remains fragmentary. For example, although more than 15 genes have been implicated in the development ofnonsyndromic hypospadias,2 one of the most common forms of 46,XY DSD,~ mutations in these genes account for 〈20% of the cases.3

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