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Antioxidative,antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk:In-vitro,in-silico and molecular interaction studies

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Food Bioscience 2022年第3期47卷 583-594页

作者： Jodhani Keyur Ashokbhai Bethsheba Basaiawmoit Sujit Das Amar Sakure Ruchika Maurya mahendra bishnoi Kanthi Kiran Kondepudi Srichandan Padhi Amit Kumar Rai Zhenbin Liu Subrota Hatia Deptt.of Dairy Microbiology Anand Agricultural UniversityAnand388110GujaratIndia Deptt.of Rural Development and Agricultural Production North-Eastern Hill UniversityTura CampusTura794002MeghalayaIndia Deptt.of Agriculture Biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for Biotechnology FaridabadHaryana121001India Healthy Gut Research Group Food & Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Institute of Bioresources and Sustainable Development Regional CentreTadong737102SikkimIndia School of Food and Biological Engineering Shaanxi University of Science and Technology18Xi'an710021China

The antioxidative,antimicrobial,and anti-inflammatory properties of fermented sheep milk with *** (KGL4),as well as the generation of antioxidative and antimicrobial peptides,are evaluated in the *** and antibacterial activities in sheep milk fermented with KGL4 increased with incubation hours,along with varied antioxidative properties (ABTS assay:35.12%,hydroxyl free radical scavenging assay:29.12%,superoxide free radical scavenging activity:36.38%).Antimicrobial activity of fermented sheep milk against *** (19 mm),*** (15.67 mm),*** (14 mm),and *** (13 mm) was also ***,after 48 h,the KGL4 showed maximum proteolysis (10.40 mg/ml) at 2.5% rate of addition sheep *** antioxidative and antimicrobial activities of fermented sheep milk fractions (3 kDa and 10 kDa permeates and retentates) were also *** highest ABTS activity (26.90%) was found in 10 kDa permeate,whereas the 3 kDa retentate had higher hydroxyl free radical scavenging activity (69.20%) and 3 kDa permeate showed maximum superoxide free radical scavenging activity (32.85%).The 10 kDa retentate had shown maximum antimicrobial activity against *** (13.67 mm) and *** (17.00 mm).Proteins spotted on 2D gel electrophoresis of KGL4 were varied from 10 to 70 ***-LC/MS was used to identify 5 novel peptide sequences from 2-D gel *** in the BIOPEP database confirmed the antioxidative and antimicrobial effects of the novel fermented sheep milk *** sheep milk with KGL4 (SMKGL4) significantly reduced excessive TNF-α,IL-6,& IL-1β production in LPS-activated RAW 264.7 cells.

关键词： Fermentation Sheep milk Lactobacillus fermentum Antioxidative Antimicrobial Anti-inflammatory Peptides

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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA bishnoi NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP SINGH TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

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Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

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Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh Kumar Saini mahendra Singh Devendra Singh Prem Manohar Seervi Pera Jayavardhan Reddy Neelam Ramana Reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

Purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of PubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

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Cellulose-based smart materials:Novel synthesis techniques,properties,and applications in energy storage and conversion devices

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Electron 2024年第2期2卷 159-195页

作者： Pariksha bishnoi Samarjeet Singh Siwal Vijay Kumar Thakur Department of Chemistry M.M.Engineering CollegeMaharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryanaIndia Biorefining and Advanced Materials Research Center Scotland's Rural College(SRUC)EdinburghUK 3School of WaterEnergy and EnvironmentCranfield UniversityCranfieldUK

There has been a significant scope toward the cutting-edge in-vestigations in hierarchical carbon nanostructured electrodes originating from cellulosic materials,such as cellulose nanofibers,available from natural cellulose and bacterial *** of energy storage systems(ESSs)are typically established upon inorganic/metal mixtures,carbonaceous implications,and petroleum-derived hydrocarbon ***,these conventional substances may need help fulfilling the ever-increasing needs of *** has grown significantly as an impressive 1D element due to its natural availability,eco-friend-liness,recyclability,structural identity,simple transformation,and dimensional ***,in this review article,we have discussed the role and overview of cellulose-based hydrogels in ***,the extraction sources and solvents used for dissolution have been dis-cussed in ***,the properties(such as self-healing,trans-parency,strength and swelling behavior),and applications(such as flexible batteries,fuel cells,solar cells,flexible supercapacitors and carbon-based derived from cellulose)in energy storage devices and conclusion with existing challenges have been updated with recent findings.

