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CRX-527 as a candidate adjuvant in a recombinant BCG-based malaria vaccine

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 1-7页

作者： Nor munirah zakaria muhammad Adamu Abbas Rapeah Suppian School of Health Sciences Universiti Sains MalaysiaHealth Campus16150 Kubang KerianKota BharuKelantanMalaysia Department of medical microbiology and Parasitology College of Health SciencesBayero University KanoP.M.B.3011BUKKano Nigeria

Objective:To investigate the role of CRX-527,a Toll-like receptor 4 agonist,as the possible adjuvant for recombinant mycobacterium bovis Bacillus Calmette-Guerin expressing merozoite surface protein 1C(BCG-mSP-1C).methods:The mice were immunized with BCG and BCG-mSP-1C in the presence and absence of *** untreated mice(injected with PBS-T80 only)were the negative *** ability of CRX-527 to enhance IgG and its subclasses,as well as IL-4 and IFN-γproduction in the serum and spleen supernatant was evaluated using ***:mice immunized with BCG-mSP-1C exhibited the highest production of IgGs,IL-4 and IFN-γafter third *** addition,CRX-527 further promoted the production of total IgG and IgG subclasses as well as IFN-γand IL-4 in the serum and splenocytes of immunized ***:CRX-527 has the potential as an adjuvant candidate for the candidate *** study is needed to verify appropriate dosage for immunization and its efficacy.

关键词： CRX-527 BCG BCG-mSP-1C TLR-4 agonists Cytokine IgG malaria

Effects of Heat and mass Transfer on the Perfect Conducting Polar Fluid Over a Stretching Sheet Due to Thermal Radiation

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Advances in Applied mathematics and mechanics 2010年第1期2卷 86-106页

作者： m.zakaria Department of mathematics Faculty of ScienceAl-Baha UniversityP.O.Box 1988 Al-Baha Kingdom of Saudi Arabia

The objectives of the present study are to investigate the effects of heat and mass transfer on the unsteady flow of a perfect conducting polar fluid over a flat sheet with a linear velocity in the presence of thermal *** approximation method developed in zakaria[***.10(2002),***.155(2005)]is adopted to solve the *** effects of Alfven velocity,mass transfer,various material parameters,Prandtl number,Schmidt number and relaxation time on the velocity,angular velocity,temperature and concentration are discussed and illustrated graphically.

关键词： Heat and mass transfer relaxation time perfectly conducting polar fluid

measurement of Radon Concentration and Estimation of Cancer Risk in Twenty-Four model Houses in the Town of Koudougou

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Open Journal of Applied Sciences 2024年第1期14卷 193-204页

作者： moumouni Derra Luc Telado Bambara Karim Kaboré Yalgado zakaria Sawadogo Ousmane Cissé François Zougmoré Physics Department University Norbert Zongo Koudougou Burkina Faso Physics and Chemical Department Institute of Sciences and Technology “Ecole Normale Supérieure” Ouagadougou Burkina Faso Physics Department Virtual University Ouagadougou Burkina Faso Laboratory of materials and Environment University Joseph Ki-Zerbo Ouagadougou Burkina Faso

The objective of our study is to evaluate the concentration of radon (86Rn) inside houses in the town of Koudougou in order to estimate its impact on the health of the population. Indeed, when uranium-rich minerals are found near the surface of the ground, radon concentrations can reach tens of becquerels per cubic meter in enclosed spaces. Given the nature of the geological base of Burkina Faso, this situation is quite probable and certain places that are sometimes poorly ventilated (house, school, office, etc.) can have radon levels high enough to constitute a health problem for occupants. Thus, twenty-four (24) sample houses were identified. In each house, the Corentium digital detector was between 0.8 m and 2 m for at least one week in a place where the occupants estimate that they spend more time of time and measure the concentration of radon in the long term and short term. The recorded data allowed us to determine the Absorbed Dose and the Annual Effective Dose of radon gas for each house in order to estimate the Risk of Cancer and the probable Number of Cases of Lung Cancer per million inhabitants. Thus, the results indicate that the long-term radon concentration varies between 6 Bq/m3 and 285 Bq/m3 respectively in houses 11 and 4 compared to 1 Bq/m3 to 208 Bq/m3 in the short term in the same houses. Also, in the long term, in control houses 1, 3 and 4, the radon level is above the recommended threshold interval. For the short term, these are houses 1, 3, 4 and 17 respectively with 110 Bq/m3, 142 Bq/m3, 208 Bq/m3 and 105 Bq/m3. As for the long-term and short-term effective doses, only houses 1, 3, 4, 17 and 24 have values between 3 - 10 Sv/year. The estimation of the relative risk of lung cancer gives values relatively close to unity and between 1.006 and 1.142 with an average of 1.035 and that of the Number of Lung Cancer Cases per million inhabitants gives va

关键词： Radon Absorbed Dose Annual Effective Dose Cancer Risk

Identification of microorganisms in Poultry Farms in N’djamena and the Border Areas of Hadjer-Lamis and Chari-Baguirmi Chad

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Journal of Agricultural Chemistry and Environment 2024年第2期13卷 223-234页

