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CRX-527 as a candidate adjuvant in a recombinant BCG-based malaria vaccine

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 1-7页

作者： Nor munirah zakaria muhammad Adamu Abbas Rapeah Suppian School of Health Sciences Universiti Sains MalaysiaHealth Campus16150 Kubang KerianKota BharuKelantanMalaysia Department of medical microbiology and Parasitology College of Health SciencesBayero University KanoP.M.B.3011BUKKano Nigeria

Objective:To investigate the role of CRX-527,a Toll-like receptor 4 agonist,as the possible adjuvant for recombinant mycobacterium bovis Bacillus Calmette-Guerin expressing merozoite surface protein 1C(BCG-mSP-1C).methods:The mice were immunized with BCG and BCG-mSP-1C in the presence and absence of *** untreated mice(injected with PBS-T80 only)were the negative *** ability of CRX-527 to enhance IgG and its subclasses,as well as IL-4 and IFN-γproduction in the serum and spleen supernatant was evaluated using ***:mice immunized with BCG-mSP-1C exhibited the highest production of IgGs,IL-4 and IFN-γafter third *** addition,CRX-527 further promoted the production of total IgG and IgG subclasses as well as IFN-γand IL-4 in the serum and splenocytes of immunized ***:CRX-527 has the potential as an adjuvant candidate for the candidate *** study is needed to verify appropriate dosage for immunization and its efficacy.

关键词： CRX-527 BCG BCG-mSP-1C TLR-4 agonists Cytokine IgG malaria

Effects of Heat and mass Transfer on the Perfect Conducting Polar Fluid Over a Stretching Sheet Due to Thermal Radiation

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Advances in Applied mathematics and mechanics 2010年第1期2卷 86-106页

作者： m.zakaria Department of mathematics Faculty of ScienceAl-Baha UniversityP.O.Box 1988 Al-Baha Kingdom of Saudi Arabia

The objectives of the present study are to investigate the effects of heat and mass transfer on the unsteady flow of a perfect conducting polar fluid over a flat sheet with a linear velocity in the presence of thermal *** approximation method developed in zakaria[***.10(2002),***.155(2005)]is adopted to solve the *** effects of Alfven velocity,mass transfer,various material parameters,Prandtl number,Schmidt number and relaxation time on the velocity,angular velocity,temperature and concentration are discussed and illustrated graphically.

关键词： Heat and mass transfer relaxation time perfectly conducting polar fluid

measurement of Radon Concentration and Estimation of Cancer Risk in Twenty-Four model Houses in the Town of Koudougou

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Open Journal of Applied Sciences 2024年第1期14卷 193-204页

作者： moumouni Derra Luc Telado Bambara Karim Kaboré Yalgado zakaria Sawadogo Ousmane Cissé François Zougmoré Physics Department University Norbert Zongo Koudougou Burkina Faso Physics and Chemical Department Institute of Sciences and Technology “Ecole Normale Supérieure” Ouagadougou Burkina Faso Physics Department Virtual University Ouagadougou Burkina Faso Laboratory of materials and Environment University Joseph Ki-Zerbo Ouagadougou Burkina Faso

The objective of our study is to evaluate the concentration of radon (86Rn) inside houses in the town of Koudougou in order to estimate its impact on the health of the population. Indeed, when uranium-rich minerals are found near the surface of the ground, radon concentrations can reach tens of becquerels per cubic meter in enclosed spaces. Given the nature of the geological base of Burkina Faso, this situation is quite probable and certain places that are sometimes poorly ventilated (house, school, office, etc.) can have radon levels high enough to constitute a health problem for occupants. Thus, twenty-four (24) sample houses were identified. In each house, the Corentium digital detector was between 0.8 m and 2 m for at least one week in a place where the occupants estimate that they spend more time of time and measure the concentration of radon in the long term and short term. The recorded data allowed us to determine the Absorbed Dose and the Annual Effective Dose of radon gas for each house in order to estimate the Risk of Cancer and the probable Number of Cases of Lung Cancer per million inhabitants. Thus, the results indicate that the long-term radon concentration varies between 6 Bq/m3 and 285 Bq/m3 respectively in houses 11 and 4 compared to 1 Bq/m3 to 208 Bq/m3 in the short term in the same houses. Also, in the long term, in control houses 1, 3 and 4, the radon level is above the recommended threshold interval. For the short term, these are houses 1, 3, 4 and 17 respectively with 110 Bq/m3, 142 Bq/m3, 208 Bq/m3 and 105 Bq/m3. As for the long-term and short-term effective doses, only houses 1, 3, 4, 17 and 24 have values between 3 - 10 Sv/year. The estimation of the relative risk of lung cancer gives values relatively close to unity and between 1.006 and 1.142 with an average of 1.035 and that of the Number of Lung Cancer Cases per million inhabitants gives va

