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A Novel Approach to Heart Failure Prediction and Classification through Advanced Deep Learning Model

World Journal of Cardiovascular Diseases 2023年第9期13卷 586-604页

作者： abdalla Mahgoub Dubai United Arab Emirates

In this study, the author will investigate and utilize advanced machine learning models related to two different methodologies to determine the best and most effective way to predict individuals with heart failure and cardiovascular diseases. The first methodology involves a list of classification machine learning algorithms, and the second methodology involves the use of a deep learning algorithm known as MLP or Multilayer Perceptrons. Globally, hospitals are dealing with cases related to cardiovascular diseases and heart failure as they are major causes of death, not only for overweight individuals but also for those who do not adopt a healthy diet and lifestyle. Often, heart failures and cardiovascular diseases can be caused by many factors, including cardiomyopathy, high blood pressure, coronary heart disease, and heart inflammation [1]. Other factors, such as irregular shocks or stress, can also contribute to heart failure or a heart attack. While these events cannot be predicted, continuous data from patients’ health can help doctors predict heart failure. Therefore, this data-driven research utilizes advanced machine learning and deep learning techniques to better analyze and manipulate the data, providing doctors with informative decision-making tools regarding a person’s likelihood of experiencing heart failure. In this paper, the author employed advanced data preprocessing and cleaning techniques. Additionally, the dataset underwent testing using two different methodologies to determine the most effective machine-learning technique for producing optimal predictions. The first methodology involved employing a list of supervised classification machine learning algorithms, including Naïve Bayes (NB), KNN, logistic regression, and the SVM algorithm. The second methodology utilized a deep learning (DL) algorithm known as Multilayer Perceptrons (MLPs). This algorithm provided the author with the flexibility to experiment with different layer sizes and activation

关键词： Heart Disease Prediction Cardiovascular Disease Machine Learning Algorithms Lazy Predict Multilayer Perceptrons (MLPs) Data Science Techniques and Analysis Deep Learning Activation Functions

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Association of Blastocystis hominis with colorectal cancer:A systematic review of in vitro and in vivo evidences

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 734-745页

作者： Vinoth Kumarasamy Wahib Mohammed Atroosh Deepa Anbazhagan Mona Mohamed Ibrahim abdalla Meram Azzani Department of Microbiology and Parasitology Faculty of MedicineBioscience and NursingMAHSA UniversityJenjarom 42610SelangorMalaysia Department of Preclinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanKajang 43000SelangorMalaysia Department of Parasitology Faculty of MedicineUniversiti MalayaKuala Lumpur 50603Wilayah PersekutuanMalaysia Department of Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversity of AdenAden 00Yemen Human Biology Department International Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Community Medicine Faculty of MedicineBioscience and NursingMAHSA UniversityJenjarom 42610SelangorMalaysia

BACKGROUND Recently,there have been several findings that showed intestinal colonisation of Blastocystis hominis(Blastocystis)as a risk factor to the worsening of colorectal cancer(CRC).However,studies have shown controversial results in the pathogenicity of *** To review systematically the evidence available on the association between CRC and Blastocystis and the prevalence of Blastocystis in CRC patients and to investigate cytopathic and immunological effects of Blastocystis in in vitro and in vivo *** PRISMA guidelines were utilised in conducting this systematic *** articles published before February 2,2020 were ***,Science Direct,Scopus and Google scholar databases were *** searching was carried out to find articles missed during the online *** Out of 12 studies selected for this systematic review,seven studies confirmed the prevalence of Blastocystis and found it to be between 2%-28%in CRC patients,whereby subtype 1 and subtype 3 were predominantly seen.A total of four studies employing in vitro human colorectal carcinoma cell line study models showed significant cytopathic and immunological effects of *** addition,one in vivo experimental animal model study showed that there was a significant effect of infection with Blastocystis on exacerbation of colorectal *** Blastocystis is a commonly identified microorganism in CRC *** studies have provided supportive data that Blastocystis could exacerbate existing CRC via alteration in host immune response and increased oxidative *** studies of CRC and Blastocystis should attempt to determine the various stages of CRC that are most likely to be associated with Blastocystis and its relationship with other intestinal bacteria.

