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北京“23•7”特大洪水复盘分析

水力发电学报 2024年第4期43卷 12-22页

作者：麦合木提·图达吉童瑞徐宝宁周睿杨龚傲凡曾净季明峰戚友存倪广恒田富强清华大学水圈科学与水利工程全国重点实验室北京100084 清华大学水利水电工程系北京100084 清华大学水利部水圈科学重点实验室北京100084 北京市水文总站北京100089 中国科学院地理科学与资源研究所陆地水循环及地表过程重点实验北京100101

本文分别采用地面雨量站和雷达反演降雨数据,利用北京山区洪水预报模型对北京“23•7”暴雨洪水开展了复盘分析。结果表明,雷达反演降雨与地面雨量站测量结果一致性较强,可较好地反映降雨的时空变异性;同时,利用二者分别驱动水文模型后... 详细信息

本文分别采用地面雨量站和雷达反演降雨数据,利用北京山区洪水预报模型对北京“23•7”暴雨洪水开展了复盘分析。结果表明,雷达反演降雨与地面雨量站测量结果一致性较强,可较好地反映降雨的时空变异性;同时,利用二者分别驱动水文模型后所得的预报效果也基本一致,说明在水文预报工作中雷达反演降雨可作为地面站网的可靠替代品。本文改进的考虑北京山区产流特点的水文模型可对大部分预报断面做出较高精度的模拟。北京山区水文过程具有很强的非线性,基于不同量级历史洪水率定的水文模型参数具有不确定性,为了适应产汇流和洪水演进规律的变化,提高洪水预报的可靠性,预报实践时需要结合实况数据及时优化模型参数,完善洪水预报方案。

关键词：洪水复盘洪水预报 “23•7”特大洪水雷达反演降雨

Central corneal thickness measurements in premature infants

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 496-500页

作者： Murat Gunay Gokhan Celik Betul Onal Gunay mahmut Dogru Tugba Gursoy Husnu Fahri Ovali Department of Ophthalmology Zeynep Kamil Women and Childrens' Diseases Education and Research Hospital Department of Ophthalmology Umraniye Education and Research Hospital Department of Pediatrics Zeynep Kamil Women and Childrens' Diseases Education and Research Hospital Department of Neonatology Zeynep Kamil Women and Childrens' Diseases Education and Research Hospital

AIM:To evaluate the central corneal thickness(CCT)measurements of premature infantsMETHODS:The premature infants who were born between 25-34wk of gestational age(GA)were retrieved for the *** CCT measurements were performed within the first 2d of their life under topical anesthesia by using an ultrasonic ***:The mean CCT of 200 eyes was 647.79±63.94μ*** mean CCT of the right and left eyes were similar(647.30±64.72μm and 648.29±63.47μm consecutively).The mean CCT of the girls was 642.08±54.89μm and the boys was 653.07±71.14μm,with no statistically significant difference(P>0.05).But there was a negative correlation of the CCT with GA and birth weight(BW)(P<0.01).CONCLUSION:The CCT values of premature babies were negatively correlated with GA and BW.

关键词： central corneal thickness measurement prematurity

Characterization of genomic,physiological,and probiotic features Lactiplantibacillus plantarum DY46 strain isolated from traditional lactic acid fermented shalgam beverage

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Food Bioscience 2022年第2期46卷 251-263页

作者： Ahmet E.Yetiman Abdullah Keskin Büs¸ra Nur Darendeli Seyfullah Enes Kotil Fatih Ortakci mahmut Dogan Erciyes University Faculty of EngineeringFood Engineering DepartmentKayseriTurkey Abdullah Gül University Faculty of EngineeringNanotechnology EngineeringKayseriTurkey Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey Department of Biophysics Bahcesehir University Medical SchoolKadikoyIstanbulTurkey Abdullah Gül University Faculty of Life and Natural SciencesDepartment of BioengineeringKayseriTurkey