关键词： Radon Absorbed Dose Annual Effective Dose Cancer Risk

Identification of microorganisms in Poultry Farms in N’djamena and the Border Areas of Hadjer-Lamis and Chari-Baguirmi Chad

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Journal of Agricultural Chemistry and Environment 2024年第2期13卷 223-234页

作者： Abakar Abbo zakaria Bebanto Antipas Ban-Bo Nadine Terei Bongo Naré Richard Gandolo Abdelsalam Adoum Doutoum Labortoire de Rattachement IRED (Institut de Recherches en Elevage pour le Dé veloppement) University of N&#8217Djamena N&#8217Djamena Chad Laboratory of Biochemistry-Cellular and molecular Biology-microbiology (L2BCm) Faculty of Exact and Applied Sciences University of N&#8217Djamena N&#8217Djamena Chad Livestock Research Institute for Development (IRED) N&#8217Djamena Chad Adam Barka University of Abé ch&#233 Ab&#233ch&#233 Chad

Introduction: On the outskirts of Ndjamena, semi-industrial poultry farming and traditional poultry farming are practised informally on almost all poultry farms in Chad. This type of poultry farming is faced with real health problems attributable to a lack of monitoring of the vaccination schedule, inadequate compliance with biosecurity measures and poor application of the Ichikawa rule based on the 5 m’s. Objective: The aim of this article is to identify the microorganisms responsible for contamination of poultry farms in the study area. method: The study was carried out from 28/04/2022 to 31/01/2023 on the basis of 300 samples taken from feed, drinking water, droppings and scrapings from poultry housing surfaces in the 30 farms that served as a framework for our research. Sampling was of the simple random type, and farms were selected on the basis of the farmers’ consent. The data were recorded on pre-established survey forms. Our study was cross-sectional, descriptive and prospective. Bacteria were isolated using the reference method NF EN ISO 6579 for Salmonella spp. and cultured on the specific medium eosin methylene blue (EmB) for Escherichia coli, Pseudomonas and Citrobacter freundii. Results: The following results emerged from this study: Escherichia coli (5.33%), Pseudomonas (1.33%), Citrobacter freundii (12%) and Salmonella paratyphi (21.68%). Conclusion: Of the 300 samples analysed, 121 (40.33%) were contaminated with pathogens. This high level of contamination is a health problem. The study shows that biosecurity is less satisfactory on the farms visited. Nevertheless, farms with a very satisfactory level of biosafety ensure food safety and variety for the population.

关键词： microorganisms Identification Poultry Farms N’Djamena Hadjer-Lamis Chari-Baguirmi(Chad)

Influence of potassium fertilization and foliar application of zinc and phosphorus on growth,yield components,yield and fiber properties of Egyptian cotton(Gossypium barbadense L.)

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Journal of Plant Ecology 2008年第4期1卷 259-270页

作者： zakaria m.Sawan mahmoud H.mahmoud Amal H.El-Guibali Cotton Research Institute Agricultural Research CenterMinistry of Agriculture and Land Reclamation9 Gamaa StreetGiza 12619Egypt Soils Water and Environment Research InstituteAgricultural Research CenterMinistry of Agriculture and Land Reclamation9 Gamaa StreetGiza 12619Egypt