关键词： Blastocystis hominis Colorectal cancer Cytopathic effect Immunological effect

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Characterization of a Watermelon mosaic virus Isolate Inducing a Severe Disease in Watermelon in Saudi Arabia

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Journal of Agricultural Science and Technology(A) 2018年第4期8卷 220-229页

作者： Adyatma Irawan Santosa Ibrahim Mohamed Al-Shahwan Omer Ahmed abdalla Mohamed Ali Al-Saleh mahmoud Ahmed Amer Plant Protection Department College of Food and Agriculture SciencesKing Saud UniversityP.O.Box 2460Riyadh11451Saudi Arabia

In one of the field visits to cucurbits-growing areas in vicinity of Riyadh city during 2013-2015,severe virus disease-like symptoms were observed on watermelon in Al-Ammariyah *** inoculation of the different plant species used in the host range study,from the collected symptomatic watermelon samples,produced mosaic symptoms on Citrullus lanatus,Cucumis sativus,Cucurbita pepo,***,*** *** and Nicotiana benthamiana,but chlorotic local lesions on Chenopodium *** symptoms were observed on the rest of the other inoculated plant *** virus was transmitted by Aphis gossypii and *** in a non-persistent *** electron microscopic examination of watermelon samples using the leaf dip method revealed only microscopic filamentous shaped virus particles measuring 750 nm in length and 12 nm in diameter in *** revealed positive results only to Watermelon mosaic virus(WMV)and negative to Zucchini yellow mosaic virus(ZYMV),Papaya ringspot virus(PRSV),Cucumber mosaic virus(CMV)and Squash mosaic virus(SqMV).Specific bands of approximately 825 bp were formed on agarose gel following electrophoresis of the reverse transcriptase-polymerase chain reaction(RT-PCR)products of each of the naturally infected ***,and artificially infected ***,***,***,and *** homology tree that was constructed from multiple sequence alignments of the detected Saudi Arabian isolate of WMV(WMV-SA)with 18 other isolates of WMV from nine different countries indicated close relationships between *** isolates from Spain and two other isolates from Iran were more closely related to the WMV-SA whereas the isolate from Poland was the least.

关键词： Watermelon ELISA nucleotide sequence RT-PCR Saudi Arabia Watermelon mosaic virus

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Role of biliary complications in chronic graft rejection after living donor liver transplantation

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World Journal of Hepatology 2022年第5期14卷 1050-1052页

作者： Aiman Obed abdalla Bashir Anwar Jarrad Laszlo Fuzesi Hepatobiliary and Liver Transplant Unit Jordan HospitalAmman 52112Jordan Department of General Surgery Jordan HospitalAmman 52112Jordan Department of Hepatology Jordan HospitalAmman 52112Jordan Department of Pathology Faculty of MedicineUniversity AugsburgAugsburg 86156Germany

Postoperative biliary complications remain a substantial challenge after living donor liver transplantation,especially due to its heterogeneous clinical presentation.

关键词： Chronic graft rejection Biliary complications Living donor liver transplantation Graft survival Cholangiopathy

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Naringenin suppresses NLRP3 inflammasome activation via the mRNA-208a signaling pathway in isoproterenol-induced myocardial infarction

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Asian Pacific Journal of Tropical Biomedicine 2023年第10期13卷 443-450页

作者： Ayman Eldourghamy Toka Hossam Mohammed abdalla Hussein Amal Abdel-Aziz Samir A.El-masry Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteSadat UniversityEgypt Department of Medical Labs Faculty of Applied Medical Sciences TechnologyOctober 6 UniversityEgypt Department of Biotechnology Faculty of Applied Health Sciences TechnologyOctober 6 UniversityEgypt Molecular Biology Department Genetic Engineering and Biotechnology Research InstituteSadat UniversityEgypt

Objective:To investigate the cardioprotective effect of naringenin against isoproterenol(ISO)-induced cardiotoxicity in ***:Rats were divided into five groups:the normal group,the ISO group(85 mg/kg b.w.);the ISO+naringenin(50 mg/kg b.w.)group,the ISO+naringenin(100 mg/kg b.w.)group and the ISO+propranolol(10 mg/kg b.w.)*** creatine kinase-MB(CK-MB),cardiac troponin T,lactate dehydrogenase,brain natriuretic peptide(BNP),and IL-10,as well as cardiac transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and malondialdehyde(MDA)were *** addition,NLRP3 and mRNA-208a expressions were evaluated by RT-PCR *** examination was also performed to assess cardiac ***:Naringenin treatment significantly decreased plasma lactate dehydrogenase,CK-MB,cardiac troponin T,BNP,and IL-10,as well as cardiac TGF-β1,VEGF,and MDA while increasing p-Akt and superoxide dismutase in ISO-administered *** also reduced NLRP3 and mRNA-208a gene expression ***,naringenin improved ISO-induced cardiac ***:Naringenin attenuates myocardial dysfunction in ISO-treated rats by decreasing oxidative stress and increasing cardiac endogenous antioxidant system,which may be modulated partly by improvement of NLRP3 and mRNA-208a gene expression.