Lactiplantibacillus plantarum is a significant probiotic where it could be found in ubiquitous *** this study,a new *** strain DY46 was isolated from a traditional lactic-acid-fermented beverage called *** whole genome of the DY46 was sequenced and obtained sequences were assembled into a 3.32 Mb draft genome using PATRIC(3.6.8.).The DY46 genome consists of a single circular chromosome of 3,332,827 bp that is predicted to carry 3219 genes,including 61 tRNA genes,2 rRNA *** genome has a GC content of 44.3%includes 98 predicted pseudogenes,25 complete or partial transposases and 3 intact *** genes encoding enzymes related in the intact EMP(Embden-Meyerhof-Parnas)and PK(phosphoketolase)pathways were predicted using BlastKOALA which is an indicator of having facultative heterofermentative ***46 genome also predicted to carry genes of Pln E,Pln F and Pln K showing the antimicrobial potential of this bacterium which can be linked to in vitro antagonism tests that DY46 can inhibit *** *** ATCC14028,*** ATCC13883,and *** ***,it is determined that all resistome found in its genome were intrinsically originated and the strain was found to be tolerant to acid and bile concentrations by mimicking human gastrointestinal *** conclusion,*** DY46 is a promising bacterium that appears to have certain probiotic properties,confirmed by“in vitro”and“in silico”analyses,and is a potential dietary supplement candidate that may provide functional benefits to the host.

关键词： Shalgam Lactiplantibacillus plantarum Probiotic Genome Carbohydrate fermentation patterns

Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface:Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering

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Genes & Diseases 2022年第4期9卷 1008-1023页

作者： Murat Taner Vurat ŞükranŞeker Özge Lalegül-Ülker mahmut Parmaksiz Ayşe Eser Elçin Yaşar Murat Elçin Tissue Engineering Biomaterials and Nanobiotechnology LaboratoryAnkara University Faculty of ScienceAnkara University Stem Cell InstituteAnkara 06100Turkey Biovalda Health Technologies Inc.Ankara 06100Turkey

While periodontal (PD) disease is among principal causes of tooth loss worldwide, regulation of concomitant soft and mineralized PD tissues, and PD pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical models and in vitro platforms have limitations in simulating human physiology. Here, we have harnessed three-dimensional bioprinting (3DBP) technology for developing a multi-cellular microtissue model resembling PD ligament-alveolar bone (PDL-AB) biointerface for the first time. 3DBP parameters were optimized;the physical, chemical, rheological, mechanical, and thermal properties of the constructs were assessed. Constructs containing gelatin methacryloyl (Gel-MA) and hydroxyapatite-magnetic iron oxide nanoparticles showed higher level of compressive strength when compared with that of Gel-MA constructs. Bioprinted self-supporting microtissue was cultured under flow in a microfluidic platform for >10 days without significant loss of shape fidelity. Confocal microscopy analysis indicated that encapsulated cells were homogenously distributed inside the matrix and preserved their viability for >7 days under microfluidic conditions. Immunofluorescence analysis showed the cohesion of stromal cell surface marker-1+ human PDL fibroblasts containing PDL layer with the osteocalcin+ human osteoblasts containing mineralized layer in time, demonstrating some permeability of the printed constructs to cell migration. Preliminary tetracycline interaction study indicated the uptake of model drug by the cells inside the 3D-microtissue. Also, the non-toxic levels of tetracycline were determined for the encapsulated cells. Thus, the effects of tetracyclines on PDL-AB have clinical significance for treating PD diseases. This 3D-bioprinted multi-cellular periodontal/osteoblastic microtissue model has potential as an in vitro platform for studying processes of the human PDL.