作者： Abakar Abbo zakaria Bebanto Antipas Ban-Bo Nadine Terei Bongo Naré Richard Gandolo Abdelsalam Adoum Doutoum Labortoire de Rattachement IRED (Institut de Recherches en Elevage pour le Dé veloppement) University of N&#8217Djamena N&#8217Djamena Chad Laboratory of Biochemistry-Cellular and molecular Biology-microbiology (L2BCm) Faculty of Exact and Applied Sciences University of N&#8217Djamena N&#8217Djamena Chad Livestock Research Institute for Development (IRED) N&#8217Djamena Chad Adam Barka University of Abé ch&#233 Ab&#233ch&#233 Chad

Introduction: On the outskirts of Ndjamena, semi-industrial poultry farming and traditional poultry farming are practised informally on almost all poultry farms in Chad. This type of poultry farming is faced with real health problems attributable to a lack of monitoring of the vaccination schedule, inadequate compliance with biosecurity measures and poor application of the Ichikawa rule based on the 5 m’s. Objective: The aim of this article is to identify the microorganisms responsible for contamination of poultry farms in the study area. method: The study was carried out from 28/04/2022 to 31/01/2023 on the basis of 300 samples taken from feed, drinking water, droppings and scrapings from poultry housing surfaces in the 30 farms that served as a framework for our research. Sampling was of the simple random type, and farms were selected on the basis of the farmers’ consent. The data were recorded on pre-established survey forms. Our study was cross-sectional, descriptive and prospective. Bacteria were isolated using the reference method NF EN ISO 6579 for Salmonella spp. and cultured on the specific medium eosin methylene blue (EmB) for Escherichia coli, Pseudomonas and Citrobacter freundii. Results: The following results emerged from this study: Escherichia coli (5.33%), Pseudomonas (1.33%), Citrobacter freundii (12%) and Salmonella paratyphi (21.68%). Conclusion: Of the 300 samples analysed, 121 (40.33%) were contaminated with pathogens. This high level of contamination is a health problem. The study shows that biosecurity is less satisfactory on the farms visited. Nevertheless, farms with a very satisfactory level of biosafety ensure food safety and variety for the population.

关键词： microorganisms Identification Poultry Farms N’Djamena Hadjer-Lamis Chari-Baguirmi(Chad)

Influence of potassium fertilization and foliar application of zinc and phosphorus on growth,yield components,yield and fiber properties of Egyptian cotton(Gossypium barbadense L.)

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Journal of Plant Ecology 2008年第4期1卷 259-270页

作者： zakaria m.Sawan mahmoud H.mahmoud Amal H.El-Guibali Cotton Research Institute Agricultural Research CenterMinistry of Agriculture and Land Reclamation9 Gamaa StreetGiza 12619Egypt Soils Water and Environment Research InstituteAgricultural Research CenterMinistry of Agriculture and Land Reclamation9 Gamaa StreetGiza 12619Egypt

Aims Supplying optimal quantities of mineral nutrients to growing crop plants is one way to improve crop *** need to be used rationally in order to avoid a negative ecological impact and undesirable effects on the sustainability of agricultural production *** application of nutrients also affects the farmer’s *** order to calculate the amount of fertilizer to be applied to crops,it is necessary to develop recommendation programmers that adjust nutrient rates to crop *** Experiments in two successive seasons were conducted to investigate the effect of K fertilization and foliar application of Zn and P on yield and fiber properties of cotton *** ***(0.0 and 47.4 kg of K ha^(-1))was soil applied,while chelated zinc(0.0 and 57.6 g of Zn ha^(-1),applied twice at 70 and 85 days after sowing‘DAS’)and phosphorus(0.0,576,1152 and 1728 g of P ha^(-1),applied twice at 80 and 95 DAS)were applied to the *** findings Dry matter yield,total chlorophyll concentration,K,Zn and P uptake per plant,number of opened bolls per plant,boll weight,seed index,lint index,seed cotton yield per plant,seed cotton and lint yield ha^(-1) and earliness of harvest increased with the application of K,Zn and *** generally had no significant effect on lint percentage and fiber properties,with exceptions,for micronaire reading and flat bundle strength,and uniformity ratio,where the mean values of these characters were significantly increased over the untreated control by applying K,and for the micronaire reading in the first season,when applying P at 1728 g ha^(-1),and uniformity ratio in the second season,when applying Pat 1152 and 1728 g ha^(-1),where the mean values of these characters were significantly increased over the untreated control by applying *** the conditions of this study,applying K fertilization at 47.4 kg ha^(-1) combined with spraying cotton plants with zinc at 57.6 g ha^(-1) and also with P at

关键词： cotton fiber properties phosphorus potassium yield and yield components zinc

Climatic variables: Evaporation, sunshine, relative humidity, soil and air temperature and its adverse effects on cotton production

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Information Processing in Agriculture 2018年第1期5卷 134-148页

作者： zakaria m.Sawan Cotton Research Institute Agricultural Research CenterMinistry of Agriculture&Land Reclamation9 Gamaa Street12619 GizaEgypt