关键词： Naringenin Isoproterenol Myocardial infarction Antioxidants NLRP3 mRNA-208a

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Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study

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World Journal of Hepatology 2021年第8期13卷 939-948页

作者： Ali Madian Ahmed Eliwa Hytham abdalla Haitham A Azeem Aly Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineAl-Azhar University-CairoCairo 11754Egypt Department of Chest Diseases Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Department of Internal Medicine Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt

BACKGROUND Clearly,infection with severe acute respiratory syndrome coronavirus 2 is not limited to the lung but also affects other *** need predictive models to determine patients’prognoses and to improve health care resource allocation during the coronavirus disease 2019(COVID-19)*** treating COVID-19,we observed differential outcome prediction weights for markers of hepatocellular injury among hospitalized *** To investigate the association between hepatocellular injury and all-cause inhospital mortality among patients with *** This multicentre study employed a retrospective cohort *** adult patients admitted to Al-Azhar University Hospital,Assiut,Egypt and Abo Teeg General Hospital,Assiut,Egypt with confirmed COVID-19 from June 1,2020,to July 30,2020 were *** categorized our cohort into three groups of(1)patients with COVID-19 presenting normal aminotransferase levels;(2)patients with COVID-19 presenting one-fold higher aminotransferase levels;and(3)patients with COVID-19 presenting two-fold higher aminotransferase *** analysed the association between elevated aminotransferase levels and all-cause in-hospital *** survival analysis was performed using the Kaplan–Meier method and tested by log-rank *** In total,376 of 419 patients met the inclusion criteria,while 29(8%)patients in our cohort died during the hospital *** median age was 40 years(range:28-56 years),and 51%were males(n=194).At admission,54%of the study cohort had liver *** pattern of liver injury was hepatocellular injury with an aspartate aminotransferase(AST)*** AST levels were independently associated with all-cause in-hospital mortality in the logistic regression analysis.A one-fold increase in serum AST levels among patients with COVID-19 led to an eleven-fold increase in in-hospital mortality(P<0.001).Admission AST levels correlated with C-reactive protein(r=0.2;P<0.003)and serum fer

关键词： COVID-19 Liver injury Aspartate amino transferase All-cause in-hospital mortality Serum ferritin SARS-CoV-2

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Mechanical performance of cold mix asphalt containing cup lump rubber as a sustainable bio-modifier

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 424-440页

作者： Syed Abdul Ghafar Muhammad Naqiuddin Mohd Warid Norhidayah Abdul Hassan Zulfiqar Ali Jattak Ashraf abdalla Mohammed Radwan Faculty of Civil Engineering Universiti Teknologi MalaysiaSkudai 81310Malaysia Department of Civil Engineering Balochistan University of Information TechnologyEngineering&Management SciencesQuettaPakistan Department of Civil Engineering Balochistan University of Engineering and TechnologyKhuzdarPakistan Department of Civil Engineering Faculty of EngineeringUniversity of TripoliTripoliLibya

The road construction industry aims to contribute to the protection of already compromised *** mix asphalt(CMA)is a measure initiated by the road industry to protect the environment and preserve *** having additional benefits,CMA has attracted little attention due to its inferior ***'s performance is enhanced using a sustainable binder bio-modifier,natural cup lump rubber(CLR)is one of *** study evaluated the tensile properties,rutting,moisture susceptibility,and adhesion properties of CLR-modified CMA(CMA-CR).The tensile property was enhanced by 26%due to CLR ***-CR had excellent rutting resistance of less than 2 mm rut depth at 10,000 load cycles,showing 70%improvement compared with conventional *** susceptibility evaluation indicated that CMA-CR had tensile strength ratio(TSR)value of 104%,satisfying the minimum 80%requirement of AASHTO *** also retained more than 96%bitumen *** moisture damage resistance was improved by 12%and 10%in terms of TSR and stripping,*** durability results revealed that the CMA-CR mixture prevented higher mass loss,representing 14%improvement compared with conventional CMA.

关键词： Cup lump rubber Cup lump modified cold mix asphalt Moisture damage Tensile property Rutting Digital imaging

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The genetic regulation of skeletal muscle development:insights from chicken studies

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Frontiers of Agricultural Science and Engineering 2017年第3期4卷 295-304页

作者： Wen LUO Bahareldin A.abdalla Qinghua NIE Xiquan ZHANG Department of Animal Genetics Breeding and ReproductionCollege of Animal ScienceSouth China Agricultural University Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken GeneticsBreeding and ReproductionMinistry of AgricultureSouth China Agricultural University

Skeletal muscle development is a complex multi-process trait regulated by various genetic *** chicken embryo is an ideal model system for studying skeletal muscle development. However, only a small proportion of the genetic factors affecting skeletal muscle development have been identified in chicken. The aim of this review is to summarize recent knowledge about the genetic factors involved in the regulation of skeletal muscle development in the chicken, such as gene polymorphisms, epigenetic modification, noncoding RNAs and transcription factors, which can influence skeletal muscle development at the genome, epigenome,transcriptome and proteome levels. Research on the regulation of skeletal muscle development in chicken is not yet comprehensive and most of the candidate genes and single nucleotide polymorphisms related to chicken muscle growth remain to be verified in experimental studies. In addition, the data derived from transcriptome sequencing and genome-wide association studies still require further investigation and analysis and comprehensive studies on the regulation of chicken skeletal muscle development will continue as a major research focus.