关键词： 3D bioprinting Alveolar bone Microtissue model Organ-on-a-chip .Periodontal ligament Periodontal tissue engineering Periodontal-osteoblastic biointer face Periodontium-on-a-chip

Usability of Polymer Concrete as a Machine-Making Material Regarding Fatigue Strength

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World Journal of Engineering and Technology 2013年第3期1卷 59-64页

作者： Ergun Ates mahmut Nedim Gerger Department of Mechanical Engineering Faculty of Engineering and ArchitectureBalikesir UniversityBalikesirTurkey

In many studies conducted on polymer concretes of different structures, some of the mechanical behaviours such as compression, bending, damping, and fatigue have been investigated. Specimens and experimental taxonomy used in the majority of these studies explore the idea of using polymer concrete either as a construction material or as a material for building the body of machine tools. The experimental methodology and specimens used in this study to investigate the fatigue strength were chosen according to the machine-making material. In “rotational flexural fatigue” experiments conducted using high compressive strength composite materials, fatigue strength values were observed to be lower than previous studies.

关键词： Fatigue Composite Epoxy Polymer Matrix

Prosthetic design of reverse shoulder arthroplasty contributes to scapular notching and instability

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World Journal of Orthopedics 2016年第11期7卷 738-745页

作者： Gazi Huri Filippo Familiari Nima Salari Steve A Petersen mahmut Nedim Doral Edward G Mc Farland Department of Orthopaedic and Traumatology Surgery Hacettepe University Medical School Division of Shoulder Surgery Department of Orthopaedic Surgerythe Johns Hopkins University

AIM To evaluate whether implant design, glenoid positioning, and other factors influenced instability and scapular notching in reverse total shoulder *** We retrospectively reviewed records of patients who had undergone reverse total shoulder arthroplasty by the senior author from July 2004 through October 2011 and who had at least 24 mo of follow-up. The 58 patients who met the criteria had 65 arthroplasties: 18 with a Grammont-type prosthesis(Grammont group) and 47 with a lateral-based prosthesis(lateral-design group). We compared the groups by rates of scapular notching and instability and by radiographic markers of glenoid position and tilt. We also compared glenoid sphere sizes and the number of subscapularis tendon repairs between the groups. Rates were compared using the Fisher exact test. Notching severity distribution was compared using the χ2 test of association. Significance was set at P < *** The Grammont group had a higher incidence of scapular notching(13 of 18; 72%) than the lateral-design group(11 of 47; 23%)(P < 0.001) and a higher incidence of instability(3 of 18; 17%) than the lateral-design group(0 of 47; 0%)(P = 0.019). Glenoid position, glenoid sphere size, and subscapularis tendon repair were not predictive of scapular notching or instability, independent of implantdesign. With the lateral-based prosthesis, each degree of inferior tilt of the baseplate was associated with a 7.3% reduction in the odds of developing notching(odds ratio 0.937, 95%CI: 0.894-0.983). CONCLUSION The lateral-based prosthesis was associated with less instability and notching compared with the Grammonttype prosthesis. Prosthesis design appears to be more important than glenoid positioning.

关键词： Arthroplasty Reverse Instability Scapular notching Shoulder

A novel mutation of SGK-1 gene in central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 23-28页

作者： mahmut Akyol Muhammet Kazιm Erol Ozdemir Ozdemir Deniz Turgut Coban Ahmet Burak Bilgin Esin Sogutlu Sari Elif Betul Turkoglu Department of Medical Biology and Genetics Akdeniz University Faculty of Medicine Department of Ophthalmology Antalya Education and Research Hospital Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Akdeniz University Faculty of Medicine Department of Ophthalmology Balιkesir University Faculty of Medicine