Aims Supplying optimal quantities of mineral nutrients to growing crop plants is one way to improve crop *** need to be used rationally in order to avoid a negative ecological impact and undesirable effects on the sustainability of agricultural production *** application of nutrients also affects the farmer’s *** order to calculate the amount of fertilizer to be applied to crops,it is necessary to develop recommendation programmers that adjust nutrient rates to crop *** Experiments in two successive seasons were conducted to investigate the effect of K fertilization and foliar application of Zn and P on yield and fiber properties of cotton *** ***(0.0 and 47.4 kg of K ha^(-1))was soil applied,while chelated zinc(0.0 and 57.6 g of Zn ha^(-1),applied twice at 70 and 85 days after sowing‘DAS’)and phosphorus(0.0,576,1152 and 1728 g of P ha^(-1),applied twice at 80 and 95 DAS)were applied to the *** findings Dry matter yield,total chlorophyll concentration,K,Zn and P uptake per plant,number of opened bolls per plant,boll weight,seed index,lint index,seed cotton yield per plant,seed cotton and lint yield ha^(-1) and earliness of harvest increased with the application of K,Zn and *** generally had no significant effect on lint percentage and fiber properties,with exceptions,for micronaire reading and flat bundle strength,and uniformity ratio,where the mean values of these characters were significantly increased over the untreated control by applying K,and for the micronaire reading in the first season,when applying P at 1728 g ha^(-1),and uniformity ratio in the second season,when applying Pat 1152 and 1728 g ha^(-1),where the mean values of these characters were significantly increased over the untreated control by applying *** the conditions of this study,applying K fertilization at 47.4 kg ha^(-1) combined with spraying cotton plants with zinc at 57.6 g ha^(-1) and also with P at

关键词： cotton fiber properties phosphorus potassium yield and yield components zinc

Optical and magnetic properties of perovskite materials:Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3)

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Journal of Rare Earths 2022年第4期40卷 652-659,I0005页

作者： Fatima El Bachraoui zakaria Chchiyai Youssef Tamraoui Hassan El moussaoui Jones Alami Bouchaib manoun materials Science Energy and Nano-engineering Department(MSN)University Mohammed VI Polytechnic43150BenguerirMorocco Hassan First University of Settat FSTRayonnement-Matière et InstrumentationS3M26000SettatMorocco materials and Nanomaterials Center Moroccan Foundation for Advanced ScienceInnovation and Research10100RabatMorocco

Structural,optical and magnetic properties are reported for new synthesized perovskite ***_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid state reaction.X-ray analysis confirms that both compositions show feature of perovskite *** refinement method was used to confirm the phase formation and investigate the structure and space *** study demonstrates the formation of orthorhombic structure with Pnma space group for Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) while the composition Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) structure adopts Pbnm ***–vis spectroscopy measurements show very broad and intense UV–visible light absorption,the estimated band gap ranges between 2.07 and 2.15 *** measurements were carried out for the compositions Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3).The hysteresis loops of both samples at 300 and 10 K show a strong ferromagnetic *** temperature dependent magnetization at 0.05 T under field-cooled(FC)and zero field cooled(ZFC)modes shows magnetic frustration or spin glass-like behavior.

关键词： Perovskites Co-substitution effect Phase transition Band gap Ferromagnetic Visible light absorption

Climatic variables: Evaporation, sunshine, relative humidity, soil and air temperature and its adverse effects on cotton production

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Information Processing in Agriculture 2018年第1期5卷 134-148页

作者： zakaria m.Sawan Cotton Research Institute Agricultural Research CenterMinistry of Agriculture&Land Reclamation9 Gamaa Street12619 GizaEgypt

Cotton yield is a function of growth rates,flower production rates,and flower and boll retention during the fruiting *** on the relationship between climatic factors and the cotton plant’s ability to produce and sustain flower buds,flowers,and bolls will allow one to model plant responses to conditions that frequently occur in the field and to predict developmental rate or the formation of these *** study investigates the statistical relationship between various climatic factors and overall flower and boll ***,the relationship between climatic factors and production of flowers and bolls obtained during the development periods of the flowering and boll ***,predicting effects of climatic factors during different convenient intervals(in days)on cotton flower and boll production compared with daily ***,sunshine duration,relative humidity,surface soil temperature at 1800 h,and maximum air temperature,are the important climatic factors that significantly affect flower and boll *** five-day interval was found to be more adequately and sensibly related to yield ***;minimum humidity and sunshine duration were the most effective climatic factors during preceding and succeeding periods on boll production and *** was a negative correlation between flower and boll production and either evaporation or sunshine duration,while that correlation with minimum relative humidity was positive.