关键词： chicken epigenetic modification miRNAs skeletal muscle development SNP transcription factor

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Unconstrained Hand Dorsal Veins Image Database and Recognition System

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Computers, Materials & Continua 2022年第12期73卷 5063-5073页

作者： Mustafa M.Al Rifaee Mohammad M.abdallah Mosa I.Salah Ayman M.abdalla Faculty of Science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Architecture and Design Al-Zaytoonah University of JordanAmman11733Jordan

Hand veins can be used effectively in biometric recognition since they are internal organs that,in contrast to fingerprints,are robust under external environment effects such as dirt and paper ***,they form a complex rich shape that is unique,even in identical twins,and allows a high degree of ***,most currently employed hand-based biometric systems rely on hand-touch devices to capture images with the desired *** the start of the COVID-19 pandemic,most handbased biometric systems have become undesirable due to their possible impact on the spread of the ***,new contactless hand-based biometric recognition systems and databases are desired to keep up with the rising hygiene *** contribution of this research is the creation of a database for hand dorsal veins images obtained contact-free with a variation in capturing distance and rotation *** database consists of 1548 images collected from 86 participants whose ages ranged from 19 to 84 *** the other research contribution,a novel geometrical feature extraction method has been developed based on the Curvelet *** method is useful for extracting robust rotation invariance features from vein *** database attributes and the veins recognition results are analyzed to demonstrate their efficacy.

关键词： Biometric recognition contactless hand biometrics veins recognition Curvelet transform image segmentation feature extraction

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Electrospun polyvinyl alcohol fibres incorporating an antimicrobial gel for enzymatically controlled reactive oxygen species release

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Bio-Design and Manufacturing 2024年第6期7卷 899-925页

作者： Joel Yupanqui Mieles Cian Vyas Evangelos Daskalakis Mohamed Hassan James Birkett abdalla M.Omar Gavin Humphreys Carl Diver Paulo Bartolo Department of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Department of Chemistry University of ManchesterManchester M139PLUK Division of Pharmacy and Optometry University of ManchesterManchester M139PLUK Department of Engineering Manchester Metropolitan UniversityManchester M139PLUK

Wounds pose a risk to the skin,our body's primary defence against *** rise of antibiotic resistance has prompted the development of novel ***-101^(■)is an antimicrobial gel that delivers therapeutic levels of hydrogen peroxide(H_(2)O_(2)),a reactive oxygen species,directly to the wound *** this study,electrospinning was used to incorporate RO-101^(■)into a polyvinyl alcohol(PVA)sub-micron fibrous mesh that can act as a delivery agent,achieve a sustained release profile,and provide a barrier against *** incorporation of this gel into sub-micron fibres was confirmed via nuclear magnetic resonance ***,scanning electron microscopy exhibited smooth and uniform meshes with diameters in the 200-500 nm ***/RO-101 electrospun meshes generated H_(2)O_(2) in concentrations exceeding 1 m M/(g·m L)(1 m M=1 mmol/L)after 24 h,and the role of sterilisation on H_(2)O_(2) release was ***/RO-101meshes exhibited antimicrobial activity against both Gram-positive Staphylococcus aureus(***)and Gram-negative Pseudomonas aeruginosa(***)bacteria,achieving viable count reductions of up to 1 log unit CFU/mm^(2)(CFU:colony-forming units).Moreover,these meshes were capable of disrupting biofilm formation,even against multidrug-resistant organisms such as methicillin-resistant ***(MRSA).Furthermore,increasing the RO-101^(■)concentration resulted in higher H_(2)O_(2) production and an enhanced antimicrobial effect,while fibroblast cell viability and proliferation tests showed a concentration-dependent response with high cytocompatibility at low RO-101^(■)*** study therefore demonstrates the potential of highly absorbent PVA/RO-101 meshes as potential antimicrobial wound dressings.

关键词： Antimicrobial Electrospinning Hydrogen peroxide Polyvinyl alcohol Reactive oxygen species Tissue engineering Wound dressing

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