关键词： batteries cellulose-based materials energy storage devices fuel cells hydrogels supercapacitors

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Rice-wheat comparative genomics:Gains and gaps

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The Crop Journal 2024年第3期12卷 656-669页

作者： Akila Wijerathna-Yapa Ruchi bishnoi Buddhini Ranawaka Manu Maya Magar Hafeez Ur Rehman Swati G.Bharad Michal T.Lorenc Vinita Ramtekey Sasha Gohar Charu Lata Md.Harun-Or-Rashid Maryam Razzaq Muhammad Sajjad Bhoja *** School of Agriculture and Food Sustainability The University of QueenslandSt LuciaQLD 4072Australia ARC Centre of Excellence for Plant Success in Nature and Agriculture The University of QueenslandSt LuciaQLD 4072Australia Department of Genetics and Plant Breeding College of AgricultureUmmedganj-KotaAgriculture UniversityKotaRajasthan 324001India Centre for Agriculture and the Bioeconomy Queensland University of Technology(QUT)2 George StreetBrisbaneQLD 4000Australia UWA School of Agriculture and Environment The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Nepal Agriculture Research Council KhumaltarLalitpurNepal Department of Agronomy University of AgricultureFaisalabad 38040Pakistan Department of Agricultural Botany Dr Panjabrao Deshmukh Krishi VidyapeethAkola 444104MaharashtraIndia ICAR-Indian Institute of Seed Science MauUttar Pradesh 275103India School of Natural Sciences Macquarie UniversityMacquarie ParkNSW 2109Australia ICAR-Indian Institute of Wheat and Barley Research Flowrdale 54642ShimlaIndia International Maize and Wheat Improvement Center(CIMMYT)Bangladesh Office Gulshan-2Dhaka 1212Bangladesh Center for Seed Science University of AgricultureFaisalabad 38000Pakistan Department of Biosciences COMSATS University IslamabadPark RoadTarlai KalanIslamabad 45550Pakistan CGIAR’s Excellence in Breeding(EiB)Platform/Accelerated Breeding Initiative International Maize and Wheat Improvement Center(CIMMYT)El Batán 56237Mexico

Rice and wheat provide nearly 40%of human calorie and protein *** share a common ancestor and belong to the Poaceae(grass)*** their genetic homology is crucial for developing new cultivars with enhanced *** wheat genes and gene families have been characterized based on their rice ***–wheat orthology can identify genetic regions that regulate similar traits in both ***–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.

关键词： Comparative genomics Orthologs Genes Synteny Genetic engineering Molecular breeding

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Probabilistic Analysis of Slope Using Finite Element Approach and Limit Equilibrium Approach around Amalpata Landslide of West Central, Nepal

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International Journal of Geosciences 2024年第5期15卷 416-432页

作者： mahendra Acharya Khomendra Bhandari Sandesh Dhakal Aasish Giri Prabin Kafle Central Department of Geology Tribhuvan University Kathmandu Nepal Department of Geology Tri-Chandra Multiple Campus Tribhuvan University Kathmandu Nepal Sri Revana Siddeshwara Institute of Technology Visvesvaraya Technological University Bengaluru India

The stability study of the ongoing and recurring Amalpata landslide in Baglung in Nepal’s Gandaki Province is presented in this research. The impacted slope is around 200 meters high, with two terraces that have different slope inclinations. The lower bench, located above the basement, consistently fails and sets others up for failure. The fluctuating water level of the slope, which travels down the slope masses, exacerbates the slide problem. The majority of these rocks are Amalpata landslide area experiences several structural disruptions. The area’s stability must be evaluated in order to prevent and control more harm from occurring to the nearby agricultural land and people living along the slope. The slopes’ failures increase the damages of house existing in nearby area and the erosion of the slope. Two modeling techniques the finite element approach and the limit equilibrium method were used to simulate the slope. The findings show that, in every case, the terrace above the basement is where the majority of the stress is concentrated, with a safety factor of near unity. Using probabilistic slope stability analysis, the failure probability was predicted to be between 98.90% and 100%.