Cotton yield is a function of growth rates,flower production rates,and flower and boll retention during the fruiting *** on the relationship between climatic factors and the cotton plant’s ability to produce and sustain flower buds,flowers,and bolls will allow one to model plant responses to conditions that frequently occur in the field and to predict developmental rate or the formation of these *** study investigates the statistical relationship between various climatic factors and overall flower and boll ***,the relationship between climatic factors and production of flowers and bolls obtained during the development periods of the flowering and boll ***,predicting effects of climatic factors during different convenient intervals(in days)on cotton flower and boll production compared with daily ***,sunshine duration,relative humidity,surface soil temperature at 1800 h,and maximum air temperature,are the important climatic factors that significantly affect flower and boll *** five-day interval was found to be more adequately and sensibly related to yield ***;minimum humidity and sunshine duration were the most effective climatic factors during preceding and succeeding periods on boll production and *** was a negative correlation between flower and boll production and either evaporation or sunshine duration,while that correlation with minimum relative humidity was positive.

关键词： Cotton flower and boll production Evaporation Relative humidity Sunshine duration Temperature

Application of Biochars for Soil Constraints:Challenges and Solutions

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Pedosphere 2015年第5期25卷 631-638页

作者： zakaria m.SOLAImAN Hossain m.ANAWAR Soil Biology and molecular Ecology Group School of Earth and Environment (M087) and UWA Institute of AgricultureThe University of Western Australia School of Earth and Environment (m087) and UWA Institute of Agriculture The University of Western Australia

Biochar addition to soil is currently being considered as a means to sequester carbon while simultaneously improving soil health,soil fertility and agronomic benefits. The focus of this special issue is on current research on the effects of biochar application to soil for overcoming diverse soil constraints and recommending further research relating to biochar application to soil. The biochar research has progressed considerably with important key findings on agronomic benefits, carbon sequestration, greenhouse gas emissions, soil acidity, soil fertility, soil health, soil salinity, etc., but more research is required before definitive recommendations can be made to end-users regarding the effects of biochar application across a range of soils, climates and land management practices.

关键词： agronomic benefits carbon sequestration greenhouse gas emissions pH soil fertility soil health soil salinity

Biochar:An Emerging Panacea for Remediation of Soil Contaminants from mining,Industry and Sewage Wastes

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Pedosphere 2015年第5期25卷 654-665页

作者： Hossain m.ANAWAR Farjana AKTER zakaria m.SOLAImAN Vladimir STREZOV School of Earth and Environment (m087) and UWA Institute of Agriculture The University of Western Australia Sher-e-Bangla Agricultural University Department of Environmental Sciences Faculty of Science and EngineeringMacquarie University

mine tailings, waste rock piles, acid mine drainage, industrial wastewater, and sewage sludge have contaminated a vast area of cultivable and fallow lands, with a consequence of deterioration of soil and water quality and watercourses due to the erosion of contaminated soils for absence of vegetative cover. High concentrations of toxic elements, organic contaminants, acidic soils, and harsh climatic conditions have made it difficult to re-establish vegetation and produce crops there. Recently, a significant body of work has focussed on the suitability and potentiality of biochar as a soil remediation tool that increases seed emergence, soil and crop productivity, above ground biomass, and vegetation cover on mine tailings, waste rock piles, and industrial and sewage waste- contaminated soils by increasing soil nutrients and water-holding capacity, amelioration of soil acidity, and stimulation of microbial diversity and functions. This review addresses： i） the functional properties of biochar, and microbial cycling of nutrients in soil; ii） bioremediation, especially phytoremediation of mine railings, industrial waste, sewage sludge, and contaminated soil using biochar; iii） impact of biochar on reduction of acid production, acid mine drainage treatment, and geochemical dynamics in mine railings; and iv） treatment of metal and organic contaminants in soils using biochar, and restoration of degraded land.

关键词： acid mine drainage contaminated soil interaction mine railings mining waste phytoremediation phytostabilization revegetation

Development of an Energy Efficiency Design Index for Inland Vessels of Bangladesh

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Journal of marine Science and Application 2020年第2期19卷 275-282页

作者： Sohanur Rahman N.m.Golam.zakaria Ankerbeer Engineering and Design KolhamThe Netherlands Bangladesh University of Engineering&Technology DhakaBangladesh

more than 10000 different types of ship ply the waters of Bangladesh all year round,but the performance of these ships in terms of CO2 emission is not known and regulations related to energy efficiency of inland waterway ships remain *** paper attempts to assess the present situation of inland class vessels in terms of Energy Efficiency Design Index(EEDI).With the use of a developed database of inland vessels in Bangladesh,EEDI reference lines for different types of inland vessels in Bangladesh were established and then compared with those of other *** present EEDI of existing inland vessels was *** indicate that most of the existing vessels do not meet the current EEDI ***,new guidelines are necessary to achieve EEDI compliance in the near *** recommendations were proposed for improving CO2 emissions,with the socioeconomic and technical factors in Bangladesh taken into consideration.

关键词： Inland waterways vessel CO2 emission ImO Energy Efficiency Design Index(EEDI)