关键词： Cotton flower and boll production Evaporation Relative humidity Sunshine duration Temperature

Strength Performance and microstructure Characteristic of Naturally-Bonded Fiberboard Composite from malaysian Bamboo(Bambusa vulgaris)

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Journal of Renewable materials 2022年第10期10卷 2581-2591页

作者： Shahril Anuar Bahari mohd Nazarudin zakaria Syaiful Osman Falah Abu mohamad Jani Saad Reza Hosseinpourpia Eco-Technology Program Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Shah Alam40450Malaysia Engineering Research Centre Malaysian Agricultural Research and Development Institute(MARDI)Serdang43400Malaysia Department of Forestry and Wood Technology Linnaeus UniversityVäxjö35195Sweden

This study investigated the mechanical properties and microstructural characteristics of fiberboard composite produced by naturally-bonded malaysian bamboo fiber(Bambusa vulgaris).The components that obtained through soda pulping of bamboo culms such as fiber and black liquor,were used for the preparation of high-density fibreboard composite at two target densities of 850 and 950 kg/m^(3).The bamboo fiberboard composite(BFC)were then produced at 200°C and two pressing parameters of 125 and 175 s/*** mechanical properties,e.g.,flexural strength and internal bonding(IB)of BFC samples were evaluated according to BS EN 310:1993 and BS EN 319:1993,*** was found that the mechanical performance of the composite with 850 kg/m^(3)density was significantly higher than 950 kg/m^(3)ones,especially for the samples with 125 s/mm pressing *** characteristic of the BFC samples illustrated that the fiber linkages were cracked in the composites with higher density,e.g.,the composite with the density of 950 kg/m^(3)and also black liquor were slightly degraded at longer pressing time,which led to the reduction in mechanical properties,especially in IB strength.

关键词： Bamboo fiber naturally-bonded black liquor mechanical properties SEm composite

Complementary effect of zoo compost with mineral nitrogen fertilisation increases wheat yield and nutrition in a low-nutrient soil

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Pedosphere 2022年第2期32卷 339-347页

作者： muhammad S.A.KHAN Lynette K.ABBOTT zakaria m.SOLAImAN Peter R.mAWSON Ian S.WAITE Sasha N.JENKINS School of Agriculture and Environment Institute of AgricultureThe University of Western AustraliaPerth WA 6009Australia Perth Zoo Department of BiodiversityConservation and AttractionsPerth WA 6151Australia Agricultural Officer(Headquarters) DirectorateSoil Fertility Research InstituteAgriculture DepartmentGovernment of the PunjabLahore 53700Pakistan

Excess nitrogen(N) fertiliser use in agriculture is associated with water pollution and greenhouse gas *** practices and programs to reduce N fertiliser application continue to be developed,inefficient fertiliser use *** that reduce mineral N fertiliser application are needed in a sustainable agricultural ecosystem to control leaching and gaseous losses for environmental *** study evaluated whether fully or partially replacing mineral N fertiliser with zoo compost(Perth Zoo) could be a good mitigation strategy to reduce mineral N fertiliser application without affecting wheat yield and *** achieve this,a glasshouse experiment was conducted to assess the complementary effect of zoo compost and mineral N fertiliser on wheat yield and nutrition in a sandy soil of southwestern ***,a chlorophyll meter was used to determine whether there was a correlation between chlorophyll content and soil mineral N content,grain N uptake,and grain protein content at the tillering(42 d after sowing(DAS)) and heading(63 DAS) growth *** standard practice for N application for this soil type in this area,100 kg ha^(-1),was used with a soil bulk density of 1.3 g cm^(-3) to calculate the amount of mineral N(urea,46% N) and Perth Zoo compost(ZC)(0.69% N) for each *** comprised a control(no nutrients added,T1),mineral N only(100 kg N ha^(-1),T2),ZC only(100 kg N ha^(-1),T7),and combinations of mineral N and ZC at different rates(mineral N at 100 kg N ha^(-1)+ ZC at 25 kg N ha^(-1)(T3),mineral N at 75 kg N ha^(-1)+ ZC at 25 kg N ha^(-1)(T4),mineral N at 75 kg N ha^(-1)+ ZC at 50 kg N ha^(-1)(T5),and mineral N at 50 kg N ha^(-1)+ ZC at 50 kg N ha^(-1)(T6)).The T6 treatment significantly increased grain yield(by 26%) relative to the T2 ***,the T7 treatment did not affect grain yield when compared to the T2 *** treatments with mineral N and ZC in combination significantly improved the

关键词： chlorophyll meter SPAD measurement integrated nutrient management nitrogen use efficiency reduced N fertiliser application wheat yield