AIM: To investigate the association of serum glucocorticoid kinase gene-1(SGK-1) DNA variants with chronic central serous chorioretinopathy(CSC).METHODS: We enrolled 32 eyes of 32 patients who were diagnosed with chronic CSC and composed 32 normal eyes as a control group. Peripheral blood was used for DNA extraction and polymerase chain reaction amplification. SGK1 gene was sequenced by using Big Dye Terminator v3.1 cycle sequencing Kit(Applied Biosystems, Foster City, CA, USA). The SGK-1 gene and its variants were investigated in CSC patient group and control ***: We identified a new polymorphism M32 V in two person in the patient group [Minor allele frequency(MAF) =0.009] on the region of 1-60 amino acids. The rs1057293 was located in the encoder region of the SGK- 1 gene but not associated with CSC(P =0.68). An intrinsic rs1743966 is also not associated(P =0.28).CONCLUSION: The new polymorphism M32 V is located on the region of 1-60 amino acids which is necessary for localization to the mitochondria in CSC patient. This mutation is probably important for the energy metabolism and plays an important role in the cellular response to hyperosmotic stress and other stress stimuli. Both rs1057293 and rs1743966 are not associated with CSC.

关键词： central serous chorioretinopathy mutation polymerase chain reaction serum glucocorticoid kinase gene-1

Quality of life of elderly nursing home residents and its correlates in Kayseri. A descriptive-analytical design: A cross-sectional study

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Health 2013年第2期5卷 212-221页

作者： Vesile Senol Ferhan Soyuer mahmut Argun H.B.Vocational School of Health Erciyes UniversityKayseriTurkey Department of Orthopedy and Traumatology School of MedicineErciyes UniversityKayseriTurkey

Purpose: To define the level of quality of life in an elderly population and to investigate the effects of selected variables, such as anemia, fatigue, depression and sleep disorders, on the quality of life. Design and Methods: The study was conducted in Gazio?lu Nursing Home, located in the city center of Kayseri, on 136 subjects ≥65 in the year 2008-2009. Data were collected using the Geriatric Depression Scale (GDS), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI) and the World Health Organization Quality of Life-OLD (WHOQOL- OLD) Module. In the statistical analysis mean ± standard deviation, student’s t-test, ANOVA and Spearman correlation analysis were used. Re- sults: The mean total score of quality of life was 43.45 ± 10.30. Of the residents 47.0% had a poor quality of life. Autonomy had the lowest (35.70 ± 19.96) and intimacy had the highest (48.75 ± 17.96) subdomain scores. Fatigue significantly decreased the total and autonomy, social par- ticipation and death and dying subdomain scores. Anemia had a significant adverse effect on intimacy, depression on autonomy and intimacy and sleep disorder on death and dying. There were negative correlations between fatigue with past-present-future activities and social participation, depression with social participation, intimacy, death and dying and glucose levels with social participation and intimacy. Implications: About half of the subjects had a poor quality of life. Fatigue was the sole factor to negatively affect the total score in WHOQOL-OLD. Depression, anemia and sleep disorder adversely affected the autonomy, social participation, intimacy, death and dying subdomain scores but not in all.

关键词： Aged Anemia Fatigue Depression Sleep Disorder Quality of Life

随机预定需求下的客房分配:酒店收益管理博弈

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国际商务研究 2012年第3期33卷 69-80页

作者：宋敬普 mahmut Parlar 上海对外贸易学院上海201620 麦克马斯特大学商学院

本文研究具有两个不同消费级别的两家酒店在完全信息条件下收益管理的单期静态博弈。讨论了酒店分别在竞争与合作两种情况下,对于低价房间预留数目的设定策略。在竞争情况下,证明了纳什均衡唯一解的存在性。在合作情况下,分析了两酒店... 详细信息

本文研究具有两个不同消费级别的两家酒店在完全信息条件下收益管理的单期静态博弈。讨论了酒店分别在竞争与合作两种情况下,对于低价房间预留数目的设定策略。在竞争情况下,证明了纳什均衡唯一解的存在性。在合作情况下,分析了两酒店的节省成本及目标函数的凹性。在合作情况下,提出了使两酒店总收益大幅度提高的条件。最后,用一些算例(假设客房预定需求变量服从截断正态分布)分析了在每种情况下的酒店最优管理方案。

关键词：酒店收益管理博弈论纳什均衡合作博弈