关键词： Finite Element Approach Limit Equilibrium Method Slope Factor of Safety

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Integrated adsorption and photocatalytic removal of methylene blue dye from aqueous solution by hierarchical Nb_(2)O_(5)@PAN/PVDF/ANO composite nanofibers

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Nano Materials Science 2024年第1期6卷 96-105页

作者： Aditya Rianjanu Kurniawan Deny Pratama Marpaung Elisabeth Kartini Arum Melati Rizky Aflaha Yudha Gusti Wibowo I Putu mahendra Nursidik Yulianto Januar Widakdo Kuwat Triyana Hutomo Suryo Wasisto Tarmizi Taher Department of Materials Engineering Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Center for Green and Sustainable Materials Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Department of Environmental Engineering Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Department of Physics Faculty of Mathematics and Natural SciencesUniversitas Gadjah MadaSekip Utara PO Box BLS 21Yogyakarta55281Indonesia Department of Mining Engineering Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Department of Chemistry Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Research Center for Photonics National Research and Innovation Agency(BRIN)Kawasan Puspitek SerpongTangerang Selatan15314Indonesia Department of Physics Faculty of Mathematics and Natural SciencesUniversitas IndonesiaDepok16424Indonesia PT Nanosense Instrument Indonesia UmbulharjoYogyakarta55167Indonesia Department of Chemical Engineering Faculty of EngineeringUniversitas Gadjah MadaJl Grafika No.2Yogyakarta55281Indonesia

This work presents the development of hierarchical niobium pentoxide(Nb_(2)O_(5))-based composite nanofiber membranes for integrated adsorption and photocatalytic degradation of methylene blue(MB)pollutants from aqueous *** Nb_(2)O_(5) nanorods were vertically grown using a hydrothermal process on a base electrospun nanofibrous membrane made of polyacrylonitrile/polyvinylidene fluoride/ammonium niobate(V)oxalate hydrate(Nb_(2)O_(5)@PAN/PVDF/ANO).They were characterized using field-emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD)analysis,and Fourier transform infrared(FTIR)*** composite nanofibers possessed a narrow optical bandgap energy of 3.31 eV and demonstrated an MB degradation efficiency of 96%after 480 min contact *** pseudo-first-order kinetic study was also conducted,in which Nb_(2)O_(5)@PAN/PVDF/ANO nanofibers have kinetic constant values of 1.29×10^(-2) min^(-1) and 0.30×10^(-2) min^(-1) for adsorption and photocatalytic degradation of MB aqueous solutions,*** values are 17.7 and 7.8 times greater than those of PAN/PVDF/ANO nanofibers without Nb_(2)O_(5) *** their outstanding photocatalytic performance,the developed membrane materials exhibit advantageous characteristics in recycling,which subsequently widen their practical use in environmental remediation applications.

关键词： Hierarchical nanostructure Composite nanofiber Niobium pentoxide Dye degradation Synergetic adsorption and photocatalysis

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Comment on: Observation of peripheral refraction in myopic anisometropia in young adults

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1385-1386页

作者： Suraj Kumar Chaurasiya mahendra Singh Pradeep Agarwal Yu-Qin Du Yue-Hua Zhou Ming-Wei Ding Ming-Xu Zhang Yu-Juan Guo Shan-Shan Ge Department of Optometry and Vision Science CL Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)MoradabadUttar Pradesh 244001India Department of Paediatric and Neuro Ophthalmology CL Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)MoradabadUttar Pradesh 244001India Eye School of Chengdu University of TCM Ineye Hospital of Chengdu University of TCMChengdu 610036Sichuan ProvinceChina Beijing Ming Vision and Ophthalmology Beijing 100010China

Dear Editor,We read with great interest the recently published article titled“Observation of peripheral refraction in myopic anisometropia in young adults”by Du et al[1].The study conducted at the InEye Hospital of Chengdu University of TCM provides valuable insights into the relationship between anisometropia and peripheral refraction in myopic young *** commend the authors for their thorough investigation and adherence to ethical *** the study contributes significantly to our understanding of myopic anisometropia,we would like to draw attention to some limitations that merit consideration for a comprehensive interpretation of the findings.

关键词： Observation young insight

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Impact of binary blends of biodiesels on fuel quality,engine performance and emission characteristics

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Clean Energy 2023年第2期7卷 417-425页

作者： Sandeep Gupta mahendra Pal Sharma Department of Hydro and Renewable Energy Indian Institute of Technology RoorkeeUttarakhand(247667)India

The incessant pressure of energy requirements by the growing global populace has led to the exploration of unconventional methods to produce renewable and sustainable *** these,biodiesel is most suited to the present needs of eco-friendly standards to keep the atmosphere free from residual *** fuel-modification methods were developed over a couple of decades to make biodiesel suitable for diesel *** the present research,Jatropha curcas biodiesel and waste-cooking-oil(WCO)biodiesel were used to craft a unique binary blend to obtain desirable fuel properties and operational suitability for the diesel *** blend with 80% WCO biodiesel and 20% *** biodiesel,which had the most suitable fuel properties,was tested on a four-stroke single-cylinder vertical diesel *** emissions and operational parameters were analysed and compared with *** results of the study indicated that engine emissions for binary blend,carbon monoxide and unburnt hydrocarbon emissions were highly reduced,and carbon dioxide and nitrogen oxide(NO_(x))emissions increased relative to *** full load,NO_(x) emission was found to be 51.32% higher than that from diesel and 3.8% lower than that from WCO *** performance showed that for the binary blend,at full load,the brake-specific fuel consumption was 396.82 g/kWh,which was 15.26% higher,and the brake thermal efficiency was 22.7%,which was 2.74% lower than regular diesel *** present study suggests that the binary blend of *** biodiesel and WCO biodiesel can be a promising approach towards advancements in the fuel properties of biodiesels.

关键词： binary blends waste-cooking-oil biodiesel Jatropha curcas biodiesel engine emission engine performance

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Understanding human-leopard conflict in the ‘Mid-hill’ region of western Nepal

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Journal of Mountain Science 2023年第12期20卷 3464-3475页

作者： LAMICHHANE Saroj THAPA Arjun THAPA mahendra Singh PANTHI Saroj GIORDANO Anthony J School of Forestry and Natural Resources Management Institute of ForestryKirtipur 44613Nepal Institute of Fundamental Research and Studies(InFeRS) Baniyatar 44608Nepal Institute of Zoology Chinese Academy of SciencesBeijing 100101China Institute of Forestry Office of DeanKirtipur 44613Nepal Ministry of Industry TourismForest and EnvironmentKaski 33700Nepal SPECIES-The Society for the Preservation of Endangered Carnivores and their International Ecology Study VenturaCA 93006USA

Livestock rearing and agriculture are the main sources of community-based livelihoods in western *** the rural mid-hills region of Gandaki Province,leopards are the top predator and frequently depredate livestock and attack *** patterns of human-leopard conflicts(HLC) in Nepal are poorly known at the provincial and national scales,which are essential to formulating effective conflict mitigation strategies and implementing them in the *** study aims to analyze the spatiotemporal pattern of HLC by applying Maxent modeling to covariates relating to known and registered conflict cases(n=842) collected from Nepalese government *** found that cases of HLC have been increasing significantly over the past five *** also concluded that mid-elevation,south-facing slopes were more susceptible to HLC,but that mean annual temperature was by far the most important predictor of HLC;overall livestock density and proximity to roads were also important,but secondarily *** we found the increase in human fatalities to 2.16/year was significant(p0.05).However,we also found an increasing trend in livestock depredation rates for this same five-year period(p<0.05),which averaged 159.6 head/year among incidents *** also found that winter was the main season when depredations occurred,and that goats were the most depredated of all livestock.A total US $86,892.25($17,378.45/year) of economic losses were incurred by communities during this time,with 78.57% of the total value reimbursed as compensatory relief through the government’s relief *** recommend that the use of predator-proof livestock corrals,greater awareness in local communities about wildlife behavior,better animal husbandry and security practices,and a more efficient compensation program,can improve coexistence between leopard populations and human communities in western Nepal.

关键词： Coexistence Compensation Economic loss Human-wildlife conflict Livestock depredation Maximum entropy Problem animals Sustainable livelihood

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